SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AKV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2f99 AKLANONIC ACID
METHYL ESTER
CYCLASE, AKNH
(Streptomyces
galilaeus) 		3 / 3 TRP A  54
HIS A  87
MET A  91
 AKV  A1335 (-3.3A)
None
AKV  A1335 (-3.7A)
 1.38A 1l5qB-2f99A:
undetectable		 1l5qB-2f99A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 2f99 AKLANONIC ACID
METHYL ESTER
CYCLASE, AKNH
(Streptomyces
galilaeus) 		5 / 12 TYR A 125
MET A  91
THR A  58
PHE A 101
LEU A 132
 AKV  A1335 (-4.6A)
AKV  A1335 (-3.7A)
None
None
None
 1.48A 2mjiA-2f99A:
0.8		 2mjiA-2f99A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 2f99 AKLANONIC ACID
METHYL ESTER
CYCLASE, AKNH
(Streptomyces
galilaeus) 		4 / 7 HIS A 107
ASP A 121
HIS A 119
VAL A  52
 None
AKV  A1335 (-2.7A)
None
None
 0.99A 4hvrA-2f99A:
undetectable		 4hvrA-2f99A:
21.91