SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'A1R'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2H42_B_VIAB902_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	3uel	POLY(ADP-RIBOSE) GLYCOHYDROLASE (Rattus norvegicus)	5 / 12	ALA A 844 ILE A 820 VAL A 861 ALA A 862 ILE A 722	None None None None A1R A1001 (-4.2A)	1.09A	2h42B-3uelA: undetectable	2h42B-3uelA: 18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FPJ_B_SAMB301_1 (PUTATIVE UNCHARACTERIZED PROTEIN)	3uel	POLY(ADP-RIBOSE) GLYCOHYDROLASE (Rattus norvegicus)	4 / 7	GLN A 831 GLY A 867 GLY A 873 ALA A 822	None A1R A1001 (-2.9A) None A1R A1001 ( 4.6A)	0.84A	3fpjB-3uelA: undetectable	3fpjB-3uelA: 19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KR2_A_ROCA101_2 (PROTEASE PR5-SQV)	3uel	POLY(ADP-RIBOSE) GLYCOHYDROLASE (Rattus norvegicus)	5 / 11	LEU A 714 ALA A 860 GLY A 726 ILE A 722 VAL A 716	None None None A1R A1001 (-4.2A) None	1.15A	5kr2B-3uelA: undetectable	5kr2B-3uelA: 9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	3uel	POLY(ADP-RIBOSE) GLYCOHYDROLASE (Rattus norvegicus)	4 / 6	ASP A 733 VAL A 818 GLU A 751 ALA A 870	None None A1R A1001 (-4.2A) A1R A1001 (-3.8A)	1.23A	6djzB-3uelA: undetectable	6djzB-3uelA: 17.47

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2H42_B_VIAB902_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","3uel","POLY(ADP-RIBOSE) GLYCOHYDROLASE","Rattus norvegicus",5,"ALA A 844;ILE A 820;VAL A 861;ALA A 862;ILE A 722","None;None;None;None;A1R A1001 (-4.2A)","1.09A","2h42B-3uelA:undetectable",null],["3FPJ_B_SAMB301_1","PUTATIVE UNCHARACTERIZED PROTEIN","3uel","POLY(ADP-RIBOSE) GLYCOHYDROLASE","Rattus norvegicus",4,"GLN A 831;GLY A 867;GLY A 873;ALA A 822","None;A1R A1001 (-2.9A);None;A1R A1001 ( 4.6A)","0.84A","3fpjB-3uelA:undetectable","2h42B-3uelA:18.68"],["5KR2_A_ROCA101_2","PROTEASE PR5-SQV;PROTEASE PR5-SQV","3uel","POLY(ADP-RIBOSE) GLYCOHYDROLASE","Rattus norvegicus",5,"LEU A 714;ALA A 860;GLY A 726;ILE A 722;VAL A 716","None;None;None;A1R A1001 (-4.2A);None","1.15A","5kr2B-3uelA:undetectable","3fpjB-3uelA:19.39"],["6DJZ_B_GMJB301_1","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","3uel","POLY(ADP-RIBOSE) GLYCOHYDROLASE","Rattus norvegicus",4,"ASP A 733;VAL A 818;GLU A 751;ALA A 870","None;None;A1R A1001 (-4.2A);A1R A1001 (-3.8A)","1.23A","6djzB-3uelA:undetectable","5kr2B-3uelA:9.69"]]