SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'A3P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		5 / 9 THR A  20
SER A  12
HIS A  37
ALA A  88
THR A  94
 A3P  A 301 (-2.8A)
None
OAQ  A 302 ( 4.6A)
None
None
 1.38A 1c9sF-5bykA:
undetectable
1c9sG-5bykA:
undetectable		 1c9sF-5bykA:
21.92
1c9sG-5bykA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMJ_A_RTLA401_0
(RETINOL DEHYDRATASE)		 1bo6 ESTROGEN
SULFOTRANSFERASE
(Mus
musculus) 		5 / 11 TYR A  81
LEU A  89
LYS A 106
HIS A 108
PHE A 255
 VO4  A 302 ( 4.9A)
None
VO4  A 302 (-3.0A)
VO4  A 302 (-3.9A)
A3P  A 301 ( 4.6A)
 1.06A 1fmjA-1bo6A:
33.7		 1fmjA-1bo6A:
30.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 9 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.19A 1gtnG-1q1qA:
undetectable
1gtnH-1q1qA:
undetectable		 1gtnG-1q1qA:
13.61
1gtnH-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 1bo6 ESTROGEN
SULFOTRANSFERASE
(Mus
musculus) 		4 / 4 LEU A 143
PRO A 152
LEU A 144
ARG A 257
 None
None
None
A3P  A 301 (-4.0A)
 1.19A 1hrkB-1bo6A:
undetectable		 1hrkB-1bo6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4gbm CURM
SULFOTRANSFERASE
(Moorea
producens) 		4 / 5 TYR A 248
LEU A 229
THR A  43
ARG A  46
 None
None
A3P  A 406 ( 3.6A)
None
 1.20A 1i2wA-4gbmA:
undetectable		 1i2wA-4gbmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		4 / 5 TYR A 248
LEU A 229
THR A  43
ARG A  46
 A3P  A 401 (-4.6A)
None
A3P  A 401 (-3.6A)
None
 1.36A 1i2wA-4goxA:
undetectable		 1i2wA-4goxA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		3 / 3 ARG A  22
ARG A 264
ARG A  86
 None
A3P  A 401 (-3.6A)
None
 1.05A 1l7fA-5iufA:
undetectable		 1l7fA-5iufA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		3 / 3 ARG A  22
ARG A 264
ARG A  86
 None
A3P  A 401 (-3.6A)
None
 1.04A 1l7hA-5iufA:
undetectable		 1l7hA-5iufA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 4 HIS A 284
ALA A 287
PHE A 265
GLY A 283
 A3P  A 402 (-3.7A)
A3P  A 401 ( 4.7A)
None
A3P  A 401 (-3.4A)
 1.37A 1mj2B-5iufA:
undetectable		 1mj2B-5iufA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 4 HIS A 284
ALA A 287
PHE A 265
GLY A 283
 A3P  A 402 (-3.7A)
A3P  A 401 ( 4.7A)
None
A3P  A 401 (-3.4A)
 1.36A 1mj2D-5iufA:
undetectable		 1mj2D-5iufA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 4 HIS A 284
ALA A 287
PHE A 265
GLY A 283
 A3P  A 402 (-3.7A)
A3P  A 401 ( 4.7A)
None
A3P  A 401 (-3.4A)
 1.39A 1mjoB-5iufA:
undetectable		 1mjoB-5iufA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 4 HIS A 284
ALA A 287
PHE A 265
GLY A 283
 A3P  A 402 (-3.7A)
A3P  A 401 ( 4.7A)
None
A3P  A 401 (-3.4A)
 1.42A 1mjoA-5iufA:
undetectable		 1mjoA-5iufA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 4 HIS A 284
ALA A 287
PHE A 265
GLY A 283
 A3P  A 402 (-3.7A)
A3P  A 401 ( 4.7A)
None
A3P  A 401 (-3.4A)
 1.36A 1mjoD-5iufA:
undetectable		 1mjoD-5iufA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		4 / 7 LEU A 246
LEU A 183
SER A  70
VAL A  66
 None
None
A3P  A 400 ( 4.5A)
None
 0.88A 1tyrB-1fmlA:
undetectable		 1tyrB-1fmlA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		5 / 9 THR A  20
SER A  12
HIS A  37
ALA A  88
THR A  94
 A3P  A 301 (-2.8A)
None
OAQ  A 302 ( 4.6A)
None
None
 1.40A 1utdA-5bykA:
undetectable
1utdK-5bykA:
undetectable		 1utdA-5bykA:
21.92
1utdK-5bykA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3hyk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Bacillus
anthracis) 		4 / 6 ARG A  53
ILE A 101
GLY A  52
HIS A 103
 A3P  A 124 (-3.3A)
A3P  A 124 (-3.8A)
None
MG  A 120 ( 3.3A)
 0.97A 1wmqA-3hykA:
undetectable		 1wmqA-3hykA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3hyk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Bacillus
anthracis) 		4 / 6 ARG A  53
ILE A 101
GLY A  52
HIS A 103
 A3P  A 124 (-3.3A)
A3P  A 124 (-3.8A)
None
MG  A 120 ( 3.3A)
 0.98A 1wmqB-3hykA:
undetectable		 1wmqB-3hykA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3hyk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Bacillus
anthracis) 		4 / 6 ARG A  53
ILE A 101
GLY A  52
HIS A 103
 A3P  A 124 (-3.3A)
A3P  A 124 (-3.8A)
None
MG  A 120 ( 3.3A)
 0.95A 1wpuA-3hykA:
