SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ACM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 6 GLN A 130
ASP A 122
HIS A 107
CYH A  68
 None
None
ACM  A 301 (-4.0A)
ACM  A 301 (-1.7A)
 1.47A 1ekjG-2ijaA:
undetectable
1ekjH-2ijaA:
undetectable		 1ekjG-2ijaA:
20.13
1ekjH-2ijaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 6 GLN A 130
ASP A 122
VAL A  71
HIS A 107
 None
None
None
ACM  A 301 (-4.0A)
 1.23A 1ekjG-2ijaA:
undetectable
1ekjH-2ijaA:
undetectable		 1ekjG-2ijaA:
20.13
1ekjH-2ijaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 7 LEU A  69
ARG A 197
SER A 215
GLY A 104
 ACM  A 301 ( 4.8A)
None
None
None
 0.98A 3hcrB-2ijaA:
undetectable		 3hcrB-2ijaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 6 PHE A  37
CYH A  68
VAL A  93
PHE A 217
 None
ACM  A 301 (-1.7A)
None
ACM  A 301 (-4.2A)
 0.70A 3ltwA-2ijaA:
32.5		 3ltwA-2ijaA:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 9 GLY A 140
ALA A 164
ASP A 165
GLY A 170
LEU A 203
 ACM  A 803 (-3.7A)
None
ACM  A 803 ( 4.8A)
None
None
 1.03A 3ogpB-2p0wA:
undetectable		 3ogpB-2p0wA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 140
ALA A 164
ASP A 165
GLY A 170
LEU A 203
 ACM  A 803 (-3.7A)
None
ACM  A 803 ( 4.8A)
None
None
 0.98A 3ogqB-2p0wA:
undetectable		 3ogqB-2p0wA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens) 		4 / 8 VAL A  59
TRP A  67
HIS A  73
ASN A  72
 None
ACM  A 301 (-4.7A)
None
None
 1.17A 6gneB-2ijaA:
undetectable		 6gneB-2ijaA:
20.20