SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ALF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 10 GLU A1096
ALA A2179
LEU A2178
LEU A2215
GLU A1068
 ALF  A1501 ( 3.1A)
None
None
None
None
 1.46A 1a29A-3cmtA:
undetectable		 1a29A-3cmtA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 10 GLU A2096
ALA A3179
LEU A3178
LEU A3215
GLU A2068
 ALF  A2501 ( 3.3A)
None
None
None
None
 1.46A 1a29A-3cmtA:
undetectable		 1a29A-3cmtA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 10 GLU A3096
ALA A4179
LEU A4178
LEU A4215
GLU A3068
 ALF  A3501 ( 3.2A)
None
None
None
None
 1.44A 1a29A-3cmtA:
undetectable		 1a29A-3cmtA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 1oh9 ACETYLGLUTAMATE
KINASE
(Escherichia
coli) 		4 / 5 LEU A  14
SER A 147
LEU A  80
GLY A  10
 None
NLG  A1260 ( 3.7A)
NLG  A1260 ( 4.7A)
ALF  A1261 ( 3.1A)
 0.81A 1a4lC-1oh9A:
undetectable		 1a4lC-1oh9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 8 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.65A 1f5lA-1zcaA:
undetectable		 1f5lA-1zcaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 8 SER A  44
SER A  47
GLY A 203
GLY A  40
 GDP  A 401 (-3.6A)
MG  A 356 ( 1.9A)
ALF  A 355 (-3.3A)
None
 0.72A 1f5lA-2ik8A:
undetectable		 1f5lA-2ik8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wf7 BETA-PHOSPHOGLUCOMUT
ASE
(Lactococcus
lactis) 		5 / 8 THR A  16
GLY A  11
GLY A 119
LEU A 122
SER A 114
 None
MG  A1220 ( 4.5A)
None
None
ALF  A1219 (-2.8A)
 1.21A 1jhqA-2wf7A:
undetectable		 1jhqA-2wf7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wf7 BETA-PHOSPHOGLUCOMUT
ASE
(Lactococcus
lactis) 		5 / 9 THR A  16
GLY A  11
GLY A 119
LEU A 122
SER A 114
 None
MG  A1220 ( 4.5A)
None
None
ALF  A1219 (-2.8A)
 1.24A 1jhrA-2wf7A:
undetectable		 1jhrA-2wf7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wf7 BETA-PHOSPHOGLUCOMUT
ASE
(Lactococcus
lactis) 		5 / 8 THR A  16
GLY A  11
GLY A 119
LEU A 122
SER A 114
 None
MG  A1220 ( 4.5A)
None
None
ALF  A1219 (-2.8A)
 1.19A 1jhvA-2wf7A:
undetectable		 1jhvA-2wf7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wf7 BETA-PHOSPHOGLUCOMUT
ASE
(Lactococcus
lactis) 		5 / 9 THR A  16
GLY A  11
GLY A 119
LEU A 122
SER A 114
 None
MG  A1220 ( 4.5A)
None
None
ALF  A1219 (-2.8A)
 1.20A 1jhyA-2wf7A:
2.3		 1jhyA-2wf7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.86A 1jnoA-5jcpB:
undetectable		 1jnoA-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.86A 1jnoB-5jcpB:
undetectable		 1jnoB-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wf7 BETA-PHOSPHOGLUCOMUT
ASE
(Lactococcus
lactis) 		5 / 9 THR A  16
GLY A  11
GLY A 119
LEU A 122
SER A 114
 None
MG  A1220 ( 4.5A)
None
None
ALF  A1219 (-2.8A)
 1.22A 1l4nA-2wf7A:
undetectable		 1l4nA-2wf7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wf7 BETA-PHOSPHOGLUCOMUT
ASE
(Lactococcus
lactis) 		5 / 9 THR A  16
GLY A  11
GLY A 119
LEU A 122
SER A 114
 None
MG  A1220 ( 4.5A)
None
None
ALF  A1219 (-2.8A)
 1.21A 1l5kA-2wf7A:
undetectable		 1l5kA-2wf7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wf7 BETA-PHOSPHOGLUCOMUT
ASE
(Lactococcus
lactis) 		5 / 9 THR A  16
GLY A  11
GLY A 119
LEU A 122
SER A 114
 None
MG  A1220 ( 4.5A)
None
None
ALF  A1219 (-2.8A)
 1.21A 1l5mA-2wf7A:
undetectable		 1l5mA-2wf7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.91A 1magA-5jcpB:
