SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AGM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 7 MET A 326
ILE B 381
ARG B 384
GLY A 474
 AGM  A 274 (-3.9A)
AGM  A 274 (-3.7A)
None
None
 1.20A 2pnjB-5n28A:
undetectable		 2pnjB-5n28A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanosarcina
barkeri) 		5 / 12 ASN A1290
GLY A1294
GLY A1278
TYR A1336
MET A1337
 None
None
None
None
AGM  A1285 (-3.9A)
 1.23A 2zw9A-1e6yA:
undetectable		 2zw9A-1e6yA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
(Methanothermobac
ter
marburgensis) 		4 / 5 TYR A 480
ALA A 313
TYR A 325
MET A 270
 None
None
None
AGM  A 274 ( 4.0A)
 1.24A 3d91A-5a8rA:
undetectable		 3d91A-5a8rA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		4 / 5 ASN A1494
ARG B2381
ASN B2376
ALA A1283
 AGM  A1285 ( 3.7A)
None
None
None
 1.13A 3frqA-1e6yA:
0.5		 3frqA-1e6yA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		4 / 7 ASN A1494
ARG B2381
ASN B2376
ALA A1283
 AGM  A1285 ( 3.7A)
None
None
None
 1.15A 3frqB-1e6yA:
0.4		 3frqB-1e6yA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanosarcina
barkeri) 		4 / 6 PRO A1292
GLY A1293
ASN A1494
LEU A1281
 None
None
AGM  A1285 ( 3.7A)
AGM  A1285 ( 3.8A)
 0.81A 3zqtA-1e6yA:
0.0		 3zqtA-1e6yA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 1mro METHYL-COENZYME M
REDUCTASE
(Methanothermobac
ter
marburgensis) 		4 / 6 PRO A 278
GLY A 279
ASN A 474
LEU A 267
 None
None
AGM  A 271 ( 3.7A)
AGM  A 271 ( 3.8A)
 0.79A 3zqtA-1mroA:
undetectable		 3zqtA-1mroA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		4 / 6 PRO A 281
GLY A 282
ASN A 476
LEU A 270
 None
None
AGM  A 274 ( 3.6A)
AGM  A 274 ( 3.8A)
 0.84A 3zqtA-5n28A:
undetectable		 3zqtA-5n28A:
16.52