SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ADA'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NX9_A_AICA5001_1 (ALPHA-AMINO ACIDESTER HYDROLASE) |
5ols | RHAMNOGALACTURONANLYASE (Bacteroidesthetaiotaomicron) | 4 / 8 | TYR A 184ARG A 160GLU A 157HIS A 153 | NoneNoneNoneADA A 604 ( 3.9A) | 1.27A | 1nx9A-5olsA:undetectable | 1nx9A-5olsA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NX9_B_AICB5002_1 (ALPHA-AMINO ACIDESTER HYDROLASE) |
5ols | RHAMNOGALACTURONANLYASE (Bacteroidesthetaiotaomicron) | 4 / 8 | TYR A 184ARG A 160GLU A 157HIS A 153 | NoneNoneNoneADA A 604 ( 3.9A) | 1.27A | 1nx9B-5olsA:undetectable | 1nx9B-5olsA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NX9_C_AICC5003_1 (ALPHA-AMINO ACIDESTER HYDROLASE) |
5ols | RHAMNOGALACTURONANLYASE (Bacteroidesthetaiotaomicron) | 4 / 8 | TYR A 184ARG A 160GLU A 157HIS A 153 | NoneNoneNoneADA A 604 ( 3.9A) | 1.26A | 1nx9C-5olsA:undetectable | 1nx9C-5olsA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NX9_D_AICD5004_1 (ALPHA-AMINO ACIDESTER HYDROLASE) |
5ols | RHAMNOGALACTURONANLYASE (Bacteroidesthetaiotaomicron) | 4 / 8 | TYR A 184ARG A 160GLU A 157HIS A 153 | NoneNoneNoneADA A 604 ( 3.9A) | 1.27A | 1nx9D-5olsA:undetectable | 1nx9D-5olsA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1WOP_A_FFOA2887_1 (AMINOMETHYLTRANSFERASE) |
5xqo | PCRGLX PROTEIN (Penicilliumchrysogenum) | 3 / 3 | ASP A 711GLU A 587ARG A 845 | NoneADA A1004 ( 3.7A)None | 0.81A | 1wopA-5xqoA:undetectable | 1wopA-5xqoA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2F6D_A_ACRA996_1 (GLUCOAMYLASE GLU1) |
5xqo | PCRGLX PROTEIN (Penicilliumchrysogenum) | 4 / 7 | HIS A 635ASP A 903GLY A 580TYR A 581 | ADA A1004 ( 4.1A)NoneNoneNone | 0.99A | 2f6dA-5xqoA:5.5 | 2f6dA-5xqoA:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2JC9_A_ADNA1497_1 (CYTOSOLIC PURINE5'-NUCLEOTIDASE) |
2uvj | ABC TYPE PERIPLASMICSUGAR-BINDINGPROTEIN (Yersiniaenterocolitica) | 4 / 7 | ARG A 143THR A 141ASN A 92GLN A 189 | ADA A1431 ( 2.8A)ADA A1433 ( 4.5A)NoneADA A1432 ( 2.8A) | 1.11A | 2jc9A-2uvjA:undetectable | 2jc9A-2uvjA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2JC9_A_ADNA1497_1 (CYTOSOLIC PURINE5'-NUCLEOTIDASE) |
2uvj | ABC TYPE PERIPLASMICSUGAR-BINDINGPROTEIN (Yersiniaenterocolitica) | 4 / 7 | ARG A 143THR A 272ASN A 90GLN A 189 | ADA A1431 ( 2.8A)ADA A1433 (-3.4A)ADA A1433 (-3.0A)ADA A1432 ( 2.8A) | 1.01A | 2jc9A-2uvjA:undetectable | 2jc9A-2uvjA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2VAV_C_CSCC1383_1 (ACETYL-COA--DEACETYLCEPHALOSPORIN CACETYLTRANSFERASE) |
4mij | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Polaromonassp.JS666) | 5 / 12 | ARG A 174TYR A 197GLN A 177HIS A 39VAL A 95 | GTR A 405 (-3.0A)GTR A 405 ( 3.7A)NoneADA A 406 ( 4.0A)None | 1.43A | 2vavC-4mijA:0.0 | 2vavC-4mijA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BXO_A_SAMA238_1 (N,N-DIMETHYLTRANSFERASE) |
2uvj | ABC TYPE PERIPLASMICSUGAR-BINDINGPROTEIN (Yersiniaenterocolitica) | 3 / 3 | TYR A 229GLU A 187ASP A 68 | NoneADA A1431 (-3.2A)None | 0.65A | 3bxoA-2uvjA:undetectable | 3bxoA-2uvjA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BXO_B_SAMB238_1 (N,N-DIMETHYLTRANSFERASE) |
