SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '9XK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5okt CASEIN KINASE I
ISOFORM DELTA
(Homo
sapiens) 		7 / 12 ILE C  15
ALA C  36
LYS C  38
GLU C  52
MET C  82
LEU C 135
ASP C 149
 9XK  C 301 (-4.2A)
9XK  C 301 ( 3.7A)
9XK  C 301 ( 4.6A)
None
9XK  C 301 (-4.2A)
9XK  C 301 (-4.6A)
None
 0.76A 4qmnA-5oktC:
24.5		 4qmnA-5oktC:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5okt CASEIN KINASE I
ISOFORM DELTA
(Homo
sapiens) 		7 / 11 ILE C  15
ALA C  36
LYS C  38
GLU C  52
MET C  82
LEU C 135
ASP C 149
 9XK  C 301 (-4.2A)
9XK  C 301 ( 3.7A)
9XK  C 301 ( 4.6A)
None
9XK  C 301 (-4.2A)
9XK  C 301 (-4.6A)
None
 0.88A 4qmsA-5oktC:
24.6		 4qmsA-5oktC:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5okt CASEIN KINASE I
ISOFORM DELTA
(Homo
sapiens) 		6 / 12 ILE C  15
GLY C  16
ALA C  36
MET C  82
LEU C  85
GLY C  86
 9XK  C 301 (-4.2A)
None
9XK  C 301 ( 3.7A)
9XK  C 301 (-4.2A)
9XK  C 301 (-3.8A)
9XK  C 301 (-3.7A)
 0.68A 4qmzA-5oktC:
25.1		 4qmzA-5oktC:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5okt CASEIN KINASE I
ISOFORM DELTA
(Homo
sapiens) 		5 / 10 ILE C  15
ALA C  36
LYS C  38
LEU C  84
LEU C 135
 9XK  C 301 (-4.2A)
9XK  C 301 ( 3.7A)
9XK  C 301 ( 4.6A)
9XK  C 301 (-3.7A)
9XK  C 301 (-4.6A)
 0.45A 4rz7A-5oktC:
23.1		 4rz7A-5oktC:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5okt CASEIN KINASE I
ISOFORM DELTA
(Homo
sapiens) 		6 / 12 GLY C  16
GLY C  18
PHE C  20
ALA C  36
LYS C  38
ASP C 149
 None
None
None
9XK  C 301 ( 3.7A)
9XK  C 301 ( 4.6A)
None
 0.90A 5hieC-5oktC:
20.7		 5hieC-5oktC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5okt CASEIN KINASE I
ISOFORM DELTA
(Homo
sapiens) 		3 / 3 LYS C  38
LEU C 135
ASP C 149
 9XK  C 301 ( 4.6A)
9XK  C 301 (-4.6A)
None
 0.85A 5zv2A-5oktC:
19.9		 5zv2A-5oktC:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 5okt CASEIN KINASE I
ISOFORM DELTA
(Homo
sapiens) 		5 / 12 TYR C  56
ILE C 148
LEU C 135
ALA C  36
LEU C  84
 9XK  C 301 (-4.3A)
9XK  C 301 ( 3.6A)
9XK  C 301 (-4.6A)
9XK  C 301 ( 3.7A)
9XK  C 301 (-3.7A)
 1.40A 5zwrB-5oktC:
undetectable		 5zwrB-5oktC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 5okt CASEIN KINASE I
ISOFORM DELTA
(Homo
sapiens) 		5 / 12 GLN C 190
ASP C 195
ASP C 132
ASP C 149
ILE C 148
 GOL  C 309 (-2.9A)
GOL  C 309 (-3.6A)
None
None
9XK  C 301 ( 3.6A)
 1.43A 6fzbB-5oktC:
0.7		 6fzbB-5oktC:
19.05