SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AE2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1dbj IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		6 / 8 GLY H  33
ASN H  35
TRP H  50
GLY H  95
TYR H  97
TRP H 100
 AE2  H 229 (-3.5A)
AE2  H 229 (-2.9A)
AE2  H 229 (-4.2A)
AE2  H 229 (-3.2A)
AE2  H 229 ( 4.2A)
AE2  H 229 (-3.9A)
 0.54A 1dbbH-1dbjH:
29.0
1dbbL-1dbjH:
17.6		 1dbbH-1dbjH:
100.00
1dbbL-1dbjH:
28.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 1dbj IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		4 / 7 ASN H  35
TRP H  50
GLY H  95
TRP H 100
 AE2  H 229 (-2.9A)
AE2  H 229 (-4.2A)
AE2  H 229 (-3.2A)
AE2  H 229 (-3.9A)
 1.23A 2o5yH-1dbjH:
22.8
2o5yL-1dbjH:
15.8		 2o5yH-1dbjH:
73.64
2o5yL-1dbjH:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 1dbj IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 11 GLN H   6
PHE H  91
ASN H  35
GLY H 104
ALA H  40
 None
None
AE2  H 229 (-2.9A)
None
None
 1.20A 4a6nA-1dbjH:
undetectable		 4a6nA-1dbjH:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1dbj IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 12 GLY H  33
ASN H  52
ILE H  51
ALA H  78
PHE H  69
 AE2  H 229 (-3.5A)
None
None
None
None
 1.12A 4dx5B-1dbjH:
2.2		 4dx5B-1dbjH:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1dbj IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 12 GLY H  33
ASN H  52
ILE H  51
ALA H  78
PHE H  69
 AE2  H 229 (-3.5A)
None
None
None
None
 1.10A 4u8vB-1dbjH:
0.4		 4u8vB-1dbjH:
13.47