SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AGS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 1njf DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		4 / 5 HIS A  23
LEU A 178
LEU A  57
GLY A  50
 None
None
None
AGS  A 402 (-3.2A)
 1.15A 1a4lB-1njfA:
undetectable		 1a4lB-1njfA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 1njf DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		4 / 7 ARG A  11
ASP A 126
ASP A  94
ARG A   8
 AGS  A 402 (-3.0A)
None
None
None
 1.38A 1ceaB-1njfA:
undetectable		 1ceaB-1njfA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 656
ALA A 685
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-4.0A)
AGS  A 902 (-3.5A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.12A 1ddsB-5c1bA:
undetectable		 1ddsB-5c1bA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 LEU D 192
GLY D  70
THR D  74
VAL D  46
ASP D  43
 None
AGS  D 804 (-3.0A)
None
None
None
 1.17A 1dz8A-1sxjD:
0.0		 1dz8A-1sxjD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 LEU D 192
GLY D  70
THR D  74
VAL D  46
ASP D  43
 None
AGS  D 804 (-3.0A)
None
None
None
 1.15A 1dz8B-1sxjD:
0.0		 1dz8B-1sxjD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 LEU D 192
GLY D  70
THR D  74
VAL D  46
ASP D  43
 None
AGS  D 804 (-3.0A)
None
None
None
 1.16A 1dz9B-1sxjD:
0.0		 1dz9B-1sxjD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 SER H 764
VAL H 765
LEU H 664
PRO H 537
GLU H 774
 None
None
None
AGS  H 902 (-4.8A)
None
 1.33A 1equA-6chsH:
undetectable		 1equA-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  50
GLU A  53
LEU A  80
LEU A  40
 None
AGS  A3001 ( 4.8A)
None
None
 0.89A 1ereE-2pmiA:
undetectable		 1ereE-2pmiA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  50
GLU A  53
LEU A  80
LEU A  40
 None
AGS  A3001 ( 4.8A)
None
None
 0.87A 1ereF-2pmiA:
undetectable		 1ereF-2pmiA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
ASN A 787
LEU A 789
ASP A 800
PHE A 946
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
AGS  A1985 (-4.8A)
 0.57A 1fmoE-4crsA:
39.3		 1fmoE-4crsA:
37.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.77A 1iepA-4crsA:
20.6		 1iepA-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
GLY A 743
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 ( 4.5A)
 0.72A 1iepB-4crsA:
16.7		 1iepB-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		6 / 12 ILE A 656
ALA A 685
LEU A 526
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-4.0A)
AGS  A 902 (-3.5A)
AGS  A 902 (-3.9A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.43A 1jolB-5c1bA:
undetectable		 1jolB-5c1bA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLU B 132
ILE B 151
GLN B 125
ALA A 379
ARG A 515
 AGS  A 801 (-3.9A)
None
None
None
AGS  A 801 (-3.5A)
 1.22A 1ki7B-1sxjB:
undetectable		 1ki7B-1sxjB:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5a30 MITOCHONDRIAL
PROTEIN
(Gallus
gallus) 		5 / 11 LEU A 300
LEU A 306
ALA A 327
VAL A 307
ARG A 272
 None
None
AGS  A1529 (-3.7A)
None
None
 1.42A 1kt6A-5a30A:
undetectable		 1kt6A-5a30A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5a30 MITOCHONDRIAL
PROTEIN
(Gallus
gallus) 		5 / 11 LEU A 300
LEU A 306
ALA A 327
VAL A 307
ARG A 272
 None
None
AGS  A1529 (-3.7A)
None
None
 1.37A 1kt7A-5a30A:
undetectable		 1kt7A-5a30A:
16.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
ALA A 455
LYS A 457
GLU A 474
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.89A 1m17A-3fzpA:
31.8		 1m17A-3fzpA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
ALA A 684
TYR A 739
ALA A 740
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
AGS  A1985 (-4.8A)
 0.53A 1muoA-4crsA:
20.6		 1muoA-4crsA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.69A 1opjA-4crsA:
15.9		 1opjA-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
VAL A 721
GLY A 743
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 ( 4.5A)
 0.67A 1opjB-4crsA:
20.4		 1opjB-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 462
GLY A 676
GLY A 471
ILE A 650
TYR A 680
 None
AGS  A1723 (-3.6A)
AGS  A1723 (-3.1A)
None
None
 1.04A 1p91B-2iutA:
2.5		 1p91B-2iutA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ARG C 131
GLY B  54
GLU C 135
ILE B  23
 AGS  B 802 ( 2.7A)
AGS  B 802 (-3.2A)
None
AGS  B 802 (-4.4A)
 0.85A 1pk7B-1sxjC:
undetectable		 1pk7B-1sxjC:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 12 GLY A 239
GLY A 240
GLU A 261
ASP A 283
ASN A 306
 AGS  A 502 (-3.3A)
AGS  A 502 ( 4.9A)
AGS  A 502 (-2.4A)
AGS  A 502 (-2.9A)
AGS  A 502 (-2.8A)
 0.95A 1qzzA-4j9vA:
8.3		 1qzzA-4j9vA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		5 / 11 ALA A 357
ALA A 182
LEU A 208
LEU A 188
GLN A 189
 None
AGS  A1600 (-4.5A)
None
None
None
 1.13A 1rlbF-1xpoA:
0.0		 1rlbF-1xpoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.93A 1t46A-4crsA:
20.9		 1t46A-4crsA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.72A 1t46A-4crsA:
20.9		 1t46A-4crsA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		4 / 7 VAL B  90
VAL B 325
ARG B  49
CYH B  10
 None
None
None
AGS  B1342 ( 4.5A)
 1.16A 1t46A-3zeuB:
undetectable		 1t46A-3zeuB:
23.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 9 LEU A 431
VAL A 439
ALA A 455
MET A 502
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
None
AGS  A 999 (-4.5A)
 0.80A 1xbbA-3fzpA:
33.4		 1xbbA-3fzpA:
38.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 9 LEU A 663
VAL A 671
ALA A 684
MET A 737
ALA A 740
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
AGS  A1985 (-3.9A)
None
AGS  A1985 (-4.8A)
 0.57A 1xbbA-4crsA:
23.6		 1xbbA-4crsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 12 GLY A 239
GLY A 240
GLU A 261
ASP A 283
ASN A 306
 AGS  A 502 (-3.3A)
AGS  A 502 ( 4.9A)
AGS  A 502 (-2.4A)
AGS  A 502 (-2.9A)
AGS  A 502 (-2.8A)
 1.19A 1xdsA-4j9vA:
6.3		 1xdsA-4j9vA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 12 GLY A 239
GLY A 240
GLU A 261
ASP A 283
ASN A 306
 AGS  A 502 (-3.3A)
AGS  A 502 ( 4.9A)
AGS  A 502 (-2.4A)
AGS  A 502 (-2.9A)
AGS  A 502 (-2.8A)
 1.08A 1xdsB-4j9vA:
7.4		 1xdsB-4j9vA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		4 / 5 CYH B  10
PRO B 327
THR B  55
THR B  13
 AGS  B1342 ( 4.5A)
CL  B1338 (-4.1A)
None
None
 0.97A 1ymxB-3zeuB:
undetectable		 1ymxB-3zeuB:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4tl9 CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 8 GLY A  51
PHE A 247
ILE A 239
GLN A  58
 AGS  A 303 (-3.2A)
None
AGS  A 303 ( 3.9A)
None
 0.96A 2a8tB-4tl9A:
undetectable		 2a8tB-4tl9A:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		12 / 12 PRO A  50
LYS A  54
THR A  55
ASN A  76
GLY A  78
ARG A  82
PHE A  93
ARG A 104
ALA A 131
THR A 132
ARG A 195
TYR A 199
 None
AGS  A 503 (-2.9A)
AGS  A 503 (-3.3A)
AGS  A 503 ( 4.3A)
None
None
None
None
None
None
None
None
 0.53A 2axnA-1k6mA:
50.8		 2axnA-1k6mA:
64.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 LYS B  55
ASP A 586
ASN B 145
 AGS  B 802 (-2.5A)
None
AGS  B 802 (-3.1A)
 1.12A 2bm9A-1sxjB:
2.5		 2bm9A-1sxjB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		3 / 3 LYS A 524
ASP A 627
ASN A 624
 AGS  A 902 (-3.0A)
None
AGS  A 902 (-2.7A)
 0.92A 2bm9A-5c1bA:
2.5		 2bm9A-5c1bA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 MET H 404
ILE H 222
LEU H 269
GLY H 424
ILE H 396
 None
None
AGS  H 901 (-4.4A)
AGS  H 901 (-3.5A)
AGS  H 901 ( 4.2A)
 1.26A 2e7fA-6chsH:
2.3		 2e7fA-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 MET H 404
ILE H 222
LEU H 269
GLY H 424
ILE H 396
 None
None
AGS  H 901 (-4.4A)
AGS  H 901 (-3.5A)
AGS  H 901 ( 4.2A)
 1.20A 2e7fB-6chsH:
2.3		 2e7fB-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 VAL A 671
LYS A 686
VAL A 721
ASP A 744
ASN A 787
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.0A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.63A 2eufB-4crsA:
27.1		 2eufB-4crsA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 11 GLY A 666
VAL A 671
ALA A 684
MET A 737
TYR A 739
ALA A 740
LEU A 789
 AGS  A1985 (-2.9A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
AGS  A1985 (-3.9A)
AGS  A1985 (-4.8A)
 0.53A 2evaA-4crsA:
23.2		 2evaA-4crsA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 THR A 360
THR A 361
ALA A 363
ARG B 128
GLY A 356
 MG  A 811 ( 2.9A)
AGS  A 801 (-3.7A)
None
AGS  A 801 (-3.6A)
AGS  A 801 (-3.5A)
 1.21A 2f162-1sxjA:
undetectable		 2f162-1sxjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 THR A 360
THR A 361
ALA A 363
ARG B 128
GLY A 356
 MG  A 811 ( 2.9A)
AGS  A 801 (-3.7A)
None
AGS  A 801 (-3.6A)
AGS  A 801 (-3.5A)
 1.21A 2f16N-1sxjA:
undetectable		 2f16N-1sxjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
MET A 737
TYR A 739
LYS A 784
ASN A 787
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
AGS  A1985 ( 3.8A)
MG  A1986 ( 3.2A)
AGS  A1985 ( 3.3A)
 0.69A 2fumB-4crsA:
26.1		 2fumB-4crsA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
MET A 737
TYR A 739
ASN A 787
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
MG  A1986 ( 3.2A)
 0.52A 2fumC-4crsA:
24.6		 2fumC-4crsA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
GLY A 666
VAL A 671
ALA A 684
MET A 737
LYS A 784
ASN A 787
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
AGS  A1985 ( 3.8A)
MG  A1986 ( 3.2A)
 0.90A 2fumD-4crsA:
24.7		 2fumD-4crsA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  34
LYS A  36
GLU A  53
MET A  57
VAL A  66
PHE A  84
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
AGS  A3001 ( 4.5A)
None
 0.81A 2gqgA-2pmiA:
23.3		 2gqgA-2pmiA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.60A 2gqgB-4crsA:
24.1		 2gqgB-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.53A 2gqgB-4crsA:
24.1		 2gqgB-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 2hyyA-4crsA:
20.8		 2hyyA-4crsA:
26.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		4 / 6 LEU A 431
VAL A 487
ILE A 500
ARG A 548
 AGS  A 999 ( 4.4A)
None
