SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AGL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ESW_A_ACRA651_1
(AMYLOMALTASE)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		6 / 12 SER A 134
TYR A 136
GLN A 336
HIS A 374
GLU A 420
HIS A 472
 GLC  A 605 ( 2.8A)
HMC  A 606 ( 4.0A)
AGL  A 607 ( 3.6A)
AGL  A 607 ( 3.8A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
 0.84A 1eswA-5csuA:
48.3		 1eswA-5csuA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ESW_A_ACRA651_1
(AMYLOMALTASE)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		8 / 12 SER A 134
TYR A 136
GLU A 420
HIS A 472
ASP A 473
ASN A 537
PRO A 539
TRP A 546
 GLC  A 605 ( 2.8A)
HMC  A 606 ( 4.0A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
HMC  A 606 ( 2.8A)
GLC  A 605 ( 3.7A)
GLC  A 605 ( 3.6A)
None
 0.48A 1eswA-5csuA:
48.3		 1eswA-5csuA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ESW_A_ACRA651_1
(AMYLOMALTASE)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		6 / 12 SER A 134
TYR A 136
HIS A 374
GLU A 420
HIS A 472
TRP A 546
 GLC  A 605 ( 2.8A)
HMC  A 606 ( 4.0A)
AGL  A 607 ( 3.8A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
None
 0.71A 1eswA-5csuA:
48.3		 1eswA-5csuA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ESW_A_ACRA651_1
(AMYLOMALTASE)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		6 / 12 TYR A 136
GLN A 336
TRP A 338
HIS A 374
GLU A 420
HIS A 472
 HMC  A 606 ( 4.0A)
AGL  A 607 ( 3.6A)
HMC  A 606 ( 3.6A)
AGL  A 607 ( 3.8A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
 0.83A 1eswA-5csuA:
48.3		 1eswA-5csuA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ESW_A_ACRA651_1
(AMYLOMALTASE)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		5 / 12 TYR A 136
TRP A 338
GLU A 420
HIS A 472
ASP A 473
 HMC  A 606 ( 4.0A)
HMC  A 606 ( 3.6A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
HMC  A 606 ( 2.8A)
 0.92A 1eswA-5csuA:
48.3		 1eswA-5csuA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OWC_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		10 / 11 SER A 134
TYR A 136
GLN A 336
TRP A 338
ASP A 373
HIS A 472
ASP A 473
ASN A 537
PRO A 539
TRP A 546
 GLC  A 605 ( 2.8A)
HMC  A 606 ( 4.0A)
AGL  A 607 ( 3.6A)
HMC  A 606 ( 3.6A)
HMC  A 606 ( 3.0A)
HMC  A 606 ( 3.8A)
HMC  A 606 ( 2.8A)
GLC  A 605 ( 3.7A)
GLC  A 605 ( 3.6A)
None
 0.71A 2owcA-5csuA:
49.3		 2owcA-5csuA:
38.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OWW_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		10 / 11 SER A 134
TYR A 136
GLN A 336
TRP A 338
ASP A 373
HIS A 472
ASP A 473
ASN A 537
PRO A 539
TRP A 546
 GLC  A 605 ( 2.8A)
HMC  A 606 ( 4.0A)
AGL  A 607 ( 3.6A)
HMC  A 606 ( 3.6A)
HMC  A 606 ( 3.0A)
HMC  A 606 ( 3.8A)
HMC  A 606 ( 2.8A)
GLC  A 605 ( 3.7A)
GLC  A 605 ( 3.6A)
None
 0.52A 2owwA-5csuA:
50.0		 2owwA-5csuA:
38.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		5 / 12 ARG A 371
ASP A 373
GLU A 420
HIS A 472
ASP A 473
 HMC  A 606 ( 3.7A)
HMC  A 606 ( 3.0A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
HMC  A 606 ( 2.8A)
 0.89A 3aicA-5csuA:
5.5		 3aicA-5csuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		5 / 12 ARG A 371
ASP A 373
GLU A 420
HIS A 472
ASP A 473
 HMC  A 606 ( 3.7A)
HMC  A 606 ( 3.0A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
HMC  A 606 ( 2.8A)
 0.89A 3aicE-5csuA:
5.5		 3aicE-5csuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		5 / 12 ARG A 371
ASP A 373
GLU A 420
HIS A 472
ASP A 473
 HMC  A 606 ( 3.7A)
HMC  A 606 ( 3.0A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
HMC  A 606 ( 2.8A)
 0.86A 3aicF-5csuA:
5.2		 3aicF-5csuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		5 / 12 ARG A 371
ASP A 373
GLU A 420
HIS A 472
ASP A 473
 HMC  A 606 ( 3.7A)
HMC  A 606 ( 3.0A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
HMC  A 606 ( 2.8A)
 0.94A 3aicH-5csuA:
5.4		 3aicH-5csuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		3 / 3 GLU A 420
ARG A 371
GLN A 336
 AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.7A)
AGL  A 607 ( 3.6A)
 0.97A 4rtbA-5csuA:
4.3		 4rtbA-5csuA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		12 / 12 ASP A 329
LEU A 330
GLN A 336
TRP A 338
ARG A 371
ASP A 373
GLU A 420
GLY A 423
PHE A 446
HIS A 456
HIS A 472
ASP A 473
 GLC  A 608 ( 3.5A)
BGC  A 609 ( 3.6A)
AGL  A 607 ( 3.6A)
HMC  A 606 ( 3.6A)
HMC  A 606 ( 3.7A)
HMC  A 606 ( 3.0A)
AGL  A 607 ( 2.7A)
GLC  A 608 ( 3.6A)
BGC  A 609 ( 4.1A)
BGC  A 609 ( 4.3A)
HMC  A 606 ( 3.8A)
HMC  A 606 ( 2.8A)
 0.31A 5csyB-5csuA:
60.3		 5csyB-5csuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC
(Arabidopsis
thaliana) 		5 / 5 TYR A 136
PHE A 331
HIS A 374
LEU A 422
PRO A 539
 HMC  A 606 ( 4.0A)
GLC  A 608 ( 4.7A)
AGL  A 607 ( 3.8A)
GLC  A 608 ( 3.8A)
GLC  A 605 ( 3.6A)
 0.13A 5csyB-5csuA:
60.3		 5csyB-5csuA:
100.00