SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ACF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		12 / 12 ARG A 125
GLU A 205
GLU A 206
SER A 209
PHE A 357
TYR A 547
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
None
None
ACF  A 800 (-4.5A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.26A 1x70A-2g5tA:
58.6		 1x70A-2g5tA:
99.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		3 / 3 ARG A 358
SER A 630
TYR A 631
 None
ACF  A 800 (-1.3A)
None
 0.76A 1x70A-2g5tA:
58.6		 1x70A-2g5tA:
99.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		12 / 12 ARG A 125
GLU A 205
GLU A 206
SER A 209
ARG A 358
SER A 630
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
None
None
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.32A 1x70B-2g5tA:
57.8		 1x70B-2g5tA:
99.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		3 / 3 PHE A 357
TYR A 547
TYR A 631
 None
ACF  A 800 (-4.5A)
None
 0.18A 1x70B-2g5tA:
57.8		 1x70B-2g5tA:
99.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 12 GLU A 205
GLU A 206
PHE A 357
TRP A 629
SER A 630
TYR A 631
VAL A 656
TYR A 662
TYR A 666
VAL A 711
HIS A 740
 ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
None
None
ACF  A 800 (-1.3A)
None
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
 0.25A 2rguA-2g5tA:
57.7		 2rguA-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 12 GLU A 205
GLU A 206
PHE A 357
TYR A 547
TRP A 629
SER A 630
TYR A 631
VAL A 656
TYR A 662
TYR A 666
HIS A 740
 ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
None
ACF  A 800 (-4.5A)
None
ACF  A 800 (-1.3A)
None
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
 0.49A 2rguA-2g5tA:
57.7		 2rguA-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		5 / 12 GLU A 206
SER A 630
VAL A 656
TYR A 662
VAL A 711
 ACF  A 800 (-3.2A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
None
 1.24A 2rguA-2g5tA:
57.7		 2rguA-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		5 / 12 GLU A 206
TYR A 547
SER A 630
VAL A 656
TYR A 662
 ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
 1.35A 2rguA-2g5tA:
57.7		 2rguA-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 11 GLU A 205
GLU A 206
TYR A 547
TRP A 629
SER A 630
TYR A 631
VAL A 656
TYR A 662
TYR A 666
VAL A 711
HIS A 740
 ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
None
ACF  A 800 (-1.3A)
None
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
 0.47A 2rguB-2g5tA:
57.3		 2rguB-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		5 / 11 TRP A 629
TYR A 634
TYR A 662
VAL A 711
HIS A 740
 None
None
ACF  A 800 (-4.1A)
None
None
 1.11A 2rguB-2g5tA:
57.3		 2rguB-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		12 / 12 ARG A 125
GLU A 205
GLU A 206
TYR A 547
SER A 630
TYR A 631
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.24A 3bjmA-2g5tA:
57.9		 3bjmA-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		5 / 12 TYR A 634
TYR A 662
ASN A 710
VAL A 711
HIS A 740
 None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
 1.07A 3bjmA-2g5tA:
57.9		 3bjmA-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		12 / 12 ARG A 125
GLU A 205
GLU A 206
PHE A 357
TYR A 547
SER A 630
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
None
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.30A 3bjmB-2g5tA:
57.8		 3bjmB-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		7 / 12 GLU A 205
PHE A 357
TYR A 547
SER A 630
VAL A 656
TYR A 662
VAL A 711
 ACF  A 800 (-3.6A)
None
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
None
 1.34A 3bjmB-2g5tA:
57.8		 3bjmB-2g5tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		3 / 3 TYR A 670
GLU A 205
ASP A 739
 None
ACF  A 800 (-3.6A)
None
 0.74A 3bxoA-2g5tA:
undetectable		 3bxoA-2g5tA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		3 / 3 TYR A 670
GLU A 205
ASP A 739
 None
ACF  A 800 (-3.6A)
None
 0.81A 3bxoB-2g5tA:
undetectable		 3bxoB-2g5tA:
15.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 12 ARG A 125
GLU A 205
GLU A 206
TYR A 547
SER A 630
TYR A 631
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.64A 3g0bA-2g5tA:
54.6		 3g0bA-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 12 ARG A 125
GLU A 205
GLU A 206
TYR A 547
TYR A 631
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
None
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.47A 3g0bA-2g5tA:
54.6		 3g0bA-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		5 / 12 GLU A 205
TYR A 547
SER A 630
TYR A 662
VAL A 711
 ACF  A 800 (-3.6A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
ACF  A 800 (-4.1A)
None
 1.39A 3g0bA-2g5tA:
54.6		 3g0bA-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		6 / 12 SER A 630
TYR A 634
TYR A 662
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
 1.28A 3g0bA-2g5tA:
54.6		 3g0bA-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 12 ARG A 125
GLU A 205
GLU A 206
TYR A 547
SER A 630
TYR A 631
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.65A 3g0bB-2g5tA:
54.1		 3g0bB-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 12 ARG A 125
GLU A 205
GLU A 206
TYR A 547
TYR A 631
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
None
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.48A 3g0bB-2g5tA:
54.1		 3g0bB-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		5 / 12 GLU A 205
TYR A 547
SER A 630
TYR A 662
VAL A 711
 ACF  A 800 (-3.6A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
ACF  A 800 (-4.1A)
