SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ALO'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_A_FFOA1002_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172 ALA A 173 ASN A 341 ARG A 357	None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A) None None ALO A 502 (-3.0A)	0.77A	1dfoA-2vmxA: 61.2	1dfoA-2vmxA: 59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_A_FFOA1002_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 SER A 172 ALA A 173 ASN A 341 SER A 349 PRO A 350 ARG A 357	None PLP A 501 ( 3.4A) ALO A 502 (-3.9A) None None None None ALO A 502 (-3.0A)	0.66A	1dfoA-2vmxA: 61.2	1dfoA-2vmxA: 59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_A_FFOA1002_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 12	LEU A 117 GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172	None None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A)	1.33A	1dfoA-2vmxA: 61.2	1dfoA-2vmxA: 59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_B_FFOB2002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172 ALA A 173 ASN A 341 ARG A 357	None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A) None None ALO A 502 (-3.0A)	0.77A	1dfoB-2vmxA: 62.3	1dfoB-2vmxA: 59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_B_FFOB2002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 SER A 172 ALA A 173 ASN A 341 SER A 349 PRO A 350 ARG A 357	None PLP A 501 ( 3.4A) ALO A 502 (-3.9A) None None None None ALO A 502 (-3.0A)	0.66A	1dfoB-2vmxA: 62.3	1dfoB-2vmxA: 59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_B_FFOB2002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 12	LEU A 117 GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172	None None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A)	1.33A	1dfoB-2vmxA: 62.3	1dfoB-2vmxA: 59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_C_FFOC3002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172 ALA A 173 ASN A 341 ARG A 357	None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A) None None ALO A 502 (-3.0A)	0.77A	1dfoC-2vmxA: 62.2	1dfoC-2vmxA: 59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_C_FFOC3002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 SER A 172 ALA A 173 ASN A 341 SER A 349 PRO A 350 ARG A 357	None PLP A 501 ( 3.4A) ALO A 502 (-3.9A) None None None None ALO A 502 (-3.0A)	0.66A	1dfoC-2vmxA: 62.2	1dfoC-2vmxA: 59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_C_FFOC3002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 12	LEU A 117 GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172	None None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A)	1.32A	1dfoC-2vmxA: 62.2	1dfoC-2vmxA: 59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_D_FFOD4002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172 ALA A 173 ASN A 341 ARG A 357	None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A) None None ALO A 502 (-3.0A)	0.77A	1dfoD-2vmxA: 61.2	1dfoD-2vmxA: 59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_D_FFOD4002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 SER A 172 ALA A 173 ASN A 341 SER A 349 PRO A 350 ARG A 357	None PLP A 501 ( 3.4A) ALO A 502 (-3.9A) None None None None ALO A 502 (-3.0A)	0.66A	1dfoD-2vmxA: 61.2	1dfoD-2vmxA: 59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_D_FFOD4002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 12	LEU A 117 GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172	None None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A)	1.33A	1dfoD-2vmxA: 61.2	1dfoD-2vmxA: 59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_A_FFOA1293_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172 ALA A 173 ASN A 341 ARG A 357	