SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'A9Y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_B_SAMB1293_1 (GLYCINE N-METHYLTRANSFERASE)	5xzb	CYCLIC GMP-AMP SYNTHASE (Mus musculus)	4 / 5	ARG A 364 ASP A 213 SER A 199 SER A 368	A9Y A 602 (-3.5A) None None None	1.49A	1kiaB-5xzbA: undetectable	1kiaB-5xzbA: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_J_ZPCJ1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5xzb	CYCLIC GMP-AMP SYNTHASE (Mus musculus)	4 / 5	GLU A 202 GLU A 371 TYR A 421 HIS A 422	None None A9Y A 602 (-4.0A) A9Y A 602 ( 4.5A)	1.45A	4a97J-5xzbA: undetectable	4a97J-5xzbA: 19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CK2_C_IPHC101_0 (INSULIN A CHAIN INSULIN B CHAIN)	5xzb	CYCLIC GMP-AMP SYNTHASE (Mus musculus)	4 / 4	ILE A 493 LEU A 452 HIS A 422 ALA A 426	None None A9Y A 602 ( 4.5A) None	0.99A	6ck2C-5xzbA: undetectable 6ck2D-5xzbA: undetectable	6ck2C-5xzbA: 3.71 6ck2D-5xzbA: 7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6JMJ_A_ASCA201_0 (PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE)	5xzb	CYCLIC GMP-AMP SYNTHASE (Mus musculus)	4 / 5	GLY A 325 THR A 322 HIS A 467 SER A 366	None None A9Y A 602 (-4.1A) None	1.11A	6jmjA-5xzbA: undetectable	6jmjA-5xzbA: 19.06

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KIA_B_SAMB1293_1","GLYCINE N-METHYLTRANSFERASE","5xzb","CYCLIC GMP-AMP SYNTHASE","Mus musculus",4,"ARG A 364;ASP A 213;SER A 199;SER A 368","A9Y A 602 (-3.5A);None;None;None","1.49A","1kiaB-5xzbA:undetectable",null],["4A97_J_ZPCJ1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL","5xzb","CYCLIC GMP-AMP SYNTHASE","Mus musculus",4,"GLU A 202;GLU A 371;TYR A 421;HIS A 422","None;None;A9Y A 602 (-4.0A);A9Y A 602 ( 4.5A)","1.45A","4a97J-5xzbA:undetectable","1kiaB-5xzbA:21.51"],["6CK2_C_IPHC101_0","INSULIN A CHAIN;INSULIN B CHAIN","5xzb","CYCLIC GMP-AMP SYNTHASE","Mus musculus",4,"ILE A 493;LEU A 452;HIS A 422;ALA A 426","None;None;A9Y A 602 ( 4.5A);None","0.99A","6ck2C-5xzbA:undetectable;6ck2D-5xzbA:undetectable","4a97J-5xzbA:19.34"],["6JMJ_A_ASCA201_0","PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE","5xzb","CYCLIC GMP-AMP SYNTHASE","Mus musculus",4,"GLY A 325;THR A 322;HIS A 467;SER A 366","None;None;A9Y A 602 (-4.1A);None","1.11A","6jmjA-5xzbA:undetectable","6ck2C-5xzbA:3.71;6ck2D-5xzbA:7.32"]]