2uvj | ABC TYPE PERIPLASMICSUGAR-BINDINGPROTEIN (Yersiniaenterocolitica) | 3 / 3 | TYR A 229GLU A 187ASP A 68 | NoneADA A1431 (-3.2A)None | 0.66A | 3bxoB-2uvjA:undetectable | 3bxoB-2uvjA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K13_A_THHA642_1 (5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINEMETHYLTRANSFERASE) |
5ols | RHAMNOGALACTURONANLYASE (Bacteroidesthetaiotaomicron) | 3 / 3 | ASN A 324ASP A 280ARG A 125 | RAM A 607 (-2.8A) CA A 602 ( 3.2A)ADA A 604 ( 3.0A) | 0.87A | 3k13A-5olsA:undetectable | 3k13A-5olsA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K9F_H_LFXH0_1 (DNA TOPOISOMERASE 4SUBUNIT ADNA TOPOISOMERASE 4SUBUNIT B) |
4pr7 | OLIGOGALACTURONATE-SPECIFIC PORIN KDGM (Dickeyadadantii) | 4 / 6 | SER A 75ARG A 112GLY A 79GLU A 61 | NoneADA A 309 ( 3.7A)OCT A 304 (-4.7A)ADA A 309 ( 4.9A) | 1.15A | 3k9fA-4pr7A:undetectable3k9fB-4pr7A:undetectable3k9fD-4pr7A:undetectable | 3k9fA-4pr7A:19.113k9fB-4pr7A:19.113k9fD-4pr7A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UBO_B_ADNB353_2 (ADENOSINE KINASE) |
2o04 | PECTATE LYASE (Bacillussubtilis) | 4 / 5 | SER A 316ILE A 250GLY A 311PRO A 281 | NoneADA A 401 (-4.3A)NoneNone | 1.05A | 3uboB-2o04A:undetectable | 3uboB-2o04A:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FEV_E_KANE301_1 (AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE APHA1-IAB) |
4n8y | PUTATIVE TRAP-TYPEC4-DICARBOXYLATETRANSPORT SYSTEM,BINDING PERIPLASMICPROTEIN (DCTPSUBUNIT) (Bradyrhizobiumsp.BTAi1) | 5 / 11 | SER A 229HIS A 228ASN A 206GLU A 205GLU A 233 | NoneNoneADA A 401 (-2.9A)NoneGTR A 402 (-2.8A) | 1.28A | 4fevE-4n8yA:undetectable | 4fevE-4n8yA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FEW_C_KANC301_1 (AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE APHA1-IAB) |
4n8y | PUTATIVE TRAP-TYPEC4-DICARBOXYLATETRANSPORT SYSTEM,BINDING PERIPLASMICPROTEIN (DCTPSUBUNIT) (Bradyrhizobiumsp.BTAi1) | 5 / 12 | ASN A 206GLU A 233SER A 229HIS A 228ARG A 166 | ADA A 401 (-2.9A)GTR A 402 (-2.8A)NoneNoneADA A 401 (-3.0A) | 1.35A | 4fewC-4n8yA:0.04fewD-4n8yA:0.14fewF-4n8yA:0.8 | 4fewC-4n8yA:22.064fewD-4n8yA:22.064fewF-4n8yA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FEW_E_KANE301_1 (AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE APHA1-IAB) |
4n8y | PUTATIVE TRAP-TYPEC4-DICARBOXYLATETRANSPORT SYSTEM,BINDING PERIPLASMICPROTEIN (DCTPSUBUNIT) (Bradyrhizobiumsp.BTAi1) | 5 / 11 | ASN A 206GLU A 205GLU A 233SER A 229HIS A 228 | ADA A 401 (-2.9A)NoneGTR A 402 (-2.8A)NoneNone | 1.27A | 4fewE-4n8yA:0.04fewF-4n8yA:0.8 | 4fewE-4n8yA:22.064fewF-4n8yA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4GKH_H_KANH301_1 (AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE APHA1-IAB) |
4n8y | PUTATIVE TRAP-TYPEC4-DICARBOXYLATETRANSPORT SYSTEM,BINDING PERIPLASMICPROTEIN (DCTPSUBUNIT) (Bradyrhizobiumsp.BTAi1) | 5 / 10 | SER A 229HIS A 228ASN A 206GLU A 205GLU A 233 | NoneNoneADA A 401 (-2.9A)NoneGTR A 402 (-2.8A) | 1.27A | 4gkhG-4n8yA:0.14gkhH-4n8yA:0.3 | 4gkhG-4n8yA:22.064gkhH-4n8yA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4GKI_D_KAND301_1 (AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE APHA1-IAB) |