None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A) None None ALO A 502 (-3.0A)	0.79A	1eqbA-2vmxA: 61.0	1eqbA-2vmxA: 58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_A_FFOA1293_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 SER A 172 ALA A 173 ASN A 341 SER A 349 PRO A 350 ARG A 357	None PLP A 501 ( 3.4A) ALO A 502 (-3.9A) None None None None ALO A 502 (-3.0A)	0.66A	1eqbA-2vmxA: 61.0	1eqbA-2vmxA: 58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_A_GLYA1292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 8	SER A 31 HIS A 122 SER A 172 HIS A 200 LYS A 226 ARG A 357	ALO A 502 (-2.7A) PLP A 501 ( 3.4A) ALO A 502 (-3.9A) ALO A 502 ( 3.9A) PLP A 501 ( 3.6A) ALO A 502 (-3.0A)	0.50A	1eqbA-2vmxA: 61.0 1eqbB-2vmxA: 62.1	1eqbA-2vmxA: 58.85 1eqbB-2vmxA: 58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_B_FFOB2293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172 ALA A 173 ASN A 341 ARG A 357	None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A) None None ALO A 502 (-3.0A)	0.79A	1eqbB-2vmxA: 62.1	1eqbB-2vmxA: 58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_B_FFOB2293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 SER A 172 ALA A 173 ASN A 341 SER A 349 PRO A 350 ARG A 357	None PLP A 501 ( 3.4A) ALO A 502 (-3.9A) None None None None ALO A 502 (-3.0A)	0.67A	1eqbB-2vmxA: 62.1	1eqbB-2vmxA: 58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_B_GLYB2292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 8	SER A 31 HIS A 122 SER A 172 HIS A 200 LYS A 226 ARG A 357	ALO A 502 (-2.7A) PLP A 501 ( 3.4A) ALO A 502 (-3.9A) ALO A 502 ( 3.9A) PLP A 501 ( 3.6A) ALO A 502 (-3.0A)	0.51A	1eqbA-2vmxA: 61.0 1eqbB-2vmxA: 62.1	1eqbA-2vmxA: 58.85 1eqbB-2vmxA: 58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_C_FFOC3293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172 ALA A 173 ASN A 341 ARG A 357	None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A) None None ALO A 502 (-3.0A)	0.80A	1eqbC-2vmxA: 62.0	1eqbC-2vmxA: 58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_C_FFOC3293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 SER A 172 ALA A 173 ASN A 341 SER A 349 PRO A 350 ARG A 357	None PLP A 501 ( 3.4A) ALO A 502 (-3.9A) None None None None ALO A 502 (-3.0A)	0.67A	1eqbC-2vmxA: 62.0	1eqbC-2vmxA: 58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_C_GLYC3292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 8	SER A 31 HIS A 122 SER A 172 HIS A 200 LYS A 226 ARG A 357	ALO A 502 (-2.7A) PLP A 501 ( 3.4A) ALO A 502 (-3.9A) ALO A 502 ( 3.9A) PLP A 501 ( 3.6A) ALO A 502 (-3.0A)	0.51A	1eqbC-2vmxA: 62.0 1eqbD-2vmxA: 61.5	1eqbC-2vmxA: 58.85 1eqbD-2vmxA: 58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_D_FFOD4293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172 ALA A 173 ASN A 341 ARG A 357	None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A) None None ALO A 502 (-3.0A)	0.79A	1eqbD-2vmxA: 61.5	1eqbD-2vmxA: 58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_D_FFOD4293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 SER A 172 ALA A 173 ASN A 341 SER A 349 PRO A 350 ARG A 357	None PLP A 501 ( 3.4A) ALO A 502 (-3.9A) None None None None ALO A 502 (-3.0A)	0.67A	1eqbD-2vmxA: 61.5	1eqbD-2vmxA: 58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_D_GLYD4292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 8	SER A 31 HIS A 122 SER A 172 HIS A 200 LYS A 226 ARG A 357	ALO A 502 (-2.7A) PLP A 501 ( 3.4A) ALO A 502 (-3.9A) ALO A 502 ( 3.9A) PLP A 501 ( 3.6A) ALO A 502 (-3.0A)	0.50A	1eqbC-2vmxA: 62.0 1eqbD-2vmxA: 61.5	1eqbC-2vmxA: 58.85 1eqbD-2vmxA: 58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_A_FFOA505_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	