SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AKB'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_A_GLYA1292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1fc4	2-AMINO-3-KETOBUTYRA TE CONENZYME A LIGASE (Escherichia coli)	5 / 8	HIS A 136 SER A 185 HIS A 213 LYS A 244 ARG A 368	PLP A1201 ( 3.4A) AKB A1200 ( 2.9A) PLP A1201 ( 3.9A) PLP A1201 ( 2.9A) AKB A1200 (-2.6A)	0.94A	1eqbA-1fc4A: 29.3 1eqbB-1fc4A: 29.1	1eqbA-1fc4A: 26.22 1eqbB-1fc4A: 26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_B_GLYB2292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1fc4	2-AMINO-3-KETOBUTYRA TE CONENZYME A LIGASE (Escherichia coli)	5 / 8	HIS A 136 SER A 185 HIS A 213 LYS A 244 ARG A 368	PLP A1201 ( 3.4A) AKB A1200 ( 2.9A) PLP A1201 ( 3.9A) PLP A1201 ( 2.9A) AKB A1200 (-2.6A)	0.94A	1eqbA-1fc4A: 29.3 1eqbB-1fc4A: 29.1	1eqbA-1fc4A: 26.22 1eqbB-1fc4A: 26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_C_GLYC3292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1fc4	2-AMINO-3-KETOBUTYRA TE CONENZYME A LIGASE (Escherichia coli)	5 / 8	HIS A 136 SER A 185 HIS A 213 LYS A 244 ARG A 368	PLP A1201 ( 3.4A) AKB A1200 ( 2.9A) PLP A1201 ( 3.9A) PLP A1201 ( 2.9A) AKB A1200 (-2.6A)	0.93A	1eqbC-1fc4A: 29.2 1eqbD-1fc4A: 28.9	1eqbC-1fc4A: 26.22 1eqbD-1fc4A: 26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_D_GLYD4292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1fc4	2-AMINO-3-KETOBUTYRA TE CONENZYME A LIGASE (Escherichia coli)	5 / 8	HIS A 136 SER A 185 HIS A 213 LYS A 244 ARG A 368	PLP A1201 ( 3.4A) AKB A1200 ( 2.9A) PLP A1201 ( 3.9A) PLP A1201 ( 2.9A) AKB A1200 (-2.6A)	0.93A	1eqbC-1fc4A: 29.2 1eqbD-1fc4A: 28.9	1eqbC-1fc4A: 26.22 1eqbD-1fc4A: 26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA3_A_STRA1001_1 (MINERALOCORTICOID RECEPTOR)	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C 57)	5 / 12	LEU A 204 LEU A 166 GLN A 10 LEU A 73 THR A 202	None NAD A 402 (-3.8A) NAD A 402 (-3.8A) AKB A 401 (-4.1A) None	1.43A	1ya3A-5y1gA: undetectable	1ya3A-5y1gA: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AA5_B_STRB302_1 (MINERALOCORTICOID RECEPTOR)	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C 57)	5 / 12	LEU A 204 LEU A 166 GLN A 10 LEU A 73 THR A 202	None NAD A 402 (-3.8A) NAD A 402 (-3.8A) AKB A 401 (-4.1A) None	1.45A	2aa5B-5y1gA: undetectable	2aa5B-5y1gA: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OAX_A_SNLA1001_1 (MINERALOCORTICOID RECEPTOR)	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C 57)	5 / 12	LEU A 204 LEU A 166 GLN A 10 LEU A 73 THR A 202	None NAD A 402 (-3.8A) NAD A 402 (-3.8A) AKB A 401 (-4.1A) None	1.47A	2oaxA-5y1gA: undetectable	2oaxA-5y1gA: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VMY_A_GLYA502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1fc4	2-AMINO-3-KETOBUTYRA TE CONENZYME A LIGASE (Escherichia coli)	4 / 7	HIS A 136 HIS A 213 LYS A 244 ARG A 368	PLP A1201 ( 3.4A) PLP A1201 ( 3.9A) PLP A1201 ( 2.9A) AKB A1200 (-2.6A)	0.61A	2vmyA-1fc4A: 29.6 2vmyB-1fc4A: 29.4	2vmyA-1fc4A: 26.01 2vmyB-1fc4A: 26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VMY_B_GLYB502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1fc4	