SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ADA'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron)
4 / 8 TYR A 184
ARG A 160
GLU A 157
HIS A 153
None
None
None
ADA  A 604 ( 3.9A)
1.27A 1nx9A-5olsA:
undetectable
1nx9A-5olsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron)
4 / 8 TYR A 184
ARG A 160
GLU A 157
HIS A 153
None
None
None
ADA  A 604 ( 3.9A)
1.27A 1nx9B-5olsA:
undetectable
1nx9B-5olsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron)
4 / 8 TYR A 184
ARG A 160
GLU A 157
HIS A 153
None
None
None
ADA  A 604 ( 3.9A)
1.26A 1nx9C-5olsA:
undetectable
1nx9C-5olsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron)
4 / 8 TYR A 184
ARG A 160
GLU A 157
HIS A 153
None
None
None
ADA  A 604 ( 3.9A)
1.27A 1nx9D-5olsA:
undetectable
1nx9D-5olsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)
5xqo PCRGLX PROTEIN
(Penicillium
chrysogenum)
3 / 3 ASP A 711
GLU A 587
ARG A 845
None
ADA  A1004 ( 3.7A)
None
0.81A 1wopA-5xqoA:
undetectable
1wopA-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)
5xqo PCRGLX PROTEIN
(Penicillium
chrysogenum)
4 / 7 HIS A 635
ASP A 903
GLY A 580
TYR A 581
ADA  A1004 ( 4.1A)
None
None
None
0.99A 2f6dA-5xqoA:
5.5
2f6dA-5xqoA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Yersinia
enterocolitica)
4 / 7 ARG A 143
THR A 141
ASN A  92
GLN A 189
ADA  A1431 ( 2.8A)
ADA  A1433 ( 4.5A)
None
ADA  A1432 ( 2.8A)
1.11A 2jc9A-2uvjA:
undetectable
2jc9A-2uvjA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Yersinia
enterocolitica)
4 / 7 ARG A 143
THR A 272
ASN A  90
GLN A 189
ADA  A1431 ( 2.8A)
ADA  A1433 (-3.4A)
ADA  A1433 (-3.0A)
ADA  A1432 ( 2.8A)
1.01A 2jc9A-2uvjA:
undetectable
2jc9A-2uvjA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_C_CSCC1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)
4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas
sp.
JS666)
5 / 12 ARG A 174
TYR A 197
GLN A 177
HIS A  39
VAL A  95
GTR  A 405 (-3.0A)
GTR  A 405 ( 3.7A)
None
ADA  A 406 ( 4.0A)
None
1.43A 2vavC-4mijA:
0.0
2vavC-4mijA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Yersinia
enterocolitica)
3 / 3 TYR A 229
GLU A 187
ASP A  68
None
ADA  A1431 (-3.2A)
None
0.65A 3bxoA-2uvjA:
undetectable
3bxoA-2uvjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Yersinia
enterocolitica)
3 / 3 TYR A 229
GLU A 187
ASP A  68
None
ADA  A1431 (-3.2A)
None
0.66A 3bxoB-2uvjA:
undetectable
3bxoB-2uvjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron)
3 / 3 ASN A 324
ASP A 280
ARG A 125
RAM  A 607 (-2.8A)
CA  A 602 ( 3.2A)
ADA  A 604 ( 3.0A)
0.87A 3k13A-5olsA:
undetectable
3k13A-5olsA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)
4pr7 OLIGOGALACTURONATE-S
PECIFIC PORIN KDGM

(Dickeya
dadantii)
4 / 6 SER A  75
ARG A 112
GLY A  79
GLU A  61
None
ADA  A 309 ( 3.7A)
OCT  A 304 (-4.7A)
ADA  A 309 ( 4.9A)
1.15A 3k9fA-4pr7A:
undetectable
3k9fB-4pr7A:
undetectable
3k9fD-4pr7A:
undetectable
3k9fA-4pr7A:
19.11
3k9fB-4pr7A:
19.11
3k9fD-4pr7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)
2o04 PECTATE LYASE
(Bacillus
subtilis)
4 / 5 SER A 316
ILE A 250
GLY A 311
PRO A 281
None
ADA  A 401 (-4.3A)
None
None
1.05A 3uboB-2o04A:
undetectable
3uboB-2o04A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)