7 / 12	GLY A 120 ALA A 173 ASN A 341 SER A 349 PRO A 350 GLY A 351 ARG A 357	None None None None None None ALO A 502 (-3.0A)	0.46A	2vmyB-2vmxA: 67.7	2vmyB-2vmxA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_A_FFOA505_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	7 / 12	GLY A 120 HIS A 122 ALA A 173 ASN A 341 SER A 349 GLY A 351 ARG A 357	None PLP A 501 ( 3.4A) None None None None ALO A 502 (-3.0A)	0.57A	2vmyB-2vmxA: 67.7	2vmyB-2vmxA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_A_FFOA505_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 12	GLY A 120 HIS A 122 LEU A 123 VAL A 129 ALA A 173 ARG A 357	None PLP A 501 ( 3.4A) None None None ALO A 502 (-3.0A)	0.52A	2vmyB-2vmxA: 67.7	2vmyB-2vmxA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_A_FFOA505_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 12	GLY A 120 HIS A 122 VAL A 129 ALA A 173 ASN A 341 ARG A 357	None PLP A 501 ( 3.4A) None None None ALO A 502 (-3.0A)	0.44A	2vmyB-2vmxA: 67.7	2vmyB-2vmxA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_A_FFOA505_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 12	HIS A 122 LEU A 123 VAL A 129 SER A 172 ALA A 173 ARG A 357	PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A) None ALO A 502 (-3.0A)	0.72A	2vmyB-2vmxA: 67.7	2vmyB-2vmxA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_A_FFOA505_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	7 / 12	HIS A 122 SER A 172 ALA A 173 ASN A 341 SER A 349 GLY A 351 ARG A 357	PLP A 501 ( 3.4A) ALO A 502 (-3.9A) None None None None ALO A 502 (-3.0A)	0.66A	2vmyB-2vmxA: 67.7	2vmyB-2vmxA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_A_FFOA505_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 12	HIS A 122 VAL A 129 SER A 172 ALA A 173 ASN A 341 ARG A 357	PLP A 501 ( 3.4A) None ALO A 502 (-3.9A) None None ALO A 502 (-3.0A)	0.66A	2vmyB-2vmxA: 67.7	2vmyB-2vmxA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_A_GLYA502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	5 / 7	SER A 31 HIS A 122 HIS A 200 LYS A 226 ARG A 357	ALO A 502 (-2.7A) PLP A 501 ( 3.4A) ALO A 502 ( 3.9A) PLP A 501 ( 3.6A) ALO A 502 (-3.0A)	0.26A	2vmyA-2vmxA: 67.4 2vmyB-2vmxA: 67.7	2vmyA-2vmxA: 100.00 2vmyB-2vmxA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_B_FFOB505_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172 ALA A 173 ASN A 339 ARG A 357	None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A) None None ALO A 502 (-3.0A)	0.89A	2vmyA-2vmxA: 67.4	2vmyA-2vmxA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_B_FFOB505_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	9 / 12	GLY A 120 HIS A 122 SER A 172 ALA A 173 ASN A 339 SER A 349 PRO A 350 GLY A 351 ARG A 357	None PLP A 501 ( 3.4A) ALO A 502 (-3.9A) None None None None None ALO A 502 (-3.0A)	0.94A	2vmyA-2vmxA: 67.4	2vmyA-2vmxA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_B_FFOB505_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	8 / 12	GLY A 120 HIS A 122 VAL A 129 SER A 172 ALA A 173 ASN A 339 GLY A 351 ARG A 357	None PLP A 501 ( 3.4A) None ALO A 502 (-3.9A) None None None ALO A 502 (-3.0A)	0.99A	2vmyA-2vmxA: 67.4	2vmyA-2vmxA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_B_FFOB505_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 12	LEU A 117 GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172	None None PLP A 501 ( 3.4A) None None ALO A 502 (-3.9A)	1.22A	2vmyA-2vmxA: 67.4	2vmyA-2vmxA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_B_GLYB502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	6 / 8	SER A 31 HIS A 122 SER A 172 HIS A 200 LYS A 226 ARG A 357	ALO A 502 (-2.7A) PLP A 501 ( 3.4A) ALO A 502 (-3.9A) ALO A 502 ( 