SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '9L9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_B_SVRB501_2 (PHOSPHOLIPASE A2)	4cjx	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE (Trypanosoma brucei)	5 / 11	VAL A 271 GLY A 273 PRO A 277 SER A 281 THR A 279	None 9L9 A1300 (-3.4A) 9L9 A1300 (-4.1A) None 9L9 A1300 ( 4.8A)	1.14A	3bjwB-4cjxA: 0.9	3bjwB-4cjxA: 18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_E_SVRE503_1 (PHOSPHOLIPASE A2)	4cjx	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE (Trypanosoma brucei)	5 / 11	VAL A 271 GLY A 273 PRO A 277 SER A 281 THR A 279	None 9L9 A1300 (-3.4A) 9L9 A1300 (-4.1A) None 9L9 A1300 ( 4.8A)	1.19A	3bjwE-4cjxA: 0.9	3bjwE-4cjxA: 18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_F_SVRF502_3 (PHOSPHOLIPASE A2)	4cjx	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE (Trypanosoma brucei)	5 / 12	VAL A 271 GLY A 273 PRO A 277 SER A 281 THR A 279	None 9L9 A1300 (-3.4A) 9L9 A1300 (-4.1A) None 9L9 A1300 ( 4.8A)	1.28A	3bjwF-4cjxA: 0.8	3bjwF-4cjxA: 18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_H_SVRH504_3 (PHOSPHOLIPASE A2)	4cjx	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE (Trypanosoma brucei)	5 / 11	VAL A 271 GLY A 273 PRO A 277 SER A 281 THR A 279	None 9L9 A1300 (-3.4A) 9L9 A1300 (-4.1A) None 9L9 A1300 ( 4.8A)	1.21A	3bjwH-4cjxA: undetectable	3bjwH-4cjxA: 18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB302_1 (BIFUNCTIONAL PROTEIN FOLD)	4cjx	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE (Trypanosoma brucei)	6 / 12	GLN A 100 LEU A 101 PRO A 102 LYS A 109 ASP A 123 THR A 146	9L9 A1300 (-3.5A) 9L9 A1300 (-4.1A) NAP A1301 (-4.7A) None 9L9 A1300 (-3.0A) None	1.01A	6debB-4cjxA: 39.4	6debB-4cjxA: 11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB302_1 (BIFUNCTIONAL PROTEIN FOLD)	4cjx	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE (Trypanosoma brucei)	7 / 12	GLN A 100 LEU A 101 PRO A 102 LYS A 109 ASP A 123 THR A 146 THR A 279	9L9 A1300 (-3.5A) 9L9 A1300 (-4.1A) NAP A1301 (-4.7A) None 9L9 A1300 (-3.0A) None 9L9 A1300 ( 4.8A)	0.75A	6debB-4cjxA: 39.4	6debB-4cjxA: 11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB302_1 (BIFUNCTIONAL PROTEIN FOLD)	4cjx	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE (Trypanosoma brucei)	6 / 12	LEU A 101 PRO A 102 ASP A 123 THR A 146 ILE A 174 THR A 279	9L9 A1300 (-4.1A) NAP A1301 (-4.7A) 9L9 A1300 (-3.0A) None 9L9 A1300 ( 4.3A) 9L9 A1300 ( 4.8A)	0.90A	6debB-4cjxA: 39.4	6debB-4cjxA: 11.97

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3BJW_B_SVRB501_2","PHOSPHOLIPASE A2","4cjx","C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE","Trypanosoma brucei",5,"VAL A 271;GLY A 273;PRO A 277;SER A 281;THR A 279","None;9L9 A1300 (-3.4A);9L9 A1300 (-4.1A);None;9L9 A1300 ( 4.8A)","1.14A","3bjwB-4cjxA:0.9",null],["3BJW_E_SVRE503_1","PHOSPHOLIPASE A2","4cjx","C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE","Trypanosoma brucei",5,"VAL A 271;GLY A 273;PRO A 277;SER A 281;THR A 279","None;9L9 A1300 (-3.4A);9L9 A1300 (-4.1A);None;9L9 A1300 ( 4.8A)","1.19A","3bjwE-4cjxA:0.9","3bjwB-4cjxA:18.12"],["3BJW_F_SVRF502_3","PHOSPHOLIPASE A2","4cjx","C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE","Trypanosoma brucei",5,"VAL A 271;GLY A 273;PRO A 277;SER A 281;THR A 279","None;9L9 A1300 (-3.4A);9L9 A1300 (-4.1A);None;9L9 A1300 ( 4.8A)","1.28A","3bjwF-4cjxA:0.8","3bjwE-4cjxA:18.12"],["3BJW_H_SVRH504_3","PHOSPHOLIPASE A2","4cjx","C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE","Trypanosoma brucei",5,"VAL A 271;GLY A 273;PRO A 277;SER A 281;THR A 279","None;9L9 A1300 (-3.4A);9L9 A1300 (-4.1A);None;9L9 A1300 ( 4.8A)","1.21A","3bjwH-4cjxA:undetectable","3bjwF-4cjxA:18.12"],["6DEB_B_MTXB302_1","BIFUNCTIONAL PROTEIN FOLD","4cjx","C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE","Trypanosoma brucei",6,"GLN A 100;LEU A 101;PRO A 102;LYS A 109;ASP A 123;THR A 146","9L9 A1300 (-3.5A);9L9 A1300 (-4.1A);NAP A1301 (-4.7A);None;9L9 A1300 (-3.0A);None","1.01A","6debB-4cjxA:39.4","3bjwH-4cjxA:18.12"],["6DEB_B_MTXB302_1","BIFUNCTIONAL PROTEIN FOLD","4cjx","C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE","Trypanosoma brucei",7,"GLN A 100;LEU A 101;PRO A 102;LYS A 109;ASP A 123;THR A 146;THR A 279","9L9 A1300 (-3.5A);9L9 A1300 (-4.1A);NAP A1301 (-4.7A);None;9L9 A1300 (-3.0A);None;9L9 A1300 ( 4.8A)","0.75A","6debB-4cjxA:39.4","6debB-4cjxA:11.97"],["6DEB_B_MTXB302_1","BIFUNCTIONAL PROTEIN FOLD","4cjx","C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE","Trypanosoma brucei",6,"LEU A 101;PRO A 102;ASP A 123;THR A 146;ILE A 174;THR A 279","9L9 A1300 (-4.1A);NAP A1301 (-4.7A);9L9 A1300 (-3.0A);None;9L9 A1300 ( 4.3A);9L9 A1300 ( 4.8A)","0.90A","6debB-4cjxA:39.4","6debB-4cjxA:11.97"]]