SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AAE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		5 / 12 ALA A 126
GLY A 101
ASP A 349
GLY A 350
ARG A 347
 AAE  A 501 (-3.7A)
None
None
None
None
 0.97A 1sqfA-3i09A:
2.5		 1sqfA-3i09A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		4 / 8 TYR A 145
SER A 104
TYR A 121
HIS A 142
 None
AAE  A 501 (-2.5A)
None
None
 1.25A 2bteA-3i09A:
undetectable		 2bteA-3i09A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		4 / 8 TYR A 145
SER A 104
TYR A 121
HIS A 142
 None
AAE  A 501 (-2.5A)
None
None
 1.25A 2bteD-3i09A:
undetectable		 2bteD-3i09A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		5 / 12 HIS A 200
LEU A 253
GLY A 228
PHE A 175
ALA A 225
 None
None
EDO  A   8 ( 4.0A)
AAE  A 501 (-3.6A)
None
 1.00A 2oc8A-3i09A:
undetectable		 2oc8A-3i09A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		4 / 7 ALA A 107
THR A 106
ALA A 105
TYR A  40
 None
None
None
AAE  A 501 ( 4.0A)
 0.94A 2ql8A-3i09A:
undetectable
2ql8B-3i09A:
undetectable		 2ql8A-3i09A:
15.92
2ql8B-3i09A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		4 / 8 TYR A 145
SER A 104
TYR A 121
HIS A 142
 None
AAE  A 501 (-2.5A)
None
None
 1.29A 2v0gA-3i09A:
undetectable		 2v0gA-3i09A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		4 / 7 TYR A 173
ASN A 123
HIS A 142
ALA A 128
 AAE  A 501 (-4.5A)
None
None
None
 1.23A 3frqB-3i09A:
undetectable		 3frqB-3i09A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		3 / 3 TYR A  40
GLY A 228
ASP A 258
 AAE  A 501 ( 4.0A)
EDO  A   8 ( 4.0A)
EDO  A   8 (-3.3A)
 0.70A 3ou6C-3i09A:
2.4		 3ou6C-3i09A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		5 / 12 HIS A 200
LEU A 253
GLY A 228
PHE A 175
ALA A 225
 None
None
EDO  A   8 ( 4.0A)
AAE  A 501 (-3.6A)
None
 1.02A 3sufA-3i09A:
undetectable		 3sufA-3i09A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		4 / 4 ASN A 123
ALA A 107
GLY A 101
THR A 102
 None
None
None
AAE  A 501 (-4.0A)
 1.19A 4bboC-3i09A:
undetectable		 4bboC-3i09A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		4 / 6 ASP A  74
ALA A  41
THR A  34
THR A 102
 None
None
None
AAE  A 501 (-4.0A)
 1.38A 4z4cA-3i09A:
4.9		 4z4cA-3i09A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		4 / 5 ASP A  74
ALA A  41
THR A  34
THR A 102
 None
None
None
AAE  A 501 (-4.0A)
 1.37A 4z4gA-3i09A:
4.8		 4z4gA-3i09A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		4 / 6 ASP A  74
ALA A  41
THR A  34
THR A 102
 None
None
None
AAE  A 501 (-4.0A)
 1.33A 4z4iA-3i09A:
5.0		 4z4iA-3i09A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN
(Burkholderia
mallei) 		5 / 12 HIS A 200
LEU A 253
GLY A 228
PHE A 175
ALA A 225
 None
None
EDO  A   8 ( 4.0A)
AAE  A 501 (-3.6A)
None
 1.03A 6c2mA-3i09A:
undetectable		 6c2mA-3i09A:
12.16