SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '9WS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.75A 1iepA-5w5jA:
23.4		 1iepA-5w5jA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
GLY A 101
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 ( 4.0A)
 0.74A 1iepB-5w5jA:
19.2		 1iepB-5w5jA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 9 LEU A  24
VAL A  32
ALA A  45
LEU A  79
TYR A  97
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
None
9WS  A 401 (-4.6A)
 0.82A 1muoA-5w5jA:
8.2		 1muoA-5w5jA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.68A 1opjA-5w5jA:
23.1		 1opjA-5w5jA:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 11 GLY A  27
VAL A  32
ALA A  45
TYR A  97
SER A 102
LEU A 153
 None
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
None
9WS  A 401 (-4.6A)
 0.60A 2evaA-5w5jA:
21.7		 2evaA-5w5jA:
31.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  24
ALA A  45
ILE A  93
THR A  95
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.83A 2gqgA-5w5jA:
19.1		 2gqgA-5w5jA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
ILE A  93
THR A  95
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.63A 2gqgB-5w5jA:
24.1		 2gqgB-5w5jA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  32
ALA A  45
THR A  95
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.76A 2hyyA-5w5jA:
19.2		 2hyyA-5w5jA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  32
ALA A  45
THR A  95
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.73A 2hyyB-5w5jA:
19.3		 2hyyB-5w5jA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  32
ALA A  45
ILE A  93
THR A  95
LEU A 153
ALA A 163
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.84A 2hyyD-5w5jA:
19.3		 2hyyD-5w5jA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  24
SER A  25
ALA A  45
LYS A  47
THR A  95
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
None
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.76A 2itoA-5w5jA:
23.2		 2itoA-5w5jA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  24
VAL A  32
ALA A  45
LYS A  47
THR A  95
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.74A 2itzA-5w5jA:
13.0		 2itzA-5w5jA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 ALA A  45
LEU A  79
TYR A  97
MET A  98
GLY A 101
ALA A 163
 9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
None
None
9WS  A 401 ( 4.3A)
9WS  A 401 ( 4.0A)
 0.57A 2wgjA-5w5jA:
23.6		 2wgjA-5w5jA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  32
ALA A  45
LEU A  79
TYR A  97
MET A  98
GLY A 101
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
None
None
9WS  A 401 ( 4.3A)
 0.64A 2wgjA-5w5jA:
23.6		 2wgjA-5w5jA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 9 LEU A  24
VAL A  32
ALA A  45
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.59A 2xp2A-5w5jA:
23.1		 2xp2A-5w5jA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 ALA A  45
ILE A  93
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.47A 2y6oA-5w5jA:
24.6		 2y6oA-5w5jA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 ALA A  45
LYS A  47
ILE A  93
THR A  95
MET A  98
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.81A 2zvaA-5w5jA:
23.8		 2zvaA-5w5jA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
ALA A  45
ILE A  93
THR A  95
MET A  98
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.78A 2zvaA-5w5jA:
23.8		 2zvaA-5w5jA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 10 LEU A  24
ALA A  45
LYS A  47
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.69A 3aoxA-5w5jA:
10.0		 3aoxA-5w5jA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 11 LEU A  24
VAL A  32
ALA A  45
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.59A 3g0eA-5w5jA:
22.0		 3g0eA-5w5jA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 11 LEU A  24
VAL A  32
ALA A  45
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.60A 3g0fA-5w5jA:
22.6		 3g0fA-5w5jA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 10 LEU A  24
VAL A  32
ALA A  45
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.54A 3g0fB-5w5jA:
8.9		 3g0fB-5w5jA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
ILE A  93
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.58A 3g5dA-5w5jA:
24.0		 3g5dA-5w5jA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
TYR A  97
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.64A 3g5dA-5w5jA:
24.0		 3g5dA-5w5jA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
TYR A  97
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.76A 3g5dB-5w5jA:
19.5		 3g5dB-5w5jA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.61A 3gvuA-5w5jA:
12.1		 3gvuA-5w5jA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
ALA A  45
LYS A  47
ILE A  93
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.66A 3k54A-5w5jA:
24.9		 3k54A-5w5jA:
29.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  32