None
None
 0.96A 2hyyA-3fzpA:
31.8		 2hyyA-3fzpA:
41.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.72A 2hyyB-4crsA:
20.9		 2hyyB-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.61A 2hyyC-4crsA:
21.0		 2hyyC-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
ILE A 708
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 1.01A 2hyyC-4crsA:
21.0		 2hyyC-4crsA:
26.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		8 / 12 LEU A 431
VAL A 439
ALA A 455
LYS A 457
GLU A 474
GLY A 508
LEU A 556
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
AGS  A 999 ( 3.9A)
 1.32A 2itzA-3fzpA:
31.6		 2itzA-3fzpA:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		5 / 12 ILE A 201
ILE A 283
ALA A 250
THR A 254
ALA A 219
 None
None
AGS  A1383 ( 4.6A)
None
None
 1.18A 2j0dA-1gjvA:
0.6		 2j0dA-1gjvA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 7 LEU D 168
LEU D  62
PRO C  55
GLU C 118
ARG D 154
 None
None
AGS  C 803 (-4.1A)
AGS  C 803 ( 4.9A)
AGS  C 803 (-4.6A)
 1.46A 2jn3A-1sxjD:
undetectable		 2jn3A-1sxjD:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		4 / 7 GLY A  12
GLY A   9
VAL A  70
LEU A 358
 None
AGS  A 501 (-3.4A)
None
None
 0.79A 2oa1B-4j9vA:
6.3		 2oa1B-4j9vA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 MET H 404
ILE H 222
LEU H 269
GLY H 424
ILE H 396
 None
None
AGS  H 901 (-4.4A)
AGS  H 901 (-3.5A)
AGS  H 901 ( 4.2A)
 1.26A 2ogyA-6chsH:
2.2		 2ogyA-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 MET H 404
ILE H 222
LEU H 269
GLY H 424
ILE H 396
 None
None
AGS  H 901 (-4.4A)
AGS  H 901 (-3.5A)
AGS  H 901 ( 4.2A)
 1.23A 2ogyB-6chsH:
2.4		 2ogyB-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.77A 2oiqA-4crsA:
4.8		 2oiqA-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		4 / 7 ILE A  45
ILE A 219
LEU A 243
ILE A 217
 None
AGS  A 503 ( 4.3A)
None
None
 0.85A 2q83A-1k6mA:
undetectable		 2q83A-1k6mA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ILE B  47
PRO B  17
LEU B  20
ILE B  23
 None
AGS  B 802 (-4.4A)
None
AGS  B 802 (-4.4A)
 0.87A 2q83A-1sxjB:
2.0		 2q83A-1sxjB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 ILE B  47
PRO B  17
LEU B  20
ILE B  23
 None
AGS  B 802 (-4.4A)
None
AGS  B 802 (-4.4A)
 0.83A 2q83B-1sxjB:
2.8		 2q83B-1sxjB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 7 SER C 254
ARG C 257
PHE E 256
ILE E 255
 None
None
AGS  E2001 (-4.8A)
None
 1.22A 2qb4A-5v8fC:
undetectable		 2qb4A-5v8fC:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		3 / 3 LEU A 340
PRO A 341
ARG A 252
 AGS  A1383 (-3.9A)
K  A1380 ( 4.6A)
None
 0.49A 2qd5A-1gjvA:
undetectable		 2qd5A-1gjvA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 6 ARG 6 798
PHE 6 709
ILE 6 678
PHE 6 641
 AGS  22001 (-3.6A)
None
None
None
 1.10A 2qeiA-5udb6:
undetectable		 2qeiA-5udb6:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		4 / 6 ARG 7 687
PHE 7 594
ILE 7 563
PHE 7 526
 AGS  72001 (-2.3A)
None
None
None
 0.99A 2qeiA-5v8f7:
undetectable		 2qeiA-5v8f7:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 6 SER C 254
ARG C 257
PHE E 256
ILE E 255
 None
None
AGS  E2001 (-4.8A)
None
 1.22A 2qeiA-5v8fC:
undetectable		 2qeiA-5v8fC:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ARG A  13
SER A  59
ASP A 160
ALA A  64
 AGS  A1402 (-4.2A)
None
None
AGS  A1402 (-4.9A)
 1.36A 2rk8A-5dacA:
3.0		 2rk8A-5dacA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 12 GLY A 131
VAL A 138
ALA A 149
LEU A 200
GLY A 206
ASP A 289
 AGS  A1438 ( 3.8A)
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
None
AGS  A1438 (-2.7A)
 0.71A 2wgjA-4uyaA:
25.3		 2wgjA-4uyaA:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		6 / 9 VAL A  21
ALA A  34
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
None
None
None
AGS  A3001 (-2.8A)
 0.72A 2xp2A-2pmiA:
21.5		 2xp2A-2pmiA:
25.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 9 LEU A 431
VAL A 439
ALA A 455
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
None
 0.76A 2xp2A-3fzpA:
13.9		 2xp2A-3fzpA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
ALA A 684
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.69A 2xp2A-4crsA:
8.2		 2xp2A-4crsA:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 9 VAL A 138
ALA A 149
LEU A 200
GLY A 206
LEU A 270
ASP A 289
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
None
AGS  A1438 (-4.7A)
AGS  A1438 (-2.7A)
 0.67A 2xp2A-4uyaA:
27.3		 2xp2A-4uyaA:
31.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 VAL A 439
ALA A 455
LEU A 504
GLY A 508
GLU A 509
LEU A 556
 AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-3.8A)
AGS  A 999 (-4.5A)
 0.55A 2y7jA-3fzpA:
23.8		 2y7jA-3fzpA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 6 ARG A 225
ILE A  21
LEU A 184
GLU A 256
 AGS  A1272 (-3.6A)
None
None
None
 1.07A 2ya7A-2xj9A:
undetectable		 2ya7A-2xj9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 6 ARG A 225
ILE A  21
LEU A 184
GLU A 256
 AGS  A1272 (-3.6A)
None
None
None
 1.07A 2ya7B-2xj9A:
undetectable		 2ya7B-2xj9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 6 ARG A 225
ILE A  21
LEU A 184
GLU A 256
 AGS  A1272 (-3.6A)
None
None
None
 1.04A 2ya7D-2xj9A:
undetectable		 2ya7D-2xj9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 8 ALA A  34
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-3.5A)
None
None
None
AGS  A3001 (-2.8A)
 0.63A 2yfxA-2pmiA:
21.3		 2yfxA-2pmiA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 169
ASP A 151
LEU A 139
ARG A 175
 None
AGS  A3001 (-2.8A)
None
None
 1.24A 2ziaA-2pmiA:
undetectable		 2ziaA-2pmiA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  34
LYS A  36
GLU A  53
MET A  57
VAL A  66
MET A  85
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
None
None
 0.66A 2zvaA-2pmiA:
23.5		 2zvaA-2pmiA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
ALA A 684
LYS A 686
GLU A 705
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.81A 2zvaA-4crsA:
18.6		 2zvaA-4crsA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
ALA A 684
LYS A 686
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.81A 2zvaA-4crsA:
18.6		 2zvaA-4crsA:
24.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 10 LEU A 431
ALA A 455
LYS A 457
VAL A 487
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.99A 3aoxA-3fzpA:
30.9		 3aoxA-3fzpA:
35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 VAL A 439
ALA A 455
LEU A 489
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.62A 3bbtB-3fzpA:
30.3		 3bbtB-3fzpA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 12 VAL A 138
ALA A 149
GLY A 206
LEU A 270
THR A 288
PHE A 290
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
AGS  A1438 (-4.7A)
AGS  A1438 ( 4.7A)
None
 0.62A 3bbtB-4uyaA:
26.6		 3bbtB-4uyaA:
34.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		7 / 12 VAL A 138
ALA A 149
LEU A 198
GLY A 206
LEU A 270
THR A 288
PHE A 290
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
None
AGS  A1438 (-4.7A)
AGS  A1438 ( 4.7A)
None
 0.61A 3bbtD-4uyaA:
20.7		 3bbtD-4uyaA:
34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1zun SULFATE
ADENYLYLTRANSFERASE
SUBUNIT 2
(Pseudomonas
syringae) 		5 / 12 LEU A  84
ALA A  46
GLY A 133
VAL A 205
ILE A  35
 None
None
AGS  A 600 (-2.9A)
None
None
 1.05A 3c6gA-1zunA:
undetectable		 3c6gA-1zunA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		8 / 12 LEU A 431
GLY A 432
GLU A 441
ALA A 455
LYS A 457
VAL A 487
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 ( 4.2A)
None
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
None
AGS  A 999 (-4.5A)
 0.65A 3c7qA-3fzpA:
30.9		 3c7qA-3fzpA:
34.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
ALA A 684
LYS A 686
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.60A 3c7qA-4crsA:
19.9		 3c7qA-4crsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		5 / 10 LEU A 468
VAL A 476
LYS A 491
VAL A 527
ASP A 613
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-2.8A)
None
None
 0.66A 3cs9A-5o0yA:
20.9		 3cs9A-5o0yA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 ALA A 684
GLU A 705
LEU A 720
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 3cs9A-4crsA:
16.3		 3cs9A-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
LEU A 720
GLY A 743
ALA A 799
 AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 ( 4.5A)
 0.70A 3cs9B-4crsA:
17.0		 3cs9B-4crsA:
26.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		5 / 9 LEU A 431
VAL A 439
VAL A 487
ILE A 500
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
None
None
AGS  A 999 (-4.5A)
 0.69A 3cs9B-3fzpA:
31.6		 3cs9B-3fzpA:
41.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 9 LEU A 663
VAL A 671
LYS A 686
VAL A 721
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.8A)
 0.84A 3cs9B-4crsA:
17.0		 3cs9B-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		4 / 6 LEU A 468
VAL A 476
LYS A 491
ASP A 613
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-2.8A)
None
 0.61A 3cs9D-5o0yA:
20.1		 3cs9D-5o0yA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		4 / 6 VAL A 476
LYS A 491
LEU A 599
ASP A 613
 AGS  A 801 (-4.0A)
AGS  A 801 (-2.8A)
None
None
 0.80A 3cs9D-5o0yA:
20.1		 3cs9D-5o0yA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		3 / 3 ASP A 744
ASP A 800
ASP A 947
 AGS  A1985 (-4.0A)
AGS  A1985 ( 3.3A)
None
 0.77A 3douA-4crsA:
undetectable		 3douA-4crsA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
GLY A 666
GLY A 669
VAL A 671
ALA A 684
MET A 737
ASN A 787
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
 0.61A 3eygA-4crsA:
18.1		 3eygA-4crsA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
GLY A 669
VAL A 671
ALA A 684
LYS A 686
MET A 737
ASN A 787
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
AGS  A1985 (-4.2A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
 0.64A 3eygA-4crsA:
18.1		 3eygA-4crsA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 11 ALA A 685
LEU A 526
