SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'A2N'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 6 ALA A  51
SER A  54
PHE A  62
ASN A 112
ASP A 114
 A2N  A1000 (-3.5A)
None
A2N  A1000 (-3.8A)
None
None
 0.71A 1yc2A-3pkjA:
22.7		 1yc2A-3pkjA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 5 ALA A  51
PHE A  62
ASN A 112
ASP A 114
 A2N  A1000 (-3.5A)
A2N  A1000 (-3.8A)
None
None
 0.67A 1yc2D-3pkjA:
22.7		 1yc2D-3pkjA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 ILE A  59
PHE A  62
ASN A 112
ASP A 114
 None
A2N  A1000 (-3.8A)
None
None
 0.38A 1yc2E-3pkjA:
24.2		 1yc2E-3pkjA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 7 ALA A  51
SER A  54
ILE A  59
ASN A 112
ASP A 114
 A2N  A1000 (-3.5A)
None
None
None
None
 0.43A 1yc5A-3pkjA:
24.7		 1yc5A-3pkjA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 SER A  54
ILE A  59
ASP A  61
ASP A 114
 None
None
A2N  A1000 (-4.0A)
None
 0.82A 1yc5A-3pkjA:
24.7		 1yc5A-3pkjA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 5 ALA A  51
ILE A  59
ASN A 112
ASP A 114
 A2N  A1000 (-3.5A)
None
None
None
 0.40A 2h4jA-3pkjA:
24.6		 2h4jA-3pkjA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 LEU A 108
THR A 213
GLY A 212
GLY A  52
LEU A  96
 None
A2N  A1000 (-3.8A)
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
 1.04A 2uvnA-3pkjA:
undetectable		 2uvnA-3pkjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		3 / 3 THR A  49
SER A 110
PHE A  62
 None
None
A2N  A1000 (-3.8A)
 0.87A 3d4sA-3pkjA:
undetectable		 3d4sA-3pkjA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 4 ARG A  88
ASP A  61
GLY A  50
THR A  92
 None
A2N  A1000 (-4.0A)
A2N  A1000 (-3.2A)
None
 1.30A 3k4vB-3pkjA:
undetectable		 3k4vB-3pkjA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 ASN A 112
ILE A  59
PHE A  80
PHE A  62
 None
None
None
A2N  A1000 (-3.8A)
 1.20A 3tvxB-3pkjA:
undetectable		 3tvxB-3pkjA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.09A 3uboB-3pkjA:
4.9		 3uboB-3pkjA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 4 ASN A 112
ALA A  51
GLY A  50
THR A 213
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.2A)
A2N  A1000 (-3.8A)
 1.22A 4bboC-3pkjA:
undetectable		 4bboC-3pkjA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4e3aA-3pkjA:
4.7		 4e3aA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.03A 4jkuB-3pkjA:
4.7		 4jkuB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4k8pA-3pkjA:
4.6		 4k8pA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4k8pB-3pkjA:
4.7		 4k8pB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.04A 4k8tA-3pkjA:
4.8		 4k8tA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.04A 4k8tB-3pkjA:
4.6		 4k8tB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.04A 4k93A-3pkjA:
3.3		 4k93A-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4k93B-3pkjA:
4.9		 4k93B-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.04A 4k9cA-3pkjA:
undetectable		 4k9cA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4k9cB-3pkjA:
4.6		 4k9cB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.06A 4k9iA-3pkjA:
4.6		 4k9iA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4k9iB-3pkjA:
4.0		 4k9iB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.03A 4kadA-3pkjA:
3.2		 4kadA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4kadB-3pkjA:
3.2		 4kadB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.04A 4lbxA-3pkjA:
4.7		 4lbxA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4lbxB-3pkjA:
4.7		 4lbxB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.03A 4lc4A-3pkjA:
4.9		 4lc4A-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.04A 4lc4B-3pkjA:
4.7		 4lc4B-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 ILE A  59
PHE A  62
ASN A 112
ASP A 114
 None
A2N  A1000 (-3.8A)
None
None
 0.33A 4rmjA-3pkjA:
19.5		 4rmjA-3pkjA:
24.30