SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ACA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 7 ASP A  55
TRP A  62
ARG A  71
TRP A  72
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.1A)
 0.98A 1b2iA-2pk4A:
12.6		 1b2iA-2pk4A:
48.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 7 ASP A  57
TRP A  62
PHE A  64
TRP A  72
 ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 4.1A)
ACA  A 100 ( 3.1A)
 1.20A 1b2iA-2pk4A:
12.6		 1b2iA-2pk4A:
48.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 7 TRP A  62
PHE A  64
ARG A  71
TRP A  72
 ACA  A 100 ( 3.6A)
ACA  A 100 ( 4.1A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.1A)
 1.08A 1b2iA-2pk4A:
12.6		 1b2iA-2pk4A:
48.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 8 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.6A)
 0.53A 1ceaA-2pk4A:
undetectable
1ceaB-2pk4A:
15.9		 1ceaA-2pk4A:
51.22
1ceaB-2pk4A:
51.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 7 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.6A)
 0.50A 1ceaB-2pk4A:
15.9		 1ceaB-2pk4A:
51.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 7 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.6A)
 0.57A 1cebA-2pk4A:
15.9		 1cebA-2pk4A:
51.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 7 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.6A)
 0.53A 1cebB-2pk4A:
15.8		 1cebB-2pk4A:
51.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE
(Arthrobacter
sp.
KI72) 		5 / 11 GLY A 124
LEU A  74
GLY A 149
HIS A 167
GLU A 212
 ACA  A 601 ( 3.9A)
None
None
None
None
 1.17A 1iolA-3a2qA:
undetectable		 1iolA-3a2qA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE
(Arthrobacter
sp.
KI72) 		5 / 12 ARG A 191
PHE A 238
VAL A 363
ALA A 210
ALA A 209
 None
None
None
ACA  A 601 ( 4.9A)
None
 1.20A 1n5xA-3a2qA:
undetectable		 1n5xA-3a2qA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE
(Arthrobacter
sp.
KI72) 		5 / 12 ARG A 191
PHE A 238
VAL A 363
ALA A 210
ALA A 209
 None
None
None
ACA  A 601 ( 4.9A)
None
 1.20A 1n5xB-3a2qA:
undetectable		 1n5xB-3a2qA:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 8 ASP A  55
ASP A  57
TRP A  62
TRP A  72
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.1A)
 0.79A 1pk2A-2pk4A:
9.5		 1pk2A-2pk4A:
42.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE
(Arthrobacter
sp.
KI72) 		5 / 12 ILE A 177
ALA A 172
GLN A 420
PRO A 267
ASN A 266
 None
ACA  A 602 (-3.6A)
None
None
None
 1.33A 1u70A-3a2qA:
undetectable		 1u70A-3a2qA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE
(Arthrobacter
sp.
KI72) 		4 / 7 GLU A 323
ALA A 171
ASN A 169
ALA A 210
 None
ACA  A 602 ( 3.3A)
None
ACA  A 601 ( 4.9A)
 1.07A 2ejfA-3a2qA:
undetectable		 2ejfA-3a2qA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_D_BEZD2002_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE
(Arthrobacter
sp.
KI72) 		5 / 9 GLN A 126
GLY A 124
LEU A  74
ASP A 202
ASN A 125
 None
ACA  A 601 ( 3.9A)
None
ACA  A 601 ( 4.7A)
ACA  A 601 ( 3.7A)
 1.12A 2ok6B-3a2qA:
0.0
2ok6D-3a2qA:
0.0		 2ok6B-3a2qA:
22.24
2ok6D-3a2qA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE
(Arthrobacter
sp.
KI72) 		5 / 10 GLN A 126
GLY A 124
LEU A  74
ASP A 202
ASN A 125
 None
ACA  A 601 ( 3.9A)
None
ACA  A 601 ( 4.7A)
ACA  A 601 ( 3.7A)
 1.12A 2ok6A-3a2qA:
undetectable
2ok6H-3a2qA:
undetectable		 2ok6A-3a2qA:
22.24
2ok6H-3a2qA:
15.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		6 / 7 ASP A  55
ASP A  57
TRP A  62
PHE A  64
ARG A  71
TRP A  72
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 4.1A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.1A)
 0.35A 3kivA-2pk4A:
17.5		 3kivA-2pk4A:
85.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE
(Arthrobacter
sp.
KI72) 		4 / 4 SER A 150
ASP A 202
ASP A 204
ALA A 171
 ACA  A 601 ( 2.7A)
ACA  A 601 ( 4.7A)
None
ACA  A 602 ( 3.3A)
 1.31A 3uj6A-3a2qA:
undetectable		 3uj6A-3a2qA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE
(Arthrobacter
sp.
KI72) 		5 / 12 ALA A 174
VAL A 175
GLY A 153
GLU A 130
ALA A 156
 ACA  A 602 ( 3.0A)
None
None
None
None
 1.15A 5n5dA-3a2qA:
undetectable		 5n5dA-3a2qA:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 5nwu WTFP-TAG,GP41
(Human
immunodeficiency
virus
1;
unidentified) 		4 / 7 GLN A  22
LEU A  25
ASP A  28
ALA A  31
 ACA  A  18 ( 4.1A)
None
None
None
 1.02A 5nwvA-5nwuA:
undetectable		 5nwvA-5nwuA:
88.89