SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ADX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 11 LEU B 431
ALA B 429
LEU B 451
LEU B 449
SER B 416
 ADX  B2700 (-4.6A)
None
None
None
None
 1.26A 1ictA-1xnjB:
undetectable
1ictC-1xnjB:
undetectable		 1ictA-1xnjB:
11.43
1ictC-1xnjB:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 501
GLU A 528
ALA A 533
LEU A 504
 ADX  A1613 (-4.3A)
None
None
None
 1.16A 1sn5A-4bzxA:
undetectable		 1sn5A-4bzxA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 501
ASN A 500
VAL A 520
ALA A 522
 ADX  A1613 (-4.3A)
ADX  A1613 (-3.5A)
None
ADX  A1613 (-3.6A)
 0.95A 2cizA-4bzxA:
undetectable		 2cizA-4bzxA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)
(Homo
sapiens) 		5 / 11 LEU A 202
ALA A  63
ILE A 132
VAL A 156
VAL A 158
 None
DAT  A 300 (-4.3A)
ADX  A 400 (-3.9A)
None
None
 0.99A 2nnpB-2peyA:
undetectable		 2nnpB-2peyA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 4 ALA B 417
VAL B 520
PHE B 418
THR B 435
 None
ADX  B2700 (-4.1A)
ADX  B2700 (-4.3A)
None
 1.42A 2pkkA-1xnjB:
2.3		 2pkkA-1xnjB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 4maf ATP SULFURYLASE
(Glycine
max) 		4 / 4 ALA A 244
VAL A 347
PHE A 245
THR A 262
 None
ADX  A 900 (-4.1A)
ADX  A 900 (-4.4A)
None
 1.42A 2pkkA-4mafA:
undetectable		 2pkkA-4mafA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 1i2d ATP SULFURYLASE
(Penicillium
chrysogenum) 		4 / 6 LEU A 362
ARG A 199
PRO A 201
VAL A 348
 None
ADX  A 574 (-3.7A)
None
None
 1.16A 2ygoA-1i2dA:
0.0		 2ygoA-1i2dA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 12 SER B 305
ASN B 303
GLY B 542
ASP B 523
PHE B 418
 None
None
None
None
ADX  B2700 (-4.3A)
 1.45A 3a25A-1xnjB:
undetectable		 3a25A-1xnjB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 12 SER A 305
ASN A 303
GLY A 542
ASP A 523
PHE A 418
 None
None
None
None
ADX  A 100 (-4.3A)
 1.35A 3a25A-2qjfA:
undetectable		 3a25A-2qjfA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 4maf ATP SULFURYLASE
(Glycine
max) 		5 / 12 SER A 130
ASN A 128
GLY A 369
ASP A 350
PHE A 245
 None
None
None
None
ADX  A 900 (-4.4A)
 1.28A 3a25A-4mafA:
undetectable		 3a25A-4mafA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 8 SER B 133
PHE B 131
VAL B 116
LEU B  95
 None
ADX  B2805 (-4.6A)
None
None
 1.04A 3jq7C-1xnjB:
4.5		 3jq7C-1xnjB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)
(Homo
sapiens) 		4 / 8 SER A 133
PHE A 131
VAL A 116
LEU A  95
 None
ADX  A 400 (-4.7A)
None
None
 0.98A 3jq7C-2peyA:
5.2		 3jq7C-2peyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)
(Homo
sapiens) 		5 / 8 GLY A 184
SER A 190
GLY A 187
ILE A 132
LEU A  60
 ADX  A 400 (-4.8A)
None
None
ADX  A 400 (-3.9A)
None
 1.34A 3v1nA-2peyA:
2.5		 3v1nA-2peyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1i2d ATP SULFURYLASE
(Penicillium
chrysogenum) 		5 / 10 PHE A 185
ARG A 192
TRP A 190
ALA A 219
ALA A 295
 None
None
None
None
ADX  A 574 (-4.5A)