undetectable		 1wpuA-3hykA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3hyk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Bacillus
anthracis) 		4 / 6 ARG A  53
ILE A 101
GLY A  52
HIS A 103
 A3P  A 124 (-3.3A)
A3P  A 124 (-3.8A)
None
MG  A 120 ( 3.3A)
 0.96A 1wpuB-3hykA:
undetectable		 1wpuB-3hykA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3hyk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Bacillus
anthracis) 		4 / 6 ARG A  53
ILE A 101
GLY A  52
HIS A 103
 A3P  A 124 (-3.3A)
A3P  A 124 (-3.8A)
None
MG  A 120 ( 3.3A)
 0.95A 1wrqA-3hykA:
undetectable		 1wrqA-3hykA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3hyk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Bacillus
anthracis) 		4 / 6 ARG A  53
ILE A 101
GLY A  52
HIS A 103
 A3P  A 124 (-3.3A)
A3P  A 124 (-3.8A)
None
MG  A 120 ( 3.3A)
 0.95A 1wrqB-3hykA:
undetectable		 1wrqB-3hykA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1
(Escherichia
coli;
Gallus
gallus) 		4 / 6 GLU A1255
ASP A1259
PHE A1324
ARG A1328
 A3P  A 673 ( 4.5A)
None
None
None
 1.29A 2a3bB-3f5fA:
undetectable		 2a3bB-3f5fA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5tiw SULFOTRANSFERASE
(Schistosoma
haematobium) 		3 / 3 SER A 132
ASP A 100
CYH A 104
 A3P  A 301 (-2.5A)
OAQ  A 302 (-2.5A)
None
 1.16A 2br4E-5tiwA:
undetectable		 2br4E-5tiwA:
19.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 1bo6 ESTROGEN
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PHE A  24
PRO A  47
LYS A  48
LYS A 106
HIS A 108
MET A 248
 None
VO4  A 302 (-4.2A)
A3P  A 301 ( 2.9A)
VO4  A 302 (-3.0A)
VO4  A 302 (-3.9A)
None
 0.67A 2d06A-1bo6A:
40.5		 2d06A-1bo6A:
49.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 1g3m ESTROGEN
SULFOTRANSFERASE
(Homo
sapiens) 		7 / 10 PHE A  23
PRO A  46
LYS A  47
LYS A 105
HIS A 107
PHE A 141
MET A 247
 PCQ  A 712 ( 4.6A)
PCQ  A 712 ( 4.3A)
A3P  A 701 (-2.7A)
PCQ  A 712 (-3.0A)
PCQ  A 712 (-3.9A)
PCQ  A 712 (-4.7A)
None
 0.62A 2d06A-1g3mA:
43.3		 2d06A-1g3mA:
50.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		6 / 10 PRO A  55
LYS A  56
HIS A 117
PHE A 151
ALA A 155
MET A 257
 None
A3P  A 401 (-2.8A)
None
None
None
None
 0.66A 2d06A-2reoA:
32.0		 2d06A-2reoA:
51.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 3ckl SULFOTRANSFERASE
FAMILY CYTOSOLIC 1B
MEMBER 1
(Homo
sapiens) 		6 / 10 PHE A  24
PRO A  47
LYS A  48
LYS A 107
HIS A 109
MET A 146
 STL  A 501 (-4.5A)
STL  A 501 ( 4.5A)
A3P  A 601 (-2.7A)
A3P  A 601 ( 4.8A)
STL  A 501 (-3.8A)
None
 1.19A 2d06A-3cklA:
45.3		 2d06A-3cklA:
53.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 3ckl SULFOTRANSFERASE
FAMILY CYTOSOLIC 1B
MEMBER 1
(Homo
sapiens) 		7 / 10 PHE A  24
PRO A  47
LYS A  48
LYS A 107
HIS A 109
PHE A 143
MET A 249
 STL  A 501 (-4.5A)
STL  A 501 ( 4.5A)
A3P  A 601 (-2.7A)
A3P  A 601 ( 4.8A)
STL  A 501 (-3.8A)
STL  A 501 (-4.6A)
None
 0.51A 2d06A-3cklA:
45.3		 2d06A-3cklA:
53.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		8 / 10 PHE A  24
PRO A  47
LYS A  48
LYS A 106
HIS A 108
ALA A 146
VAL A 148
MET A 145
 None
None
A3P  A2001 (-3.1A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.7A)
None
 1.34A 2d06A-3qvuA:
48.8		 2d06A-3qvuA:
97.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		9 / 10 PHE A  24
PRO A  47
LYS A  48
LYS A 106
HIS A 108
PHE A 142
ALA A 146
VAL A 148
MET A 248
 None
None
A3P  A2001 (-3.1A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 (-4.8A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.7A)
NPO  A 296 ( 4.3A)
 0.42A 2d06A-3qvuA:
48.8		 2d06A-3qvuA:
97.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		5 / 10 PHE A  84
LYS A  48
ALA A 146
VAL A 148
MET A 145
 None
A3P  A2001 (-3.1A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.7A)
None
 1.33A 2d06A-3qvuA:
48.8		 2d06A-3qvuA:
97.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		5 / 10 PHE A  84
LYS A  48
PHE A 142
ALA A 146
VAL A 148
 None
A3P  A2001 (-3.1A)
NPO  A 296 (-4.8A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.7A)
 1.08A 2d06A-3qvuA:
48.8		 2d06A-3qvuA:
97.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 5mek CYTOSOLIC
SULFOTRANSFERASE 18
(Arabidopsis
thaliana) 		5 / 10 PRO A  92
LYS A  93
HIS A 155
PHE A 189
VAL A 305
 EDO  A 410 (-4.1A)
