SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ACH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_A_RIOA500_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN
(Sinorhizobium
meliloti) 		5 / 9 HIS A 208
ASP A 157
ASN A 156
GLU A 153
VAL A  71
 None
ACH  A   1 (-2.9A)
ACH  A   1 (-2.7A)
ACH  A   1 ( 4.6A)
None
 1.28A 1s3zA-2rinA:
0.0
1s3zB-2rinA:
0.1		 1s3zA-2rinA:
19.74
1s3zB-2rinA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 SER A 181
GLU A 153
ILE A 152
TRP A  43
GLY A 158
 None
ACH  A   1 ( 4.6A)
None
ACH  A   1 (-3.2A)
ACH  A   1 (-4.0A)
 1.12A 3k2hB-2rinA:
undetectable		 3k2hB-2rinA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 SER A 181
GLU A 153
ILE A 152
TRP A  43
GLY A 158
 None
ACH  A   1 ( 4.6A)
None
ACH  A   1 (-3.2A)
ACH  A   1 (-4.0A)
 1.18A 3nrrA-2rinA:
undetectable		 3nrrA-2rinA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 SER A 181
GLU A 153
ILE A 152
TRP A  43
GLY A 158
 None
ACH  A   1 ( 4.6A)
None
ACH  A   1 (-3.2A)
ACH  A   1 (-4.0A)
 1.19A 3nrrB-2rinA:
undetectable		 3nrrB-2rinA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN
(Sinorhizobium
meliloti) 		4 / 8 ASN A 213
PRO A 209
PHE A 214
TRP A 205
 None
None
None
ACH  A   1 (-3.4A)
 1.42A 4v2zC-2rinA:
undetectable		 4v2zC-2rinA:
14.93