SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ALS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE
(Homo
sapiens) 		5 / 12 GLY A 144
ASP A  53
MET A 142
GLY A 171
LEU A 194
 None
CA  A 604 ( 3.4A)
None
ALS  A  91 ( 4.4A)
None
 1.14A 1kiaC-1fsuA:
undetectable		 1kiaC-1fsuA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 1p49 STERYL-SULFATASE
(Homo
sapiens) 		4 / 5 ASP A 169
GLU A 174
THR A 165
LEU A 167
 None
None
ALS  A  75 ( 3.8A)
None
 1.14A 1u18B-1p49A:
undetectable		 1u18B-1p49A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1p49 STERYL-SULFATASE
(Homo
sapiens) 		4 / 7 SER A  95
LEU A  74
THR A  76
GLY A 109
 None
ALS  A  75 ( 4.0A)
ALS  A  75 ( 4.4A)
None
 0.96A 2ddwB-1p49A:
undetectable		 2ddwB-1p49A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE
(Homo
sapiens) 		4 / 4 LEU A 129
PRO A 130
LEU A  99
ARG A  95
 None
None
None
ALS  A  91 (-4.6A)
 1.39A 2hrcA-1fsuA:
0.0		 2hrcA-1fsuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE
(Homo
sapiens) 		5 / 12 GLY A 302
GLY A 328
SER A 298
ASP A  53
HIS A 242
 None
None
None
CA  A 604 ( 3.4A)
ALS  A  91 (-3.7A)
 1.26A 3dlcA-1fsuA:
undetectable		 3dlcA-1fsuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 HIS A 335
LYS A 347
ALA A 346
ASP A  45
 CA  A1551 (-3.3A)
ALS  A  84 ( 2.6A)
None
CA  A1551 (-3.0A)
 0.97A 4k0bB-5fqlA:
undetectable		 4k0bB-5fqlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 HIS A 335
LYS A 347
TYR A 300
ASP A  45
 CA  A1551 (-3.3A)
ALS  A  84 ( 2.6A)
None
CA  A1551 (-3.0A)
 0.84A 4k0bB-5fqlA:
undetectable		 4k0bB-5fqlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 HIS A 335
LYS A 347
ALA A 346
ASP A  45
 CA  A1551 (-3.3A)
ALS  A  84 ( 2.6A)
None
CA  A1551 (-3.0A)
 1.04A 4l7iB-5fqlA:
undetectable		 4l7iB-5fqlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 HIS A 335
LYS A 347
TYR A 300
ASP A  45
 CA  A1551 (-3.3A)
ALS  A  84 ( 2.6A)
None
CA  A1551 (-3.0A)
 0.88A 4l7iB-5fqlA:
undetectable		 4l7iB-5fqlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 7 HIS A 229
ASP A  45
LYS A 227
SER A 201
 ALS  A  84 ( 4.0A)
CA  A1551 (-3.0A)
None
None
 1.17A 4odjA-5fqlA:
undetectable		 4odjA-5fqlA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1p49 STERYL-SULFATASE
(Homo
sapiens) 		5 / 12 ASP A 310
ASP A  35
LYS A 134
SER A 295
TYR A 257
 None
CA  A 605 (-3.1A)
ALS  A  75 ( 2.8A)
None
None
 1.31A 5hfjE-1p49A:
undetectable		 5hfjE-1p49A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 1p49 STERYL-SULFATASE
(Homo
sapiens) 		4 / 8 PRO A 405
PHE A 118
SER A  78
ASN A 400
 None
None
ALS  A  75 ( 4.7A)
None
 0.72A 5l1fA-1p49A:
3.5
5l1fB-1p49A:
3.9		 5l1fA-1p49A:
20.42
5l1fB-1p49A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 8 THR A 355
SER A  87
SER A  90
ASP A  98
 None
ALS  A  84 ( 4.6A)
None
None
 1.07A 5l5fY-5fqlA:
0.0
5l5fZ-5fqlA:
0.0		 5l5fY-5fqlA:
17.99
5l5fZ-5fqlA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 6 ASP A  45
ASP A  46
HIS A 335
HIS A 229
 CA  A1551 (-3.0A)
CA  A1551 (-3.0A)
CA  A1551 (-3.3A)
ALS  A  84 ( 4.0A)
 0.93A 5ncdA-5fqlA:
undetectable
5ncdD-5fqlA:
2.1		 5ncdA-5fqlA:
20.34
5ncdD-5fqlA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		4 / 6 ASP A  45
ASP A  46
HIS A 335
HIS A 229
 CA  A1551 (-3.0A)
CA  A1551 (-3.0A)
CA  A1551 (-3.3A)
ALS  A  84 ( 4.0A)
 0.87A 5nelA-5fqlA:
undetectable
5nelD-5fqlA:
undetectable		 5nelA-5fqlA:
20.34
5nelD-5fqlA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens) 		5 / 12 ILE A  43
ASP A  45
HIS A 138
PRO A 139
SER A  87
 None
CA  A1551 (-3.0A)
ALS  A  84 ( 3.7A)
None
ALS  A  84 ( 4.6A)
 1.49A 6fbpA-5fqlA:
undetectable
6fbpB-5fqlA:
undetectable		 6fbpA-5fqlA:
9.90
6fbpB-5fqlA:
9.90