3.9A) PLP A 501 ( 3.6A) ALO A 502 (-3.0A)	0.54A	2vmyA-2vmxA: 67.4 2vmyB-2vmxA: 67.7	2vmyA-2vmxA: 100.00 2vmyB-2vmxA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXC_A_ROCA401_2 (PROTEASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	3 / 3	ARG A 357 LEU A 312 THR A 227	ALO A 502 (-3.0A) None None	0.77A	3oxcA-2vmxA: undetectable	3oxcA-2vmxA: 14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SPK_B_TPVB100_1 (HIV-1 PROTEASE)	2vmx	SERINE HYDROXYMETHYLTRANSFE RASE (Geobacillus stearothermophil us)	5 / 9	ARG A 357 LEU A 312 ASN A 310 VAL A 285 GLY A 203	ALO A 502 (-3.0A) None None None None	1.23A	3spkA-2vmxA: undetectable	3spkA-2vmxA: 15.40

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DFO_A_FFOA1002_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172;ALA A 173;ASN A 341;ARG A 357","None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A);None;None;ALO A 502 (-3.0A)","0.77A","1dfoA-2vmxA:61.2",null],["1DFO_A_FFOA1002_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;SER A 172;ALA A 173;ASN A 341;SER A 349;PRO A 350;ARG A 357","None;PLP A 501 ( 3.4A);ALO A 502 (-3.9A);None;None;None;None;ALO A 502 (-3.0A)","0.66A","1dfoA-2vmxA:61.2","1dfoA-2vmxA:59.09"],["1DFO_A_FFOA1002_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"LEU A 117;GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172","None;None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A)","1.33A","1dfoA-2vmxA:61.2","1dfoA-2vmxA:59.09"],["1DFO_B_FFOB2002_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172;ALA A 173;ASN A 341;ARG A 357","None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A);None;None;ALO A 502 (-3.0A)","0.77A","1dfoB-2vmxA:62.3","1dfoA-2vmxA:59.09"],["1DFO_B_FFOB2002_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;SER A 172;ALA A 173;ASN A 341;SER A 349;PRO A 350;ARG A 357","None;PLP A 501 ( 3.4A);ALO A 502 (-3.9A);None;None;None;None;ALO A 502 (-3.0A)","0.66A","1dfoB-2vmxA:62.3","1dfoB-2vmxA:59.09"],["1DFO_B_FFOB2002_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"LEU A 117;GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172","None;None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A)","1.33A","1dfoB-2vmxA:62.3","1dfoB-2vmxA:59.09"],["1DFO_C_FFOC3002_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172;ALA A 173;ASN A 341;ARG A 357","None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A);None;None;ALO A 502 (-3.0A)","0.77A","1dfoC-2vmxA:62.2","1dfoB-2vmxA:59.09"],["1DFO_C_FFOC3002_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;SER A 172;ALA A 173;ASN A 341;SER A 349;PRO A 350;ARG A 357","None;PLP A 501 ( 3.4A);ALO A 502 (-3.9A);None;None;None;None;ALO A 502 (-3.0A)","0.66A","1dfoC-2vmxA:62.2","1dfoC-2vmxA:59.09"],["1DFO_C_FFOC3002_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"LEU A 117;GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172","None;None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A)","1.32A","1dfoC-2vmxA:62.2","1dfoC-2vmxA:59.09"],["1DFO_D_FFOD4002_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172;ALA A 173;ASN A 341;ARG A 357","None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A);None;None;ALO A 502 (-3.0A)","0.77A","1dfoD-2vmxA:61.2","1dfoC-2vmxA:59.09"],["1DFO_D_FFOD4002_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;SER A 172;ALA A 173;ASN A 341;SER A 349;PRO A 350;ARG A 357","None;PLP A 501 ( 3.4A);ALO A 502 (-3.9A);None;None;None;None;ALO A 502 (-3.0A)","0.66A","1dfoD-2vmxA:61.2","1dfoD-2vmxA:59.09"],["1DFO_D_FFOD4002_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"LEU A 