(Bradyrhizobium
sp.
BTAi1)
5 / 11 SER A 229
HIS A 228
ASN A 206
GLU A 205
GLU A 233
None
None
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
1.28A 4fevE-4n8yA:
undetectable
4fevE-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)

(Bradyrhizobium
sp.
BTAi1)
5 / 12 ASN A 206
GLU A 233
SER A 229
HIS A 228
ARG A 166
ADA  A 401 (-2.9A)
GTR  A 402 (-2.8A)
None
None
ADA  A 401 (-3.0A)
1.35A 4fewC-4n8yA:
0.0
4fewD-4n8yA:
0.1
4fewF-4n8yA:
0.8
4fewC-4n8yA:
22.06
4fewD-4n8yA:
22.06
4fewF-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)

(Bradyrhizobium
sp.
BTAi1)
5 / 11 ASN A 206
GLU A 205
GLU A 233
SER A 229
HIS A 228
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
None
None
1.27A 4fewE-4n8yA:
0.0
4fewF-4n8yA:
0.8
4fewE-4n8yA:
22.06
4fewF-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)

(Bradyrhizobium
sp.
BTAi1)
5 / 10 SER A 229
HIS A 228
ASN A 206
GLU A 205
GLU A 233
None
None
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
1.27A 4gkhG-4n8yA:
0.1
4gkhH-4n8yA:
0.3
4gkhG-4n8yA:
22.06
4gkhH-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)

(Bradyrhizobium
sp.
BTAi1)
5 / 11 SER A 229
HIS A 228
ASN A 206
GLU A 205
GLU A 233
None
None
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
1.30A 4gkiC-4n8yA:
undetectable
4gkiD-4n8yA:
undetectable
4gkiC-4n8yA:
22.06
4gkiD-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)

(Bradyrhizobium
sp.
BTAi1)
5 / 10 SER A 229
HIS A 228
ASN A 206
GLU A 205
GLU A 233
None
None
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
1.29A 4gkiG-4n8yA:
0.8
4gkiH-4n8yA:
0.2
4gkiG-4n8yA:
22.06
4gkiH-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Yersinia
enterocolitica)
3 / 3 ASN A  90
ASP A 388
ASP A 190
ADA  A1433 (-3.0A)
ADA  A1432 ( 4.7A)
ADA  A1431 (-3.0A)
0.75A 4obwD-2uvjA:
undetectable
4obwD-2uvjA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
5xqo PCRGLX PROTEIN
(Penicillium
chrysogenum)
5 / 12 GLU A 587
ASN A 902
ASP A 903
ILE A 904
PHE A 544
ADA  A1004 ( 3.7A)
RAM  A1003 ( 4.1A)
None
None
None
1.09A 4u8yB-5xqoA:
undetectable
4u8yB-5xqoA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas
sp.
JS666)
3 / 3 ASP A  37
ARG A 174
ARG A 154
None
GTR  A 405 (-3.0A)
ADA  A 406 ( 3.0A)
0.96A 4x5iA-4mijA:
undetectable
4x5iA-4mijA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)

(Bradyrhizobium
sp.
BTAi1)
3 / 3 ASP A  29
ARG A 166
ARG A 145
None
ADA  A 401 (-3.0A)
GTR  A 402 (-3.0A)
0.98A 4x5iA-4n8yA:
undetectable
4x5iA-4n8yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)
3b8y ENDO-PECTATE LYASE
(Dickeya
chrysanthemi)
4 / 7 ASP A 173
GLY A 174
HIS A 176
ASP A 195
None
None
None
ADA  A 903 (-3.0A)
1.00A 5nnwD-3b8yA:
undetectable
5nnwD-3b8yA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)
3b8y ENDO-PECTATE LYASE
(Dickeya
chrysanthemi)
4 / 7 ASP A 173
GLY A 174
HIS A 176
ASP A 195
None
None
None
ADA  A 903 (-3.0A)
1.07A 5no9D-3b8yA:
undetectable
5no9D-3b8yA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)
3b8y ENDO-PECTATE LYASE
(Dickeya
chrysanthemi)
4 / 5 ASP A 223
PRO A 306
GLU A 310
ARG A 252
None
None
None
ADA  A 901 ( 3.7A)
1.36A 5uxcA-3b8yA:
undetectable
5uxcA-3b8yA:
20.79