2-AMINO-3-KETOBUTYRA TE CONENZYME A LIGASE (Escherichia coli)	5 / 8	HIS A 136 SER A 185 HIS A 213 LYS A 244 ARG A 368	PLP A1201 ( 3.4A) AKB A1200 ( 2.9A) PLP A1201 ( 3.9A) PLP A1201 ( 2.9A) AKB A1200 (-2.6A)	0.97A	2vmyA-1fc4A: 29.6 2vmyB-1fc4A: 29.5	2vmyA-1fc4A: 26.01 2vmyB-1fc4A: 26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UA1_A_08YA600_1 (CYTOCHROME P450 3A4)	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C 57)	5 / 12	ARG A 203 ILE A 275 ALA A 113 THR A 134 ALA A 268	None None AKB A 401 ( 4.4A) None None	1.35A	3ua1A-5y1gA: undetectable	3ua1A-5y1gA: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UA1_A_08YA600_1 (CYTOCHROME P450 3A4)	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C 57)	5 / 12	ASP A 179 ILE A 213 THR A 178 PHE A 107 ALA A 70	None None AKB A 401 (-3.3A) None NAD A 402 (-3.7A)	1.32A	3ua1A-5y1gA: undetectable	3ua1A-5y1gA: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QTU_B_SAMB301_1 (PUTATIVE METHYLTRANSFERASE BUD23)	1fc4	2-AMINO-3-KETOBUTYRA TE CONENZYME A LIGASE (Escherichia coli)	4 / 5	TYR A 52 GLN A 370 SER A 185 ASP A 113	None None AKB A1200 ( 2.9A) None	1.17A	4qtuB-1fc4A: 2.6	4qtuB-1fc4A: 18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V2Z_A_Y70A151_1 (CEREBLON ISOFORM 4)	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C 57)	4 / 7	PRO A 272 PHE A 115 TRP A 271 TYR A 136	None None AKB A 401 (-4.5A) AKB A 401 (-4.5A)	1.48A	4v2zA-5y1gA: undetectable	4v2zA-5y1gA: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XI3_B_29SB601_1 (ESTROGEN RECEPTOR)	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C 57)	6 / 12	ALA A 215 LEU A 219 LEU A 235 ARG A 281 GLY A 165 LEU A 166	None None None None AKB A 401 ( 3.7A) NAD A 402 (-3.8A)	1.45A	4xi3B-5y1gA: undetectable	4xi3B-5y1gA: 18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XI3_C_29SC601_1 (ESTROGEN RECEPTOR)	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C 57)	6 / 12	ALA A 215 LEU A 219 LEU A 235 ARG A 281 GLY A 165 LEU A 166	None None None None AKB A 401 ( 3.7A) NAD A 402 (-3.8A)	1.44A	4xi3C-5y1gA: undetectable	4xi3C-5y1gA: 18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AMI_B_EF2B151_1 (CEREBLON ISOFORM 4)	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C 57)	4 / 8	PRO A 272 PHE A 115 TRP A 271 TYR A 136	None None AKB A 401 (-4.5A) AKB A 401 (-4.5A)	1.45A	5amiB-5y1gA: undetectable	5amiB-5y1gA: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AMK_A_EF2A151_1 (CEREBLON ISOFORM 4)	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C 57)	4 / 8	PRO A 272 PHE A 115 TRP A 271 TYR A 136	None None AKB A 401 (-4.5A) AKB A 401 (-4.5A)	1.36A	5amkA-5y1gA: undetectable	5amkA-5y1gA: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OH1_B_EF2B202_0 (CEREBLON ISOFORM 4)	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C 57)	4 / 7	PRO A 272 PHE A 115 TRP A 271 TYR A 136	None None AKB A 401 (-4.5A) AKB A 401 (-4.5A)	1.48A	5oh1B-5y1gA: undetectable	5oh1B-5y1gA: 14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OH3_B_9V2B202_0 (CEREBLON ISOFORM 4)	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C 57)	4 / 7	PRO A 272 PHE A 115 TRP A 271 TYR A 136	None None AKB A 401 (-4.5A) AKB A 401 (-4.5A)	1.44A	5oh3B-5y1gA: undetectable	5oh3B-5y1gA: 17.89