4n8y | PUTATIVE TRAP-TYPEC4-DICARBOXYLATETRANSPORT SYSTEM,BINDING PERIPLASMICPROTEIN (DCTPSUBUNIT) (Bradyrhizobiumsp.BTAi1) | 5 / 11 | SER A 229HIS A 228ASN A 206GLU A 205GLU A 233 | NoneNoneADA A 401 (-2.9A)NoneGTR A 402 (-2.8A) | 1.30A | 4gkiC-4n8yA:undetectable4gkiD-4n8yA:undetectable | 4gkiC-4n8yA:22.064gkiD-4n8yA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4GKI_H_KANH301_1 (AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE APHA1-IAB) |
4n8y | PUTATIVE TRAP-TYPEC4-DICARBOXYLATETRANSPORT SYSTEM,BINDING PERIPLASMICPROTEIN (DCTPSUBUNIT) (Bradyrhizobiumsp.BTAi1) | 5 / 10 | SER A 229HIS A 228ASN A 206GLU A 205GLU A 233 | NoneNoneADA A 401 (-2.9A)NoneGTR A 402 (-2.8A) | 1.29A | 4gkiG-4n8yA:0.84gkiH-4n8yA:0.2 | 4gkiG-4n8yA:22.064gkiH-4n8yA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OBW_D_SAMD601_1 (2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOLMETHYLASE,MITOCHONDRIAL) |
2uvj | ABC TYPE PERIPLASMICSUGAR-BINDINGPROTEIN (Yersiniaenterocolitica) | 3 / 3 | ASN A 90ASP A 388ASP A 190 | ADA A1433 (-3.0A)ADA A1432 ( 4.7A)ADA A1431 (-3.0A) | 0.75A | 4obwD-2uvjA:undetectable | 4obwD-2uvjA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4U8Y_B_MIYB1102_1 (MULTIDRUG EFFLUXPUMP SUBUNIT ACRB) |
5xqo | PCRGLX PROTEIN (Penicilliumchrysogenum) | 5 / 12 | GLU A 587ASN A 902ASP A 903ILE A 904PHE A 544 | ADA A1004 ( 3.7A)RAM A1003 ( 4.1A)NoneNoneNone | 1.09A | 4u8yB-5xqoA:undetectable | 4u8yB-5xqoA:5.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4X5I_A_FOLA201_1 (DIHYDROFOLATEREDUCTASE) |
4mij | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Polaromonassp.JS666) | 3 / 3 | ASP A 37ARG A 174ARG A 154 | NoneGTR A 405 (-3.0A)ADA A 406 ( 3.0A) | 0.96A | 4x5iA-4mijA:undetectable | 4x5iA-4mijA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4X5I_A_FOLA201_1 (DIHYDROFOLATEREDUCTASE) |
4n8y | PUTATIVE TRAP-TYPEC4-DICARBOXYLATETRANSPORT SYSTEM,BINDING PERIPLASMICPROTEIN (DCTPSUBUNIT) (Bradyrhizobiumsp.BTAi1) | 3 / 3 | ASP A 29ARG A 166ARG A 145 | NoneADA A 401 (-3.0A)GTR A 402 (-3.0A) | 0.98A | 4x5iA-4n8yA:undetectable | 4x5iA-4n8yA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NNW_D_GCSD302_1 (25 KDA PROTEINELICITOR) |
3b8y | ENDO-PECTATE LYASE (Dickeyachrysanthemi) | 4 / 7 | ASP A 173GLY A 174HIS A 176ASP A 195 | NoneNoneNoneADA A 903 (-3.0A) | 1.00A | 5nnwD-3b8yA:undetectable | 5nnwD-3b8yA:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NO9_D_95ZD302_1 (25 KDA PROTEINELICITOR) |
3b8y | ENDO-PECTATE LYASE (Dickeyachrysanthemi) | 4 / 7 | ASP A 173GLY A 174HIS A 176ASP A 195 | NoneNoneNoneADA A 903 (-3.0A) | 1.07A | 5no9D-3b8yA:undetectable | 5no9D-3b8yA:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UXC_A_ZITA307_1 (PREDICTEDAMINOGLYCOSIDEPHOSPHOTRANSFERASE) |
3b8y | ENDO-PECTATE LYASE (Dickeyachrysanthemi) | 4 / 5 | ASP A 223PRO A 306GLU A 310ARG A 252 | NoneNoneNoneADA A 901 ( 3.7A) | 1.36A | 5uxcA-3b8yA:undetectable | 5uxcA-3b8yA:20.79 |