ALA A  45
THR A  95
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.73A 3k5vA-5w5jA:
23.3		 3k5vA-5w5jA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  32
ALA A  45
THR A  95
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.73A 3k5vB-5w5jA:
23.4		 3k5vB-5w5jA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  24
GLY A  27
VAL A  32
ALA A  45
TYR A  97
SER A 102
LEU A 153
 9WS  A 401 ( 4.2A)
None
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
None
9WS  A 401 (-4.6A)
 0.64A 3lxnA-5w5jA:
23.4		 3lxnA-5w5jA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 9 ALA A  45
LYS A  47
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.66A 3miyB-5w5jA:
24.9		 3miyB-5w5jA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.76A 3ms9A-5w5jA:
19.3		 3ms9A-5w5jA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.79A 3mssA-5w5jA:
19.3		 3mssA-5w5jA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  24
ALA A  45
THR A  95
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.52A 3mssB-5w5jA:
19.4		 3mssB-5w5jA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.77A 3mssC-5w5jA:
19.3		 3mssC-5w5jA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  24
ALA A  45
THR A  95
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.51A 3mssD-5w5jA:
19.4		 3mssD-5w5jA:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
ALA A  45
LYS A  47
THR A  95
TYR A  97
GLY A 101
GLU A 112
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
 0.84A 3octA-5w5jA:
24.3		 3octA-5w5jA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
TYR A  97
GLY A 101
GLU A 112
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
 0.75A 3octA-5w5jA:
24.3		 3octA-5w5jA:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A  32
ALA A  45
ILE A  93
THR A  95
TYR A  97
LEU A 153
ALA A 163
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.68A 3oezB-5w5jA:
23.7		 3oezB-5w5jA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 12 VAL A  32
ALA A  45
LYS A  47
LEU A  79
THR A  95
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
 0.57A 3og7A-5w5jA:
26.7		 3og7A-5w5jA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  24
ALA A  45
THR A  95
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.57A 3pyyA-5w5jA:
19.8		 3pyyA-5w5jA:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.67A 3pyyB-5w5jA:
20.1		 3pyyB-5w5jA:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
TYR A  97
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.74A 3qlgB-5w5jA:
23.8		 3qlgB-5w5jA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
ILE A  93
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.49A 3sxrA-5w5jA:
24.0		 3sxrA-5w5jA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.42A 3sxrB-5w5jA:
23.5		 3sxrB-5w5jA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  24
ALA A  45
ILE A  93
THR A  95
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.59A 3ue4A-5w5jA:
19.4		 3ue4A-5w5jA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  24
ALA A  45
LYS A  47
ILE A  93
THR A  95
MET A  98
GLY A 101
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
 0.71A 3ue4A-5w5jA:
19.4		 3ue4A-5w5jA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  24
VAL A  32
ALA A  45
ILE A  93
THR A  95
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.64A 3ue4B-5w5jA:
19.7		 3ue4B-5w5jA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  45
LEU A  79
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.50A 3zbfA-5w5jA:
24.1		 3zbfA-5w5jA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  24
ALA A  45
LYS A  47
THR A  95
LEU A 135
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.68A 3zosA-5w5jA:
22.1		 3zosA-5w5jA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 9 LEU A  24
ILE A  78
TYR A  97
MET A  98
ILE A 162
 9WS  A 401 ( 4.2A)
None
None
None
None
 0.47A 3zosB-5w5jA:
22.2		 3zosB-5w5jA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 9 LEU A  24
ILE A 162
TYR A  97
MET A  98
ILE A 152
 9WS  A 401 ( 4.2A)
None
None
None
None
 0.83A 3zosB-5w5jA:
22.2		 3zosB-5w5jA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 9 LEU A  24
VAL A  32
ALA A  45
MET A  98
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.80A 4anqA-5w5jA:
22.7		 4anqA-5w5jA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 9 LEU A  24
VAL A  32
ALA A  45
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.54A 4ansA-5w5jA:
22.7		 4ansA-5w5jA:
27.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 ALA A  45
LYS A  47
LEU A  79
ILE A  93
THR A  95
LEU A 153
ALA A 163
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.62A 4c8bA-5w5jA:
35.5		 4c8bA-5w5jA:
92.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 5 VAL A  32
ILE A  78
TYR A  97
MET A  98
ILE A 162
 9WS  A 401 ( 4.6A)
None
None
None
None
 0.39A 4c8bA-5w5jA:
35.5		 4c8bA-5w5jA:
92.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 5 VAL A  32