A3P  A 401 ( 2.8A)
EDO  A 410 ( 4.2A)
None
EDO  A 423 (-4.0A)
 1.11A 2d06A-5mekA:
29.7		 2d06A-5mekA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 3ckl SULFOTRANSFERASE
FAMILY CYTOSOLIC 1B
MEMBER 1
(Homo
sapiens) 		5 / 10 PHE A  24
PRO A  47
LYS A 107
HIS A 109
MET A 146
 STL  A 501 (-4.5A)
STL  A 501 ( 4.5A)
A3P  A 601 ( 4.8A)
STL  A 501 (-3.8A)
None
 1.04A 2d06B-3cklA:
45.3		 2d06B-3cklA:
53.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 3ckl SULFOTRANSFERASE
FAMILY CYTOSOLIC 1B
MEMBER 1
(Homo
sapiens) 		7 / 10 PHE A  24
PRO A  47
LYS A 107
HIS A 109
PHE A 143
TYR A 241
MET A 249
 STL  A 501 (-4.5A)
STL  A 501 ( 4.5A)
A3P  A 601 ( 4.8A)
STL  A 501 (-3.8A)
STL  A 501 (-4.6A)
None
None
 0.54A 2d06B-3cklA:
45.3		 2d06B-3cklA:
53.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		3 / 3 THR A 615
PRO A 706
TYR A 757
 A3P  A 301 (-4.9A)
None
None
 0.92A 2dxrA-1nstA:
0.0		 2dxrA-1nstA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1bo6 ESTROGEN
SULFOTRANSFERASE
(Mus
musculus) 		4 / 4 LEU A 143
PRO A 152
LEU A 144
ARG A 257
 None
None
None
A3P  A 301 (-4.0A)
 1.09A 2hrcA-1bo6A:
0.0		 2hrcA-1bo6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 1bo6 ESTROGEN
SULFOTRANSFERASE
(Mus
musculus) 		4 / 4 LEU A 143
PRO A 152
LEU A 144
ARG A 257
 None
None
None
A3P  A 301 (-4.0A)
 1.20A 2hrcB-1bo6A:
undetectable		 2hrcB-1bo6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4eec STAL
(Streptomyces
toyocaensis) 		4 / 6 PRO A 170
LEU A 174
ARG A 167
GLY A  14
 None
None
None
A3P  A 301 (-3.4A)
 1.22A 2hs2B-4eecA:
undetectable		 2hs2B-4eecA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN
(Danio
rerio;
Escherichia
coli) 		5 / 9 LEU A1260
HIS A1158
HIS A1101
MET A1189
LEU A1190
 None
GNS  A1402 ( 3.9A)
A3P  A1401 (-3.9A)
None
None
 1.32A 2jihA-5t03A:
undetectable		 2jihA-5t03A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 185
VAL A  68
THR A  79
 A3P  A 400 (-2.8A)
None
None
 0.83A 2nnkA-1fmlA:
0.0		 2nnkA-1fmlA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 312
VAL A 293
THR A  77
 A3P  A 400 (-3.7A)
None
A3P  A 400 (-3.6A)
 0.78A 2nnkA-1fmlA:
0.0		 2nnkA-1fmlA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		4 / 6 THR A 759
ARG A 763
THR A 615
ASP A 708
 None
None
A3P  A 301 (-4.9A)
None
 1.13A 2okcB-1nstA:
undetectable		 2okcB-1nstA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1bo6 ESTROGEN
SULFOTRANSFERASE
(Mus
musculus) 		4 / 4 LEU A 143
PRO A 152
LEU A 144
ARG A 257
 None
None
None
A3P  A 301 (-4.0A)
 1.19A 2pnjB-1bo6A:
undetectable		 2pnjB-1bo6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		5 / 9 LEU A 352
ILE A 336
ALA A 320
GLY A 164
LEU A 315
 None
None
None
A3P  A1302 (-3.3A)
None
 1.14A 2v0mB-1t8tA:
undetectable		 2v0mB-1t8tA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1
(Escherichia
coli;
Gallus
gallus) 		5 / 12 THR A1254
VAL A1162
VAL A1251
PHE A1221
TYR A1317
 A3P  A 673 ( 4.8A)
None
None
None
None
 1.47A 2y03B-3f5fA:
undetectable		 2y03B-3f5fA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1
(Escherichia
coli;
Gallus
gallus) 		5 / 12 THR A1254
VAL A1162
VAL A1251
PHE A1221
TYR A1317
 A3P  A 673 ( 4.8A)
None
None
None
None
 1.43A 2y04B-3f5fA:
undetectable		 2y04B-3f5fA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 LEU A 173
PHE A 269
LEU A  44
LEU A 279
TYR A 218
 None
A3P  A 401 (-4.7A)
A3P  A 401 (-3.8A)
A3P  A 401 (-3.9A)
A3P  A 401 (-4.8A)
 1.49A 3adsA-4goxA:
undetectable		 3adsA-4goxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1bo6 ESTROGEN
SULFOTRANSFERASE
(Mus
musculus) 		3 / 3 PRO A 152
LEU A 144
ARG A 257
 None
None
A3P  A 301 (-4.0A)
 0.78A 3aqiA-1bo6A:
undetectable		 3aqiA-1bo6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		4 / 7 LEU A 246
LEU A 183
SER A  70
VAL A  66
 None
None
A3P  A 400 ( 4.5A)
None
 0.81A 3d2tA-1fmlA:
undetectable		 3d2tA-1fmlA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1
(Escherichia
coli;
Gallus
gallus) 		5 / 12 THR A1254
VAL A1162
VAL A1251
PHE A1221
TYR A1317
 A3P  A 673 ( 4.8A)
None
None
None
None
 1.43A 3d4sA-3f5fA:
undetectable		 3d4sA-3f5fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		4 / 7 LEU A 159
ARG A  46
SER A 169