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EQB_A_GLYA1292_0","SERINE HYDROXYMETHYLTRANSFERASE","1fc4","2-AMINO-3-KETOBUTYRATE CONENZYME A LIGASE","Escherichia coli",5,"HIS A 136;SER A 185;HIS A 213;LYS A 244;ARG A 368","PLP A1201 ( 3.4A);AKB A1200 ( 2.9A);PLP A1201 ( 3.9A);PLP A1201 ( 2.9A);AKB A1200 (-2.6A)","0.94A","1eqbA-1fc4A:29.3;1eqbB-1fc4A:29.1",null],["1EQB_B_GLYB2292_0","SERINE HYDROXYMETHYLTRANSFERASE","1fc4","2-AMINO-3-KETOBUTYRATE CONENZYME A LIGASE","Escherichia coli",5,"HIS A 136;SER A 185;HIS A 213;LYS A 244;ARG A 368","PLP A1201 ( 3.4A);AKB A1200 ( 2.9A);PLP A1201 ( 3.9A);PLP A1201 ( 2.9A);AKB A1200 (-2.6A)","0.94A","1eqbA-1fc4A:29.3;1eqbB-1fc4A:29.1","1eqbA-1fc4A:26.22;1eqbB-1fc4A:26.22"],["1EQB_C_GLYC3292_0","SERINE HYDROXYMETHYLTRANSFERASE","1fc4","2-AMINO-3-KETOBUTYRATE CONENZYME A LIGASE","Escherichia coli",5,"HIS A 136;SER A 185;HIS A 213;LYS A 244;ARG A 368","PLP A1201 ( 3.4A);AKB A1200 ( 2.9A);PLP A1201 ( 3.9A);PLP A1201 ( 2.9A);AKB A1200 (-2.6A)","0.93A","1eqbC-1fc4A:29.2;1eqbD-1fc4A:28.9","1eqbA-1fc4A:26.22;1eqbB-1fc4A:26.22"],["1EQB_D_GLYD4292_0","SERINE HYDROXYMETHYLTRANSFERASE","1fc4","2-AMINO-3-KETOBUTYRATE CONENZYME A LIGASE","Escherichia coli",5,"HIS A 136;SER A 185;HIS A 213;LYS A 244;ARG A 368","PLP A1201 ( 3.4A);AKB A1200 ( 2.9A);PLP A1201 ( 3.9A);PLP A1201 ( 2.9A);AKB A1200 (-2.6A)","0.93A","1eqbC-1fc4A:29.2;1eqbD-1fc4A:28.9","1eqbC-1fc4A:26.22;1eqbD-1fc4A:26.22"],["1YA3_A_STRA1001_1","MINERALOCORTICOID RECEPTOR","5y1g","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","uncultured archaeon MedDCM-OCT-S05-C57",5,"LEU A 204;LEU A 166;GLN A  10;LEU A  73;THR A 202","None;NAD A 402 (-3.8A);NAD A 402 (-3.8A);AKB A 401 (-4.1A);None","1.43A","1ya3A-5y1gA:undetectable","1eqbC-1fc4A:26.22;1eqbD-1fc4A:26.22"],["2AA5_B_STRB302_1","MINERALOCORTICOID RECEPTOR","5y1g","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","uncultured archaeon MedDCM-OCT-S05-C57",5,"LEU A 204;LEU A 166;GLN A  10;LEU A  73;THR A 202","None;NAD A 402 (-3.8A);NAD A 402 (-3.8A);AKB A 401 (-4.1A);None","1.45A","2aa5B-5y1gA:undetectable","1ya3A-5y1gA:21.30"],["2OAX_A_SNLA1001_1","MINERALOCORTICOID RECEPTOR","5y1g","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","uncultured archaeon MedDCM-OCT-S05-C57",5,"LEU A 204;LEU A 166;GLN A  10;LEU A  73;THR A 202","None;NAD A 402 (-3.8A);NAD A 402 (-3.8A);AKB A 401 (-4.1A);None","1.47A","2oaxA-5y1gA:undetectable","2aa5B-5y1gA:20.29"],["2VMY_A_GLYA502_0","SERINE HYDROXYMETHYLTRANSFERASE","1fc4","2-AMINO-3-KETOBUTYRATE CONENZYME A LIGASE","Escherichia coli",4,"HIS A 136;HIS A 213;LYS A 244;ARG A 368","PLP A1201 ( 3.4A);PLP A1201 ( 3.9A);PLP A1201 ( 2.9A);AKB A1200 (-2.6A)","0.61A","2vmyA-1fc4A:29.6;2vmyB-1fc4A:29.4","2oaxA-5y1gA:21.53"],["2VMY_B_GLYB502_0","SERINE HYDROXYMETHYLTRANSFERASE","1fc4","2-AMINO-3-KETOBUTYRATE CONENZYME A LIGASE","Escherichia coli",5,"HIS A 136;SER A 185;HIS A 213;LYS A 244;ARG A 368","PLP A1201 ( 3.4A);AKB A1200 ( 2.9A);PLP