SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AIC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 1h8s MUTANT AL2 6E7P9G
(Mus
musculus) 		4 / 7 ALA A  37
TYR A  39
TYR A  97
PHE A 101
 None
None
AIC  A1000 (-4.8A)
None
 1.21A 2ajvH-1h8sA:
13.8
2ajvL-1h8sA:
20.0		 2ajvH-1h8sA:
24.14
2ajvL-1h8sA:
37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1h8s MUTANT AL2 6E7P9G
(Mus
musculus) 		4 / 5 TYR A  39
GLN A  92
LEU A  99
PHE A 101
 None
AIC  A1000 (-3.3A)
AIC  A1000 (-4.5A)
None
 0.50A 3ls4L-1h8sA:
21.0		 3ls4L-1h8sA:
39.69