SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ACX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 6 TRP A 192
GLY A 249
PHE A 253
SER A 248
 ACX  A 401 (-3.9A)
None
None
None
 1.32A 2a3cA-4femA:
undetectable		 2a3cA-4femA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 6 TRP A 192
GLY A 249
PHE A 253
SER A 248
 ACX  A 401 (-3.9A)
None
None
None
 1.34A 2a3cB-4femA:
undetectable		 2a3cB-4femA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		4 / 5 TRP A 360
GLY A 202
PHE A 278
PHE A 174
 ACX  A 901 (-3.6A)
None
None
None
 0.97A 2qr2A-2zymA:
undetectable
2qr2B-2zymA:
undetectable		 2qr2A-2zymA:
20.34
2qr2B-2zymA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 237
GLU A 256
LYS A 221
PHE A 222
 None
None
ACX  A 401 (-2.9A)
None
 1.46A 3rv5C-4femA:
undetectable
3rv5D-4femA:
undetectable		 3rv5C-4femA:
16.56
3rv5D-4femA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 7 PHE A 222
ASN A 252
GLY A 231
ILE A 278
PHE A 263
 None
ACX  A 401 (-3.1A)
None
None
None
 1.39A 4ejjA-4femA:
undetectable		 4ejjA-4femA:
23.17