SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '9FS'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HEG_A_BAXA1_1 (MITOGEN-ACTIVATED PROTEIN KINASE 14)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	5 / 12	VAL A 131 VAL A 139 ALA A 150 LYS A 152 ILE A 174	None 9FS A 501 (-4.5A) 9FS A 501 (-3.4A) None None	0.64A	3hegA-5vo1A: 20.2	3hegA-5vo1A: 29.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3MIY_B_B49B2_1 (TYROSINE-PROTEIN KINASE ITK/TSK)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	6 / 9	ALA A 150 LYS A 152 PHE A 192 GLY A 196 LEU A 243 SER A 253	9FS A 501 (-3.4A) None 9FS A 501 (-4.3A) 9FS A 501 (-3.6A) 9FS A 501 (-4.7A) 9FS A 501 ( 4.3A)	0.83A	3miyB-5vo1A: 27.9	3miyB-5vo1A: 34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	5 / 12	VAL A 139 ALA A 150 LYS A 152 CYH A 193 PHE A 255	9FS A 501 (-4.5A) 9FS A 501 (-3.4A) None 9FS A 501 (-4.3A) None	0.74A	3og7A-5vo1A: 27.3	3og7A-5vo1A: 37.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OHT_A_1N1A1000_1 (P38A)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	6 / 12	VAL A 131 GLY A 132 VAL A 139 ALA A 150 ILE A 174 LEU A 243	None 9FS A 501 (-3.7A) 9FS A 501 (-4.5A) 9FS A 501 (-3.4A) None 9FS A 501 (-4.7A)	0.89A	3ohtA-5vo1A: 14.9	3ohtA-5vo1A: 28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AGD_A_B49A2000_1 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	5 / 11	ALA A 150 PHE A 192 CYH A 193 GLY A 196 LEU A 243	9FS A 501 (-3.4A) 9FS A 501 (-4.3A) 9FS A 501 (-4.3A) 9FS A 501 (-3.6A) 9FS A 501 (-4.7A)	0.46A	4agdA-5vo1A: 23.8	4agdA-5vo1A: 27.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ANS_A_VGHA9000_1 (ALK TYROSINE KINASE RECEPTOR)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	6 / 9	VAL A 139 ALA A 150 MET A 190 GLY A 196 LEU A 243 ASP A 254	9FS A 501 (-4.5A) 9FS A 501 (-3.4A) 9FS A 501 (-3.6A) 9FS A 501 (-3.6A) 9FS A 501 (-4.7A) None	0.66A	4ansA-5vo1A: 26.1	4ansA-5vo1A: 30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KS8_A_B49A701_1 (SERINE/THREONINE-PRO TEIN KINASE PAK 6)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	6 / 10	ALA A 150 MET A 190 PHE A 192 GLY A 196 LEU A 243 SER A 253	9FS A 501 (-3.4A) 9FS A 501 (-3.6A) 9FS A 501 (-4.3A) 9FS A 501 (-3.6A) 9FS A 501 (-4.7A) 9FS A 501 ( 4.3A)	0.69A	4ks8A-5vo1A: 24.2	4ks8A-5vo1A: 29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U0I_A_0LIA1001_2 (MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT,MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	7 / 12	ALA A 150 LYS A 152 CYH A 193 GLY A 196 HIS A 234 LEU A 243 ASP A 254	9FS A 501 (-3.4A) None 9FS A 501 (-4.3A) 9FS A 501 (-3.6A) None 9FS A 501 (-4.7A) None	0.82A	4u0iA-5vo1A: 24.9	4u0iA-5vo1A: 29.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4V04_A_0LIA1772_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	4 / 8	ILE A 174 ARG A 235 LEU A 243 ILE A 252	None None 9FS A 501 (-4.7A) None	0.84A	4v04A-5vo1A: 25.7	4v04A-5vo1A: 35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XV2_B_P06B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	5 / 12	ALA A 150 LYS A 152 CYH A 193 ASP A 254 PHE A 255	9FS A 501 (-3.4A) None 9FS A 501 (-4.3A) None None	0.92A	4xv2B-5vo1A: 27.3	4xv2B-5vo1A: 36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5AJQ_A_DB8A800_1 (SERINE/THREONINE-PRO TEIN KINASE 10)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	7 / 12	ALA A 150 LYS A 152 PHE A 192 CYH A 193 GLY A 196 LEU A 243 ASP A 254	9FS A 501 (-3.4A) None 9FS A 501 (-4.3A) 9FS A 501 (-4.3A) 9FS A 501 (-3.6A) 9FS A 501 (-4.7A) None	1.31A	5ajqA-5vo1A: 