117;GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172","None;None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A)","1.33A","1dfoD-2vmxA:61.2","1dfoD-2vmxA:59.09"],["1EQB_A_FFOA1293_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172;ALA A 173;ASN A 341;ARG A 357","None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A);None;None;ALO A 502 (-3.0A)","0.79A","1eqbA-2vmxA:61.0","1dfoD-2vmxA:59.09"],["1EQB_A_FFOA1293_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;SER A 172;ALA A 173;ASN A 341;SER A 349;PRO A 350;ARG A 357","None;PLP A 501 ( 3.4A);ALO A 502 (-3.9A);None;None;None;None;ALO A 502 (-3.0A)","0.66A","1eqbA-2vmxA:61.0","1eqbA-2vmxA:58.85"],["1EQB_A_GLYA1292_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"SER A  31;HIS A 122;SER A 172;HIS A 200;LYS A 226;ARG A 357","ALO A 502 (-2.7A);PLP A 501 ( 3.4A);ALO A 502 (-3.9A);ALO A 502 ( 3.9A);PLP A 501 ( 3.6A);ALO A 502 (-3.0A)","0.50A","1eqbA-2vmxA:61.0;1eqbB-2vmxA:62.1","1eqbA-2vmxA:58.85"],["1EQB_B_FFOB2293_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172;ALA A 173;ASN A 341;ARG A 357","None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A);None;None;ALO A 502 (-3.0A)","0.79A","1eqbB-2vmxA:62.1","1eqbA-2vmxA:58.85;1eqbB-2vmxA:58.85"],["1EQB_B_FFOB2293_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;SER A 172;ALA A 173;ASN A 341;SER A 349;PRO A 350;ARG A 357","None;PLP A 501 ( 3.4A);ALO A 502 (-3.9A);None;None;None;None;ALO A 502 (-3.0A)","0.67A","1eqbB-2vmxA:62.1","1eqbB-2vmxA:58.85"],["1EQB_B_GLYB2292_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"SER A  31;HIS A 122;SER A 172;HIS A 200;LYS A 226;ARG A 357","ALO A 502 (-2.7A);PLP A 501 ( 3.4A);ALO A 502 (-3.9A);ALO A 502 ( 3.9A);PLP A 501 ( 3.6A);ALO A 502 (-3.0A)","0.51A","1eqbA-2vmxA:61.0;1eqbB-2vmxA:62.1","1eqbB-2vmxA:58.85"],["1EQB_C_FFOC3293_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172;ALA A 173;ASN A 341;ARG A 357","None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A);None;None;ALO A 502 (-3.0A)","0.80A","1eqbC-2vmxA:62.0","1eqbA-2vmxA:58.85;1eqbB-2vmxA:58.85"],["1EQB_C_FFOC3293_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;SER A 172;ALA A 173;ASN A 341;SER A 349;PRO A 350;ARG A 357","None;PLP A 501 ( 3.4A);ALO A 502 (-3.9A);None;None;None;None;ALO A 502 (-3.0A)","0.67A","1eqbC-2vmxA:62.0","1eqbC-2vmxA:58.85"],["1EQB_C_GLYC3292_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"SER A  31;HIS A 122;SER A 172;HIS A 200;LYS A 226;ARG A 357","ALO A 502 (-2.7A);PLP A 501 ( 3.4A);ALO A 502 (-3.9A);ALO A 502 ( 3.9A);PLP A 501 ( 3.6A);ALO A 502 (-3.0A)","0.51A","1eqbC-2vmxA:62.0;1eqbD-2vmxA:61.5","1eqbC-2vmxA:58.85"],["1EQB_D_FFOD4293_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172;ALA A 173;ASN A 341;ARG A 357","None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A);None;None;ALO A 502 (-3.0A)","0.79A","1eqbD-2vmxA:61.5","1eqbC-2vmxA:58.85;1eqbD-2vmxA:58.85"],["1EQB_D_FFOD4293_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;SER A 172;ALA A 173;ASN A 341;SER A 349;PRO A 350;ARG A 357","None;PLP A 501 ( 3.4A);ALO A 502 (-3.9A);None;None;None;None;ALO A 502 (-3.0A)","0.67A","1eqbD-2vmxA:61.5","1eqbD-2vmxA:58.85"],["1EQB_D_GLYD4292_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"SER A  31;HIS A 122;SER A 172;HIS A 200;LYS A 226;ARG A 357","ALO A 502 (-2.7A);PLP A 501 ( 3.4A);ALO A 502 (-3.9A);ALO A 502 ( 3.9A);PLP A 501 ( 3.6A);ALO A 502 (-3.0A)","0.50A","1eqbC-2vmxA:62.0;1eqbD-2vmxA:61.5","1eqbD-2vmxA:58.85"],["2VMY_A_FFOA505_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",7,"GLY A 120;ALA A 173;ASN A 341;SER A 349;PRO A 350;GLY A 351;ARG A 357","None;None;None;None;None;None;ALO A 502 (-3.0A)","0.46A","2vmyB-2vmxA:67.7","1eqbC-2vmxA:58.85;1eqbD-2vmxA:58.85"],["2VMY_A_FFOA505_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",7,"GLY