SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AFY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE
(Streptomyces
peucetius) 		5 / 10 PHE A 277
ILE A 282
ALA A 275
VAL A 325
VAL A 262
 None
None
AFY  A 401 (-3.6A)
None
None
 0.92A 3me6A-5wgcA:
undetectable		 3me6A-5wgcA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE
(Streptomyces
peucetius) 		4 / 8 PHE A 277
ILE A 282
ALA A 275
VAL A 325
 None
None
AFY  A 401 (-3.6A)
None
 0.70A 3me6B-5wgcA:
undetectable		 3me6B-5wgcA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE
(Streptomyces
peucetius) 		5 / 9 PHE A 277
ILE A 282
ALA A 275
VAL A 325
VAL A 262
 None
None
AFY  A 401 (-3.6A)
None
None
 0.92A 3me6C-5wgcA:
undetectable		 3me6C-5wgcA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE
(Streptomyces
peucetius) 		5 / 9 PHE A 277
ILE A 282
ALA A 275
VAL A 325
VAL A 262
 None
None
AFY  A 401 (-3.6A)
None
None
 0.97A 3me6D-5wgcA:
undetectable		 3me6D-5wgcA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE
(Streptomyces
peucetius) 		5 / 12 LEU A  30
LEU A  39
ARG A  37
GLY A 162
THR A 163
 None
None
None
None
AFY  A 401 (-3.4A)
 1.17A 3okxB-5wgcA:
undetectable		 3okxB-5wgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE
(Streptomyces
peucetius) 		5 / 12 GLY A 268
LEU A 264
ALA A 275
GLN A 241
VAL A 327
 None
None
AFY  A 401 (-3.6A)
None
AFY  A 401 ( 4.6A)
 0.97A 4htfA-5wgcA:
undetectable		 4htfA-5wgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE
(Streptomyces
peucetius) 		5 / 12 GLY A 268
LEU A 264
ALA A 275
GLN A 241
VAL A 327
 None
None
AFY  A 401 (-3.6A)
None
AFY  A 401 ( 4.6A)
 0.97A 4htfB-5wgcA:
undetectable		 4htfB-5wgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE
(Streptomyces
peucetius) 		5 / 9 LEU A 298
ALA A 305
VAL A 263
THR A 163
THR A 288
 None
None
None
AFY  A 401 (-3.4A)
None
 1.42A 5w5vA-5wgcA:
undetectable		 5w5vA-5wgcA:
undetectable