SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AE1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 6 HIS A  68
HIS A  70
HIS A 201
HIS A 230
ASP A 285
 ZN  A 601 (-3.6A)
ZN  A 601 ( 3.6A)
ZN  A 602 ( 2.8A)
ZN  A 602 ( 3.5A)
AE1  A 401 ( 2.6A)
 0.86A 1fweC-1pojA:
21.8		 1fweC-1pojA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		4 / 8 ASP A 204
ASP A 167
ASP A 285
THR A 254
 None
None
AE1  A 401 ( 2.6A)
None
 0.83A 1m4iA-1pojA:
undetectable		 1m4iA-1pojA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 8 THR A  82
GLY A  75
ARG A 169
ILE A 302
PRO A 291
 None
AE1  A 401 (-3.5A)
AE1  A 401 (-3.3A)
None
AE1  A 401 (-4.4A)
 1.48A 1rxcB-1pojA:
undetectable		 1rxcB-1pojA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 8 THR A  82
GLY A  75
ARG A 169
ILE A 302
PRO A 291
 None
AE1  A 401 (-3.5A)
AE1  A 401 (-3.3A)
None
AE1  A 401 (-4.4A)
 1.46A 1rxcE-1pojA:
undetectable		 1rxcE-1pojA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 8 THR A  82
GLY A  75
ARG A 169
ILE A 302
PRO A 291
 None
AE1  A 401 (-3.5A)
AE1  A 401 (-3.3A)
None
AE1  A 401 (-4.4A)
 1.48A 1rxcK-1pojA:
undetectable		 1rxcK-1pojA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 12 HIS A  68
ASP A 285
LEU A 103
GLY A 102
PHE A 307
 ZN  A 601 (-3.6A)
AE1  A 401 ( 2.6A)
KCX  A 162 ( 4.2A)
None
None
 1.25A 1v8bD-1pojA:
undetectable		 1v8bD-1pojA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 12 THR A 106
GLY A 288
GLY A  74
GLY A  76
VAL A  87
 AE1  A 401 (-3.1A)
AE1  A 401 ( 4.1A)
AE1  A 401 (-3.4A)
None
None
 0.94A 2b25A-1pojA:
undetectable		 2b25A-1pojA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		4 / 8 ASP A 167
SER A 205
ARG A 233
GLY A 297
 None
None
AE1  A 401 (-2.8A)
None
 1.02A 4af0A-1pojA:
6.1		 4af0A-1pojA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 12 GLY A 105
HIS A  68
ASP A 285
HIS A 230
GLY A 288
 AE1  A 401 (-3.1A)
ZN  A 601 (-3.6A)
AE1  A 401 ( 2.6A)
ZN  A 602 ( 3.5A)
AE1  A 401 ( 4.1A)
 1.26A 4bz6C-1pojA:
undetectable		 4bz6C-1pojA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		6 / 12 HIS A  68
GLY A 102
ASP A 285
HIS A  70
PRO A  85
GLY A 286
 ZN  A 601 (-3.6A)
None
AE1  A 401 ( 2.6A)
ZN  A 601 ( 3.6A)
None
None
 1.46A 4bz6C-1pojA:
undetectable		 4bz6C-1pojA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 8 THR A  82
GLY A  75
ARG A 169
ILE A 302
PRO A 291
 None
AE1  A 401 (-3.5A)
AE1  A 401 (-3.3A)
None
AE1  A 401 (-4.4A)
 1.42A 4e1vA-1pojA:
undetectable		 4e1vA-1pojA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 8 THR A  82
GLY A  75
ARG A 169
ILE A 302
PRO A 291
 None
AE1  A 401 (-3.5A)
AE1  A 401 (-3.3A)
None
AE1  A 401 (-4.4A)
 1.46A 4e1vC-1pojA:
undetectable		 4e1vC-1pojA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 8 THR A  82
GLY A  75
ARG A 169
ILE A 302
PRO A 291
 None
AE1  A 401 (-3.5A)
AE1  A 401 (-3.3A)
None
AE1  A 401 (-4.4A)
 1.46A 4e1vD-1pojA:
undetectable		 4e1vD-1pojA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 8 THR A  82
GLY A  75
ARG A 169
ILE A 302
PRO A 291
 None
AE1  A 401 (-3.5A)
AE1  A 401 (-3.3A)
None
AE1  A 401 (-4.4A)
 1.47A 4e1vE-1pojA:
undetectable		 4e1vE-1pojA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 8 THR A  82
GLY A  75
ARG A 169
ILE A 302
PRO A 291
 None
AE1  A 401 (-3.5A)
AE1  A 401 (-3.3A)
None
AE1  A 401 (-4.4A)
 1.48A 4e1vH-1pojA:
undetectable		 4e1vH-1pojA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		4 / 5 HIS A  68
HIS A 201
HIS A 230
ASP A 285
 ZN  A 601 (-3.6A)
ZN  A 602 ( 2.8A)
ZN  A 602 ( 3.5A)
AE1  A 401 ( 2.6A)
 0.93A 4h9mA-1pojA:
22.6		 4h9mA-1pojA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 6 HIS A  68
HIS A  70
HIS A 201
HIS A 230
ASP A 285
 ZN  A 601 (-3.6A)
ZN  A 601 ( 3.6A)
ZN  A 602 ( 2.8A)
ZN  A 602 ( 3.5A)
AE1  A 401 ( 2.6A)
 0.78A 4ubpC-1pojA:
21.1		 4ubpC-1pojA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1poj ISOASPARTYL
DIPEPTIDASE
(Escherichia
coli) 		5 / 8 VAL A  87
PHE A 307
GLY A 306
ALA A 305
GLY A 288
 None
None
None
None
AE1  A 401 ( 4.1A)
 1.32A 4zjzB-1pojA:
undetectable		 4zjzB-1pojA:
22.82