SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AG8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R15_C_NCAC439_0 (ADP-RIBOSYL CYCLASE)	4lix	ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Arabidopsis thaliana)	3 / 3	TRP A 505 PHE A 329 TRP A 333	None AG8 A 901 (-3.7A) AG8 A 901 (-4.6A)	1.40A	1r15C-4lixA: undetectable	1r15C-4lixA: 17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R15_F_NCAF469_0 (ADP-RIBOSYL CYCLASE)	4lix	ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Arabidopsis thaliana)	3 / 3	TRP A 505 PHE A 329 TRP A 333	None AG8 A 901 (-3.7A) AG8 A 901 (-4.6A)	1.40A	1r15F-4lixA: undetectable	1r15F-4lixA: 17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R15_G_NCAG479_0 (ADP-RIBOSYL CYCLASE)	4lix	ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Arabidopsis thaliana)	3 / 3	TRP A 505 PHE A 329 TRP A 333	None AG8 A 901 (-3.7A) AG8 A 901 (-4.6A)	1.39A	1r15G-4lixA: undetectable	1r15G-4lixA: 17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R15_H_NCAH489_0 (ADP-RIBOSYL CYCLASE)	4lix	ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Arabidopsis thaliana)	3 / 3	TRP A 505 PHE A 329 TRP A 333	None AG8 A 901 (-3.7A) AG8 A 901 (-4.6A)	1.40A	1r15H-4lixA: undetectable	1r15H-4lixA: 17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UWH_A_BAXA1723_2 (B-RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE)	4lix	ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Arabidopsis thaliana)	4 / 6	ILE A 208 VAL A 171 ILE A 220 ILE A 226	AG8 A 901 (-4.3A) None None None	0.82A	1uwhA-4lixA: undetectable	1uwhA-4lixA: 16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WG8_B_SAMB3141_1 (PREDICTED S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	4lix	ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Arabidopsis thaliana)	3 / 3	HIS A 263 ASP A 380 ASN A 425	AG8 A 901 (-3.9A) AG8 A 901 ( 3.7A) None	0.86A	1wg8B-4lixA: undetectable	1wg8B-4lixA: 18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_C_SAMC1003_0 (SAM DEPENDENT METHYLTRANSFERASE)	4lix	ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Arabidopsis thaliana)	5 / 12	PHE A 329 PHE A 324 SER A 116 ALA A 312 GLY A 319	AG8 A 901 (-3.7A) None None None None	1.30A	2igtC-4lixA: undetectable	2igtC-4lixA: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K7G_B_ACTB902_0 (3-HYDROXYPROLINE DEHYDRATSE)	4lix	ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Arabidopsis thaliana)	4 / 7	ASP A 119 SER A 291 HIS A 263 SER A 289	None None AG8 A 901 (-3.9A) None	1.19A	4k7gB-4lixA: undetectable	4k7gB-4lixA: 18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KR4_C_AICC401_1 (OUTER MEMBRANE PROTEIN F)	4lix	ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Arabidopsis thaliana)	4 / 8	TYR A 494 ARG A 340 ASP A 379 ARG A 386	None None AG8 A 901 ( 4.6A) None	1.36A	4kr4C-4lixA: undetectable	4kr4C-4lixA: 17.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1R15_C_NCAC439_0","ADP-RIBOSYL CYCLASE","4lix","ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Arabidopsis thaliana",3,"TRP A 505;PHE A 329;TRP A 333","None;AG8 A 901 (-3.7A);AG8 A 901 (-4.6A)","1.40A","1r15C-4lixA:undetectable",null],["1R15_F_NCAF469_0","ADP-RIBOSYL CYCLASE","4lix","ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Arabidopsis thaliana",3,"TRP A 505;PHE A 329;TRP A 333","None;AG8 A 901 (-3.7A);AG8 A 901 (-4.6A)","1.40A","1r15F-4lixA:undetectable","1r15C-4lixA:17.00"],["1R15_G_NCAG479_0","ADP-RIBOSYL CYCLASE","4lix","ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Arabidopsis thaliana",3,"TRP A 505;PHE A 329;TRP A 333","None;AG8 A 901 (-3.7A);AG8 A 901 (-4.6A)","1.39A","1r15G-4lixA:undetectable","1r15F-4lixA:17.00"],["1R15_H_NCAH489_0","ADP-RIBOSYL CYCLASE","4lix","ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Arabidopsis thaliana",3,"TRP A 505;PHE A 329;TRP A 333","None;AG8 A 901 (-3.7A);AG8 A 901 (-4.6A)","1.40A","1r15H-4lixA:undetectable","1r15G-4lixA:17.00"],["1UWH_A_BAXA1723_2","B-RAF PROTO-ONCOGENE SERINE\/THREONINE-PROTEIN KINASE","4lix","ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Arabidopsis thaliana",4,"ILE A 208;VAL A 171;ILE A 220;ILE A 226","AG8 A 901 (-4.3A);None;None;None","0.82A","1uwhA-4lixA:undetectable","1r15H-4lixA:17.00"],["1WG8_B_SAMB3141_1","PREDICTED S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","4lix","ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Arabidopsis thaliana",3,"HIS A 263;ASP A 380;ASN A 425","AG8 A 901 (-3.9A);AG8 A 901 ( 3.7A);None","0.86A","1wg8B-4lixA:undetectable","1uwhA-4lixA:16.99"],["2IGT_C_SAMC1003_0","SAM DEPENDENT METHYLTRANSFERASE","4lix","ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Arabidopsis thaliana",5,"PHE A 329;PHE A 324;SER A 116;ALA A 312;GLY A 319","AG8 A 901 (-3.7A);None;None;None;None","1.30A","2igtC-4lixA:undetectable","1wg8B-4lixA:18.17"],["4K7G_B_ACTB902_0","3-HYDROXYPROLINE DEHYDRATSE","4lix","ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Arabidopsis thaliana",4,"ASP A 119;SER A 291;HIS A 263;SER A 289","None;None;AG8 A 901 (-3.9A);None","1.19A","4k7gB-4lixA:undetectable","2igtC-4lixA:18.57"],["4KR4_C_AICC401_1","OUTER MEMBRANE PROTEIN F","4lix","ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Arabidopsis thaliana",4,"TYR A 494;ARG A 340;ASP A 379;ARG A 386","None;None;AG8 A 901 ( 4.6A);None","1.36A","4kr4C-4lixA:undetectable","4k7gB-4lixA:18.55"]]