undetectable		 1magA-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.91A 1magB-5jcpB:
undetectable		 1magB-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.88A 1ng8A-5jcpB:
undetectable		 1ng8A-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.88A 1ng8B-5jcpB:
undetectable		 1ng8B-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.91A 1nruA-5jcpB:
undetectable		 1nruA-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.91A 1nruB-5jcpB:
undetectable		 1nruB-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 8 THR A 499
GLY A 495
GLN A 665
ARG A 865
 MG  A1006 ( 3.3A)
ADP  A1004 ( 3.2A)
ALF  A1005 (-3.0A)
ALF  A1005 (-3.1A)
 0.92A 1rxcB-2xzoA:
undetectable		 1rxcB-2xzoA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 8 THR A 499
GLY A 495
GLN A 665
ARG A 865
 MG  A1006 ( 3.3A)
ADP  A1004 ( 3.2A)
ALF  A1005 (-3.0A)
ALF  A1005 (-3.1A)
 0.88A 1rxcI-2xzoA:
undetectable		 1rxcI-2xzoA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A  99
ALA A  98
GLU A  96
LEU A 107
ILE A 102
 None
None
ALF  A 501 ( 3.2A)
None
None
 0.95A 1s9pD-3cmtA:
undetectable		 1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A1099
ALA A1098
GLU A1096
LEU A1107
ILE A1102
 None
None
ALF  A1501 ( 3.1A)
None
None
 0.95A 1s9pD-3cmtA:
undetectable		 1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A2099
ALA A2098
GLU A2096
LEU A2107
ILE A2102
 None
None
ALF  A2501 ( 3.3A)
None
None
 0.95A 1s9pD-3cmtA:
undetectable		 1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A3099
ALA A3098
GLU A3096
LEU A3107
ILE A3102
 None
None
ALF  A3501 ( 3.2A)
None
None
 0.95A 1s9pD-3cmtA:
undetectable		 1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A4099
ALA A4098
GLU A4096
LEU A4107
ILE A4102
 None
None
ALF  A4501 ( 3.3A)
None
None
 0.94A 1s9pD-3cmtA:
undetectable		 1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmu PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A  99
ALA A  98
GLU A  96
LEU A 107
ILE A 102
 None
None
ALF  A 501 ( 2.4A)
None
None
 1.01A 1s9pD-3cmuA:
undetectable		 1s9pD-3cmuA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmu PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A2099
ALA A2098
GLU A2096
LEU A2107
ILE A2102
 None
None
ALF  A2501 ( 2.5A)
None
None
 1.01A 1s9pD-3cmuA:
undetectable		 1s9pD-3cmuA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmu PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A3099
ALA A3098
GLU A3096
LEU A3107
ILE A3102
 None
None
ALF  A3501 ( 2.7A)
None
None
 1.01A 1s9pD-3cmuA:
undetectable		 1s9pD-3cmuA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 6 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.77A 1tnlA-1zcaA:
undetectable		 1tnlA-1zcaA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3cmu PROTEIN RECA
(Escherichia
coli) 		4 / 8 LYS A1248
THR A 209
SER A  70
ARG A 226
 ALF  A 501 (-2.1A)
None
ADP  A 502 (-2.9A)
None
 1.08A 1xr2B-3cmuA:
undetectable		 1xr2B-3cmuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3cmu PROTEIN RECA
(Escherichia
coli) 		4 / 8 LYS A2248
THR A1209
SER A1070
ARG A1226
 ALF  A1501 (-2.3A)
None
ADP  A1502 (-2.9A)
None
 1.07A 1xr2B-3cmuA:
undetectable		 1xr2B-3cmuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3cmu PROTEIN RECA
(Escherichia
coli) 		4 / 8 LYS A3248
THR A2209
SER A2070
ARG A2226
 ALF  A2501 (-2.2A)
None
ADP  A2502 (-2.6A)
