SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AKY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQU_A_ESTA304_1
(ESTROGEN
SULFOTRANSFERASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 11 CYH A 130
HIS A 138
SER A 376
TYR A 378
GLU A 374
 FAD  A 801 (-1.7A)
FAD  A 801 (-3.6A)
None
AKY  A 601 (-4.5A)
AKY  A 601 ( 4.6A)
 1.46A 1aquA-2ipiA:
0.0
1aquB-2ipiA:
0.0		 1aquA-2ipiA:
18.30
1aquB-2ipiA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		3 / 3 TYR A 378
TYR A 450
GLU A 374
 AKY  A 601 (-4.5A)
AKY  A 601 (-4.4A)
AKY  A 601 ( 4.6A)
 0.92A 3pfgA-2ipiA:
undetectable		 3pfgA-2ipiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 THR A 336
THR A 408
GLY A  31
ASP A 415
 AKY  A 601 (-4.5A)
AKY  A 601 (-2.8A)
None
None
 0.80A 4qvvK-2ipiA:
undetectable
4qvvL-2ipiA:
undetectable		 4qvvK-2ipiA:
16.70
4qvvL-2ipiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		4 / 8 THR A 336
THR A 408
GLY A  31
ASP A 415
 AKY  A 601 (-4.5A)
AKY  A 601 (-2.8A)
None
None
 0.82A 4qvvY-2ipiA:
undetectable
4qvvZ-2ipiA:
undetectable		 4qvvY-2ipiA:
16.70
4qvvZ-2ipiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)
(Streptomyces
galilaeus) 		5 / 12 SER A 376
THR A 342
THR A 408
ALA A 407
TYR A 450
 None
AKY  A 601 ( 4.7A)
AKY  A 601 (-2.8A)
None
AKY  A 601 (-4.4A)
 1.05A 4u15B-2ipiA:
undetectable		 4u15B-2ipiA:
21.56