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-3.5A)
AGS  A 902 (-3.9A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.27A 3fl9C-5c1bA:
undetectable		 3fl9C-5c1bA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
GLY A 666
GLY A 669
VAL A 671
ALA A 684
MET A 737
TYR A 739
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
 0.59A 3fupA-4crsA:
11.5		 3fupA-4crsA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
GLY A 669
VAL A 671
ALA A 684
LYS A 686
MET A 737
TYR A 739
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
 0.69A 3fupA-4crsA:
11.5		 3fupA-4crsA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
GLY A 666
VAL A 671
ALA A 684
LYS A 686
VAL A 721
MET A 737
TYR A 739
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.2A)
None
 0.62A 3fupB-4crsA:
24.2		 3fupB-4crsA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
MET A 737
TYR A 739
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
 0.59A 3fupB-4crsA:
24.2		 3fupB-4crsA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		7 / 12 VAL A 238
GLY A 239
GLY A 241
GLU A 261
ASP A 263
ASP A 283
ALA A 284
 None
AGS  A 502 (-3.3A)
AGS  A 502 (-3.1A)
AGS  A 502 (-2.4A)
None
AGS  A 502 (-2.9A)
AGS  A 502 (-3.2A)
 0.97A 3fuuA-4j9vA:
9.8		 3fuuA-4j9vA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 5vfr 26S PROTEASOME
REGULATORY SUBUNIT
6B
(Homo
sapiens) 		5 / 12 GLY D 169
ILE D 348
LEU D 215
LYS D 212
MET D 214
 None
AGS  D 501 (-4.0A)
None
None
AGS  D 501 (-3.6A)
 1.14A 3fzgA-5vfrD:
undetectable		 3fzgA-5vfrD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 11 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.45A 3g0eA-4crsA:
19.9		 3g0eA-4crsA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 11 LEU A 663
VAL A 671
ALA A 684
TYR A 739
GLY A 743
ASP A 744
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
 0.53A 3g0fA-4crsA:
20.9		 3g0fA-4crsA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		6 / 11 LEU A 468
VAL A 476
ALA A 489
TYR A 546
CYH A 547
GLY A 549
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 ( 4.8A)
AGS  A 801 (-4.3A)
None
 0.61A 3g0fA-5o0yA:
20.9		 3g0fA-5o0yA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 10 LEU A 663
VAL A 671
ALA A 684
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
 0.38A 3g0fB-4crsA:
14.0		 3g0fB-4crsA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		6 / 10 LEU A 468
VAL A 476
ALA A 489
TYR A 546
CYH A 547
GLY A 549
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 ( 4.8A)
AGS  A 801 (-4.3A)
None
 0.66A 3g0fB-5o0yA:
21.2		 3g0fB-5o0yA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.61A 3g5dA-4crsA:
17.8		 3g5dA-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.79A 3g5dB-4crsA:
17.8		 3g5dB-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 3g5dB-4crsA:
17.8		 3g5dB-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		7 / 11 GLY A 239
GLY A 241
GLU A 261
ASP A 263
ASP A 283
ALA A 284
ASN A 306
 AGS  A 502 (-3.3A)
AGS  A 502 (-3.1A)
AGS  A 502 (-2.4A)
None
AGS  A 502 (-2.9A)
AGS  A 502 (-3.2A)
AGS  A 502 (-2.8A)
 1.23A 3grvA-4j9vA:
10.6		 3grvA-4j9vA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		7 / 12 GLY A 239
GLY A 241
GLU A 261
ASP A 263
ASP A 283
ALA A 284
ASN A 306
 AGS  A 502 (-3.3A)
AGS  A 502 (-3.1A)
AGS  A 502 (-2.4A)
None
AGS  A 502 (-2.9A)
AGS  A 502 (-3.2A)
AGS  A 502 (-2.8A)
 1.33A 3gryA-4j9vA:
10.5		 3gryA-4j9vA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 LEU A 431
VAL A 439
ALA A 455
GLU A 474
VAL A 487
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
 0.76A 3gvuA-3fzpA:
31.0		 3gvuA-3fzpA:
38.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.68A 3gvuA-4crsA:
21.0		 3gvuA-4crsA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 MET C 205
LEU C 169
ARG C 176
PRO C  21
SER C  61
 AGS  C 803 (-4.5A)
AGS  C 803 (-4.8A)
None
AGS  C 803 (-4.3A)
AGS  C 803 (-2.6A)
 1.44A 3hcnB-1sxjC:
0.2		 3hcnB-1sxjC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 701
SER A 697
VAL A 474
ALA A 478
LEU A 484
 None
None
AGS  A1723 (-3.5A)
None
None
 1.01A 3hs6A-2iutA:
undetectable		 3hs6A-2iutA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 MET A 747
HIS A 750
GLY A 742
GLY A 743
LEU A 663
 None
None
None
None
AGS  A1985 (-4.2A)
 1.00A 3i5uA-4crsA:
undetectable		 3i5uA-4crsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 MET A 747
HIS A 750
GLY A 742
GLY A 743
LEU A 663
 None
None
None
None
AGS  A1985 (-4.2A)
 1.01A 3i5uB-4crsA:
undetectable		 3i5uB-4crsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 ALA A 684
GLU A 705
LEU A 720
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.72A 3ik3A-4crsA:
20.9		 3ik3A-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
LEU A 720
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.61A 3ik3B-4crsA:
20.6		 3ik3B-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.71A 3k5vA-4crsA:
20.4		 3k5vA-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.68A 3k5vB-4crsA:
20.2		 3k5vB-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)		 5a30 MITOCHONDRIAL
PROTEIN
(Gallus
gallus) 		5 / 10 SER A 227
GLY A 225
PRO A 223
SER A 321
LEU A 320
 None
AGS  A1529 (-3.6A)
None
None
None
 1.30A 3lsfB-5a30A:
undetectable
3lsfE-5a30A:
undetectable		 3lsfB-5a30A:
22.16
3lsfE-5a30A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 5udb CELL DIVISION
CONTROL PROTEIN 6
(Saccharomyces
cerevisiae) 		4 / 8 TYR 9 105
PRO 9 109
ASP 9 266
LYS 9 268
 None
AGS  92001 (-4.5A)
None
None
 0.91A 3lsfH-5udb9:
undetectable		 3lsfH-5udb9:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 SER 6 791
ASP 2 544
ASN 2 651
 None
None
AGS  22001 (-3.0A)
 0.77A 3lslA-5udb6:
undetectable
3lslD-5udb6:
undetectable		 3lslA-5udb6:
14.63
3lslD-5udb6:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
MET A 737
TYR A 739
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 ( 4.5A)
 0.74A 3lxkA-4crsA:
24.1		 3lxkA-4crsA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
MET A 737
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.84A 3lxkA-4crsA:
24.1		 3lxkA-4crsA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		7 / 12 LEU A 468
GLY A 469
GLY A 471
VAL A 476
ALA A 489
LYS A 491
TYR A 546
 AGS  A 801 (-4.1A)
AGS  A 801 ( 4.0A)
AGS  A 801 (-3.5A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 (-2.8A)
AGS  A 801 ( 4.8A)
 0.50A 3lxnA-5o0yA:
23.8		 3lxnA-5o0yA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		3 / 3 HIS B 111
HIS B 115
MET B 112
 ZN  B1339 ( 3.2A)
ZN  B1339 ( 3.3A)
AGS  B1342 (-3.2A)
 1.00A 3mihA-3zeuB:
undetectable		 3mihA-3zeuB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		7 / 11 ALA A  34
LYS A  36
VAL A  66
PHE A  82
PHE A  84
MET A  85
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
None
AGS  A3001 ( 4.5A)
None
None
 0.65A 3miyA-2pmiA:
21.8		 3miyA-2pmiA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		6 / 9 ALA A  34
LYS A  36
PHE A  82
PHE A  84
MET A  85
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
AGS  A3001 ( 4.5A)
None
None
 0.53A 3miyB-2pmiA:
21.7		 3miyB-2pmiA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.82A 3ms9A-4crsA:
20.3		 3ms9A-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.73A 3ms9B-4crsA:
20.5		 3ms9B-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.84A 3mssA-4crsA:
20.5		 3mssA-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.63A 3mssB-4crsA:
20.5		 3mssB-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.70A 3mssB-4crsA:
20.5		 3mssB-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.84A 3mssC-4crsA:
20.5		 3mssC-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
ILE A 708
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.91A 3mssC-4crsA:
20.5		 3mssC-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.77A 3mssD-4crsA:
20.5		 3mssD-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
ALA A 684
ILE A 708
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.88A 3mssD-4crsA:
20.5		 3mssD-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		5 / 11 ASP A 328
ALA A 317
THR A 268
ILE A 267
ARG A 212
 None
None
None
None
AGS  A1600 ( 3.2A)
 1.42A 3n23A-1xpoA:
2.9		 3n23A-1xpoA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.69A 3octA-4crsA:
8.6		 3octA-4crsA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 ALA A 684
GLU A 705
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.73A 3oezA-4crsA:
16.3		 3oezA-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
None
AGS  A1985 (-4.8A)
 0.72A 3oezA-4crsA:
16.3		 3oezA-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.68A 3oezB-4crsA:
16.4		 3oezB-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 ALA A 684
GLU A 705
LEU A 720
VAL A 721
GLY A 743
ALA A 799
ASP A 800
 AGS  A1985 (-3.5A)
None
None
None
None
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 1.10A 3oxzA-4crsA:
20.6		 3oxzA-4crsA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.98A 3pghA-2xj9A:
undetectable		 3pghA-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.99A 3pghC-2xj9A:
undetectable		 3pghC-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.82A 3pyyA-4crsA:
20.4		 3pyyA-4crsA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.69A 3pyyB-4crsA:
20.4		 3pyyB-4crsA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 3qlgA-4crsA:
21.5		 3qlgA-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
VAL A 721
TYR A 739
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.79A 3qlgA-4crsA:
21.5		 3qlgA-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.75A 3qlgA-4crsA:
21.5		 3qlgA-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 3qlgA-4crsA:
21.5		 3qlgA-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.68A 3qlgB-4crsA:
22.0		 3qlgB-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.65A 3qlgB-4crsA:
22.0		 3qlgB-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 10 ILE A 234
ALA A 235
THR A  27
VAL A  23
THR A  20
 None
None