None
 1.08A 1xr2B-3cmuA:
undetectable		 1xr2B-3cmuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3cmu PROTEIN RECA
(Escherichia
coli) 		4 / 8 LYS A4248
THR A3209
SER A3070
ARG A3226
 ALF  A3501 (-2.3A)
None
ADP  A3502 (-2.7A)
None
 1.06A 1xr2B-3cmuA:
undetectable		 1xr2B-3cmuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3cmu PROTEIN RECA
(Escherichia
coli) 		4 / 8 LYS A5248
THR A4209
SER A4070
ARG A4226
 ALF  A4501 (-2.6A)
None
ADP  A4502 (-2.7A)
None
 1.07A 1xr2B-3cmuA:
undetectable		 1xr2B-3cmuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2i7d 5'(3')-DEOXYRIBONUCL
EOTIDASE, CYTOSOLIC
TYPE
(Homo
sapiens) 		3 / 3 LYS A 134
ASP A 185
ASP A 144
 ALF  A 400 (-2.8A)
None
ALF  A 400 ( 4.2A)
 0.99A 2br4D-2i7dA:
undetectable		 2br4D-2i7dA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 11 TYR A 717
GLY A 492
GLY A 661
GLU A 637
GLN A 665
 None
None
None
ALF  A1005 (-3.0A)
ALF  A1005 (-3.0A)
 1.48A 2dr2A-2xzoA:
undetectable		 2dr2A-2xzoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 11 ILE A 206
GLY A 225
GLU A 229
LEU A  52
GLY A 205
 None
ALF  A 378 (-3.2A)
None
None
None
 1.17A 2fn1A-1shzA:
undetectable		 2fn1A-1shzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2i7d 5'(3')-DEOXYRIBONUCL
EOTIDASE, CYTOSOLIC
TYPE
(Homo
sapiens) 		3 / 3 ASP A 144
ASP A 147
ASP A  12
 ALF  A 400 ( 4.2A)
None
DUR  A 300 (-3.7A)
 0.55A 2igtA-2i7dA:
2.3		 2igtA-2i7dA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2i7d 5'(3')-DEOXYRIBONUCL
EOTIDASE, CYTOSOLIC
TYPE
(Homo
sapiens) 		3 / 3 ASP A 144
ASP A 147
ASP A  12
 ALF  A 400 ( 4.2A)
None
DUR  A 300 (-3.7A)
 0.54A 2igtB-2i7dA:
2.4		 2igtB-2i7dA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 734
ASP A 341
SER A 265
GLY A 377
 ALF  A1002 (-2.6A)
MG  A1003 ( 3.9A)
MG  A1003 ( 2.1A)
None
 1.02A 2j2pD-5o6bA:
undetectable
2j2pF-5o6bA:
undetectable		 2j2pD-5o6bA:
18.81
2j2pF-5o6bA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 6 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.73A 2otvA-1zcaA:
undetectable		 2otvA-1zcaA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 1br2 MYOSIN
(Gallus
gallus) 		5 / 12 LEU A 670
SER A 179
TYR A 586
ASN A 483
ALA A 467
 None
ALF  A 999 (-2.7A)
None
None
None
 1.45A 2vdmA-1br2A:
0.0
2vdmB-1br2A:
undetectable		 2vdmA-1br2A:
19.49
2vdmB-1br2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 8 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.71A 2vinA-1zcaA:
undetectable		 2vinA-1zcaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 8 SER A  44
SER A  47
GLY A 203
GLY A  40
 GDP  A 401 (-3.6A)
MG  A 356 ( 1.9A)
ALF  A 355 (-3.3A)
None
 0.76A 2vinA-2ik8A:
undetectable		 2vinA-2ik8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2wf7 BETA-PHOSPHOGLUCOMUT
ASE
(Lactococcus
lactis) 		4 / 7 ASP A   8
SER A 114
SER A  48
LYS A 145
 ALF  A1219 ( 2.5A)
ALF  A1219 (-2.8A)
None
ALF  A1219 (-2.7A)
 1.14A 3bc9A-2wf7A:
undetectable		 3bc9A-2wf7A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2wf7 BETA-PHOSPHOGLUCOMUT
ASE
(Lactococcus
lactis) 		5 / 12 GLY A  46
ALA A 115
LEU A  44
ASP A 170
GLU A  42
 ALF  A1219 ( 3.1A)
G7P  A1221 ( 3.6A)
None
MG  A1220 (-2.5A)
None
 1.02A 3ckkA-2wf7A:
2.8		 3ckkA-2wf7A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 10 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.36A 3fhjA-2xzoA:
undetectable		 3fhjA-2xzoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 10 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.28A 3fhjB-2xzoA:
undetectable		 3fhjB-2xzoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 10 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.28A 3fhjC-2xzoA:
undetectable		 3fhjC-2xzoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 10 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.29A 3fhjE-2xzoA:
undetectable		 3fhjE-2xzoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.39A 3fi0A-2xzoA:
undetectable		 3fi0A-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.30A 3fi0C-2xzoA:
undetectable		 3fi0C-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.39A 3fi0K-2xzoA:
undetectable		 3fi0K-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.42A 3fi0L-2xzoA:
undetectable		 3fi0L-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.39A 3fi0M-2xzoA:
undetectable		 3fi0M-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.31A 3fi0N-2xzoA:
undetectable		 3fi0N-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzl ATP-DEPENDENT
HELICASE NAM7
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 597
GLN A 601
ASP A 572
ILE A 571
GLN A 576
 None
ALF  A1855 (-3.0A)
MG  A1856 ( 4.0A)
None
None
 1.45A 3fi0O-2xzlA:
undetectable		 3fi0O-2xzlA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.32A 3fi0O-2xzoA:
undetectable		 3fi0O-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzl ATP-DEPENDENT
HELICASE NAM7
(Saccharomyces
cerevisiae) 		5 / 7 GLY A 597
GLN A 601
ASP A 572
ILE A 571
GLN A 576
 None
ALF  A1855 (-3.0A)
MG  A1856 ( 4.0A)
None
None
 1.26A 3fi0P-2xzlA:
undetectable		 3fi0P-2xzlA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 7 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.15A 3fi0P-2xzoA:
undetectable		 3fi0P-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5fhh ATP-DEPENDENT DNA
HELICASE PIF1
(Homo
sapiens) 		4 / 7 GLY A 342
GLN A 346
ASP A 306
ILE A 305
 ALF  A 702 ( 4.7A)
ALF  A 702 (-2.2A)
ALF  A 702 ( 4.0A)
None
 0.73A 3fi0P-5fhhA:
undetectable		 3fi0P-5fhhA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5fhh ATP-DEPENDENT DNA
HELICASE PIF1
(Homo
sapiens) 		4 / 8 GLY A 342
GLN A 346
ASP A 306
ILE A 305
 ALF  A 702 ( 4.7A)
ALF  A 702 (-2.2A)
ALF  A 702 ( 4.0A)
None
 0.72A 3fi0Q-5fhhA:
undetectable		 3fi0Q-5fhhA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.31A 3fi0R-2xzoA:
undetectable		 3fi0R-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 709
ALA A 293
GLU A 342
ASP A 378
ALA A 260
 ALF  A1002 (-3.0A)
None
ALF  A1002 (-3.4A)
None
ALF  A1002 (-3.1A)
 1.32A 3nmuA-5o6bA:
undetectable
3nmuF-5o6bA:
undetectable		 3nmuA-5o6bA:
undetectable
3nmuF-5o6bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 6 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.64A 3rxfA-1zcaA:
undetectable		 3rxfA-1zcaA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 6 SER A  44
SER A  47
GLY A 203
GLY A  40
 GDP  A 401 (-3.6A)
MG  A 356 ( 1.9A)
ALF  A 355 (-3.3A)
None
 0.71A 3rxfA-2ik8A:
undetectable		 3rxfA-2ik8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		4 / 6 SER A  45
SER A  48
GLY A 145
GLY A  41
 GDP  A1000 (-3.9A)
MG  A1002 ( 2.3A)
ALF  A1001 (-3.5A)
None
 0.73A 3rxfA-3t34A:
undetectable		 3rxfA-3t34A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		5 / 12 ARG B 942