A 120;HIS A 122;ALA A 173;ASN A 341;SER A 349;GLY A 351;ARG A 357","None;PLP A 501 ( 3.4A);None;None;None;None;ALO A 502 (-3.0A)","0.57A","2vmyB-2vmxA:67.7","2vmyB-2vmxA:100.00"],["2VMY_A_FFOA505_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"GLY A 120;HIS A 122;LEU A 123;VAL A 129;ALA A 173;ARG A 357","None;PLP A 501 ( 3.4A);None;None;None;ALO A 502 (-3.0A)","0.52A","2vmyB-2vmxA:67.7","2vmyB-2vmxA:100.00"],["2VMY_A_FFOA505_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"GLY A 120;HIS A 122;VAL A 129;ALA A 173;ASN A 341;ARG A 357","None;PLP A 501 ( 3.4A);None;None;None;ALO A 502 (-3.0A)","0.44A","2vmyB-2vmxA:67.7","2vmyB-2vmxA:100.00"],["2VMY_A_FFOA505_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"HIS A 122;LEU A 123;VAL A 129;SER A 172;ALA A 173;ARG A 357","PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A);None;ALO A 502 (-3.0A)","0.72A","2vmyB-2vmxA:67.7","2vmyB-2vmxA:100.00"],["2VMY_A_FFOA505_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",7,"HIS A 122;SER A 172;ALA A 173;ASN A 341;SER A 349;GLY A 351;ARG A 357","PLP A 501 ( 3.4A);ALO A 502 (-3.9A);None;None;None;None;ALO A 502 (-3.0A)","0.66A","2vmyB-2vmxA:67.7","2vmyB-2vmxA:100.00"],["2VMY_A_FFOA505_1","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"HIS A 122;VAL A 129;SER A 172;ALA A 173;ASN A 341;ARG A 357","PLP A 501 ( 3.4A);None;ALO A 502 (-3.9A);None;None;ALO A 502 (-3.0A)","0.66A","2vmyB-2vmxA:67.7","2vmyB-2vmxA:100.00"],["2VMY_A_GLYA502_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",5,"SER A  31;HIS A 122;HIS A 200;LYS A 226;ARG A 357","ALO A 502 (-2.7A);PLP A 501 ( 3.4A);ALO A 502 ( 3.9A);PLP A 501 ( 3.6A);ALO A 502 (-3.0A)","0.26A","2vmyA-2vmxA:67.4;2vmyB-2vmxA:67.7","2vmyB-2vmxA:100.00"],["2VMY_B_FFOB505_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172;ALA A 173;ASN A 339;ARG A 357","None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A);None;None;ALO A 502 (-3.0A)","0.89A","2vmyA-2vmxA:67.4","2vmyA-2vmxA:100.00;2vmyB-2vmxA:100.00"],["2VMY_B_FFOB505_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",9,"GLY A 120;HIS A 122;SER A 172;ALA A 173;ASN A 339;SER A 349;PRO A 350;GLY A 351;ARG A 357","None;PLP A 501 ( 3.4A);ALO A 502 (-3.9A);None;None;None;None;None;ALO A 502 (-3.0A)","0.94A","2vmyA-2vmxA:67.4","2vmyA-2vmxA:100.00"],["2VMY_B_FFOB505_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",8,"GLY A 120;HIS A 122;VAL A 129;SER A 172;ALA A 173;ASN A 339;GLY A 351;ARG A 357","None;PLP A 501 ( 3.4A);None;ALO A 502 (-3.9A);None;None;None;ALO A 502 (-3.0A)","0.99A","2vmyA-2vmxA:67.4","2vmyA-2vmxA:100.00"],["2VMY_B_FFOB505_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"LEU A 117;GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172","None;None;PLP A 501 ( 3.4A);None;None;ALO A 502 (-3.9A)","1.22A","2vmyA-2vmxA:67.4","2vmyA-2vmxA:100.00"],["2VMY_B_GLYB502_0","SERINE HYDROXYMETHYLTRANSFERASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",6,"SER A  31;HIS A 122;SER A 172;HIS A 200;LYS A 226;ARG A 357","ALO A 502 (-2.7A);PLP A 501 ( 3.4A);ALO A 502 (-3.9A);ALO A 502 ( 3.9A);PLP A 501 ( 3.6A);ALO A 502 (-3.0A)","0.54A","2vmyA-2vmxA:67.4;2vmyB-2vmxA:67.7","2vmyA-2vmxA:100.00"],["3OXC_A_ROCA401_2","PROTEASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",3,"ARG A 357;LEU A 312;THR A 227","ALO A 502 (-3.0A);None;None","0.77A","3oxcA-2vmxA:undetectable","2vmyA-2vmxA:100.00;2vmyB-2vmxA:100.00"],["3SPK_B_TPVB100_1","HIV-1 PROTEASE;HIV-1 PROTEASE","2vmx","SERINE HYDROXYMETHYLTRANSFERASE","Geobacillus stearothermophilus",5,"ARG A 357;LEU A 312;ASN A 310;VAL A 285;GLY A 203","ALO A 502 (-3.0A);None;None;None;None","1.23A","3spkA-2vmxA:undetectable","3oxcA-2vmxA:14.32"]]