 1.48A 4fe1A-1i2dA:
0.0
4fe1J-1i2dA:
0.0		 4fe1A-1i2dA:
20.54
4fe1J-1i2dA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 1v47 ATP SULFURYLASE
(Thermus
thermophilus) 		4 / 9 TYR A 208
HIS A 168
PHE A 161
ILE A 190
 None
ADX  A 564 (-4.7A)
ADX  A 564 (-4.6A)
None
 1.27A 4jvlA-1v47A:
undetectable		 4jvlA-1v47A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 1i2d ATP SULFURYLASE
(Penicillium
chrysogenum) 		5 / 12 ARG A 437
ALA A 474
ILE A 458
GLY A 433
VAL A 502
 ADX  A 575 (-3.7A)
None
None
ADX  A 575 ( 4.3A)
None
 0.97A 4q5mA-1i2dA:
undetectable		 4q5mA-1i2dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1v47 ATP SULFURYLASE
(Thermus
thermophilus) 		5 / 11 THR A 201
GLN A 162
GLY A 192
THR A 228
ALA A 227
 None
ADX  A 564 (-3.7A)
None
None
None
 1.48A 4qvnH-1v47A:
undetectable
4qvnI-1v47A:
undetectable		 4qvnH-1v47A:
18.86
4qvnI-1v47A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1v47 ATP SULFURYLASE
(Thermus
thermophilus) 		5 / 10 THR A 201
GLN A 162
GLY A 192
THR A 228
ALA A 227
 None
ADX  A 564 (-3.7A)
None
None
None
 1.48A 4qvnV-1v47A:
undetectable
4qvnW-1v47A:
undetectable		 4qvnV-1v47A:
18.86
4qvnW-1v47A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1i2d ATP SULFURYLASE
(Penicillium
chrysogenum) 		5 / 9 ALA A 478
ILE A 412
ALA A 474
THR A 398
VAL A 500
 ADX  A 575 (-4.5A)
None
None
None
None
 1.18A 4r1zA-1i2dA:
0.2		 4r1zA-1i2dA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 460
ASN A 500
GLY A 479
SER A 454
 None
ADX  A1613 (-3.5A)
ADX  A1613 ( 3.7A)
ANP  A1614 (-3.4A)
 0.81A 4r20A-4bzxA:
1.3		 4r20A-4bzxA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1i2d ATP SULFURYLASE
(Penicillium
chrysogenum) 		5 / 12 LYS A 231
GLY A 268
TYR A 146
ALA A 312
ALA A 295
 None
None
None
None
ADX  A 574 (-4.5A)
 1.15A 4ymgA-1i2dA:
2.7		 4ymgA-1i2dA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 LEU A 220
ARG A 225
ILE A 229
PHE A 232
 ADX  A 301 ( 4.7A)
None
ADX  A 301 (-4.8A)
ADX  A 301 (-4.1A)
 1.10A 5kirB-4fxpA:
undetectable		 5kirB-4fxpA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1i2d ATP SULFURYLASE
(Penicillium
chrysogenum) 		4 / 8 ILE A 517
ALA A 520
ILE A 526
GLU A 525
 ADX  A 575 ( 4.2A)
None
None
None
 0.68A 5mvmA-1i2dA:
2.2
5mvmB-1i2dA:
2.2		 5mvmA-1i2dA:
9.43
5mvmB-1i2dA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 109
GLY A 250
ILE A 181
VAL A 106
GLY A 113
 None
None
ADX  A 301 (-3.9A)
None
SO4  A 302 (-3.2A)
 1.07A 5wyqA-4fxpA:
undetectable		 5wyqA-4fxpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 8 GLN B 419
ALA B 513
VAL B 512
ARG B 510
 ADX  B2700 (-3.9A)
None
None
None
 1.03A 6hu9a-1xnjB:
undetectable
6hu9e-1xnjB:
0.6		 6hu9a-1xnjB:
19.00
6hu9e-1xnjB:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 8 GLN A 419
ALA A 513
VAL A 512
ARG A 510
 ADX  A 100 (-3.6A)
None
None
None
 1.04A 6hu9a-2qjfA:
undetectable
6hu9e-2qjfA:
undetectable		 6hu9a-2qjfA:
19.60
6hu9e-2qjfA:
16.26