SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AEP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 5 VAL A 410
VAL A 411
PHE A 427
ARG A 350
 None
None
None
AEP  A 683 (-2.8A)
 1.25A 3bjwH-1lfwA:
0.0		 3bjwH-1lfwA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 12 GLY A 267
GLY A 276
SER A 331
ASN A 217
VAL A 218
 None
None
None
AEP  A 683 (-3.6A)
None
 1.09A 3nk7A-1lfwA:
undetectable		 3nk7A-1lfwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 6 HIS A 269
GLU A 179
ASP A 449
ASP A 119
 AEP  A 683 (-4.0A)
None
None
ZN  A1001 (-2.4A)
 1.39A 4blvA-1lfwA:
undetectable		 4blvA-1lfwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 7 ASP A 119
GLU A 154
HIS A 439
GLU A 153
 ZN  A1001 (-2.4A)
ZN  A1001 ( 1.9A)
ZN  A1001 ( 3.1A)
AEP  A 683 (-2.7A)
 1.03A 4hvrA-1lfwA:
undetectable		 4hvrA-1lfwA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		6 / 11 HIS A  87
ASP A 119
GLU A 153
GLU A 154
GLY A 413
HIS A 439
 ZN  A1002 ( 3.2A)
ZN  A1001 (-2.4A)
AEP  A 683 (-2.7A)
ZN  A1001 ( 1.9A)
None
ZN  A1001 ( 3.1A)
 0.58A 4pqaA-1lfwA:
29.9		 4pqaA-1lfwA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		6 / 11 HIS A  87
GLU A 153
GLU A 154
GLY A 413
GLY A 414
HIS A 439
 ZN  A1002 ( 3.2A)
AEP  A 683 (-2.7A)
ZN  A1001 ( 1.9A)
None
AEP  A 683 (-3.6A)
ZN  A1001 ( 3.1A)
 1.03A 4pqaA-1lfwA:
29.9		 4pqaA-1lfwA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		4 / 4 TYR A 351
ARG A 350
THR A 191
LEU A 192
 None
AEP  A 683 (-2.8A)
None
None
 1.48A 5wauj-1lfwA:
0.0		 5wauj-1lfwA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 11 SER A 271
GLY A 116
ALA A  48
ASN A 217
VAL A  91
 None
None
None
AEP  A 683 (-3.6A)
None
 1.29A 6hu9A-1lfwA:
0.1
6hu9E-1lfwA:
0.2
6hu9I-1lfwA:
0.0		 6hu9A-1lfwA:
23.11
6hu9E-1lfwA:
17.15
6hu9I-1lfwA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1lfw PEPV
(Lactobacillus
delbrueckii) 		5 / 10 SER A 271
GLY A 116
ALA A  48
ASN A 217
VAL A  91
 None
None
None
AEP  A 683 (-3.6A)
None
 1.36A 6hu9L-1lfwA:
0.0
6hu9P-1lfwA:
0.0
6hu9T-1lfwA:
0.0		 6hu9L-1lfwA:
23.11
6hu9P-1lfwA:
17.15
6hu9T-1lfwA:
9.19