SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AGP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		4 / 8 GLY A 139
ASP A 141
THR A 225
ILE A 144
 AGP  A2298 ( 3.9A)
None
None
None
 0.85A 2f9wA-1ne7A:
undetectable
2f9wB-1ne7A:
undetectable		 2f9wA-1ne7A:
21.00
2f9wB-1ne7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 9 LEU A  37
ALA A 196
ILE A 201
PRO A  40
LEU A  39
 None
None
None
AGP  A2298 (-4.0A)
None
 1.07A 3u7sA-1ne7A:
undetectable		 3u7sA-1ne7A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		4 / 8 ILE A 463
GLN A 480
THR A 425
THR A 428
 None
None
AGP  A   1 (-3.1A)
None
 0.82A 4n16A-2zj4A:
undetectable		 4n16A-2zj4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 12 THR A 474
GLU A 553
GLU A 468
LYS A 675
ASP A 666
 None
None
None
AGP  A   1 ( 4.9A)
None
 1.50A 4njjA-2zj4A:
0.7		 4njjA-2zj4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 9 THR A  44
ALA A 169
ILE A 203
GLY A 137
ASP A 141
 SO4  A2296 ( 3.7A)
None
None
AGP  A2298 (-3.8A)
None
 0.95A 4qvqK-1ne7A:
undetectable
4qvqL-1ne7A:
undetectable		 4qvqK-1ne7A:
19.05
4qvqL-1ne7A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 9 THR A  44
ALA A 169
ILE A 203
GLY A 137
ASP A 141
 SO4  A2296 ( 3.7A)
None
None
AGP  A2298 (-3.8A)
None
 0.95A 4qvqY-1ne7A:
undetectable
4qvqZ-1ne7A:
undetectable		 4qvqY-1ne7A:
19.05
4qvqZ-1ne7A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 12 ILE A 203
GLY A 137
VAL A 135
VAL A 199
ILE A   5
 None
AGP  A2298 (-3.8A)
None
None
None
 1.11A 5n0sA-1ne7A:
undetectable		 5n0sA-1ne7A:
21.85