SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ACJ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
 None
None
None
ACJ  A 478 (-3.6A)
None
 1.41A 1fkoA-3nksA:
2.2		 1fkoA-3nksA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 ALA A 397
ALA A 393
VAL A 314
LEU A 344
ASP A 349
 None
None
None
ACJ  A 478 (-4.0A)
None
 1.12A 1rlbE-3nksA:
undetectable		 1rlbE-3nksA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 12 LEU A 223
GLY A 328
GLY A 330
LEU A 332
GLY A 343
 None
None
ACJ  A1465 (-3.9A)
ACJ  A1465 (-4.2A)
ACJ  A1465 ( 4.6A)
 1.21A 1y4lA-2ivdA:
undetectable		 1y4lA-2ivdA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 11 LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
 None
None
None
ACJ  A 478 (-3.6A)
None
 1.46A 5hbmA-3nksA:
undetectable		 5hbmA-3nksA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 HIS A 415
ILE A 419
GLY A  57
LEU A 344
ALA A 172
 FAD  A 479 ( 4.9A)
ACJ  A 478 (-4.7A)
FAD  A 479 (-3.5A)
ACJ  A 478 (-4.0A)
ACJ  A 478 (-3.2A)
 0.95A 5o96C-3nksA:
undetectable
5o96D-3nksA:
undetectable		 5o96C-3nksA:
20.04
5o96D-3nksA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 233
VAL A 456
PRO A  58
PHE A 331
GLY A 345
 None
FAD  A 479 (-4.0A)
FAD  A 479 (-3.9A)
ACJ  A 478 (-4.6A)
ACJ  A 478 (-3.6A)
 1.33A 5xiqA-3nksA:
undetectable		 5xiqA-3nksA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
 None
None
None
ACJ  A 478 (-3.6A)
None
 1.35A 6bsgA-3nksA:
undetectable		 6bsgA-3nksA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
 None
None
None
ACJ  A 478 (-3.6A)
None
 1.30A 6bsiA-3nksA:
undetectable		 6bsiA-3nksA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
 None
None
None
ACJ  A 478 (-3.6A)
None
 1.33A 6bsjA-3nksA:
undetectable		 6bsjA-3nksA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 11 SER A 228
VAL A 347
GLY A 332
ALA A 107
VAL A 351
 None
ACJ  A 478 (-4.4A)
ACJ  A 478 (-4.4A)
None
None
 1.46A 6hu9A-3nksA:
undetectable
6hu9E-3nksA:
undetectable
6hu9I-3nksA:
undetectable		 6hu9A-3nksA:
23.33
6hu9E-3nksA:
17.51
6hu9I-3nksA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 SER A 228
VAL A 347
GLY A 332
ALA A 107
VAL A 351
 None
ACJ  A 478 (-4.4A)
ACJ  A 478 (-4.4A)
None
None
 1.48A 6hu9L-3nksA:
undetectable
6hu9P-3nksA:
undetectable
6hu9T-3nksA:
undetectable		 6hu9L-3nksA:
23.33
6hu9P-3nksA:
17.51
6hu9T-3nksA:
8.03