GLY A 265
 None
None
A3P  A 401 (-2.6A)
None
 1.03A 3hcrB-4goxA:
2.3		 3hcrB-4goxA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 704
GLY A 616
ALA A 619
PRO A 612
ALA A 678
 None
A3P  A 301 (-3.2A)
A3P  A 301 ( 3.7A)
None
None
 1.03A 3jayA-1nstA:
0.0		 3jayA-1nstA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 185
VAL A  68
THR A  79
 A3P  A 400 (-2.8A)
None
None
 0.80A 3k4vA-1fmlA:
0.0		 3k4vA-1fmlA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 312
VAL A 293
THR A  77
 A3P  A 400 (-3.7A)
None
A3P  A 400 (-3.6A)
 0.79A 3k4vA-1fmlA:
0.0		 3k4vA-1fmlA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 185
VAL A  68
THR A  79
 A3P  A 400 (-2.8A)
None
None
 0.84A 3k4vD-1fmlA:
0.0		 3k4vD-1fmlA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 312
VAL A 293
THR A  77
 A3P  A 400 (-3.7A)
None
A3P  A 400 (-3.6A)
 0.77A 3k4vD-1fmlA:
0.0		 3k4vD-1fmlA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		4 / 5 SER A 108
ARG A 132
GLY A 131
GLU A 196
 None
A3P  A 352 (-3.2A)
None
None
 1.19A 3k9fA-1q1qA:
undetectable
3k9fB-1q1qA:
undetectable
3k9fC-1q1qA:
1.7		 3k9fA-1q1qA:
21.68
3k9fB-1q1qA:
21.68
3k9fC-1q1qA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1bo6 ESTROGEN
SULFOTRANSFERASE
(Mus
musculus) 		5 / 10 ILE A  75
THR A  52
TRP A  53
ILE A 104
ILE A  43
 None
A3P  A 301 (-3.7A)
A3P  A 301 (-3.5A)
None
None
 1.38A 3kpbD-1bo6A:
undetectable		 3kpbD-1bo6A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1g3m ESTROGEN
SULFOTRANSFERASE
(Homo
sapiens) 		5 / 10 ILE A  74
THR A  51
TRP A  52
ILE A 103
ILE A  42
 None
A3P  A 701 (-3.6A)
A3P  A 701 (-3.4A)
None
None
 1.46A 3kpbD-1g3mA:
undetectable		 3kpbD-1g3mA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 1g3m ESTROGEN
SULFOTRANSFERASE
(Homo
sapiens) 		5 / 12 PRO A 151
LYS A  47
VAL A 134
TYR A 139
PHE A 161
 None
A3P  A 701 (-2.7A)
None
None
None
 1.39A 3meeA-1g3mA:
undetectable		 3meeA-1g3mA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 185
VAL A  68
THR A  79
 A3P  A 400 (-2.8A)
None
None
 0.70A 3ndtA-1fmlA:
0.0		 3ndtA-1fmlA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 185
VAL A  68
THR A  79
 A3P  A 400 (-2.8A)
None
None
 0.85A 3nduD-1fmlA:
0.0		 3nduD-1fmlA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 312
VAL A 293
THR A  77
 A3P  A 400 (-3.7A)
None
A3P  A 400 (-3.6A)
 0.73A 3nduD-1fmlA:
0.0		 3nduD-1fmlA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 5wrj PROTEIN-TYROSINE
SULFOTRANSFERASE 1
(Homo
sapiens) 		5 / 12 ILE A  72
ARG A  86
VAL A 290
ILE A 272
ILE A  95
 None
None
A3P  A 401 (-4.0A)
None
None
 1.12A 3ohtA-5wrjA:
undetectable
3ohtB-5wrjA:
undetectable		 3ohtA-5wrjA:
22.86
3ohtB-5wrjA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 5wrj PROTEIN-TYROSINE
SULFOTRANSFERASE 1
(Homo
sapiens) 		5 / 10 ILE A 272
ILE A  95
ILE A  72
ARG A  86
VAL A 290
 None
None
None
None
A3P  A 401 (-4.0A)
 1.10A 3ohtA-5wrjA:
undetectable
3ohtB-5wrjA:
undetectable		 3ohtA-5wrjA:
22.86
3ohtB-5wrjA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 185
VAL A  68
THR A  79
 A3P  A 400 (-2.8A)
None
None
 0.82A 3pwrA-1fmlA:
0.0		 3pwrA-1fmlA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 312
VAL A 293
THR A  77
 A3P  A 400 (-3.7A)
None
A3P  A 400 (-3.6A)
 0.76A 3pwrA-1fmlA:
0.0		 3pwrA-1fmlA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLN A  46
GLY A  51
GLY A  54
SER A 216
ALA A  49
 None
A3P  A 999 (-3.5A)
A3P  A 999 (-3.1A)
A3P  A 999 ( 4.6A)
A3P  A 999 (-3.4A)
 1.22A 3t7sB-2oq2A:
2.3		 3t7sB-2oq2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 185
VAL A  68
THR A  79
 A3P  A 400 (-2.8A)
None
None
 0.84A 3tl9A-1fmlA:
0.0		 3tl9A-1fmlA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1fml RETINOL DEHYDRATASE
(Spodoptera
frugiperda) 		3 / 3 ARG A 312
VAL A 293
THR A  77
 A3P  A 400 (-3.7A)
None
A3P  A 400 (-3.6A)
 0.79A 3tl9A-1fmlA:
0.0		 3tl9A-1fmlA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		4 / 8 HIS A 272
VAL A 222
ASP A 266
ARG A 172
 A3P  A 401 (-3.9A)
A3P  A 401 ( 4.9A)
A3P  A 401 (-3.8A)
A3P  A 401 (-2.9A)
 1.17A 3uy4A-4goxA:
undetectable		 3uy4A-4goxA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		4 / 5 THR A 617
ILE A 609
LYS A 676
GLU A 675
