SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '9U4'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5w0e CREB-BINDING PROTEIN
(Homo
sapiens) 		6 / 6 VAL A1115
LEU A1120
ILE A1122
TYR A1167
ASN A1168
VAL A1174
 9U4  A1201 (-4.6A)
9U4  A1201 ( 4.1A)
9U4  A1201 (-4.3A)
None
9U4  A1201 (-3.2A)
9U4  A1201 (-4.7A)
 0.56A 4a9kA-5w0eA:
22.4		 4a9kA-5w0eA:
75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 5w0e CREB-BINDING PROTEIN
(Homo
sapiens) 		5 / 5 VAL A1115
LEU A1120
ILE A1122
ASN A1168
VAL A1174
 9U4  A1201 (-4.6A)
9U4  A1201 ( 4.1A)
9U4  A1201 (-4.3A)
9U4  A1201 (-3.2A)
9U4  A1201 (-4.7A)
 0.38A 4a9kB-5w0eA:
22.8		 4a9kB-5w0eA:
75.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5w0e CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 6 PRO A1110
VAL A1115
TYR A1125
ASN A1168
 9U4  A1201 (-3.9A)
9U4  A1201 (-4.6A)
None
9U4  A1201 (-3.2A)
 0.45A 5pbeA-5w0eA:
17.3		 5pbeA-5w0eA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5w0e CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 8 PRO A1110
VAL A1115
LEU A1120
TYR A1167
 9U4  A1201 (-3.9A)
9U4  A1201 (-4.6A)
9U4  A1201 ( 4.1A)
None
 0.60A 5y1yA-5w0eA:
17.0		 5y1yA-5w0eA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5w0e CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 8 VAL A1115
LEU A1120
TYR A1167
ASN A1168
 9U4  A1201 (-4.6A)
9U4  A1201 ( 4.1A)
None
9U4  A1201 (-3.2A)
 0.40A 5y1yA-5w0eA:
17.0		 5y1yA-5w0eA:
20.63