SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'A97'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		4 / 6 TYR B 809
TYR B 878
HIS B 307
PRO B 299
 A97  B8009 (-4.7A)
A97  B8009 (-4.9A)
A97  B8009 (-4.4A)
None
 1.40A 1q13A-5wfcB:
undetectable		 1q13A-5wfcB:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		3 / 3 LYS B2566
TYR B 878
PRO B2563
 None
A97  B8009 (-4.9A)
None
 1.37A 2j9cC-5wfcB:
undetectable		 2j9cC-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		5 / 12 GLY B 808
TYR B 809
ASN B 880
HIS B 881
TYR B 918
 A97  B8009 (-3.4A)
A97  B8009 (-4.7A)
A97  B8009 (-3.9A)
None
None
 0.62A 3qxyA-5wfcB:
5.5		 3qxyA-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		5 / 12 GLY B 808
TYR B 809
ASN B 880
HIS B 881
TYR B 918
 A97  B8009 (-3.4A)
A97  B8009 (-4.7A)
A97  B8009 (-3.9A)
None
None
 0.62A 3rc0B-5wfcB:
5.3		 3rc0B-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		5 / 12 GLY B 808
ASN B 880
HIS B 881
TYR B 918
PHE B 922
 A97  B8009 (-3.4A)
A97  B8009 (-3.9A)
None
None
None
 1.40A 5jj0B-5wfcB:
11.9		 5jj0B-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		7 / 12 GLY B 808
TYR B 809
TYR B 878
ASN B 880
HIS B 881
TYR B 918
PHE B 922
 A97  B8009 (-3.4A)
A97  B8009 (-4.7A)
A97  B8009 (-4.9A)
A97  B8009 (-3.9A)
None
None
None
 1.41A 5kklB-5wfcB:
47.2		 5kklB-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		8 / 12 LEU B 804
CYH B 807
GLY B 808
TYR B 809
TYR B 878
ASN B 880
HIS B 881
TYR B 918
 None
None
A97  B8009 (-3.4A)
A97  B8009 (-4.7A)
A97  B8009 (-4.9A)
A97  B8009 (-3.9A)
None
None
 0.36A 5kklB-5wfcB:
47.2		 5kklB-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		8 / 10 LEU B 804
CYH B 807
GLY B 808
TYR B 809
TYR B 878
ASN B 880
HIS B 881
TYR B 918
 None
None
A97  B8009 (-3.4A)
A97  B8009 (-4.7A)
A97  B8009 (-4.9A)
A97  B8009 (-3.9A)
None
None
 0.26A 5tqrB-5wfcB:
52.9		 5tqrB-5wfcB:
undetectable