SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ACN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 4 GLY A 107
GLU A 108
ASP A  38
TYR A  80
 F42  A 351 (-3.2A)
ACN  A 352 ( 2.9A)
None
None
 1.27A 2yvlC-1rhcA:
1.3		 2yvlC-1rhcA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 THR A  74
ILE A  73
GLU A 108
PHE A   8
 None
F42  A 351 (-4.2A)
ACN  A 352 ( 2.9A)
None
 1.05A 4ac9C-1rhcA:
2.0		 4ac9C-1rhcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 THR A  74
ILE A  73
GLU A 108
PHE A   8
 None
F42  A 351 (-4.2A)
ACN  A 352 ( 2.9A)
None
 1.06A 4acaC-1rhcA:
2.6		 4acaC-1rhcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 THR A  74
ILE A  73
GLU A 108
PHE A   8
 None
F42  A 351 (-4.2A)
ACN  A 352 ( 2.9A)
None
 1.08A 4acbC-1rhcA:
2.3		 4acbC-1rhcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		5 / 12 ALA A 194
HIS A  39
GLU A  12
PHE A 255
GLU A 108
 None
ACN  A 352 ( 4.0A)
ACN  A 352 ( 4.4A)
F42  A 351 (-4.9A)
ACN  A 352 ( 2.9A)
 1.27A 4r7lA-1rhcA:
undetectable		 4r7lA-1rhcA:
19.78