23.2	5ajqA-5vo1A: 31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5AJQ_A_DB8A800_1 (SERINE/THREONINE-PRO TEIN KINASE 10)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	7 / 12	GLY A 132 ALA A 150 PHE A 192 CYH A 193 GLY A 196 LEU A 243 ASP A 254	9FS A 501 (-3.7A) 9FS A 501 (-3.4A) 9FS A 501 (-4.3A) 9FS A 501 (-4.3A) 9FS A 501 (-3.6A) 9FS A 501 (-4.7A) None	0.81A	5ajqA-5vo1A: 23.2	5ajqA-5vo1A: 31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HIE_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	4 / 7	GLY A 134 CYH A 193 ASP A 254 PHE A 255	9FS A 501 ( 4.0A) 9FS A 501 (-4.3A) None None	1.08A	5hieA-5vo1A: 27.2	5hieA-5vo1A: 34.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HIE_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	4 / 7	GLY A 137 CYH A 193 ASP A 254 PHE A 255	None 9FS A 501 (-4.3A) None None	0.97A	5hieA-5vo1A: 27.2	5hieA-5vo1A: 34.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5I9X_A_DB8A1001_1 (EPHRIN TYPE-A RECEPTOR 2)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	6 / 12	ALA A 150 ILE A 174 ILE A 188 GLY A 196 LEU A 243 SER A 253	9FS A 501 (-3.4A) None None 9FS A 501 (-3.6A) 9FS A 501 (-4.7A) 9FS A 501 ( 4.3A)	0.56A	5i9xA-5vo1A: 25.8	5i9xA-5vo1A: 31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5OWR_A_1N1A401_1 (SERINE/THREONINE-PRO TEIN KINASE 10)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	4 / 8	ALA A 150 CYH A 193 LEU A 243 ASP A 254	9FS A 501 (-3.4A) 9FS A 501 (-4.3A) 9FS A 501 (-4.7A) None	0.52A	5owrA-5vo1A: 20.4	5owrA-5vo1A: 31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5P9I_A_1E8A701_1 (TYROSINE-PROTEIN KINASE BTK)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	7 / 12	GLY A 134 VAL A 139 ALA A 150 GLY A 196 LEU A 243 SER A 253 PHE A 255	9FS A 501 ( 4.0A) 9FS A 501 (-4.5A) 9FS A 501 (-3.4A) 9FS A 501 (-3.6A) 9FS A 501 (-4.7A) 9FS A 501 ( 4.3A) None	0.72A	5p9iA-5vo1A: 28.1	5p9iA-5vo1A: 30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5P9I_A_1E8A701_1 (TYROSINE-PROTEIN KINASE BTK)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	7 / 12	VAL A 139 ALA A 150 ILE A 188 GLY A 196 LEU A 243 SER A 253 PHE A 255	9FS A 501 (-4.5A) 9FS A 501 (-3.4A) None 9FS A 501 (-3.6A) 9FS A 501 (-4.7A) 9FS A 501 ( 4.3A) None	0.71A	5p9iA-5vo1A: 28.1	5p9iA-5vo1A: 30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TE0_A_XINA401_1 (AP2-ASSOCIATED PROTEIN KINASE 1)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	6 / 12	LEU A 141 ALA A 150 PHE A 192 GLY A 196 GLN A 197 LEU A 243	None 9FS A 501 (-3.4A) 9FS A 501 (-4.3A) 9FS A 501 (-3.6A) 9FS A 501 ( 4.0A) 9FS A 501 (-4.7A)	0.69A	5te0A-5vo1A: 20.9	5te0A-5vo1A: 25.63

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3HEG_A_BAXA1_1","MITOGEN-ACTIVATED PROTEIN KINASE 14","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",5,"VAL A 131;VAL A 139;ALA A 150;LYS A 152;ILE A 174","None;9FS A 501 (-4.5A);9FS A 501 (-3.4A);None;None","0.64A","3hegA-5vo1A:20.2",null],["3MIY_B_B49B2_1","TYROSINE-PROTEIN KINASE ITK\/TSK","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",6,"ALA A 150;LYS A 152;PHE A 192;GLY A 196;LEU A 243;SER A 253","9FS A 501 (-3.4A);None;9FS A 501 (-4.3A);9FS A 501 (-3.6A);9FS A 501 (-4.7A);9FS A 501 ( 4.3A)","0.83A","3miyB-5vo1A:27.9","3hegA-5vo1A:29.41"],["3OG7_A_032A1_1","AKAP9-BRAF FUSION PROTEIN","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",5,"VAL A 139;ALA A 150;LYS A 152;CYH A 193;PHE A 255","9FS A 501 (-4.5A);9FS A 501 (-3.4A);None;9FS A 501 (-4.3A);None","0.74A","3og7A-5vo1A:27.3","3miyB-5vo1A:34.18"],["3OHT_A_1N1A1000_1","P38A","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",6,"VAL