None
None
AGS  A1272 (-3.7A)
 1.31A 3r9cA-2xj9A:
undetectable		 3r9cA-2xj9A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
TYR A 739
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.70A 3rgfA-4crsA:
16.7		 3rgfA-4crsA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 12 VAL A 138
ALA A 149
ILE A 184
ALA A 203
LEU A 251
HIS A 261
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-4.2A)
AGS  A1438 (-3.7A)
None
None
 0.54A 3rgfA-4uyaA:
20.7		 3rgfA-4uyaA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ALA A  64
GLY A  63
ARG A  13
GLN A 111
 AGS  A1402 (-4.9A)
None
AGS  A1402 (-4.2A)
None
 0.88A 3rglA-5dacA:
undetectable		 3rglA-5dacA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.93A 3rr3A-2xj9A:
undetectable		 3rr3A-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.92A 3rr3B-2xj9A:
undetectable		 3rr3B-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.93A 3rr3C-2xj9A:
undetectable		 3rr3C-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.93A 3rr3D-2xj9A:
undetectable		 3rr3D-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 11 LEU 7 590
SER 7 592
THR 7 685
THR 7 688
GLY 7 691
 None
AGS  72001 ( 4.9A)
None
None
None
 1.45A 3sfuC-5v8f7:
undetectable		 3sfuC-5v8f7:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_A_KANA304_1
(APH(2'')-ID)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ASN D 171
ASP D 227
SER E 183
GLU D  29
GLU E 159
 AGS  D 804 (-3.1A)
None
None
AGS  D 804 (-3.9A)
None
 1.08A 3sg9A-1sxjD:
3.7		 3sg9A-1sxjD:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU W 606
LEU W 405
GLY W 404
GLY W 406
 None
None
AGS  W2000 (-3.1A)
AGS  W2000 (-3.3A)
 0.82A 3si7C-3mwyW:
0.0
3si7D-3mwyW:
undetectable		 3si7C-3mwyW:
16.90
3si7D-3mwyW:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
VAL A 487
ILE A 500
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
None
None
AGS  A 999 (-4.5A)
 0.68A 3sxrA-3fzpA:
30.8		 3sxrA-3fzpA:
37.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.48A 3sxrA-4crsA:
24.4		 3sxrA-4crsA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.47A 3sxrB-4crsA:
23.9		 3sxrB-4crsA:
25.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		6 / 9 ALA A  34
VAL A  66
PHE A  82
PHE A  84
ASP A  88
LEU A 140
 AGS  A3001 (-3.5A)
None
None
AGS  A3001 ( 4.5A)
None
None
 0.70A 3ti1A-2pmiA:
29.9		 3ti1A-2pmiA:
53.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 9 VAL A  66
PHE A  82
ASP A  88
LEU A 140
ASP A 151
 None
None
None
None
AGS  A3001 (-2.8A)
 0.82A 3ti1A-2pmiA:
29.9		 3ti1A-2pmiA:
53.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 PRO B  17
SER C 159
VAL B 171
THR B  57
 AGS  B 802 (-4.4A)
None
None
AGS  B 802 (-3.8A)
 1.16A 3tneA-1sxjB:
undetectable		 3tneA-1sxjB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 3wry TM-1 PROTEIN
(Solanum
lycopersicum) 		5 / 12 ASP A  18
SER A 132
ILE A 146
THR A  19
ALA A  97
 AGS  A 501 (-2.6A)
None
None
AGS  A 501 (-3.2A)
None
 1.29A 3ua1A-3wryA:
undetectable		 3ua1A-3wryA:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
ALA A 455
LYS A 457
GLU A 474
ILE A 500
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
None
None
AGS  A 999 (-4.5A)
 1.00A 3ue4A-3fzpA:
33.1		 3ue4A-3fzpA:
41.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.84A 3ue4B-4crsA:
23.2		 3ue4B-4crsA:
26.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
MET A 502
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.74A 3ug2A-3fzpA:
31.9		 3ug2A-3fzpA:
35.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 LEU A 673
ILE A 937
GLY A 743
ASP A 791
ALA A 740
 None
None
None
None
AGS  A1985 (-3.9A)
 1.21A 3uj7B-4crsA:
undetectable		 3uj7B-4crsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 GLY A 666
GLY A 669
ALA A 684
LYS A 686
LEU A 688
VAL A 721
ASP A 800
 AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 ( 3.3A)
 0.99A 3v5wA-4crsA:
13.1		 3v5wA-4crsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 GLY A 666
GLY A 669
VAL A 671
ALA A 684
LYS A 686
LEU A 688
VAL A 721
LEU A 789
 AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.90A 3v5wA-4crsA:
13.1		 3v5wA-4crsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 209
MET B 202
ASP B 168
 None
AGS  B 802 (-4.7A)
None
 0.89A 3v5wA-1sxjB:
undetectable		 3v5wA-1sxjB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ARG D 154
LEU D 180
ALA D 142
ILE D 176
 AGS  C 803 (-4.6A)
None
None
None
 0.93A 3wsjB-1sxjD:
undetectable		 3wsjB-1sxjD:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 5 ILE A 708
VAL A 721
LEU A 789
ASP A 800
 None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 1.12A 3wzdA-4crsA:
15.7		 3wzdA-4crsA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 5 LYS A 686
ILE A 708
VAL A 721
LEU A 789
 AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.92A 3wzdA-4crsA:
15.7		 3wzdA-4crsA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-3.5A)
None
None
None
AGS  A3001 (-2.8A)
 0.47A 3zbfA-2pmiA:
23.2		 3zbfA-2pmiA:
24.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		5 / 12 ALA A 455
LEU A 504
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
 0.52A 3zbfA-3fzpA:
25.8		 3zbfA-3fzpA:
39.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
ALA A 684
LYS A 686
GLU A 705
LEU A 773
ARG A 781
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.84A 3zosA-4crsA:
20.6		 3zosA-4crsA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 ALA A 684
LYS A 686
GLU A 705
LEU A 773
ARG A 781
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.79A 3zosB-4crsA:
20.7		 3zosB-4crsA:
24.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		5 / 9 LEU A 431
ILE A 477
MET A 478
LEU A 481
ILE A 486
 AGS  A 999 ( 4.4A)
None
None
None
None
 1.14A 3zosB-3fzpA:
30.3		 3zosB-3fzpA:
33.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 354
ILE A 357
ARG A 477
GLY A 512
 None
AGS  A 801 (-4.4A)
None
None
 1.00A 4a3uB-1sxjA:
undetectable		 4a3uB-1sxjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 6 ILE A 270
TYR A 284
HIS A 216
VAL A 211
 None
None
AGS  A1162 (-3.9A)
AGS  A1162 ( 4.6A)
 1.23A 4a97I-2qf7A:
undetectable		 4a97I-2qf7A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 6 THR A 936
ILE A 937
THR A 951
PHE A 946
 None
None
None
AGS  A1985 (-4.8A)
 0.96A 4acbC-4crsA:
undetectable		 4acbC-4crsA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.67A 4ag8A-4crsA:
20.6		 4ag8A-4crsA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.8A)
 0.52A 4agcA-4crsA:
15.2		 4agcA-4crsA:
23.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 11 LEU A 431
ALA A 455
LYS A 457
VAL A 487
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
None
AGS  A 999 (-4.5A)
 0.80A 4agdA-3fzpA:
30.5		 4agdA-3fzpA:
32.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 11 LEU A 663
ALA A 684
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
 0.43A 4agdA-4crsA:
19.9		 4agdA-4crsA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 9 LEU A 663
VAL A 671
ALA A 684
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.78A 4anqA-4crsA:
21.7		 4anqA-4crsA:
26.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 9 VAL A 138
ALA A 149
LEU A 200
GLY A 206
LEU A 270
ASP A 289
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
None
AGS  A1438 (-4.7A)
AGS  A1438 (-2.7A)
 0.72A 4anqA-4uyaA:
27.0		 4anqA-4uyaA:
33.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 9 LEU A 663
VAL A 671
ALA A 684
MET A 737
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.78A 4ansA-4crsA:
21.6		 4ansA-4crsA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		4 / 6 VAL A 527
CYH A 547
LEU A 599
ILE A 611
 None
AGS  A 801 (-4.3A)
None
None
 0.87A 4asdA-5o0yA:
20.3		 4asdA-5o0yA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
ILE A 708
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 1.33A 4bkjA-4crsA:
20.4		 4bkjA-4crsA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		5 / 10 ILE A 290
LEU A 295
THR A 364
GLY A 363
GLY A 361
 AGS  A1383 ( 4.5A)
None
AGS  A1383 (-4.1A)
None
None
 1.25A 4bwlC-1gjvA:
undetectable		 4bwlC-1gjvA:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 11 LEU A 431
GLY A 432
GLY A 434
VAL A 439
ALA A 455
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 ( 4.2A)
AGS  A 999 (-3.0A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
 0.85A 4ckiA-3fzpA:
30.8		 4ckiA-3fzpA:
36.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 10 LEU A 663
VAL A 671
ALA A 684
TYR A 739
ALA A 740
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
AGS  A1985 (-4.8A)
 0.46A 4ckjA-4crsA:
24.7		 4ckjA-4crsA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
ILE A 708
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 1.04A 4csvA-4crsA:
17.1		 4csvA-4crsA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 4csvA-4crsA:
17.1		 4csvA-4crsA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 SER A 700
GLY A 701
THR A 625
VAL A 483
 None
None
None
AGS  A2001 (-4.9A)
 1.08A 4eohA-5v8fA:
undetectable		 4eohA-5v8fA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 VAL C  93
ALA C 126
THR C 123
GLU C 118
ALA C 119
 None
None
None
AGS  C 803 ( 4.9A)
None
 1.25A 4fiaA-1sxjC:
undetectable		 4fiaA-1sxjC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 VAL C  93
ALA C 126
THR C 123
GLU C 118
ALA C 119
 None
None
None
AGS  C 803 ( 4.9A)
None
 1.25A 4fiaA-1sxjC:
undetectable		 4fiaA-1sxjC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		3 / 3 GLU A 261
ASP A 263
ASP A 283
 AGS  A 502 (-2.4A)
None
AGS  A 502 (-2.9A)
 0.26A 4gc9A-4j9vA:
6.8		 4gc9A-4j9vA:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
LYS A 457
GLY A 508
LEU A 556
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.5A)
AGS  A 999 ( 3.9A)
 0.87A 4hjoA-3fzpA:
31.0		 4hjoA-3fzpA:
34.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 VAL A  12
ARG A  13
GLU A  45
LEU A  55
 None
AGS  A1402 (-4.2A)
None
None
 1.32A 4hojA-5dacA:
undetectable		 4hojA-5dacA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		7 / 12 VAL A 138
ALA A 149
ILE A 184
ASP A 263
ASN A 268
LEU A 270
ASP A 289
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-4.2A)
AGS  A1438 (-3.7A)
MG  A1439 ( 3.0A)
AGS  A1438 (-4.7A)
AGS  A1438 (-2.7A)
 0.73A 4i41A-4uyaA:
20.4		 4i41A-4uyaA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 11 VAL A 671
ALA A 684
LYS A 686
ASP A 744
LEU A 789
ASP A 800
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.78A 4iaaA-4crsA:
28.3		 4iaaA-4crsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		6 / 11 VAL A 476
ALA A 489
LYS A 491
LEU A 544
ASP A 551
LEU A 599
 AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 (-2.8A)
AGS  A 801 ( 4.0A)
None
None
 0.75A 4iaaA-5o0yA:
25.3		 4iaaA-5o0yA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 GLY A 432
VAL A 439
ALA A 455
LYS A 457
LEU A 489
GLU A 509
LEU A 556
 AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-3.8A)
AGS  A 999 (-4.5A)
 0.80A 4ifgA-3fzpA:
21.3		 4ifgA-3fzpA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 GLY A 432
VAL A 439
LYS A 457
LEU A 489
GLY A 508
GLU A 509
LEU A 556
 AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-2.5A)
None
None
AGS  A 999 (-3.8A)
AGS  A 999 (-4.5A)
 0.73A 4ifgA-3fzpA:
21.3		 4ifgA-3fzpA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		7 / 12 GLY A 131
VAL A 138
ALA A 149
LEU A 186
LEU A 198
GLY A 206
LEU A 270
 AGS  A1438 ( 3.8A)
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
None
None
AGS  A1438 (-4.7A)
 0.56A 4ifgA-4uyaA:
23.0		 4ifgA-4uyaA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1215
GLY A  33
GLY A1203
ILE A1188
SER A  37
 None
None
None
None
AGS  A2224 (-3.5A)
 0.97A 4iv0A-1w1wA:
undetectable		 4iv0A-1w1wA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1215
GLY A  33
GLY A1203
ILE A1188
SER A  37
 None
None
None
None
AGS  A2224 (-3.5A)
 0.95A 4iv0B-1w1wA:
undetectable		 4iv0B-1w1wA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 LEU B 133
ARG A 383
PRO B 153
SER B 156
 None
None
AGS  A 801 ( 4.3A)
AGS  A 801 ( 4.4A)
 1.27A 4kmmB-1sxjB:
undetectable		 4kmmB-1sxjB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		4 / 6 SER B   9
GLY B 163
ASP B 167
GLY B 268
 AGS  B1342 ( 4.9A)
ADP  B1343 (-3.3A)
ADP  B1343 (-2.9A)
AGS  B1342 (-3.1A)
 0.88A 4koeA-3zeuB:
undetectable
4koeB-3zeuB:
undetectable
4koeC-3zeuB:
undetectable		 4koeA-3zeuB:
23.53
4koeB-3zeuB:
23.53
4koeC-3zeuB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		4 / 7 SER B   9
GLY B 163
ASP B 167
GLY B 268
 AGS  B1342 ( 4.9A)
ADP  B1343 (-3.3A)
ADP  B1343 (-2.9A)
AGS  B1342 (-3.1A)
 0.86A 4koeA-3zeuB:
undetectable
4koeB-3zeuB:
undetectable
4koeD-3zeuB:
undetectable		 4koeA-3zeuB:
23.53
4koeB-3zeuB:
23.53
4koeD-3zeuB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 1njf DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		4 / 8 ARG A 215
ARG A  11
ARG A  56
ASP A  94
 AGS  A 402 (-3.3A)
AGS  A 402 (-3.0A)
None
None
 1.13A 4kr4C-1njfA:
0.0		 4kr4C-1njfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 10 ALA A 684
VAL A 721
MET A 737
GLY A 743
LEU A 789
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
 0.34A 4ks8A-4crsA:
28.9		 4ks8A-4crsA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 8 ALA A  34
LYS A  36
MET A  85
ASP A  88
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
None
None
 0.91A 4l9iB-2pmiA:
23.5		 4l9iB-2pmiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		3 / 3 ASP B 300
TRP B 329
SER B 136
 ZN  B1339 ( 2.5A)
None
AGS  B1342 (-2.9A)
 1.05A 4lrhA-3zeuB:
undetectable		 4lrhA-3zeuB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		4 / 5 TYR A  80
THR A  70
LEU A  65
THR A  55
 None
None
None
AGS  A 503 (-3.3A)
 1.44A 4mbsB-1k6mA:
0.0		 4mbsB-1k6mA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 586
ASN B 145
TYR B 163
ASP A 584
 None
AGS  B 802 (-3.1A)
None
None
 1.20A 4mdaA-1sxjA:
0.0		 4mdaA-1sxjA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		8 / 12 LEU A 431
GLY A 434
VAL A 439
ALA A 455
LYS A 457
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.0A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.64A 4mkcA-3fzpA:
32.1		 4mkcA-3fzpA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLY A 743
ASP A 744
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.66A 4mkcA-4crsA:
22.2		 4mkcA-4crsA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		6 / 7 LYS A 245
ASN A 299
ARG A 301
GLN A 303
VAL A 304
GLU A 305
 AGS  A1162 (-3.5A)
AGS  A1162 ( 3.7A)
None
None
None
None
 0.84A 4mv7A-2qf7A:
54.8		 4mv7A-2qf7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1215
GLY A  33
GLY A1203
ILE A1188
SER A  37
 None
None
None
None
AGS  A2224 (-3.5A)
 0.93A 4mwzA-1w1wA:
undetectable		 4mwzA-1w1wA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1215
GLY A  33
GLY A1203
ILE A1188
SER A  37
 None
None
None
None
AGS  A2224 (-3.5A)
 0.98A 4mwzB-1w1wA:
undetectable		 4mwzB-1w1wA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.81A 4mxxB-4crsA:
21.0		 4mxxB-4crsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		7 / 12 LEU A 468
VAL A 476
ALA A 489
LYS A 491
VAL A 527
TYR A 546
THR A 612
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 (-2.8A)
None
AGS  A 801 ( 4.8A)
None
 0.77A 4mxxB-5o0yA:
14.4		 4mxxB-5o0yA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.85A 4mxyA-4crsA:
22.7		 4mxyA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.93A 4mxyA-4crsA:
22.7		 4mxyA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.83A 4mxyA-4crsA:
22.7		 4mxyA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.81A 4mxyA-4crsA:
22.7		 4mxyA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 ALA A 684
VAL A 721
MET A 737
TYR A 739
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.83A 4mxyB-4crsA:
22.6		 4mxyB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.89A 4mxyB-4crsA:
22.6		 4mxyB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.80A 4mxyB-4crsA:
22.6		 4mxyB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.85A 4mxzA-4crsA:
22.7		 4mxzA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.93A 4mxzA-4crsA:
22.7		 4mxzA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.83A 4mxzA-4crsA:
22.7		 4mxzA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.81A 4mxzA-4crsA:
22.7		 4mxzA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 ALA A 684
VAL A 721
MET A 737
TYR A 739
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.83A 4mxzB-4crsA:
22.6		 4mxzB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.89A 4mxzB-4crsA:
22.6		 4mxzB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.80A 4mxzB-4crsA:
22.6		 4mxzB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 4tl9 CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 12 ASN A 245
LEU A  54
GLY A  27
GLY A  35
ASP A  29
 None
AGS  A 303 (-4.2A)
None
None
None
 1.12A 4n09A-4tl9A:
3.0		 4n09A-4tl9A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 11 LEU A 431
GLY A 432
VAL A 439
ALA A 455
LYS A 457
ASN A 554
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.5A)
 0.88A 4o0sA-3fzpA:
24.9		 4o0sA-3fzpA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		4 / 6 VAL A 439
ALA A 455
LYS A 457
LEU A 556
 AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.5A)
 0.66A 4o0uA-3fzpA:
8.7		 4o0uA-3fzpA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		5 / 12 LEU A  40
ALA A 173
THR A  78
ILE A 159
LYS A  50
 None
None
AGS  A 300 ( 4.7A)
None
AGS  A 300 (-2.6A)
 1.12A 4o2bB-2ozeA:
undetectable		 4o2bB-2ozeA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 8 VAL A 671
ALA A 684
ASP A 744
ASN A 787
LEU A 789
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.0A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
 0.55A 4ogrA-4crsA:
26.5		 4ogrA-4crsA:
25.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 7 ALA A  34
ASP A  88
ASN A 138
LEU A 140
ASP A 151
 AGS  A3001 (-3.5A)
None
AGS  A3001 (-3.9A)
None
AGS  A3001 (-2.8A)
 0.65A 4ogrE-2pmiA:
31.8		 4ogrE-2pmiA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 7 ALA A 684
ASP A 744
ASN A 787
LEU A 789
ASP A 800
 AGS  A1985 (-3.5A)
AGS  A1985 (-4.0A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.48A 4ogrE-4crsA:
25.9		 4ogrE-4crsA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 VAL A 671
ALA A 684
ASP A 744
ASN A 787
LEU A 789
ASP A 800
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.0A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.69A 4ogrI-4crsA:
26.5		 4ogrI-4crsA:
25.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		10 / 12 LEU A 663
GLY A 666
GLY A 669
VAL A 671
ALA A 684
LYS A 686
VAL A 721
LEU A 789
ALA A 799
PHE A 946
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 (-4.8A)
 0.57A 4otiA-4crsA:
26.0		 4otiA-4crsA:
77.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
LYS A 686
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.91A 4otwA-4crsA:
20.2		 4otwA-4crsA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 5 HIS A 216
VAL A 217
GLU A 218
LYS A 245
 AGS  A1162 (-3.9A)
None
None
AGS  A1162 (-3.5A)
 1.04A 4p6vB-2qf7A:
3.7
4p6vE-2qf7A:
undetectable		 4p6vB-2qf7A:
16.28
4p6vE-2qf7A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 1zun SULFATE
ADENYLYLTRANSFERASE
SUBUNIT 2
(Pseudomonas
syringae) 		5 / 12 GLY A 132
ALA A 134
ASN A 187
SER A  15
ILE A  18
 AGS  A 600 ( 4.5A)
AGS  A 600 ( 4.7A)
None
None
None
 1.04A 4pb1A-1zunA:
undetectable		 4pb1A-1zunA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1zun SULFATE
ADENYLYLTRANSFERASE
SUBUNIT 2
(Pseudomonas
syringae) 		5 / 12 GLY A 132
ALA A 134
ASN A 187
SER A  15
ILE A  18
 AGS  A 600 ( 4.5A)
AGS  A 600 ( 4.7A)
None
None
None
 0.97A 4pd5A-1zunA:
undetectable		 4pd5A-1zunA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		4 / 7 THR B  79
THR B 299
LEU B  29
ASN B  27
 None
AGS  B1342 (-4.1A)
None
None
 1.11A 4pfjA-3zeuB:
undetectable		 4pfjA-3zeuB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 10 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 1.09A 4ph9A-2xj9A:
undetectable		 4ph9A-2xj9A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 10 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 1.09A 4ph9B-2xj9A:
undetectable		 4ph9B-2xj9A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 ALA A 684
GLU A 705
TYR A 739
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.47A 4qmnA-4crsA:
28.8		 4qmnA-4crsA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 11 ALA A 684
LYS A 686
GLU A 705
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.81A 4qmsA-4crsA:
29.0		 4qmsA-4crsA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
LEU A 773
ARG A 781
ALA A 799
 AGS  A1985 (-3.5A)
None
None
TPO  A 816 ( 3.0A)
AGS  A1985 ( 4.5A)
 0.86A 4qrcA-4crsA:
16.0		 4qrcA-4crsA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 5 LEU A 702
SER A 701
ASP A 800
ASP A 786
 None
None
AGS  A1985 ( 3.3A)
None
 1.23A 4qtuD-4crsA:
undetectable		 4qtuD-4crsA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 THR A 360
THR A 361
ALA A 363
ARG B 128
GLY A 356
 MG  A 811 ( 2.9A)
AGS  A 801 (-3.7A)
None
AGS  A 801 (-3.6A)
AGS  A 801 (-3.5A)
 1.20A 4qvnV-1sxjA:
undetectable
4qvnb-1sxjA:
undetectable		 4qvnV-1sxjA:
16.25
4qvnb-1sxjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 THR A 360
THR A 361
ALA A 363
ARG B 128
GLY A 356
 MG  A 811 ( 2.9A)
AGS  A 801 (-3.7A)
None
AGS  A 801 (-3.6A)
AGS  A 801 (-3.5A)
 1.20A 4qvnH-1sxjA:
undetectable
4qvnN-1sxjA:
undetectable		 4qvnH-1sxjA:
16.25
4qvnN-1sxjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		5 / 11 ALA B 165
GLY B 137
GLY B 138
ALA B 161
SER B 157
 None
ADP  B1343 (-3.5A)
AGS  B1342 (-3.2A)
None
None
 0.89A 4qw1K-3zeuB:
undetectable
4qw1L-3zeuB:
undetectable		 4qw1K-3zeuB:
21.96
4qw1L-3zeuB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		7 / 12 VAL A  21
ALA A  34
LYS A  36
GLU A  53
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
AGS  A3001 (-2.8A)
 1.07A 4r7iA-2pmiA:
20.1		 4r7iA-2pmiA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 5 LEU A 663
VAL A 721
TYR A 739
ARG A 781
 AGS  A1985 (-4.2A)
None
None
TPO  A 816 ( 3.0A)
 0.72A 4r7iA-4crsA:
20.5		 4r7iA-4crsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLY A 743
ASN A 787
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.64A 4twpA-4crsA:
23.3		 4twpA-4crsA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLY A 743
ASN A 787
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.54A 4twpB-4crsA:
18.9		 4twpB-4crsA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 6 LEU A 663
VAL A 671
ARG A 781
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
TPO  A 816 ( 3.0A)
None
 0.73A 4tyjA-4crsA:
21.3		 4tyjA-4crsA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 10 LEU A 663
VAL A 671
GLU A 705
VAL A 721
TYR A 739
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
None
None
None
 0.67A 4u0iA-4crsA:
21.0		 4u0iA-4crsA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 11 LEU A 663
GLY A 666
VAL A 671
ALA A 684
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.70A 4u5jA-4crsA:
17.9		 4u5jA-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 11 LEU A 663
VAL A 671
ALA A 684
TYR A 739
GLY A 743
ASN A 787
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.56A 4u5jA-4crsA:
17.9		 4u5jA-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
ALA A 684
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
 0.58A 4u5jB-4crsA:
17.9		 4u5jB-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 7 VAL A 671
ALA A 740
ARG A 781
ILE A 798
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.9A)
TPO  A 816 ( 3.0A)
None
 0.49A 4uxqA-4crsA:
16.0		 4uxqA-4crsA:
28.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		5 / 7 VAL A 138
ILE A 184
ALA A 203
ARG A 262
ILE A 287
 AGS  A1438 (-4.4A)
AGS  A1438 (-4.2A)
AGS  A1438 (-3.7A)
None
None
 0.78A 4uxqA-4uyaA:
25.4		 4uxqA-4uyaA:
32.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.75A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
LYS A 686
TYR A 739
ARG A 781
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
 0.79A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
TYR A 739
ARG A 781
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
None
 0.48A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.68A 4v01B-4crsA:
20.8		 4v01B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
ILE A 708
TYR A 739
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
None
AGS  A1985 (-4.8A)
None
 0.70A 4v01B-4crsA:
20.8		 4v01B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 9 LEU A 663
VAL A 671
LYS A 686
TYR A 739
ARG A 781
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
None
 0.82A 4v01B-4crsA:
20.8		 4v01B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
ALA A 740
ALA A 799
GLY A 802
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
AGS  A1985 ( 4.5A)
None
 1.29A 4v04A-4crsA:
15.0		 4v04A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.75A 4v04A-4crsA:
15.0		 4v04A-4crsA:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		4 / 8 ILE A 184
ARG A 262
LEU A 270
ILE A 287
 AGS  A1438 (-4.2A)
None
AGS  A1438 (-4.7A)
None
 0.67A 4v04A-4uyaA:
26.0		 4v04A-4uyaA:
32.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 10 LEU A 663
VAL A 671
LYS A 686
TYR A 739
ARG A 781
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
 0.96A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 10 LEU A 663
VAL A 671
TYR A 739
ARG A 781
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
None
 0.79A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 ALA A 684
GLU A 705
ALA A 740
ALA A 799
ASP A 800
GLY A 802
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
None
 1.45A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.75A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 8 LEU A 663
ALA A 684
MET A 737
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
AGS  A1985 (-4.8A)
 0.41A 4wboB-4crsA:
35.4		 4wboB-4crsA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 6 LEU A 663
ALA A 684
MET A 737
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
AGS  A1985 (-4.8A)
 0.45A 4wboC-4crsA:
35.1		 4wboC-4crsA:
25.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
ALA A 455
LYS A 457
GLU A 474
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.88A 4wkqA-3fzpA:
31.3		 4wkqA-3fzpA:
35.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 656
ALA A 685
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-4.0A)
AGS  A 902 (-3.5A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.13A 4x5hA-5c1bA:
undetectable		 4x5hA-5c1bA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.74A 4xeyA-4crsA:
22.9		 4xeyA-4crsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
ALA A 684
GLU A 705
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.78A 4xliA-4crsA:
24.0		 4xliA-4crsA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
ALA A 684
LYS A 686
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.79A 4xliB-4crsA:
18.3		 4xliB-4crsA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
ALA A 684
LYS A 686
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.67A 4xliB-4crsA:
18.3		 4xliB-4crsA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
LYS A  36
GLY A 150
ASP A 151
PHE A 152
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
AGS  A3001 (-2.8A)
None
 0.91A 4xv2B-2pmiA:
22.0		 4xv2B-2pmiA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 7 GLY A 743
GLY A 742
ALA A 740
ILE A 937
 None
None
AGS  A1985 (-3.9A)
None
 0.73A 4yjiA-4crsA:
undetectable		 4yjiA-4crsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 6 PHE 6 712
ASN 6 683
PRO 6 684
ARG 6 794
 None
AGS  61101 (-1.5A)
None
None
 1.41A 4yv5B-5udb6:
undetectable		 4yv5B-5udb6:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 6 PHE 6 712
ASN 6 683
PRO 6 684
ARG 6 794
 None
AGS  61101 (-1.5A)
None
None
 1.39A 4yv5A-5udb6:
undetectable		 4yv5A-5udb6:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		4 / 6 GLY B 163
ASP B 167
GLY B 268
SER B   9
 ADP  B1343 (-3.3A)
ADP  B1343 (-2.9A)
AGS  B1342 (-3.1A)
AGS  B1342 ( 4.9A)
 0.84A 4z53A-3zeuB:
undetectable
4z53B-3zeuB:
undetectable		 4z53A-3zeuB:
19.05
4z53B-3zeuB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		4 / 7 GLY B 163
ASP B 167
GLY B 268
SER B   9
 ADP  B1343 (-3.3A)
ADP  B1343 (-2.9A)
AGS  B1342 (-3.1A)
AGS  B1342 ( 4.9A)
 0.86A 4z53A-3zeuB:
undetectable
4z53B-3zeuB:
undetectable		 4z53A-3zeuB:
19.05
4z53B-3zeuB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 1njf DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 12 ALA A  95
THR A 157
THR A  52
LEU A 124
ARG A  56
 None
AGS  A 402 ( 4.8A)
AGS  A 402 (-3.7A)
None
None
 1.37A 4z7fC-1njfA:
0.1		 4z7fC-1njfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		6 / 9 VAL A  21
ALA A  34
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
None
None
None
AGS  A3001 (-2.8A)
 0.70A 5aaaA-2pmiA:
15.1		 5aaaA-2pmiA:
25.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 9 LEU A 431
VAL A 439
ALA A 455
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
None
 0.73A 5aaaA-3fzpA:
32.1		 5aaaA-3fzpA:
34.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
ALA A 684
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.70A 5aaaA-4crsA:
22.0		 5aaaA-4crsA:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 9 VAL A 138
ALA A 149
LEU A 200
GLY A 206
LEU A 270
ASP A 289
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
None
AGS  A1438 (-4.7A)
AGS  A1438 (-2.7A)
 0.73A 5aaaA-4uyaA:
27.1		 5aaaA-4uyaA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		7 / 10 VAL A  21
ALA A  34
LYS A  36
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
None
None
AGS  A3001 (-2.8A)
 0.82A 5aabA-2pmiA:
15.1		 5aabA-2pmiA:
25.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 10 LEU A 431