None
 1.36A 3g0bB-2g5tA:
54.1		 3g0bB-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		5 / 12 GLU A 206
TYR A 547
VAL A 656
TYR A 662
VAL A 711
 ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
None
ACF  A 800 (-4.1A)
None
 1.40A 3g0bB-2g5tA:
54.1		 3g0bB-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		6 / 12 SER A 630
TYR A 634
TYR A 662
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
 1.30A 3g0bB-2g5tA:
54.1		 3g0bB-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 12 ARG A 125
GLU A 205
GLU A 206
TYR A 547
SER A 630
TYR A 631
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.68A 3g0bC-2g5tA:
54.0		 3g0bC-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 12 ARG A 125
GLU A 205
GLU A 206
TYR A 547
TYR A 631
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
None
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.49A 3g0bC-2g5tA:
54.0		 3g0bC-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		5 / 12 GLU A 205
TYR A 547
SER A 630
TYR A 662
VAL A 711
 ACF  A 800 (-3.6A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
ACF  A 800 (-4.1A)
None
 1.37A 3g0bC-2g5tA:
54.0		 3g0bC-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		5 / 12 GLU A 205
TYR A 547
VAL A 656
TYR A 662
VAL A 711
 ACF  A 800 (-3.6A)
ACF  A 800 (-4.5A)
None
ACF  A 800 (-4.1A)
None
 1.23A 3g0bC-2g5tA:
54.0		 3g0bC-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		6 / 12 SER A 630
TYR A 634
TYR A 662
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
 1.31A 3g0bC-2g5tA:
54.0		 3g0bC-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 12 ARG A 125
GLU A 205
GLU A 206
TYR A 547
SER A 630
TYR A 631
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.66A 3g0bD-2g5tA:
56.5		 3g0bD-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 12 ARG A 125
GLU A 205
GLU A 206
TYR A 547
TYR A 631
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
None
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.49A 3g0bD-2g5tA:
56.5		 3g0bD-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		5 / 12 GLU A 205
TYR A 547
SER A 630
TYR A 662
VAL A 711
 ACF  A 800 (-3.6A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
ACF  A 800 (-4.1A)
None
 1.34A 3g0bD-2g5tA:
56.5		 3g0bD-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		6 / 12 SER A 630
TYR A 634
TYR A 662
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
 1.30A 3g0bD-2g5tA:
56.5		 3g0bD-2g5tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		4 / 5 ARG A 125
ASP A 709
ASP A 739
ASP A 708
 ACF  A 800 (-3.4A)
None
None
None
 1.45A 3naiA-2g5tA:
0.0		 3naiA-2g5tA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		12 / 12 ARG A 125
GLU A 205
GLU A 206
TYR A 547
SER A 630
TYR A 631
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.22A 3w2tA-2g5tA:
57.7		 3w2tA-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		6 / 12 SER A 630
TYR A 634
TYR A 662
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
 1.28A 3w2tA-2g5tA:
57.7		 3w2tA-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		12 / 12 ARG A 125
GLU A 205
GLU A 206
TYR A 547
SER A 630
TYR A 631
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.21A 3w2tB-2g5tA:
58.1		 3w2tB-2g5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		6 / 12 SER A 630
TYR A 634
TYR A 662
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
 1.28A 3w2tB-2g5tA:
58.1		 3w2tB-2g5tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		4 / 8 ASN A 710
ASP A 708
VAL A 656
HIS A 704
 ACF  A 800 (-3.3A)
None
None
None
 1.22A 4f5zA-2g5tA:
12.7		 4f5zA-2g5tA:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 12 ARG A 125
GLU A 205
GLU A 206
ARG A 358
TYR A 547
SER A 630
VAL A 656
TYR A 662
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
None
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
 0.36A 4ffwA-2g5tA:
53.1		 4ffwA-2g5tA:
84.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		3 / 3 PHE A 357
TYR A 631
TYR A 666
 None
None
ACF  A 800 (-3.3A)
 0.26A 4ffwA-2g5tA:
53.1		 4ffwA-2g5tA:
84.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		11 / 12 ARG A 125
GLU A 205
GLU A 206
PHE A 357
TYR A 547
SER A 630
VAL A 656
TYR A 662
TYR A 666
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
None
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
 0.39A 4ffwB-2g5tA:
51.6		 4ffwB-2g5tA:
84.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		7 / 12 GLU A 205
PHE A 357
TYR A 547
SER A 630
VAL A 656
TYR A 662
VAL A 711
 ACF  A 800 (-3.6A)
None
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
None
 1.29A 4ffwB-2g5tA:
51.6		 4ffwB-2g5tA:
84.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		3 / 3 ARG A 358
TYR A 631
ASN A 710
 None
None
ACF  A 800 (-3.3A)
 0.48A 4ffwB-2g5tA:
51.6		 4ffwB-2g5tA:
84.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		12 / 12 ARG A 125
GLU A 205
GLU A 206
TYR A 547
SER A 630
TYR A 631
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.22A 6b1eB-2g5tA:
58.3		 6b1eB-2g5tA:
99.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		6 / 12 GLU A 206
TYR A 547
SER A 630
VAL A 656
TYR A 662
VAL A 711
 ACF  A 800 (-3.2A)
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
None
 1.13A 6b1eB-2g5tA:
58.3		 6b1eB-2g5tA:
99.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens) 		5 / 12 TYR A 634
TYR A 662
ASN A 710
VAL A 711
HIS A 740
 None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
 1.11A 6b1eB-2g5tA:
58.3		 6b1eB-2g5tA:
99.86