SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AG3'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 TYR A  10
HIS A  63
TYR A  62
GLY A  58
 AG3  A1001 (-4.9A)
AG3  A1001 (-4.0A)
AG3  A1001 (-4.5A)
None
 1.09A 1mxgA-2zsuA:
undetectable		 1mxgA-2zsuA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 12 GLY A  86
GLY A  88
GLY A  89
HIS A  63
ASP A 109
VAL A 112
 None
None
None
AG3  A1001 (-4.0A)
None
None
 1.40A 1n2xB-2zsuA:
13.8		 1n2xB-2zsuA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  84
GLY A  85
GLY A  86
GLU A 107
ASP A 144
 None
AG3  A1001 ( 4.9A)
None
None
None
 0.74A 1qzzA-2zsuA:
12.5		 1qzzA-2zsuA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  84
GLY A  85
GLY A  86
GLU A 107
ASP A 144
 None
AG3  A1001 ( 4.9A)
None
None
None
 0.76A 1xdsA-2zsuA:
11.3		 1xdsA-2zsuA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  84
GLY A  85
GLY A  86
GLU A 107
ASP A 144
 None
AG3  A1001 ( 4.9A)
None
None
None
 0.75A 1xdsB-2zsuA:
11.8		 1xdsB-2zsuA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A  84
GLU A 107
ASP A 161
 None
None
AG3  A1001 (-2.8A)
 0.59A 2b25B-2zsuA:
10.5		 2b25B-2zsuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A  86
ASP A  87
SER A 116
 None
AG3  A1001 (-3.0A)
None
 0.70A 2qhfA-2zsuA:
undetectable		 2qhfA-2zsuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A  84
GLU A 107
ILE A 108
ASP A 161
 None
None
None
AG3  A1001 (-2.8A)
 0.72A 3a7eA-2zsuA:
12.9		 3a7eA-2zsuA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		8 / 12 GLN A  53
TYR A  62
HIS A  63
ASP A  87
ASP A 161
ASP A 164
GLN A 194
TYR A 229
 AG3  A1001 (-3.2A)
AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.0A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
 0.49A 3b7pA-2zsuA:
37.5		 3b7pA-2zsuA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		8 / 12 GLN A  53
TYR A  62
HIS A  63
ASP A  87
ASP A 161
ASP A 164
GLN A 194
TYR A 229
 AG3  A1001 (-3.2A)
AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.0A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
 0.47A 3b7pB-2zsuA:
37.5		 3b7pB-2zsuA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLN A  53
TYR A  62
HIS A  63
GLU A 204
TYR A 229
 AG3  A1001 (-3.2A)
AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
None
AG3  A1001 (-3.7A)
 0.96A 3b7pB-2zsuA:
37.5		 3b7pB-2zsuA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A  87
ASP A 161
ASP A 164
GLU A 204
SER A 197
 AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.0A)
None
None
 1.20A 3b7pC-2zsuA:
37.8		 3b7pC-2zsuA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		8 / 12 GLN A  53
TYR A  62
HIS A  63
ASP A  87
ASP A 161
ASP A 164
SER A 197
TYR A 229
 AG3  A1001 (-3.2A)
AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.0A)
None
AG3  A1001 (-3.7A)
 0.60A 3b7pC-2zsuA:
37.8		 3b7pC-2zsuA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 12 GLN A  32
TYR A  62
GLY A  85
ASP A 109
VAL A 112
GLN A 194
 None
AG3  A1001 (-4.5A)
AG3  A1001 ( 4.9A)
None
None
AG3  A1001 ( 4.1A)
 1.22A 3bwcA-2zsuA:
33.0		 3bwcA-2zsuA:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		11 / 12 GLN A  32
TYR A  62
HIS A  63
ILE A  83
GLY A  84
ILE A 108
ASP A 109
VAL A 112
ASP A 144
GLY A 145
GLN A 194
 None
AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
None
None
None
None
None
None
None
AG3  A1001 ( 4.1A)
 0.63A 3bwcA-2zsuA:
33.0		 3bwcA-2zsuA:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		10 / 12 TYR A  62
HIS A  63
ILE A  83
GLY A  84
ASP A  87
ILE A 108
ASP A 109
VAL A 112
GLY A 145
ASP A 161
 AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
None
None
AG3  A1001 (-3.0A)
None
None
None
None
AG3  A1001 (-2.8A)
 0.39A 3bwcB-2zsuA:
32.6		 3bwcB-2zsuA:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		10 / 12 TYR A  62
HIS A  63
ILE A  83
GLY A  84
ILE A 108
ASP A 109
VAL A 112
GLY A 145
ASP A 161
GLN A 194
 AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
None
None
None
None
None
None
AG3  A1001 (-2.8A)
AG3  A1001 ( 4.1A)
 0.61A 3bwcB-2zsuA:
32.6		 3bwcB-2zsuA:
32.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 164
TYR A  62
ASP A 161
TYR A 229
TRP A 233
 AG3  A1001 (-3.0A)
AG3  A1001 (-4.5A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 1.09A 3c6mA-2zsuA:
26.0		 3c6mA-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		7 / 11 VAL A  52
TYR A  62
ASP A  87
ASP A 161
GLN A 194
TYR A 229
TRP A 233
 AG3  A1001 (-4.3A)
AG3  A1001 (-4.5A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 0.60A 3c6mA-2zsuA:
26.0		 3c6mA-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_B_SPMB501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 9 ASP A 164
TYR A  62
ASP A 161
TYR A 229
TRP A 233
 AG3  A1001 (-3.0A)
AG3  A1001 (-4.5A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 1.09A 3c6mB-2zsuA:
25.9		 3c6mB-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_B_SPMB501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 9 TYR A  62
ASP A  87
ASP A 161
GLN A 194
TYR A 229
TRP A 233
 AG3  A1001 (-4.5A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 0.57A 3c6mB-2zsuA:
25.9		 3c6mB-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_C_SPMC501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A 164
TYR A  62
ASP A 161
TYR A 229
TRP A 233
 AG3  A1001 (-3.0A)
AG3  A1001 (-4.5A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 1.09A 3c6mC-2zsuA:
25.9		 3c6mC-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_C_SPMC501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		7 / 10 VAL A  52
TYR A  62
ASP A  87
ASP A 161
GLN A 194
TYR A 229
TRP A 233
 AG3  A1001 (-4.3A)
AG3  A1001 (-4.5A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 0.59A 3c6mC-2zsuA:
25.9		 3c6mC-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_D_SPMD501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 10 TYR A  62
ASP A  87
ASP A 161
GLN A 194
TYR A 229
TRP A 233
 AG3  A1001 (-4.5A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 0.58A 3c6mD-2zsuA:
25.9		 3c6mD-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
GLY A  89
ASP A 109
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.80A 3m6vA-2zsuA:
10.6		 3m6vA-2zsuA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
GLY A  89
ASP A 109
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.80A 3m6vB-2zsuA:
10.7		 3m6vB-2zsuA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 4 GLY A  84
GLU A 107
ASP A 144
ASP A 161
 None
None
None
AG3  A1001 (-2.8A)
 0.62A 3mb5A-2zsuA:
14.3		 3mb5A-2zsuA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A  86
GLU A 107
ASP A 144
ASP A 161
 None
None
None
AG3  A1001 (-2.8A)
 0.70A 3vywC-2zsuA:
15.8		 3vywC-2zsuA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 6 HIS A  63
GLU A 107
ASP A 144
ASP A 161
 AG3  A1001 (-4.0A)
None
None
AG3  A1001 (-2.8A)
 1.19A 4blvA-2zsuA:
12.1		 4blvA-2zsuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
GLY A  89
GLY A 145
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.88A 4fp9A-2zsuA:
11.0		 4fp9A-2zsuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
GLY A  89
GLY A 145
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.88A 4fp9C-2zsuA:
10.9		 4fp9C-2zsuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
GLY A  89
GLY A 145
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.88A 4fp9F-2zsuA:
10.9		 4fp9F-2zsuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 5 GLU A   8
VAL A  16
VAL A  55
PHE A  18
 AG3  A1001 (-3.2A)
None
None
None
 0.95A 4lb0B-2zsuA:
undetectable		 4lb0B-2zsuA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  46
LEU A  54
ILE A 120
ASP A 123
GLY A  86
 None
AG3  A1001 ( 4.9A)
None
None
None
 1.02A 4lmnA-2zsuA:
undetectable		 4lmnA-2zsuA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  84
GLU A 107
ASP A 144
ASP A 161
 None
None
None
AG3  A1001 (-2.8A)
 0.77A 5ergB-2zsuA:
10.4		 5ergB-2zsuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  84
GLY A  86
ASP A 144
ASP A 161
 None
None
None
AG3  A1001 (-2.8A)
 0.67A 5ergB-2zsuA:
10.4		 5ergB-2zsuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLN A  32
LEU A 172
VAL A 160
TYR A  62
GLY A  85
 None
None
None
AG3  A1001 (-4.5A)
AG3  A1001 ( 4.9A)
 1.35A 5i8fA-2zsuA:
undetectable		 5i8fA-2zsuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  89
ASP A 144
GLY A 145
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.97A 5wwsA-2zsuA:
9.8		 5wwsA-2zsuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  85
SER A  29
GLN A  32
ILE A 108
ASP A 144
 AG3  A1001 ( 4.9A)
None
None
None
None
 1.24A 6bxnB-2zsuA:
2.7		 6bxnB-2zsuA:
21.89