VAL A 439
ALA A 455
LYS A 457
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.5A)
None
 0.97A 5aabA-3fzpA:
31.7		 5aabA-3fzpA:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 10 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.91A 5aabA-4crsA:
21.7		 5aabA-4crsA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		7 / 10 VAL A  21
ALA A  34
LYS A  36
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
None
None
AGS  A3001 (-2.8A)
 0.91A 5aacA-2pmiA:
21.3		 5aacA-2pmiA:
25.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 10 LEU A 431
VAL A 439
ALA A 455
LYS A 457
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.5A)
None
 1.07A 5aacA-3fzpA:
31.5		 5aacA-3fzpA:
34.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
ALA A 684
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.53A 5ajqA-4crsA:
24.8		 5ajqA-4crsA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.80A 5bvwA-4crsA:
20.5		 5bvwA-4crsA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 11 THR A  86
ALA A  93
GLY A 120
ALA A 116
ASP A 112
 AGS  A 400 (-3.9A)
None
None
None
AGS  A 400 (-3.6A)
 1.34A 5bxnV-1xp8A:
undetectable
5bxnW-1xp8A:
undetectable		 5bxnV-1xp8A:
19.84
5bxnW-1xp8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 656
ALA A 685
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-4.0A)
AGS  A 902 (-3.5A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.13A 5e8qB-5c1bA:
undetectable		 5e8qB-5c1bA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		4 / 7 GLY A 239
GLY A 241
GLU A 261
ASP A 283
 AGS  A 502 (-3.3A)
AGS  A 502 (-3.1A)
AGS  A 502 (-2.4A)
AGS  A 502 (-2.9A)
 0.74A 5ergB-4j9vA:
9.6		 5ergB-4j9vA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 MET A 682
GLU A 941
CYH A 659
CYH A 660
LEU A 663
 None
None
None
None
AGS  A1985 (-4.2A)
 1.42A 5fhzD-4crsA:
undetectable		 5fhzD-4crsA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
LEU A 504
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
 0.84A 5h2uA-3fzpA:
29.0		 5h2uA-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 LEU A 431
VAL A 439
ALA A 455
LYS A 457
LEU A 504
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.4A)
None
 0.86A 5h2uA-3fzpA:
29.0		 5h2uA-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		8 / 12 LEU A 431
VAL A 439
ALA A 455
LEU A 504
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.08A 5h2uB-3fzpA:
24.1		 5h2uB-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
LYS A 457
LEU A 504
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.4A)
None
AGS  A 999 ( 3.9A)
 1.10A 5h2uB-3fzpA:
24.1		 5h2uB-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		8 / 12 VAL A 439
ALA A 455
ILE A 500
LEU A 504
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.08A 5h2uB-3fzpA:
24.1		 5h2uB-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 ALA A 455
ILE A 500
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 (-3.6A)
None
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.09A 5h2uC-3fzpA:
29.2		 5h2uC-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 LEU A 431
ALA A 455
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.07A 5h2uC-3fzpA:
29.2		 5h2uC-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 LEU A 431
ALA A 455
LYS A 457
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.05A 5h2uC-3fzpA:
29.2		 5h2uC-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 ALA A 455
ILE A 500
LEU A 504
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.05A 5h2uD-3fzpA:
29.3		 5h2uD-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
ALA A 455
LEU A 504
GLY A 508
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.06A 5h2uD-3fzpA:
29.3		 5h2uD-3fzpA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
LEU A 504
LEU A 556
GLY A 566
ASP A 567
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
AGS  A 999 (-4.5A)
None
AGS  A 999 ( 3.9A)
 1.01A 5h2uD-3fzpA:
29.3		 5h2uD-3fzpA:
37.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
LYS A 686
TYR A 739
ALA A 740
PHE A 801
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-3.9A)
None
 0.81A 5hesB-4crsA:
20.8		 5hesB-4crsA:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 656
ALA A 685
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-4.0A)
AGS  A 902 (-3.5A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.15A 5hi6B-5c1bA:
undetectable		 5hi6B-5c1bA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A1188
ASP A1157
GLY A  38
ASN A  35
 None
MG  A2001 ( 4.1A)
AGS  A2224 (-3.0A)
AGS  A2224 (-3.8A)
 0.96A 5hwaA-1w1wA:
undetectable		 5hwaA-1w1wA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ILE A1273
ASP A1237
GLY A  39
ASN A  36
 None
MG  A1401 ( 3.7A)
AGS  A1402 (-3.1A)
AGS  A1402 (-3.7A)
 0.98A 5hwaA-5dacA:
undetectable		 5hwaA-5dacA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 10 ASP A 839
ALA A 799
ILE A 798
PHE A 801
VAL A 712
 None
AGS  A1985 ( 4.5A)
None
None
None
 1.25A 5i6xA-4crsA:
undetectable		 5i6xA-4crsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5mtv EH DOMAIN-CONTAINING
PROTEIN 4
(Mus
musculus) 		4 / 6 GLY A  73
THR A  72
SER A  71
ASN A 222
 AGS  A1000 (-3.1A)
None
AGS  A1000 (-3.0A)
AGS  A1000 (-3.2A)
 0.80A 5k4pA-5mtvA:
undetectable		 5k4pA-5mtvA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		4 / 8 PRO B 178
GLY B 180
PRO B 181
ASP B 167
 None
AGS  B1342 (-3.4A)
AGS  B1342 (-3.8A)
ADP  B1343 (-2.9A)
 0.92A 5kf8A-3zeuB:
undetectable		 5kf8A-3zeuB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		4 / 8 PRO B 178
GLY B 180
PRO B 181
ASP B 167
 None
AGS  B1342 (-3.4A)
AGS  B1342 (-3.8A)
ADP  B1343 (-2.9A)
 0.98A 5kgpA-3zeuB:
undetectable		 5kgpA-3zeuB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP
(Salmonella
enterica) 		4 / 8 PRO B 178
GLY B 180
PRO B 181
ASP B 167
 None
AGS  B1342 (-3.4A)
AGS  B1342 (-3.8A)
ADP  B1343 (-2.9A)
 0.96A 5kgpB-3zeuB:
undetectable		 5kgpB-3zeuB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
VAL A 721
ASP A 744
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.45A 5l2iA-4crsA:
8.0		 5l2iA-4crsA:
26.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		6 / 12 VAL A  21
ALA A  34
VAL A  66
PHE A  82
ASP A  88
LEU A 140
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
None
None
None
None
 0.91A 5l2tA-2pmiA:
14.5		 5l2tA-2pmiA:
41.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
VAL A 721
ASP A 744
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.74A 5l2tA-4crsA:
8.0		 5l2tA-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 THR A  86
ALA A  93
GLY A 120
ALA A 116
ASP A 112
 AGS  A 400 (-3.9A)
None
None
None
AGS  A 400 (-3.6A)
 1.37A 5l5zH-1xp8A:
undetectable
5l5zI-1xp8A:
undetectable		 5l5zH-1xp8A:
19.63
5l5zI-1xp8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 THR A  86
ALA A  93
GLY A 120
ALA A 116
ASP A 112
 AGS  A 400 (-3.9A)
None
None
None
AGS  A 400 (-3.6A)
 1.38A 5l5zV-1xp8A:
undetectable
5l5zW-1xp8A:
undetectable		 5l5zV-1xp8A:
19.63
5l5zW-1xp8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 9 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 AGS  A 800 (-3.9A)
AGS  A 800 ( 4.8A)
CA  A 801 ( 2.3A)
AGS  A 800 ( 4.4A)
AGS  A 800 (-4.3A)
 1.28A 5lg3B-1auxA:
undetectable		 5lg3B-1auxA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 9 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 AGS  A 800 (-3.9A)
AGS  A 800 ( 4.8A)
CA  A 801 ( 2.3A)
AGS  A 800 ( 4.4A)
AGS  A 800 (-4.3A)
 1.29A 5lg3C-1auxA:
undetectable		 5lg3C-1auxA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 9 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 AGS  A 800 (-3.9A)
AGS  A 800 ( 4.8A)
CA  A 801 ( 2.3A)
AGS  A 800 ( 4.4A)
AGS  A 800 (-4.3A)
 1.28A 5lg3D-1auxA:
0.0		 5lg3D-1auxA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 10 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 AGS  A 800 (-3.9A)
AGS  A 800 ( 4.8A)
CA  A 801 ( 2.3A)
AGS  A 800 ( 4.4A)
AGS  A 800 (-4.3A)
 1.27A 5lg3G-1auxA:
undetectable		 5lg3G-1auxA:
23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 11 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
ALA A 740
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-3.9A)
AGS  A1985 (-4.8A)
 0.30A 5lvnA-4crsA:
27.1		 5lvnA-4crsA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 11 GLY A 131
VAL A 138
ALA A 149
LEU A 200
ALA A 203
LEU A 270
 AGS  A1438 ( 3.8A)
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
AGS  A1438 (-3.7A)
AGS  A1438 (-4.7A)
 0.40A 5lvnA-4uyaA:
22.7		 5lvnA-4uyaA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		6 / 11 LEU A 468
GLY A 469
VAL A 476
ALA A 489
LEU A 544
TYR A 546
 AGS  A 801 (-4.1A)
AGS  A 801 ( 4.0A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 ( 4.0A)
AGS  A 801 ( 4.8A)
 0.37A 5lvnA-5o0yA:
27.5		 5lvnA-5o0yA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 GLY A 432
VAL A 439
ALA A 455
LYS A 457
GLU A 474
GLY A 508
GLU A 509
 AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-3.8A)
 0.76A 5mafA-3fzpA:
23.7		 5mafA-3fzpA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 10 LEU A 663
VAL A 671
LYS A 686
GLU A 705
GLY A 743
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
None
 0.68A 5mo4A-4crsA:
16.1		 5mo4A-4crsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
LEU A 720
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.56A 5mo4A-4crsA:
12.9		 5mo4A-4crsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		5 / 10 TYR A  56
ILE A 246
ILE A 156
ILE A 219
ILE A 217
 AGS  A 503 (-3.3A)
None
None
AGS  A 503 ( 4.3A)
None
 1.01A 5murE-1k6mA:
0.0		 5murE-1k6mA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 10 LEU A 431
VAL A 439
ALA A 455
VAL A 487
MET A 502
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
None
AGS  A 999 (-4.5A)
 0.77A 5n3hA-3fzpA:
22.0		 5n3hA-3fzpA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 10 LEU A 663
VAL A 671
ALA A 684
VAL A 721
MET A 737
TYR A 739
LEU A 789
PHE A 946
