SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '9NB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		5 / 12 HIS A 455
GLU A 456
HIS A 459
GLU A 487
TYR A 538
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
ZN  A 801 ( 2.3A)
None
 0.62A 1j36A-5o7eA:
undetectable		 1j36A-5o7eA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		5 / 12 HIS A 455
GLU A 456
HIS A 459
GLU A 487
TYR A 538
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
ZN  A 801 ( 2.3A)
None
 0.63A 1j36B-5o7eA:
3.8		 1j36B-5o7eA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		5 / 11 HIS A 455
GLU A 456
HIS A 459
GLU A 487
TYR A 538
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
ZN  A 801 ( 2.3A)
None
 0.60A 1j37A-5o7eA:
3.6		 1j37A-5o7eA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		5 / 11 HIS A 455
GLU A 456
HIS A 459
GLU A 487
TYR A 538
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
ZN  A 801 ( 2.3A)
None
 0.61A 1j37B-5o7eA:
3.8		 1j37B-5o7eA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		5 / 12 HIS A 455
GLU A 456
HIS A 459
GLU A 487
TYR A 538
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
ZN  A 801 ( 2.3A)
None
 0.58A 1o86A-5o7eA:
4.9		 1o86A-5o7eA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		5 / 12 HIS A 455
GLU A 456
HIS A 459
GLU A 487
TYR A 538
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
ZN  A 801 ( 2.3A)
None
 0.56A 2c6nA-5o7eA:
4.5		 2c6nA-5o7eA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		5 / 12 HIS A 455
GLU A 456
HIS A 459
GLU A 487
TYR A 538
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
ZN  A 801 ( 2.3A)
None
 0.64A 2c6nB-5o7eA:
4.2		 2c6nB-5o7eA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		4 / 7 ASN A 424
GLY A 426
THR A 437
MET A 427
 None
None
None
9NB  A 803 (-4.7A)
 1.26A 2o5yH-5o7eA:
2.4
2o5yL-5o7eA:
2.2		 2o5yH-5o7eA:
16.51
2o5yL-5o7eA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		5 / 11 HIS A 455
GLU A 456
HIS A 459
GLU A 487
TYR A 538
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
ZN  A 801 ( 2.3A)
None
 0.54A 2x8zA-5o7eA:
5.9		 2x8zA-5o7eA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		5 / 12 HIS A 455
GLU A 456
HIS A 459
GLU A 487
TYR A 538
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
ZN  A 801 ( 2.3A)
None
 0.56A 2x91A-5o7eA:
3.3		 2x91A-5o7eA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		4 / 7 GLU A 487
HIS A 455
HIS A 459
GLU A 456
 ZN  A 801 ( 2.3A)
ZN  A 801 ( 3.3A)
9NB  A 803 ( 3.2A)
9NB  A 803 (-3.5A)
 0.83A 3a6jB-5o7eA:
2.4		 3a6jB-5o7eA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		4 / 8 GLU A 487
HIS A 455
HIS A 459
GLU A 456
 ZN  A 801 ( 2.3A)
ZN  A 801 ( 3.3A)
9NB  A 803 ( 3.2A)
9NB  A 803 (-3.5A)
 0.83A 3a6jC-5o7eA:
2.3		 3a6jC-5o7eA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		4 / 8 GLU A 487
HIS A 455
HIS A 459
GLU A 456
 ZN  A 801 ( 2.3A)
ZN  A 801 ( 3.3A)
9NB  A 803 ( 3.2A)
9NB  A 803 (-3.5A)
 0.83A 3a6jF-5o7eA:
2.2		 3a6jF-5o7eA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		3 / 3 HIS A 455
GLU A 456
HIS A 459
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
 0.07A 3kecB-5o7eA:
4.3		 3kecB-5o7eA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		5 / 11 HIS A 455
GLU A 456
HIS A 459
GLU A 487
TYR A 538
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
ZN  A 801 ( 2.3A)
None
 0.60A 4c2pA-5o7eA:
4.8		 4c2pA-5o7eA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		5 / 9 GLY A 425
HIS A 455
GLU A 456
GLU A 487
TYR A 538
 None
ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
ZN  A 801 ( 2.3A)
None
 0.30A 4dprA-5o7eA:
8.6		 4dprA-5o7eA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		4 / 6 HIS A 455
HIS A 459
TYR A 531
GLU A 487
 ZN  A 801 ( 3.3A)
9NB  A 803 ( 3.2A)
None
ZN  A 801 ( 2.3A)
 1.14A 4pahA-5o7eA:
undetectable		 4pahA-5o7eA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		5 / 12 HIS A 455
GLU A 456
HIS A 459
GLU A 487
TYR A 538
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
ZN  A 801 ( 2.3A)
None
 0.27A 4r7lA-5o7eA:
7.2		 4r7lA-5o7eA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		4 / 4 HIS A 455
HIS A 459
TYR A 531
GLU A 487
 ZN  A 801 ( 3.3A)
9NB  A 803 ( 3.2A)
None
ZN  A 801 ( 2.3A)
 1.10A 5pahA-5o7eA:
undetectable		 5pahA-5o7eA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5o7e COLH PROTEIN
(Hathewaya
histolytica) 		4 / 4 HIS A 459
HIS A 455
TYR A 538
GLU A 487
 9NB  A 803 ( 3.2A)
ZN  A 801 ( 3.3A)
None
ZN  A 801 ( 2.3A)
 1.49A 5pahA-5o7eA:
undetectable		 5pahA-5o7eA:
13.96