ILE A 162
TYR A  97
MET A  98
ILE A 152
 9WS  A 401 ( 4.6A)
None
None
None
None
 1.13A 4c8bA-5w5jA:
35.5		 4c8bA-5w5jA:
92.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 10 LEU A  24
VAL A  32
ALA A  45
TYR A  97
SER A 102
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
None
9WS  A 401 (-4.6A)
 0.49A 4ckjA-5w5jA:
23.8		 4ckjA-5w5jA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
LYS A  47
THR A  95
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.58A 4hjoA-5w5jA:
23.8		 4hjoA-5w5jA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		4 / 5 TYR A 113
THR A  95
LEU A  79
THR A 149
 None
9WS  A 401 (-3.2A)
9WS  A 401 (-4.9A)
None
 1.39A 4mbsB-5w5jA:
undetectable		 4mbsB-5w5jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  24
VAL A  32
ALA A  45
ILE A  93
THR A  95
TYR A  97
GLY A 101
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
 0.66A 4mxoA-5w5jA:
23.3		 4mxoA-5w5jA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A  32
ALA A  45
LYS A  47
ILE A  93
THR A  95
TYR A  97
GLY A 101
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
 0.67A 4mxoA-5w5jA:
23.3		 4mxoA-5w5jA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
ILE A  93
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.76A 4mxoB-5w5jA:
19.3		 4mxoB-5w5jA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  24
ALA A  45
ILE A  93
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.76A 4mxxA-5w5jA:
23.2		 4mxxA-5w5jA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		9 / 12 LEU A  24
VAL A  32
ALA A  45
LYS A  47
THR A  95
TYR A  97
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.76A 4mxxB-5w5jA:
18.2		 4mxxB-5w5jA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 11 LEU A  24
VAL A  32
ALA A  45
LYS A  47
LEU A  79
ASN A 151
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
None
9WS  A 401 (-4.6A)
 0.57A 4o0sA-5w5jA:
22.4		 4o0sA-5w5jA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
LYS A  47
THR A  95
TYR A  97
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.56A 4otwA-5w5jA:
24.2		 4otwA-5w5jA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 ALA A  45
LYS A  47
LEU A  79
ILE A  93
THR A  95
SER A 102
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
 0.85A 4rzvA-5w5jA:
26.5		 4rzvA-5w5jA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  32
ALA A  45
LYS A  47
LEU A  79
THR A  95
SER A 102
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
None
 0.83A 4rzvB-5w5jA:
26.4		 4rzvB-5w5jA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
MET A  98
GLY A 101
ASN A 151
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.63A 4twpA-5w5jA:
19.7		 4twpA-5w5jA:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
MET A  98
GLY A 101
ASN A 151
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.63A 4twpB-5w5jA:
24.1		 4twpB-5w5jA:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		4 / 6 LEU A  24
VAL A  32
ILE A  78
ILE A 162
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
None
None
 0.43A 4tyjA-5w5jA:
24.6		 4tyjA-5w5jA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		9 / 11 LEU A  24
VAL A  32
ALA A  45
TYR A  97
MET A  98
GLY A 101
ASN A 151
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.57A 4u5jA-5w5jA:
24.2		 4u5jA-5w5jA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 9 LEU A  24
VAL A  32
ALA A  45
TYR A  97
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.59A 4u5jB-5w5jA:
19.4		 4u5jB-5w5jA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 12 LEU A  24
ALA A  45
LEU A 135
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.44A 4uxqA-5w5jA:
12.5		 4uxqA-5w5jA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 9 LEU A  24
VAL A  32
TYR A  97
LEU A 153
ILE A 162
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
None
9WS  A 401 (-4.6A)
None
 0.47A 4v01A-5w5jA:
23.8		 4v01A-5w5jA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 9 LEU A  24
VAL A  32
LYS A  47
TYR A  97
LEU A 153
ILE A 162
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
9WS  A 401 (-4.6A)
None
 0.66A 4v01B-5w5jA:
24.2		 4v01B-5w5jA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 11 ALA A  45
THR A  95
MET A  98
GLY A 101
ASN A 151
LEU A 153
ALA A 163
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.60A 4wa9A-5w5jA:
23.8		 4wa9A-5w5jA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 11 LEU A  24
ALA A  45
THR A  95
MET A  98
GLY A 101
ASN A 151
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
 0.74A 4wa9A-5w5jA:
23.8		 4wa9A-5w5jA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A  32
ALA A  45
THR A  95
MET A  98
GLY A 101
ASN A 151
LEU A 153
ALA A 163
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.64A 4wa9B-5w5jA:
24.2		 4wa9B-5w5jA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		4 / 6 LEU A  24
ALA A  45
MET A  98
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