 A3P  A 301 (-3.0A)
None
A3P  A 301 ( 4.5A)
None
 1.27A 4ac9C-1nstA:
2.9		 4ac9C-1nstA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		4 / 5 THR A 165
ILE A 157
LYS A 215
GLU A 214
 A3P  A1302 (-2.9A)
None
None
None
 1.37A 4ac9C-1t8tA:
3.4		 4ac9C-1t8tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3uan HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
1
(Mus
musculus) 		4 / 5 THR A  71
ILE A  63
LYS A 123
GLU A 122
 A3P  A 603 (-2.9A)
None
BDP  A   2 (-3.0A)
None
 1.27A 4ac9C-3uanA:
2.6		 4ac9C-3uanA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		4 / 5 THR A 617
ILE A 609
LYS A 676
GLU A 675
 A3P  A 301 (-3.0A)
None
A3P  A 301 ( 4.5A)
None
 1.27A 4acaC-1nstA:
5.3		 4acaC-1nstA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3uan HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
1
(Mus
musculus) 		4 / 5 THR A  71
ILE A  63
LYS A 123
GLU A 122
 A3P  A 603 (-2.9A)
None
BDP  A   2 (-3.0A)
None
 1.27A 4acaC-3uanA:
3.9		 4acaC-3uanA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		4 / 5 THR A 617
ILE A 609
LYS A 676
GLU A 675
 A3P  A 301 (-3.0A)
None
A3P  A 301 ( 4.5A)
None
 1.38A 4acbC-1nstA:
3.2		 4acbC-1nstA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens) 		4 / 5 THR A 165
ILE A 157
LYS A 215
GLU A 214
 A3P  A1302 (-2.9A)
None
None
None
 1.43A 4acbC-1t8tA:
5.1		 4acbC-1t8tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3uan HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
1
(Mus
musculus) 		4 / 5 THR A  71
ILE A  63
LYS A 123
GLU A 122
 A3P  A 603 (-2.9A)
None
BDP  A   2 (-3.0A)
None
 1.38A 4acbC-3uanA:
4.0		 4acbC-3uanA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  54
GLY A 158
VAL A  56
THR A  53
LEU A  52
 A3P  A 999 (-3.1A)
A3P  A 999 (-3.2A)
None
A3P  A 999 ( 4.6A)
None
 1.21A 4f84A-2oq2A:
undetectable		 4f84A-2oq2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		5 / 12 ILE A  65
TRP A  61
LEU A 200
VAL A 137
ALA A 138
 None
A3P  A 401 (-3.2A)
None
None
None
 1.19A 4foxD-2reoA:
undetectable		 4foxD-2reoA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 3bfx SULFOTRANSFERASE 1C2
(Homo
sapiens) 		5 / 12 ILE A  58
TRP A  54
LEU A 192
VAL A 129
ALA A 130
 None
A3P  A4000 (-3.2A)
None
None
None
 1.18A 4foxD-3bfxA:
undetectable		 4foxD-3bfxA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		4 / 8 LEU A 113
THR A  53
LEU A  49
VAL A 137
 None
A3P  A 401 ( 4.8A)
None
None
 0.94A 4iizB-2reoA:
undetectable		 4iizB-2reoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		4 / 8 LEU A 113
THR A  53
LEU A  49
VAL A 137
 None
A3P  A 401 ( 4.8A)
None
None
 0.93A 4ik6B-2reoA:
undetectable		 4ik6B-2reoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1bo6 ESTROGEN
SULFOTRANSFERASE
(Mus
musculus) 		4 / 7 MET A 196
VAL A  57
TRP A  53
GLU A 203
 None
None
A3P  A 301 (-3.5A)
None
 1.41A 4jseA-1bo6A:
0.0
4jseB-1bo6A:
0.0		 4jseA-1bo6A:
19.72
4jseB-1bo6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1bo6 ESTROGEN
SULFOTRANSFERASE
(Mus
musculus) 		4 / 7 GLU A 203
MET A 196
VAL A  57
TRP A  53
 None
None
None
A3P  A 301 (-3.5A)
 1.45A 4jseA-1bo6A:
0.0
4jseB-1bo6A:
0.0		 4jseA-1bo6A:
19.72
4jseB-1bo6A:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 1bo6 ESTROGEN
SULFOTRANSFERASE
(Mus
musculus) 		4 / 9 LYS A 106
PHE A 255
ILE A 146
MET A 248
 VO4  A 302 (-3.0A)
A3P  A 301 ( 4.6A)
None
None
 1.06A 4jvlA-1bo6A:
44.6		 4jvlA-1bo6A:
77.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 3ckl SULFOTRANSFERASE
FAMILY CYTOSOLIC 1B
MEMBER 1
(Homo
sapiens) 		4 / 9 LYS A 107
HIS A 109
PHE A 143
MET A 249
 A3P  A 601 ( 4.8A)
STL  A 501 (-3.8A)
STL  A 501 (-4.6A)
None
 0.33A 4jvlA-3cklA:
44.0		 4jvlA-3cklA:
55.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 3uan HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
1
(Mus
musculus) 		5 / 12 VAL A 121
LEU A 239
LEU A  78
LEU A  74
THR A  71
 None
None
None
None
A3P  A 603 (-2.9A)
 0.99A 4k13A-3uanA:
undetectable		 4k13A-3uanA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5x2b SULFOTRANSFERASE
(Mus
musculus) 		4 / 7 LEU D  73
PRO D  46
SER D  44
VAL D 154
 None
None
A3P  D 301 ( 4.9A)
None
 1.13A 4klrA-5x2bD:
2.1		 4klrA-5x2bD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1