A1201 ( 3.9A);PLP A1201 ( 2.9A);AKB A1200 (-2.6A)","0.97A","2vmyA-1fc4A:29.6;2vmyB-1fc4A:29.5","2vmyA-1fc4A:26.01;2vmyB-1fc4A:26.01"],["3UA1_A_08YA600_1","CYTOCHROME P450 3A4","5y1g","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","uncultured archaeon MedDCM-OCT-S05-C57",5,"ARG A 203;ILE A 275;ALA A 113;THR A 134;ALA A 268","None;None;AKB A 401 ( 4.4A);None;None","1.35A","3ua1A-5y1gA:undetectable","2vmyA-1fc4A:26.01;2vmyB-1fc4A:26.01"],["3UA1_A_08YA600_1","CYTOCHROME P450 3A4","5y1g","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","uncultured archaeon MedDCM-OCT-S05-C57",5,"ASP A 179;ILE A 213;THR A 178;PHE A 107;ALA A  70","None;None;AKB A 401 (-3.3A);None;NAD A 402 (-3.7A)","1.32A","3ua1A-5y1gA:undetectable","3ua1A-5y1gA:20.83"],["4QTU_B_SAMB301_1","PUTATIVE METHYLTRANSFERASE BUD23","1fc4","2-AMINO-3-KETOBUTYRATE CONENZYME A LIGASE","Escherichia coli",4,"TYR A  52;GLN A 370;SER A 185;ASP A 113","None;None;AKB A1200 ( 2.9A);None","1.17A","4qtuB-1fc4A:2.6","3ua1A-5y1gA:20.83"],["4V2Z_A_Y70A151_1","CEREBLON ISOFORM 4","5y1g","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","uncultured archaeon MedDCM-OCT-S05-C57",4,"PRO A 272;PHE A 115;TRP A 271;TYR A 136","None;None;AKB A 401 (-4.5A);AKB A 401 (-4.5A)","1.48A","4v2zA-5y1gA:undetectable","4qtuB-1fc4A:18.32"],["4XI3_B_29SB601_1","ESTROGEN RECEPTOR","5y1g","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","uncultured archaeon MedDCM-OCT-S05-C57",6,"ALA A 215;LEU A 219;LEU A 235;ARG A 281;GLY A 165;LEU A 166","None;None;None;None;AKB A 401 ( 3.7A);NAD A 402 (-3.8A)","1.45A","4xi3B-5y1gA:undetectable","4v2zA-5y1gA:17.89"],["4XI3_C_29SC601_1","ESTROGEN RECEPTOR","5y1g","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","uncultured archaeon MedDCM-OCT-S05-C57",6,"ALA A 215;LEU A 219;LEU A 235;ARG A 281;GLY A 165;LEU A 166","None;None;None;None;AKB A 401 ( 3.7A);NAD A 402 (-3.8A)","1.44A","4xi3C-5y1gA:undetectable","4xi3B-5y1gA:18.54"],["5AMI_B_EF2B151_1","CEREBLON ISOFORM 4","5y1g","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","uncultured archaeon MedDCM-OCT-S05-C57",4,"PRO A 272;PHE A 115;TRP A 271;TYR A 136","None;None;AKB A 401 (-4.5A);AKB A 401 (-4.5A)","1.45A","5amiB-5y1gA:undetectable","4xi3C-5y1gA:18.54"],["5AMK_A_EF2A151_1","CEREBLON ISOFORM 4","5y1g","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","uncultured archaeon MedDCM-OCT-S05-C57",4,"PRO A 272;PHE A 115;TRP A 271;TYR A 136","None;None;AKB A 401 (-4.5A);AKB A 401 (-4.5A)","1.36A","5amkA-5y1gA:undetectable","5amiB-5y1gA:17.89"],["5OH1_B_EF2B202_0","CEREBLON ISOFORM 4","5y1g","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","uncultured archaeon MedDCM-OCT-S05-C57",4,"PRO A 272;PHE A 115;TRP A 271;TYR A 136","None;None;AKB A 401 (-4.5A);AKB A 401 (-4.5A)","1.48A","5oh1B-5y1gA:undetectable","5amkA-5y1gA:17.89"],["5OH3_B_9V2B202_0","CEREBLON ISOFORM 4","5y1g","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","uncultured archaeon MedDCM-OCT-S05-C57",4,"PRO A 272;PHE A 115;TRP A 271;TYR A 136","None;None;AKB A 401 (-4.5A);AKB A 401 (-4.5A)","1.44A","5oh3B-5y1gA:undetectable","5oh1B-5y1gA:14.33"]]