SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AHB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 7 PHE A 216
GLU A 125
GLN A 132
ASN A 158
 None
AHB  A7002 (-3.2A)
None
AHB  A7002 (-3.5A)
 1.43A 1jqdA-2og7A:
0.8		 1jqdA-2og7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 11 ASN A  95
GLU A 125
ALA A 147
GLY A 148
PHE A 307
 None
AHB  A7002 (-3.2A)
None
None
None
 1.49A 1l5rA-2og7A:
undetectable		 1l5rA-2og7A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 182
LEU A 170
VAL A 168
ALA A 181
GLY A 145
 None
None
None
None
AHB  A7002 (-3.0A)
 1.00A 2vmyA-2og7A:
undetectable		 2vmyA-2og7A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 6 PRO A 214
LEU A 152
ALA A 243
PRO A 213
 None
None
None
AHB  A7002 (-4.2A)
 1.25A 3gv1A-2og7A:
undetectable
3gv1C-2og7A:
undetectable		 3gv1A-2og7A:
17.09
3gv1C-2og7A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		4 / 6 LEU A 152
ALA A 243
PRO A 213
PRO A 214
 None
None
AHB  A7002 (-4.2A)
None
 1.28A 3gv1A-2og7A:
undetectable
3gv1B-2og7A:
undetectable		 3gv1A-2og7A:
17.09
3gv1B-2og7A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 170
PHE A 307
VAL A 168
PRO A 165
ASN A 158
 None
None
None
None
AHB  A7002 (-3.5A)
 1.39A 3nuvB-2og7A:
0.0		 3nuvB-2og7A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		3 / 3 THR A 153
ASP A 241
GLU A 157
 None
AHB  A7002 (-4.3A)
FE2  A5001 (-2.5A)
 0.85A 3qowA-2og7A:
undetectable		 3qowA-2og7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2og7 ASPARAGINE OXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ASN A 158
SER A 219
ALA A 244
GLU A 157
LEU A 152
 AHB  A7002 (-3.5A)
None
None
FE2  A5001 (-2.5A)
None
 1.16A 4zjoA-2og7A:
undetectable		 4zjoA-2og7A:
17.16