(Escherichia
coli;
Gallus
gallus) 		4 / 6 THR A1254
GLN A1217
THR A1090
ASN A1079
 A3P  A 673 ( 4.8A)
None
None
None
 1.35A 4pfjB-3f5fA:
undetectable		 4pfjB-3f5fA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  76
PHE A 256
HIS A  81
ASP A 135
 A3P  A 999 (-3.9A)
None
None
None
 1.43A 4rzvB-2oq2A:
undetectable		 4rzvB-2oq2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 3uan HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
1
(Mus
musculus) 		4 / 4 ALA A 126
VAL A  66
GLY A  70
THR A  71
 SGN  A   3 (-3.4A)
None
A3P  A 603 (-3.2A)
A3P  A 603 (-2.9A)
 1.08A 4ubeA-3uanA:
2.6		 4ubeA-3uanA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		4 / 5 ARG A 132
GLY A 131
GLU A 196
SER A 108
 A3P  A 352 (-3.2A)
None
None
None
 1.16A 4z3oA-1q1qA:
undetectable
4z3oB-1q1qA:
undetectable		 4z3oA-1q1qA:
17.75
4z3oB-1q1qA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 5 ARG A 147
GLY A 146
GLU A 211
SER A 123
 A3P  A 314 (-3.0A)
None
None
None
 1.21A 4z3oA-1q20A:
1.7
4z3oB-1q20A:
undetectable		 4z3oA-1q20A:
17.33
4z3oB-1q20A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1
(Escherichia
coli;
Gallus
gallus) 		4 / 7 LYS A1083
ARG A1080
ARG A1189
ASP A1181
 A3P  A 673 (-3.3A)
None
None
None
 1.47A 5a06A-3f5fA:
undetectable		 5a06A-3f5fA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1
(Escherichia
coli;
Gallus
gallus) 		4 / 7 LYS A1083
ARG A1080
ARG A1189
ASP A1181
 A3P  A 673 (-3.3A)
None
None
None
 1.46A 5a06C-3f5fA:
undetectable		 5a06C-3f5fA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1
(Escherichia
coli;
Gallus
gallus) 		4 / 7 LYS A1083
ARG A1080
ARG A1189
ASP A1181
 A3P  A 673 (-3.3A)
None
None
None
 1.46A 5a06D-3f5fA:
undetectable		 5a06D-3f5fA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1
(Escherichia
coli;
Gallus
gallus) 		4 / 7 LYS A1083
ARG A1080
ARG A1189
ASP A1181
 A3P  A 673 (-3.3A)
None
None
None
 1.45A 5a06E-3f5fA:
undetectable		 5a06E-3f5fA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1
(Escherichia
coli;
Gallus
gallus) 		4 / 7 LYS A1083
ARG A1080
ARG A1189
ASP A1181
 A3P  A 673 (-3.3A)
None
None
None
 1.44A 5a06F-3f5fA:
undetectable		 5a06F-3f5fA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		4 / 5 SER A 123
ARG A 147
GLY A 146
GLU A 211
 None
A3P  A 314 (-3.0A)
None
None
 1.00A 5btiC-1q20A:
undetectable
5btiD-1q20A:
undetectable		 5btiC-1q20A:
20.24
5btiD-1q20A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		5 / 12 GLY A 206
GLY A 204
THR A 113
ILE A 218
LEU A  23
 None
A3P  A 301 ( 4.3A)
None
None
None
 1.01A 5bw4A-5bykA:
undetectable		 5bw4A-5bykA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 9 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.20A 5eeuC-1q1qA:
undetectable
5eeuD-1q1qA:
undetectable		 5eeuC-1q1qA:
13.61
5eeuD-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		5 / 10 THR A  20
SER A  12
HIS A  37
ALA A  88
THR A  94
 A3P  A 301 (-2.8A)
None
OAQ  A 302 ( 4.6A)
None
None
 1.42A 5eeuD-5bykA:
undetectable
5eeuE-5bykA:
undetectable		 5eeuD-5bykA:
21.92
5eeuE-5bykA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.23A 5eeuG-1q1qA:
undetectable
5eeuH-1q1qA:
undetectable		 5eeuG-1q1qA:
13.61
5eeuH-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 9 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.20A 5eevC-1q1qA:
undetectable
5eevD-1q1qA:
undetectable		 5eevC-1q1qA:
13.61
5eevD-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		5 / 10 THR A  20
SER A  12
HIS A  37
ALA A  88
THR A  94
 A3P  A 301 (-2.8A)
None
OAQ  A 302 ( 4.6A)
None
None
 1.42A 5eevD-5bykA:
undetectable
5eevE-5bykA:
undetectable		 5eevD-5bykA:
21.92
5eevE-5bykA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.23A 5eevG-1q1qA:
undetectable
5eevH-1q1qA:
undetectable		 5eevG-1q1qA:
13.61
5eevH-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 9 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.20A 5eewC-1q1qA:
undetectable
5eewD-1q1qA:
undetectable		 5eewC-1q1qA:
13.61
5eewD-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		5 / 10 THR A  20
SER A  12
HIS A  37
ALA A  88
THR A  94
 A3P  A 301 (-2.8A)
None
OAQ  A 302 ( 4.6A)
None
None
 1.42A 5eewD-5bykA:
undetectable