None
9WS  A 401 (-4.6A)
 0.61A 4wboC-5w5jA:
18.6		 4wboC-5w5jA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
LYS A  47
ILE A  93
THR A  95
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.63A 4xeyB-5w5jA:
24.2		 4xeyB-5w5jA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
ALA A  45
THR A  95
TYR A  97
MET A  98
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.58A 4xliA-5w5jA:
19.5		 4xliA-5w5jA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
ALA A  45
ILE A  93
THR A  95
TYR A  97
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.69A 4xliB-5w5jA:
24.0		 4xliB-5w5jA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 12 VAL A  32
ALA A  45
LYS A  47
LEU A  79
THR A  95
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
 0.41A 4xv2A-5w5jA:
27.1		 4xv2A-5w5jA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 9 LEU A  24
VAL A  32
ALA A  45
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.62A 5aaaA-5w5jA:
9.5		 5aaaA-5w5jA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 10 LEU A  24
VAL A  32
ALA A  45
LYS A  47
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.72A 5aacA-5w5jA:
22.9		 5aacA-5w5jA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
THR A  95
TYR A  97
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.54A 5bvwA-5w5jA:
22.6		 5bvwA-5w5jA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 12 VAL A  32
ALA A  45
LYS A  47
LEU A  79
THR A  95
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
 0.45A 5cswA-5w5jA:
26.8		 5cswA-5w5jA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 12 VAL A  32
ALA A  45
LYS A  47
LEU A  79
THR A  95
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
 0.48A 5cswB-5w5jA:
26.8		 5cswB-5w5jA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
ALA A  45
LYS A  47
ILE A  93
THR A  95
GLY A 101
GLU A 105
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
 0.72A 5h2uC-5w5jA:
18.4		 5h2uC-5w5jA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  24
ALA A  45
LYS A  47
LEU A  79
THR A  95
GLY A 101
GLU A 105
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
 0.69A 5h2uC-5w5jA:
18.4		 5h2uC-5w5jA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  24
ALA A  45
LEU A  79
THR A  95
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.59A 5h2uD-5w5jA:
24.3		 5h2uD-5w5jA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  24
VAL A  32
ALA A  45
ILE A  93
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.59A 5h2uD-5w5jA:
24.3		 5h2uD-5w5jA:
27.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  32
ALA A  45
LYS A  47
ILE A  93
THR A  95
TYR A  97
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
 0.65A 5hesB-5w5jA:
26.1		 5hesB-5w5jA:
31.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY A  27
VAL A  32
ALA A  45
LYS A  47
LEU A  79
ILE A  93
THR A  95
 None
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
 0.71A 5hieA-5w5jA:
26.6		 5hieA-5w5jA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY A  27
VAL A  32
ALA A  45
LYS A  47
LEU A  79
ILE A  93
THR A  95
 None
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
 0.71A 5hieB-5w5jA:
26.5		 5hieB-5w5jA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		6 / 12 GLY A  27
VAL A  32
ALA A  45
LYS A  47
LEU A  79
THR A  95
 None
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
 0.72A 5hieC-5w5jA:
26.9		 5hieC-5w5jA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY A  27
VAL A  32
ALA A  45
LYS A  47
LEU A  79
ILE A  93
THR A  95
 None
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
 0.71A 5hieD-5w5jA:
26.7		 5hieD-5w5jA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 ALA A  45
ILE A  93
THR A  95
TYR A  97
GLY A 101
GLU A 112
LEU A 153
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
 1.16A 5i9xA-5w5jA:
24.0		 5i9xA-5w5jA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 ALA A  45
LYS A  47
THR A  95
TYR A  97
GLY A 101
GLU A 112
LEU A 153
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
 0.98A 5i9yA-5w5jA:
14.9		 5i9yA-5w5jA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		5 / 10 LEU A  24
VAL A  32
ILE A  93
MET A  98
GLY A 101
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.9A)
None
9WS  A 401 ( 4.3A)
 0.56A 5mo4A-5w5jA:
8.3		 5mo4A-5w5jA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A  32
ALA A  45
LYS A  47
ILE A  93
THR A  95
GLY A 101
LEU A 153
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.67A 5p9iA-5w5jA:
24.6		 5p9iA-5w5jA:
30.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A  32
ALA A  45
THR A  95
TYR A  97
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.34A 6bsdA-5w5jA:
22.4		 6bsdA-5w5jA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A  32
ALA A  45
LYS A  47
ILE A  93
THR A  95
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.62A 6fnmA-5w5jA:
19.5		 6fnmA-5w5jA:
25.24