SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AMG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hr6 LECTIN
LECTIN
(Trichosanthes
anguina;
Trichosanthes
anguina) 		3 / 3 LYS B 179
ASP C 236
ASP C 146
 None
AMG  C 302 (-2.9A)
None
 0.99A 2br4D-4hr6B:
undetectable		 2br4D-4hr6B:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1f9k ACIDIC LECTIN
(Psophocarpus
tetragonolobus) 		5 / 12 GLY A  89
ALA A  87
PHE A 127
THR A 126
LEU A 155
 None
AMG  A 400 ( 3.7A)
AMG  A 400 ( 3.6A)
None
None
 0.59A 3dh0A-1f9kA:
undetectable		 3dh0A-1f9kA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4hr6 LECTIN
(Trichosanthes
anguina) 		3 / 3 ASP C  21
GLY C  24
TYR C  36
 AMG  C 301 (-2.8A)
AMG  C 301 (-3.7A)
AMG  C 301 (-3.6A)
 0.45A 3w9tC-4hr6C:
10.8		 3w9tC-4hr6C:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4hr6 LECTIN
(Trichosanthes
anguina) 		3 / 3 ASP C  21
GLY C  24
TYR C  36
 AMG  C 301 (-2.8A)
AMG  C 301 (-3.7A)
AMG  C 301 (-3.6A)
 0.45A 3w9tG-4hr6C:
11.0		 3w9tG-4hr6C:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		5 / 8 VAL A  80
ASP A 125
TYR A  78
GLY A 121
ALA A  24
 None
AMG  A 500 (-2.9A)
AMG  A 500 (-3.7A)
AMG  A 500 ( 3.7A)
None
 1.12A 4m48A-1tp8A:
undetectable		 4m48A-1tp8A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1f9k ACIDIC LECTIN
(Psophocarpus
tetragonolobus) 		5 / 12 GLY A 158
GLY A 106
THR A 212
PHE A 153
THR A  78
 NAG  A 501 (-4.2A)
AMG  A 400 (-3.2A)
None
None
NAG  A 503 ( 3.9A)
 1.26A 5eslA-1f9kA:
undetectable		 5eslA-1f9kA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 1f9k ACIDIC LECTIN
(Psophocarpus
tetragonolobus) 		4 / 8 TYR A 215
THR A 212
THR A  47
PRO A 113
 AMG  A 400 (-4.6A)
None
None
None
 1.12A 5jhdE-1f9kA:
1.4
5jhdG-1f9kA:
0.3		 5jhdE-1f9kA:
22.56
5jhdG-1f9kA:
16.03