5eewE-5bykA:
undetectable		 5eewD-5bykA:
21.92
5eewE-5bykA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.23A 5eewG-1q1qA:
undetectable
5eewH-1q1qA:
0.0		 5eewG-1q1qA:
13.61
5eewH-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 9 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.20A 5eexC-1q1qA:
undetectable
5eexD-1q1qA:
undetectable		 5eexC-1q1qA:
13.61
5eexD-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.23A 5eexG-1q1qA:
undetectable
5eexH-1q1qA:
undetectable		 5eexG-1q1qA:
13.61
5eexH-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 11 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.22A 5eexI-1q1qA:
undetectable
5eexJ-1q1qA:
undetectable		 5eexI-1q1qA:
13.61
5eexJ-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.21A 5eexA-1q1qA:
undetectable
5eexK-1q1qA:
undetectable		 5eexA-1q1qA:
13.61
5eexK-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 9 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.20A 5eeyC-1q1qA:
undetectable
5eeyD-1q1qA:
undetectable		 5eeyC-1q1qA:
13.61
5eeyD-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		5 / 10 THR A  20
SER A  12
HIS A  37
ALA A  88
THR A  94
 A3P  A 301 (-2.8A)
None
OAQ  A 302 ( 4.6A)
None
None
 1.41A 5eeyD-5bykA:
undetectable
5eeyE-5bykA:
undetectable		 5eeyD-5bykA:
21.92
5eeyE-5bykA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.23A 5eeyG-1q1qA:
undetectable
5eeyH-1q1qA:
undetectable		 5eeyG-1q1qA:
13.61
5eeyH-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 11 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.22A 5eeyI-1q1qA:
undetectable
5eeyJ-1q1qA:
undetectable		 5eeyI-1q1qA:
13.61
5eeyJ-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 9 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.20A 5eezC-1q1qA:
undetectable
5eezD-1q1qA:
undetectable		 5eezC-1q1qA:
13.61
5eezD-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.23A 5eezG-1q1qA:
undetectable
5eezH-1q1qA:
0.0		 5eezG-1q1qA:
13.61
5eezH-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 11 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.22A 5eezI-1q1qA:
undetectable
5eezJ-1q1qA:
undetectable		 5eezI-1q1qA:
13.61
5eezJ-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 9 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.20A 5ef0C-1q1qA:
undetectable
5ef0D-1q1qA:
undetectable		 5ef0C-1q1qA:
13.61
5ef0D-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		5 / 10 THR A  20
SER A  12
HIS A  37
ALA A  88
THR A  94
 A3P  A 301 (-2.8A)
None
OAQ  A 302 ( 4.6A)
None
None
 1.41A 5ef0D-5bykA:
undetectable
5ef0E-5bykA:
undetectable		 5ef0D-5bykA:
21.92
5ef0E-5bykA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.23A 5ef0G-1q1qA:
undetectable
5ef0H-1q1qA:
undetectable		 5ef0G-1q1qA:
13.61
5ef0H-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 11 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.22A 5ef0I-1q1qA:
undetectable
5ef0J-1q1qA:
undetectable		 5ef0I-1q1qA:
13.61
5ef0J-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.21A 5ef0A-1q1qA:
undetectable
5ef0K-1q1qA:
undetectable		 5ef0A-1q1qA:
13.61
5ef0K-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 9 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.20A 5ef1C-1q1qA:
undetectable
5ef1D-1q1qA:
undetectable		 5ef1C-1q1qA:
13.61
5ef1D-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		5 / 10 THR A  20
SER A  12
HIS A  37
ALA A  88
THR A  94
 A3P  A 301 (-2.8A)
None
OAQ  A 302 ( 4.6A)
None
None
 1.41A 5ef1D-5bykA:
undetectable
5ef1E-5bykA:
undetectable		 5ef1D-5bykA:
21.92
5ef1E-5bykA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.23A 5ef1G-1q1qA:
undetectable
5ef1H-1q1qA:
undetectable		 5ef1G-1q1qA:
13.61
5ef1H-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 11 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.22A 5ef1I-1q1qA:
undetectable
5ef1J-1q1qA:
undetectable		 5ef1I-1q1qA:
13.61
5ef1J-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 9 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.20A 5ef2C-1q1qA:
undetectable
5ef2D-1q1qA:
undetectable		 5ef2C-1q1qA:
13.61
5ef2D-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.23A 5ef2G-1q1qA:
undetectable
5ef2H-1q1qA:
undetectable		 5ef2G-1q1qA:
13.61
