SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AMO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ARG A 217
GLN A 231
GLU A 235
GLY A 486
GLY A 530
 AMO  A 831 (-3.0A)
AMO  A 831 (-3.2A)
None
AMO  A 831 (-3.5A)
AMO  A 831 (-4.3A)
 0.92A 1httB-1c0aA:
15.2		 1httB-1c0aA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLN A 231
GLU A 235
GLY A 486
GLY A 530
ALA A 532
 AMO  A 831 (-3.2A)
None
AMO  A 831 (-3.5A)
AMO  A 831 (-4.3A)
AMO  A 831 (-3.5A)
 0.86A 1httC-1c0aA:
14.2		 1httC-1c0aA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ARG A 217
GLN A 231
GLY A 486
GLY A 530
ALA A 532
 AMO  A 831 (-3.0A)
AMO  A 831 (-3.2A)
AMO  A 831 (-3.5A)
AMO  A 831 (-4.3A)
AMO  A 831 (-3.5A)
 0.50A 1httD-1c0aA:
14.5		 1httD-1c0aA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 ASP A 536
LEU A 535
GLY A 534
PHE A 533
 None
None
AMO  A 831 (-3.4A)
None
 0.86A 1rtsB-1c0aA:
undetectable		 1rtsB-1c0aA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A 536
LEU A 535
GLY A 534
PHE A 533
 None
None
AMO  A 831 (-3.4A)
None
 0.79A 2tsrB-1c0aA:
0.0		 2tsrB-1c0aA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 LEU A 531
GLN A 195
HIS A 448
GLY A 486
 None
AMO  A 831 (-3.7A)
AMO  A 831 (-3.9A)
AMO  A 831 (-3.5A)
 1.19A 3pp1A-1c0aA:
0.0		 3pp1A-1c0aA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 8 GLY A 485
GLY A 484
ILE A 232
LEU A 251
VAL A 234
 AMO  A 831 (-4.0A)
AMO  A 831 (-3.2A)
None
None
None
 1.18A 3v1nA-1c0aA:
undetectable		 3v1nA-1c0aA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A 536
LEU A 535
GLY A 534
PHE A 533
 None
None
AMO  A 831 (-3.4A)
None
 0.76A 4iqqD-1c0aA:
undetectable		 4iqqD-1c0aA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 8 ARG A 217
ARG A 225
PHE A 229
GLY A 484
ARG A 537
 AMO  A 831 (-3.0A)
C  B 674 (-3.1A)
AMO  A 831 (-3.2A)
AMO  A 831 (-3.2A)
AMO  A 831 (-4.0A)
 1.12A 4k87A-1c0aA:
11.8		 4k87A-1c0aA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ARG A 217
GLN A 231
GLY A 486
GLY A 530
ALA A 532
 AMO  A 831 (-3.0A)
AMO  A 831 (-3.2A)
AMO  A 831 (-3.5A)
AMO  A 831 (-4.3A)
AMO  A 831 (-3.5A)
 0.32A 5e3iA-1c0aA:
14.7		 5e3iA-1c0aA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ARG A 217
GLU A 235
GLY A 486
GLY A 530
ALA A 532
 AMO  A 831 (-3.0A)
None
AMO  A 831 (-3.5A)
AMO  A 831 (-4.3A)
AMO  A 831 (-3.5A)
 0.91A 5e3iA-1c0aA:
14.7		 5e3iA-1c0aA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 ARG A 217
GLN A 231
GLY A 486
GLY A 530
ALA A 532
 AMO  A 831 (-3.0A)
AMO  A 831 (-3.2A)
AMO  A 831 (-3.5A)
AMO  A 831 (-4.3A)
AMO  A 831 (-3.5A)
 0.34A 5e3iB-1c0aA:
15.2		 5e3iB-1c0aA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 ARG A 217
GLU A 235
GLY A 486
GLY A 530
ALA A 532
 AMO  A 831 (-3.0A)
None
AMO  A 831 (-3.5A)
AMO  A 831 (-4.3A)
AMO  A 831 (-3.5A)
 0.95A 5e3iB-1c0aA:
15.2		 5e3iB-1c0aA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 ASP A 536
LEU A 535
GLY A 534
PHE A 533
 None
None
AMO  A 831 (-3.4A)
None
 0.86A 5nooC-1c0aA:
0.0		 5nooC-1c0aA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A 536
LEU A 535
GLY A 534
PHE A 533
 None
None
AMO  A 831 (-3.4A)
None
 0.85A 5nooD-1c0aA:
0.0		 5nooD-1c0aA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 ASP A 536
LEU A 535
GLY A 534
PHE A 533
 None
None
AMO  A 831 (-3.4A)
None
 0.81A 5x5qC-1c0aA:
0.0		 5x5qC-1c0aA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 HIS A 449
SER A 487
TYR A 474
GLY A 486
 AMO  A 831 (-4.2A)
AMO  A 831 ( 4.5A)
None
AMO  A 831 (-3.5A)
 0.96A 5yodH-1c0aA:
undetectable		 5yodH-1c0aA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 10 ARG A 217
PHE A 229
GLU A 482
GLY A 534
ARG A 537
ILE A 548
 AMO  A 831 (-3.0A)
AMO  A 831 (-3.2A)
AMO  A 831 (-3.4A)
AMO  A 831 (-3.4A)
AMO  A 831 (-4.0A)
None
 0.44A 6bniA-1c0aA:
21.6		 6bniA-1c0aA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1c0a ASPARTYL TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 10 ARG A 217
PHE A 229
GLU A 482
GLY A 534
ARG A 537
ILE A 548
 AMO  A 831 (-3.0A)
AMO  A 831 (-3.2A)
AMO  A 831 (-3.4A)
AMO  A 831 (-3.4A)
AMO  A 831 (-4.0A)
None
 0.38A 6bniB-1c0aA:
27.4		 6bniB-1c0aA:
7.88