SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'A3C'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UFN_A_ROCA402_1 (HIV-1 PROTEASE)	3p5p	TAXADIENE SYNTHASE (Taxus brevifolia)	4 / 5	ARG A 754 LEU A 707 PRO A 701 ASP A 758	A3C A 911 (-3.4A) None None None	1.16A	3ufnA-3p5pA: undetectable 3ufnB-3p5pA: undetectable	3ufnA-3p5pA: 9.82 3ufnB-3p5pA: 9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A84_A_DXCA1161_0 (MAJOR POLLEN ALLERGEN BET V 1-A)	3p5p	TAXADIENE SYNTHASE (Taxus brevifolia)	5 / 12	PHE A 834 TYR A 856 VAL A 855 ALA A 589 SER A 588	A3C A 912 ( 3.8A) None None None None	1.21A	4a84A-3p5pA: undetectable	4a84A-3p5pA: 12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HBF_A_DXCA75_0 (PPCA)	3p5p	TAXADIENE SYNTHASE (Taxus brevifolia)	4 / 7	ILE A 824 LEU A 827 PHE A 602 GLY A 606	None None A3C A 911 ( 4.8A) A3C A 911 (-3.8A)	0.91A	4hbfA-3p5pA: undetectable	4hbfA-3p5pA: 6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERM_A_210A401_1 (FUSICOCCADIENE SYNTHASE)	3p5p	TAXADIENE SYNTHASE (Taxus brevifolia)	5 / 10	ASP A 613 ARG A 754 VAL A 714 ASN A 757 GLU A 765	A3C A 911 ( 3.8A) A3C A 911 (-3.4A) A3C A 911 (-4.8A) MG A 901 ( 2.7A) MG A 901 ( 2.6A)	0.83A	5ermA-3p5pA: 10.2	5ermA-3p5pA: 18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERM_B_210B704_1 (FUSICOCCADIENE SYNTHASE)	3p5p	TAXADIENE SYNTHASE (Taxus brevifolia)	5 / 9	ASP A 613 ARG A 754 VAL A 714 ASN A 757 GLU A 765	A3C A 911 ( 3.8A) A3C A 911 (-3.4A) A3C A 911 (-4.8A) MG A 901 ( 2.7A) MG A 901 ( 2.6A)	0.81A	5ermB-3p5pA: 16.4	5ermB-3p5pA: 18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I75_A_68PA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	3p5p	TAXADIENE SYNTHASE (Taxus brevifolia)	5 / 12	TYR A 684 TYR A 835 SER A 713 GLY A 715 LEU A 716	None A3C A 912 ( 4.4A) None A3C A 911 ( 4.7A) None	1.20A	5i75A-3p5pA: 2.2	5i75A-3p5pA: 21.48

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3UFN_A_ROCA402_1","HIV-1 PROTEASE;HIV-1 PROTEASE","3p5p","TAXADIENE SYNTHASE","Taxus brevifolia",4,"ARG A 754;LEU A 707;PRO A 701;ASP A 758","A3C A 911 (-3.4A);None;None;None","1.16A","3ufnA-3p5pA:undetectable;3ufnB-3p5pA:undetectable",null],["4A84_A_DXCA1161_0","MAJOR POLLEN ALLERGEN BET V 1-A","3p5p","TAXADIENE SYNTHASE","Taxus brevifolia",5,"PHE A 834;TYR A 856;VAL A 855;ALA A 589;SER A 588","A3C A 912 ( 3.8A);None;None;None;None","1.21A","4a84A-3p5pA:undetectable","3ufnA-3p5pA:9.82;3ufnB-3p5pA:9.82"],["4HBF_A_DXCA75_0","PPCA","3p5p","TAXADIENE SYNTHASE","Taxus brevifolia",4,"ILE A 824;LEU A 827;PHE A 602;GLY A 606","None;None;A3C A 911 ( 4.8A);A3C A 911 (-3.8A)","0.91A","4hbfA-3p5pA:undetectable","4a84A-3p5pA:12.45"],["5ERM_A_210A401_1","FUSICOCCADIENE SYNTHASE","3p5p","TAXADIENE SYNTHASE","Taxus brevifolia",5,"ASP A 613;ARG A 754;VAL A 714;ASN A 757;GLU A 765","A3C A 911 ( 3.8A);A3C A 911 (-3.4A);A3C A 911 (-4.8A); MG A 901 ( 2.7A); MG A 901 ( 2.6A)","0.83A","5ermA-3p5pA:10.2","4hbfA-3p5pA:6.62"],["5ERM_B_210B704_1","FUSICOCCADIENE SYNTHASE","3p5p","TAXADIENE SYNTHASE","Taxus brevifolia",5,"ASP A 613;ARG A 754;VAL A 714;ASN A 757;GLU A 765","A3C A 911 ( 3.8A);A3C A 911 (-3.4A);A3C A 911 (-4.8A); MG A 901 ( 2.7A); MG A 901 ( 2.6A)","0.81A","5ermB-3p5pA:16.4","5ermA-3p5pA:18.37"],["5I75_A_68PA701_1","SODIUM-DEPENDENT SEROTONIN TRANSPORTER","3p5p","TAXADIENE SYNTHASE","Taxus brevifolia",5,"TYR A 684;TYR A 835;SER A 713;GLY A 715;LEU A 716","None;A3C A 912 ( 4.4A);None;A3C A 911 ( 4.7A);None","1.20A","5i75A-3p5pA:2.2","5ermB-3p5pA:18.37"]]