5ef2H-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 11 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.22A 5ef2I-1q1qA:
undetectable
5ef2J-1q1qA:
undetectable		 5ef2I-1q1qA:
13.61
5ef2J-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 9 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.20A 5ef3C-1q1qA:
undetectable
5ef3D-1q1qA:
undetectable		 5ef3C-1q1qA:
13.61
5ef3D-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.23A 5ef3G-1q1qA:
undetectable
5ef3H-1q1qA:
undetectable		 5ef3G-1q1qA:
13.61
5ef3H-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 11 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.22A 5ef3I-1q1qA:
undetectable
5ef3J-1q1qA:
undetectable		 5ef3I-1q1qA:
13.61
5ef3J-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens) 		5 / 10 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.21A 5ef3A-1q1qA:
undetectable
5ef3K-1q1qA:
undetectable		 5ef3A-1q1qA:
13.61
5ef3K-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A  54
PRO A  71
THR A  57
THR A  48
 A3P  A 999 (-3.1A)
None
None
A3P  A 999 (-3.6A)
 1.01A 5h5fA-2oq2A:
2.0		 5h5fA-2oq2A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN
(Danio
rerio;
Escherichia
coli) 		5 / 12 GLY A1106
HIS A1113
GLU A1311
ILE A1187
PHE A1296
 A3P  A1401 (-3.2A)
None
None
None
None
 1.41A 5igwA-5t03A:
undetectable		 5igwA-5t03A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3ap1 PROTEIN-TYROSINE
SULFOTRANSFERASE 2
(Homo
sapiens) 		4 / 7 THR A  82
ASP A 287
ILE A 290
VAL A 289
 A3P  A   1 (-3.6A)
None
None
A3P  A   1 (-3.8A)
 0.82A 5ik1A-3ap1A:
undetectable		 5ik1A-3ap1A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 5mek CYTOSOLIC
SULFOTRANSFERASE 18
(Arabidopsis
thaliana) 		4 / 8 SER A  90
THR A  96
THR A  94
PRO A 157
 A3P  A 401 ( 4.9A)
A3P  A 401 (-3.5A)
None
None
 0.92A 5jhdE-5mekA:
undetectable
5jhdG-5mekA:
undetectable		 5jhdE-5mekA:
17.96
5jhdG-5mekA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 232
GLY A  51
ARG A 236
GLY A 218
 None
A3P  A 999 (-3.5A)
A3P  A 999 (-3.1A)
None
 1.09A 5kprA-2oq2A:
undetectable		 5kprA-2oq2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		5 / 12 VAL A  58
ASP A  57
SER A 138
THR A  67
ARG A 120
 None
None
None
A3P  A 314 ( 4.9A)
None
 1.34A 5m50B-1q20A:
undetectable		 5m50B-1q20A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		5 / 12 VAL A  58
ASP A  57
SER A 138
THR A  67
ARG A 120
 None
None
None
A3P  A 314 ( 4.9A)
None
 1.30A 5m50E-1q20A:
undetectable		 5m50E-1q20A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens) 		5 / 12 VAL A  58
ASP A  57
SER A 138
THR A  67
ARG A 120
 None
None
None
A3P  A 314 ( 4.9A)
None
 1.35A 5m54B-1q20A:
undetectable		 5m54B-1q20A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		3 / 3 LYS A 126
HIS A 122
HIS A 230
 None
None
A3P  A 301 (-4.2A)
 1.16A 5oexA-5bykA:
undetectable		 5oexA-5bykA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		3 / 3 LYS A 126
HIS A 122
HIS A 230
 None
None
A3P  A 301 (-4.2A)
 1.20A 5oexB-5bykA:
undetectable		 5oexB-5bykA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		3 / 3 LYS A 126
HIS A 122
HIS A 230
 None
None
A3P  A 301 (-4.2A)
 1.16A 5oexC-5bykA:
undetectable		 5oexC-5bykA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5byk SULFOTRANSFERASE
(Schistosoma
mansoni) 		3 / 3 LYS A 126
HIS A 122
HIS A 230
 None
None
A3P  A 301 (-4.2A)
 1.13A 5oexD-5bykA:
undetectable		 5oexD-5bykA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5tiw SULFOTRANSFERASE
(Schistosoma
haematobium) 		4 / 8 TYR A 233
THR A  35
CYH A  50
LEU A 120
 None
A3P  A 301 (-2.8A)
None
None
 1.21A 6cnjD-5tiwA:
undetectable
6cnjE-5tiwA:
undetectable		 6cnjD-5tiwA:
13.44
6cnjE-5tiwA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_2
(GLUCOAMYLASE P)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		4 / 4 TRP A  53
GLU A 203
GLU A 194
LEU A 295
 A3P  A2001 (-3.3A)
None
None
None
 1.35A 6fhwB-3qvuA:
undetectable		 6fhwB-3qvuA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		4 / 5 ILE A  42
LEU A  43
THR A  20
LEU A  21
 None
None
A3P  A 301 (-2.5A)
A3P  A 301 (-4.2A)
 0.90A 6nmpN-5tizA:
undetectable
6nmpW-5tizA:
undetectable		 6nmpN-5tizA:
17.49
6nmpW-5tizA:
16.37