SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '9S8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_B_115B1_1 (HMG-COA REDUCTASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 9	CYH B 42 LEU B 64 ALA B 88 LEU B 92 LEU B 57	9S8 B 301 (-2.0A) None None None None	1.48A	1hwiA-5odrB: undetectable	1hwiA-5odrB: 22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RLB_B_VIBB187_1 (THIT)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 12	GLU B 124 TYR B 82 GLY B 152 VAL B 230 ASN B 79	None None 9S8 B 302 ( 3.8A) None 9S8 B 302 (-4.4A)	1.46A	3rlbB-5odrB: undetectable	3rlbB-5odrB: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6D_A_SAMA1350_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 12	TYR C 52 LEU B 207 GLY B 198 ILE C 97 ALA B 196	SF4 C 202 (-4.9A) None COM B 303 (-4.0A) None 9S8 B 302 ( 4.2A)	1.15A	4a6dA-5odrC: undetectable	4a6dA-5odrC: 20.40

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HWI_B_115B1_1","HMG-COA REDUCTASE;HMG-COA REDUCTASE","5odr","HETERODISULFIDE REDUCTASE, SUBUNIT B","Methanothermococcus thermolithotrophicus",5,"CYH B  42;LEU B  64;ALA B  88;LEU B  92;LEU B  57","9S8 B 301 (-2.0A);None;None;None;None","1.48A","1hwiA-5odrB:undetectable",null],["3RLB_B_VIBB187_1","THIT","5odr","HETERODISULFIDE REDUCTASE, SUBUNIT B","Methanothermococcus thermolithotrophicus",5,"GLU B 124;TYR B  82;GLY B 152;VAL B 230;ASN B  79","None;None;9S8 B 302 ( 3.8A);None;9S8 B 302 (-4.4A)","1.46A","3rlbB-5odrB:undetectable","1hwiA-5odrB:22.85"],["4A6D_A_SAMA1350_0","HYDROXYINDOLE O-METHYLTRANSFERASE","5odr","HETERODISULFIDE REDUCTASE, SUBUNIT B;HETERODISULFIDE REDUCTASE, SUBUNIT C","Methanothermococcus thermolithotrophicus;Methanothermococcus thermolithotrophicus",5,"TYR C  52;LEU B 207;GLY B 198;ILE C  97;ALA B 196","SF4 C 202 (-4.9A);None;COM B 303 (-4.0A);None;9S8 B 302 ( 4.2A)","1.15A","4a6dA-5odrC:undetectable","3rlbB-5odrB:20.60"]]