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
AGS  A1985 (-4.8A)
 0.61A 5n3hA-4crsA:
39.0		 5n3hA-4crsA:
40.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ARG 2 656
GLY 2 546
PRO 2 545
THR 6 796
 None
AGS  22001 ( 4.4A)
AGS  22001 ( 4.4A)
None
 1.07A 5ny7A-5udb2:
undetectable		 5ny7A-5udb2:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 12 GLN A 331
GLN A 351
GLY A  13
THR A  14
GLN A 352
 None
AGS  A 501 (-3.9A)
None
None
None
 1.30A 5oj0A-4j9vA:
undetectable		 5oj0A-4j9vA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 8 ALA A 684
GLU A 705
LEU A 789
ASP A 800
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.35A 5owrA-4crsA:
22.9		 5owrA-4crsA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2oze ORF DELTA'
(Streptococcus
pyogenes) 		4 / 6 LYS A  50
VAL A 180
ILE A 174
TYR A 197
 AGS  A 300 (-2.6A)
None
None
None
 1.45A 5q1sA-2ozeA:
1.8		 5q1sA-2ozeA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 4tl9 CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 12 ALA A  87
GLY A 243
ILE A 239
SER A  56
ILE A  57
 None
None
AGS  A 303 ( 3.9A)
None
None
 0.85A 5t2zA-4tl9A:
undetectable		 5t2zA-4tl9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 673
ALA A 684
GLU A 705
VAL A 721
GLY A 743
LEU A 789
 None
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.39A 5te0A-4crsA:
26.9		 5te0A-4crsA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 656
ALA A 685
ILE A 645
LEU A 482
THR A 688
 AGS  A 902 (-4.0A)
AGS  A 902 (-3.5A)
None
AGS  A 902 ( 4.7A)
AGS  A 902 (-3.1A)
 1.12A 5ujxB-5c1bA:
undetectable		 5ujxB-5c1bA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3wry TM-1 PROTEIN
(Solanum
lycopersicum) 		4 / 4 LEU A 122
GLY A 123
SER A 148
SER A 169
 None
AGS  A 501 ( 4.1A)
None
None
 1.36A 5uunA-3wryA:
undetectable		 5uunA-3wryA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		6 / 12 ALA A  34
LYS A  36
GLU A  53
VAL A  66
LEU A  80
GLY A 150
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
None
 0.93A 5vcvA-2pmiA:
24.2		 5vcvA-2pmiA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN
(Chaetomium
thermophilum) 		6 / 10 GLY H 264
LEU H 258
ILE H 385
LEU H 259
THR H 268
ALA H 362
 AGS  H 901 (-3.2A)
None
None
None
MG  H 903 ( 3.5A)
None
 1.40A 5vm8B-6chsH:
undetectable		 5vm8B-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 9 LEU A 663
ALA A 684
VAL A 721
MET A 737
GLY A 743
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
 0.64A 5w5vA-4crsA:
14.8		 5w5vA-4crsA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		4 / 5 PHE A 336
PHE A 338
LEU A 160
PHE A 159
 AGS  A1383 (-4.1A)
None
None
None
 1.32A 5wauc-1gjvA:
1.4
5wauj-1gjvA:
0.3		 5wauc-1gjvA:
18.80
5wauj-1gjvA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 11 VAL A 238
GLY A 239
GLU A 261
ASP A 283
ALA A 284
 None
AGS  A 502 (-3.3A)
AGS  A 502 (-2.4A)
AGS  A 502 (-2.9A)
AGS  A 502 (-3.2A)
 0.79A 5x6yA-4j9vA:
3.4		 5x6yA-4j9vA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 10 VAL A 238
GLY A 239
GLU A 261
ALA A 284
ASN A 306
 None
AGS  A 502 (-3.3A)
AGS  A 502 (-2.4A)
AGS  A 502 (-3.2A)
AGS  A 502 (-2.8A)
 1.19A 5x6yB-4j9vA:
undetectable		 5x6yB-4j9vA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 10 VAL A 238
GLY A 239
GLU A 261
ASP A 283
ALA A 284
 None
AGS  A 502 (-3.3A)
AGS  A 502 (-2.4A)
AGS  A 502 (-2.9A)
AGS  A 502 (-3.2A)
 0.76A 5x6yB-4j9vA:
undetectable		 5x6yB-4j9vA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 11 VAL A 238
GLY A 239
GLU A 261
ASP A 283
ALA A 284
 None
AGS  A 502 (-3.3A)
AGS  A 502 (-2.4A)
AGS  A 502 (-2.9A)
AGS  A 502 (-3.2A)
 0.63A 5x6yC-4j9vA:
5.1		 5x6yC-4j9vA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
GLU A 474
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.81A 5y7zA-3fzpA:
22.3		 5y7zA-3fzpA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		7 / 12 LEU A 431
VAL A 439
ALA A 455
GLU A 474
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.81A 5y7zA-3fzpA:
22.3		 5y7zA-3fzpA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.68A 5y7zA-4crsA:
26.4		 5y7zA-4crsA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.68A 5y7zA-4crsA:
26.4		 5y7zA-4crsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
ALA A 684
LYS A 686
GLU A 705
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.69A 5y7zB-4crsA:
26.5		 5y7zB-4crsA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.66A 5y80A-4crsA:
25.8		 5y80A-4crsA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 GLY A 432
VAL A 439
ALA A 455
LYS A 457
LEU A 556
ASP A 567
 AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.5A)
AGS  A 999 ( 3.9A)
 0.85A 5yu9B-3fzpA:
25.1		 5yu9B-3fzpA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 12 GLY A 131
VAL A 138
ALA A 149
LEU A 198
LEU A 270
THR A 288
 AGS  A1438 ( 3.8A)
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
AGS  A1438 (-4.7A)
AGS  A1438 ( 4.7A)
 0.75A 5yu9B-4uyaA:
26.0		 5yu9B-4uyaA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		5 / 12 VAL A 138
ALA A 149
LEU A 198
GLY A 206
THR A 288
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
None
AGS  A1438 ( 4.7A)
 0.63A 5yu9C-4uyaA:
25.7		 5yu9C-4uyaA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3fzp PROTEIN TYROSINE
KINASE 2 BETA
(Homo
sapiens) 		6 / 12 VAL A 439
ALA A 455
LYS A 457
GLY A 508
LEU A 556
ASP A 567
 AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.5A)
AGS  A 999 ( 3.9A)
 0.94A 5yu9D-3fzpA:
29.9		 5yu9D-3fzpA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		3 / 3 TYR A 452
ARG A 215
THR A 454
 None
None
AGS  A1162 (-3.5A)
 0.80A 5z84J-2qf7A:
undetectable		 5z84J-2qf7A:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
TYR A 739
ALA A 740
GLY A 743
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.64A 5zv2A-4crsA:
15.8		 5zv2A-4crsA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
ALA A 740
GLY A 743
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.64A 5zv2B-4crsA:
16.1		 5zv2B-4crsA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		3 / 3 TYR A 739
LEU A 789
ASP A 800
 None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.78A 5zv2B-4crsA:
16.1		 5zv2B-4crsA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		4 / 7 HIS 3 487
ARG 3 700
GLU 3 491
ARG 3 400
 None
AGS  32001 (-3.9A)
AGS  32001 (-2.0A)
None
 1.22A 6b8kA-5udb3:
undetectable		 6b8kA-5udb3:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.69A 6bsdA-4crsA:
20.3		 6bsdA-4crsA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 693
GLY A 444
GLY A 449
ARG A 450
PRO A 430
 AGS  A1723 (-4.0A)
None
None
None
None
 1.09A 6ce2B-2iutA:
undetectable		 6ce2B-2iutA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		4 / 5 TYR A  19
LYS A  21
GLY A 264
ILE A 261
 AGS  A1393 (-4.8A)
AGS  A1393 (-2.3A)
None
AGS  A1393 ( 4.3A)
 1.31A 6debB-4a2bA:
undetectable		 6debB-4a2bA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 12 GLY A   9
ALA A   8
VAL A  47
ILE A  26
ILE A  28
 AGS  A 501 (-3.4A)
None
None
None
None
 0.83A 6dh3A-4j9vA:
undetectable		 6dh3A-4j9vA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 GLU H 769
ALA H 702
THR H 542
LEU H 544
ALA H 639
 None
AGS  H 902 (-3.5A)
MG  H 904 ( 3.3A)
None
None
 1.16A 6efnA-6chsH:
undetectable		 6efnA-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 10 GLY A 239
GLY A 241
GLU A 261
ASP A 263
THR A 305
 AGS  A 502 (-3.3A)
AGS  A 502 (-3.1A)
AGS  A 502 (-2.4A)
None
AGS  A 502 (-4.1A)
 0.78A 6exiA-4j9vA:
9.1		 6exiA-4j9vA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 10 GLY A 239
GLY A 241
GLU A 261
ASP A 263
THR A 305
 AGS  A 502 (-3.3A)
AGS  A 502 (-3.1A)
AGS  A 502 (-2.4A)
None
AGS  A 502 (-4.1A)
 0.79A 6exiB-4j9vA:
9.1		 6exiB-4j9vA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 12 GLY A 239
GLY A 241
GLU A 261
ASP A 263
THR A 305
 AGS  A 502 (-3.3A)
AGS  A 502 (-3.1A)
AGS  A 502 (-2.4A)
None
AGS  A 502 (-4.1A)
 0.79A 6exiC-4j9vA:
9.0
6exiD-4j9vA:
9.0		 6exiC-4j9vA:
9.66
6exiD-4j9vA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4j9v POTASSIUM UPTAKE
PROTEIN TRKA
(Vibrio
parahaemolyticus) 		5 / 12 GLY A 239
GLY A 241
GLU A 261
ASP A 263
THR A 305
 AGS  A 502 (-3.3A)
AGS  A 502 (-3.1A)
AGS  A 502 (-2.4A)
None
AGS  A 502 (-4.1A)
 0.77A 6exiC-4j9vA:
9.0
6exiD-4j9vA:
9.0		 6exiC-4j9vA:
9.66
6exiD-4j9vA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A  82
LYS A 174
TYR A 180
 None
AGS  A 503 (-2.9A)
None
 1.26A 6gnaA-1k6mA:
0.4		 6gnaA-1k6mA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A  82
LYS A 174
TYR A 180
 None
AGS  A 503 (-2.9A)
None
 1.26A 6gnbA-1k6mA:
0.4		 6gnbA-1k6mA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 THR A 335
GLY A 337
LEU A 213
PHE A 217
VAL A 241
 None
AGS  A1393 (-3.4A)
None
AGS  A1393 ( 4.3A)
None
 1.41A 6gnfC-4a2bA:
undetectable		 6gnfC-4a2bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 THR A 335
GLY A 338
LEU A 213
PHE A 217
VAL A 241
 None
AGS  A1393 ( 4.5A)
None
AGS  A1393 ( 4.3A)
None
 1.25A 6gnfC-4a2bA:
undetectable		 6gnfC-4a2bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 THR A 335
GLY A 338
LEU A 213
SER A 189
VAL A 241
 None
AGS  A1393 ( 4.5A)
None
None
None
 1.47A 6gnfC-4a2bA:
undetectable		 6gnfC-4a2bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 THR A 360
THR A 361
ALA A 363
ARG B 128
GLY A 356
 MG  A 811 ( 2.9A)
AGS  A 801 (-3.7A)
None
AGS  A 801 (-3.6A)
AGS  A 801 (-3.5A)
 1.23A 6hwdV-1sxjA:
undetectable
6hwdb-1sxjA:
undetectable		 6hwdV-1sxjA:
9.77
6hwdb-1sxjA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 THR A 360
THR A 361
ALA A 363
ARG B 128
GLY A 356
 MG  A 811 ( 2.9A)
AGS  A 801 (-3.7A)
None
AGS  A 801 (-3.6A)
AGS  A 801 (-3.5A)
 1.23A 6hwdH-1sxjA:
undetectable
6hwdN-1sxjA:
undetectable		 6hwdH-1sxjA:
9.77
6hwdN-1sxjA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ARG D 155
GLU C 118
ASP C 117
GLU C  81
 None
AGS  C 803 ( 4.9A)
MG  C 813 (-3.9A)
None
 1.33A 6mn5E-1sxjD:
0.0		 6mn5E-1sxjD:
12.69