GLN B  63
GLY B  12
GLY B  62
ASN B  94
 GDP  B1201 ( 3.4A)
ALF  B1203 (-3.0A)
None
ALF  B1203 (-3.3A)
None
 1.24A 3sxjA-5jcpB:
undetectable		 3sxjA-5jcpB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		5 / 12 ARG B 942
GLN B  63
GLY B  12
GLY B  62
ASN B  94
 GDP  B1201 ( 3.4A)
ALF  B1203 (-3.0A)
None
ALF  B1203 (-3.3A)
None
 1.25A 3sxjB-5jcpB:
undetectable		 3sxjB-5jcpB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		5 / 12 ARG B 942
GLN B  63
GLY B  12
GLY B  62
ASN B  94
 GDP  B1201 ( 3.4A)
ALF  B1203 (-3.0A)
None
ALF  B1203 (-3.3A)
None
 1.25A 3t7sB-5jcpB:
undetectable		 3t7sB-5jcpB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3t12 GLIDING PROTEIN MGLA
(Thermus
thermophilus) 		5 / 11 THR A  26
GLY A  24
GLY A  81
PRO A  80
ASP A 104
 MG  A 198 ( 3.1A)
GDP  A 197 (-3.2A)
ALF  A 200 (-3.6A)
ALF  A 200 (-4.9A)
None
 1.30A 3t8nD-3t12A:
undetectable
3t8nF-3t12A:
undetectable		 3t8nD-3t12A:
19.70
3t8nF-3t12A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 VAL A 527
GLU A 637
VAL A 660
ILE A 635
ALA A 620
 None
ALF  A1005 (-3.0A)
None
None
None
 1.12A 4fwdA-2xzoA:
undetectable		 4fwdA-2xzoA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wf7 BETA-PHOSPHOGLUCOMUT
ASE
(Lactococcus
lactis) 		5 / 9 THR A  16
GLY A  11
GLY A 119
LEU A 122
SER A 114
 None
MG  A1220 ( 4.5A)
None
None
ALF  A1219 (-2.8A)
 1.28A 4kqiA-2wf7A:
undetectable		 4kqiA-2wf7A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		6 / 12 GLY A  60
GLY A  57
GLY A 225
SER A  59
ALA A 348
THR A 349
 GDP  A 475 (-3.2A)
ALF  A 378 (-3.3A)
ALF  A 378 (-3.2A)
GDP  A 475 (-3.4A)
GDP  A 475 (-3.5A)
GDP  A 475 (-3.8A)
 1.35A 4uckA-1shzA:
undetectable		 4uckA-1shzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		6 / 12 GLY A  45
GLY A  42
GLY A 203
SER A  44
ALA A 326
THR A 327
 GDP  A 401 (-3.3A)
ALF  A 355 (-3.3A)
ALF  A 355 (-3.3A)
GDP  A 401 (-3.6A)
GDP  A 401 (-3.2A)
GDP  A 401 (-3.3A)
 1.40A 4uckA-2ik8A:
undetectable		 4uckA-2ik8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		6 / 12 GLY A  45
GLY A  42
GLY A 204
SER A  44
ALA A 326
THR A 327
 GDP  A 361 (-2.8A)
ALF  A 365 (-3.0A)
ALF  A 365 (-3.2A)
GDP  A 361 (-4.0A)
GDP  A 361 (-3.4A)
GDP  A 361 (-3.4A)
 1.30A 4uckA-3c7kA:
undetectable		 4uckA-3c7kA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4ekd GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(Q) SUBUNIT
ALPHA
(Mus
musculus) 		6 / 12 GLY A  51
GLY A  48
GLY A 208
SER A  50
ALA A 331
THR A 332
 GDP  A 401 (-3.2A)
ALF  A 402 (-2.9A)
ALF  A 402 (-3.1A)
GDP  A 401 (-3.9A)
GDP  A 401 (-3.2A)
GDP  A 401 (-3.6A)
 1.41A 4uckA-4ekdA:
undetectable		 4uckA-4ekdA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 3t12 GLIDING PROTEIN MGLA
(Thermus
thermophilus) 		3 / 3 MET A 120
GLN A  82
TYR A  85
 None
ALF  A 200 (-3.8A)
None
 0.73A 4udcA-3t12A:
undetectable		 4udcA-3t12A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 2wf7 BETA-PHOSPHOGLUCOMUT
ASE
(Lactococcus
lactis) 		4 / 7 PHE A 151
ILE A 178
GLY A 174
LYS A 145
 None
None
None
ALF  A1219 (-2.7A)
 1.03A 4zxiA-2wf7A:
2.8		 4zxiA-2wf7A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 1br2 MYOSIN
(Gallus
gallus) 		5 / 12 PHE A 472
TYR A 586
ILE A 466
GLY A 468
ILE A 482
 None
None
None
ALF  A 999 (-2.8A)
None
 1.12A 5ifuA-1br2A:
undetectable		 5ifuA-1br2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 258
GLN A 413
LYS A 264
 None
None
ALF  A1002 ( 2.7A)
 0.94A 5imsB-5o6bA:
undetectable		 5imsB-5o6bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2xzl ATP-DEPENDENT
HELICASE NAM7
(Saccharomyces
cerevisiae) 		3 / 3 THR A 800
PRO A 432
ASP A 598
 None
ALF  A1855 (-3.7A)
None
 0.93A 5l8dB-2xzlA:
undetectable		 5l8dB-2xzlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 THR A 864
PRO A 494
ASP A 662
 None
ALF  A1005 (-3.6A)
None
 0.90A 5l8dB-2xzoA:
undetectable		 5l8dB-2xzoA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2xzl ATP-DEPENDENT
HELICASE NAM7
(Saccharomyces
cerevisiae) 		3 / 3 THR A 800
PRO A 432
ASP A 598
 None
ALF  A1855 (-3.7A)
None
 0.93A 5mwuB-2xzlA:
undetectable		 5mwuB-2xzlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 THR A 864
PRO A 494
ASP A 662
 None
ALF  A1005 (-3.6A)
None
 0.90A 5mwuB-2xzoA:
undetectable		 5mwuB-2xzoA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 4 GLY A 193
ALA A 111
MET A 105
THR A 248
 ALF  A1001 (-3.1A)
GDP  A1003 (-4.1A)
None
GDP  A1003 ( 4.4A)
 1.49A 5n0sB-4c7oA:
5.6		 5n0sB-4c7oA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1rk2 RIBOKINASE
(Escherichia
coli) 		5 / 10 LEU A 212
ILE A 217
GLY A 216
LEU A 194
LEU A 173
 None
None
ALF  A 315 (-3.7A)
None
None
 1.11A 5twjB-1rk2A:
undetectable		 5twjB-1rk2A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1rk2 RIBOKINASE
(Escherichia
coli) 		5 / 12 LEU A 212
ILE A 217
GLY A 216
LEU A 194
LEU A 173
 None
None
ALF  A 315 (-3.7A)
None
None
 1.07A 5twjC-1rk2A:
undetectable		 5twjC-1rk2A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2xzl ATP-DEPENDENT
HELICASE NAM7
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 597
GLN A 601
ASP A 572
ILE A 571
GLN A 576
 None
ALF  A1855 (-3.0A)
MG  A1856 ( 4.0A)
None
None
 1.22A 5v0iA-2xzlA:
undetectable		 5v0iA-2xzlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.13A 5v0iA-2xzoA:
undetectable		 5v0iA-2xzoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2xzl ATP-DEPENDENT
HELICASE NAM7
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 597
GLN A 601
ASP A 572
ILE A 571
GLN A 576
 None
ALF  A1855 (-3.0A)
MG  A1856 ( 4.0A)
None
None
 1.23A 5v0iB-2xzlA:
undetectable		 5v0iB-2xzlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.15A 5v0iB-2xzoA:
undetectable		 5v0iB-2xzoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		3 / 3 LYS A1250
LEU A  77
ASP A 144
 ALF  A 501 ( 3.0A)
None
MG  A 500 (-2.9A)
 0.89A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		3 / 3 LYS A2250
LEU A1077
ASP A1144
 ALF  A1501 ( 2.7A)
None
MG  A1500 (-3.2A)
 0.88A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		3 / 3 LYS A3250
LEU A2077
ASP A2144
 ALF  A2501 ( 2.9A)
None
MG  A2500 (-3.2A)
 0.89A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		3 / 3 LYS A4250
LEU A3077
ASP A3144
 ALF  A3501 ( 2.8A)
None
MG  A3500 (-3.3A)
 0.88A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 12 TYR A 169
LEU A 146
GLY A 145
VAL A 124
ASP A 142
 None
None
ALF  A1001 (-3.5A)
None
MG  A1002 ( 3.9A)
 1.38A 6bxlB-3t34A:
undetectable		 6bxlB-3t34A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 GLY A 497
VAL A 660
ARG A 703
GLN A 665
GLY A 492
 ADP  A1004 (-3.2A)
None
ALF  A1005 ( 2.8A)
ALF  A1005 (-3.0A)
None
 1.10A 6gneB-2xzoA:
2.4		 6gneB-2xzoA:
22.26