SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'A9M'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 PHE A  19
THR A  56
VAL A  60
ARG A 129
TYR A 131
None
A9M  A1136 ( 4.3A)
A9M  A1136 (-4.8A)
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
0.89A 1cbrA-4azpA:
19.5
1cbrA-4azpA:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 PHE A  19
THR A  56
VAL A  60
ARG A 129
TYR A 131
None
A9M  A1136 ( 4.3A)
A9M  A1136 (-4.8A)
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
0.89A 1cbrB-4azpA:
19.6
1cbrB-4azpA:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 PHE A  19
TYR A  22
ALA A  36
PRO A  41
THR A  56
None
None
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.7A)
A9M  A1136 ( 4.3A)
1.03A 1mx8A-4azpA:
16.9
1mx8A-4azpA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 PHE A  19
THR A  56
VAL A  60
ARG A 129
TYR A 131
None
A9M  A1136 ( 4.3A)
A9M  A1136 (-4.8A)
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
0.71A 2cbrA-4azpA:
19.7
2cbrA-4azpA:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 PHE A  19
PRO A  41
THR A  56
ARG A 129
TYR A 131
None
A9M  A1136 ( 4.7A)
A9M  A1136 ( 4.3A)
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
1.02A 2fr3A-4azpA:
19.6
2fr3A-4azpA:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 ILE A 107
GLU A  75
LEU A  26
TYR A  22
ALA A  78
A9M  A1136 (-4.4A)
None
None
None
A9M  A1136 (-3.5A)
1.12A 2noaA-4azpA:
undetectable
2noaA-4azpA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 PHE A  19
ALA A  37
CYH A 120
ARG A 129
TYR A 131
None
None
A9M  A1136 ( 3.8A)
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
1.36A 2qm9A-4azpA:
24.3
2qm9A-4azpA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
11 / 12 PHE A  19
VAL A  28
ALA A  36
SER A  58
THR A  63
ALA A  78
ASP A  79
ARG A  81
CYH A 120
ARG A 129
TYR A 131
None
None
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
None
A9M  A1136 (-3.5A)
A9M  A1136 (-4.0A)
None
A9M  A1136 ( 3.8A)
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
0.50A 2qm9A-4azpA:
24.3
2qm9A-4azpA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
7 / 12 VAL A  28
ALA A  36
SER A  58
ALA A  78
ASP A  79
CYH A 127
TYR A 131
None
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
A9M  A1136 (-3.5A)
A9M  A1136 (-4.0A)
None
A9M  A1136 (-4.8A)
1.25A 2qm9A-4azpA:
24.3
2qm9A-4azpA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
4 / 4 TYR A  22
MET A  23
PRO A  41
ILE A 107
None
A9M  A1136 (-3.7A)
A9M  A1136 ( 4.7A)
A9M  A1136 (-4.4A)
0.63A 2qm9A-4azpA:
24.3
2qm9A-4azpA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
11 / 12 PHE A  19
TYR A  22
VAL A  28
SER A  58
THR A  63
ALA A  78
ARG A  81
ILE A 107
CYH A 120
ARG A 129
TYR A 131
None
None
None
A9M  A1136 ( 4.1A)
None
A9M  A1136 (-3.5A)
None
A9M  A1136 (-4.4A)
A9M  A1136 ( 3.8A)
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
0.50A 2qm9B-4azpA:
25.0
2qm9B-4azpA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 TYR A  22
VAL A  28
THR A  56
ARG A  81
ILE A 107
None
None
A9M  A1136 ( 4.3A)
None
A9M  A1136 (-4.4A)
1.22A 2qm9B-4azpA:
25.0
2qm9B-4azpA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 VAL A  28
SER A  58
ALA A  78
CYH A 127
TYR A 131
None
A9M  A1136 ( 4.1A)
A9M  A1136 (-3.5A)
None
A9M  A1136 (-4.8A)
1.22A 2qm9B-4azpA:
25.0
2qm9B-4azpA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
4 / 4 MET A  23
PRO A  41
ASP A  79
ARG A 109
A9M  A1136 (-3.7A)
A9M  A1136 ( 4.7A)
A9M  A1136 (-4.0A)
None
0.52A 2qm9B-4azpA:
25.0
2qm9B-4azpA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
12 / 12 PHE A  19
MET A  23
VAL A  28
PRO A  41
ASP A  79
ARG A  81
ILE A 107
ARG A 109
VAL A 118
CYH A 120
ARG A 129
TYR A 131
None
A9M  A1136 (-3.7A)
None
A9M  A1136 ( 4.7A)
A9M  A1136 (-4.0A)
None
A9M  A1136 (-4.4A)
None
None
A9M  A1136 ( 3.8A)
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
0.65A 3p6gA-4azpA:
24.1
3p6gA-4azpA:
50.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
8 / 12 PHE A  19
MET A  23
VAL A  28
PRO A  41
ASP A  79
CYH A 127
ARG A 129
TYR A 131
None
A9M  A1136 (-3.7A)
None
A9M  A1136 ( 4.7A)
A9M  A1136 (-4.0A)
None
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
1.22A 3p6gA-4azpA:
24.1
3p6gA-4azpA:
50.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
7 / 7 PHE A  19
MET A  23
ASP A  79
ILE A 107
VAL A 118
ARG A 129
TYR A 131
None
A9M  A1136 (-3.7A)
A9M  A1136 (-4.0A)
A9M  A1136 (-4.4A)
None
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
0.44A 3p6hA-4azpA:
24.1
3p6hA-4azpA:
50.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
4 / 8 GLN A  98
PHE A  73
THR A  56
THR A  63
None
None
A9M  A1136 ( 4.3A)
None
0.82A 4n16A-4azpA:
undetectable
4n16A-4azpA:
19.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 PHE A  19
TYR A  22
LEU A  32
ALA A  36
SER A  58
None
None
A9M  A1136 ( 4.1A)
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
0.80A 5h8tA-4azpA:
20.7
5h8tA-4azpA:
33.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 PHE A  19
TYR A  22
VAL A  28
ALA A  36
SER A  58
None
None
None
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
0.77A 5hbsA-4azpA:
20.6
5hbsA-4azpA:
33.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 TYR A  22
VAL A  28
LEU A  32
ALA A  36
SER A  58
None
None
A9M  A1136 ( 4.1A)
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
0.87A 5hbsA-4azpA:
20.6
5hbsA-4azpA:
33.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 PHE A  19
TYR A  22
LEU A  32
ALA A  36
SER A  58
None
None
A9M  A1136 ( 4.1A)
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
0.98A 5ljbA-4azpA:
20.6
5ljbA-4azpA:
34.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus
musculus)
5 / 12 PHE A  19
TYR A  22
LEU A  32
ALA A  36
SER A  58
None
None
A9M  A1136 ( 4.1A)
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
0.99A 5ljcA-4azpA:
20.8
5ljcA-4azpA:
34.51