A 131;GLY A 132;VAL A 139;ALA A 150;ILE A 174;LEU A 243","None;9FS A 501 (-3.7A);9FS A 501 (-4.5A);9FS A 501 (-3.4A);None;9FS A 501 (-4.7A)","0.89A","3ohtA-5vo1A:14.9","3og7A-5vo1A:37.03"],["4AGD_A_B49A2000_1","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",5,"ALA A 150;PHE A 192;CYH A 193;GLY A 196;LEU A 243","9FS A 501 (-3.4A);9FS A 501 (-4.3A);9FS A 501 (-4.3A);9FS A 501 (-3.6A);9FS A 501 (-4.7A)","0.46A","4agdA-5vo1A:23.8","3ohtA-5vo1A:28.50"],["4ANS_A_VGHA9000_1","ALK TYROSINE KINASE RECEPTOR","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",6,"VAL A 139;ALA A 150;MET A 190;GLY A 196;LEU A 243;ASP A 254","9FS A 501 (-4.5A);9FS A 501 (-3.4A);9FS A 501 (-3.6A);9FS A 501 (-3.6A);9FS A 501 (-4.7A);None","0.66A","4ansA-5vo1A:26.1","4agdA-5vo1A:27.41"],["4KS8_A_B49A701_1","SERINE\/THREONINE-PROTEIN KINASE PAK 6","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",6,"ALA A 150;MET A 190;PHE A 192;GLY A 196;LEU A 243;SER A 253","9FS A 501 (-3.4A);9FS A 501 (-3.6A);9FS A 501 (-4.3A);9FS A 501 (-3.6A);9FS A 501 (-4.7A);9FS A 501 ( 4.3A)","0.69A","4ks8A-5vo1A:24.2","4ansA-5vo1A:30.79"],["4U0I_A_0LIA1001_2","MAST\/STEM CELL GROWTH FACTOR RECEPTOR KIT,MAST\/STEM CELL GROWTH FACTOR RECEPTOR KIT","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",7,"ALA A 150;LYS A 152;CYH A 193;GLY A 196;HIS A 234;LEU A 243;ASP A 254","9FS A 501 (-3.4A);None;9FS A 501 (-4.3A);9FS A 501 (-3.6A);None;9FS A 501 (-4.7A);None","0.82A","4u0iA-5vo1A:24.9","4ks8A-5vo1A:29.50"],["4V04_A_0LIA1772_2","FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",4,"ILE A 174;ARG A 235;LEU A 243;ILE A 252","None;None;9FS A 501 (-4.7A);None","0.84A","4v04A-5vo1A:25.7","4u0iA-5vo1A:29.78"],["4XV2_B_P06B801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",5,"ALA A 150;LYS A 152;CYH A 193;ASP A 254;PHE A 255","9FS A 501 (-3.4A);None;9FS A 501 (-4.3A);None;None","0.92A","4xv2B-5vo1A:27.3","4v04A-5vo1A:35.11"],["5AJQ_A_DB8A800_1","SERINE\/THREONINE-PROTEIN KINASE 10","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",7,"ALA A 150;LYS A 152;PHE A 192;CYH A 193;GLY A 196;LEU A 243;ASP A 254","9FS A 501 (-3.4A);None;9FS A 501 (-4.3A);9FS A 501 (-4.3A);9FS A 501 (-3.6A);9FS A 501 (-4.7A);None","1.31A","5ajqA-5vo1A:23.2","4xv2B-5vo1A:36.65"],["5AJQ_A_DB8A800_1","SERINE\/THREONINE-PROTEIN KINASE 10","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",7,"GLY A 132;ALA A 150;PHE A 192;CYH A 193;GLY A 196;LEU A 243;ASP A 254","9FS A 501 (-3.7A);9FS A 501 (-3.4A);9FS A 501 (-4.3A);9FS A 501 (-4.3A);9FS A 501 (-3.6A);9FS A 501 (-4.7A);None","0.81A","5ajqA-5vo1A:23.2","5ajqA-5vo1A:31.53"],["5HIE_A_P06A801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",4,"GLY A 134;CYH A 193;ASP A 254;PHE A 255","9FS A 501 ( 4.0A);9FS A 501 (-4.3A);None;None","1.08A","5hieA-5vo1A:27.2","5ajqA-5vo1A:31.53"],["5HIE_A_P06A801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",4,"GLY A 137;CYH A 193;ASP A 254;PHE A 255","None;9FS A 501 (-4.3A);None;None","0.97A","5hieA-5vo1A:27.2","5hieA-5vo1A:34.02"],["5I9X_A_DB8A1001_1","EPHRIN TYPE-A RECEPTOR 2","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",6,"ALA A 150;ILE A 174;ILE A 188;GLY A 196;LEU A 243;SER A 253","9FS A 501 (-3.4A);None;None;9FS A 501 (-3.6A);9FS A 501 (-4.7A);9FS A 501 ( 4.3A)","0.56A","5i9xA-5vo1A:25.8","5hieA-5vo1A:34.02"],["5OWR_A_1N1A401_1","SERINE\/THREONINE-PROTEIN KINASE 10","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",4,"ALA A 150;CYH A 193;LEU A 243;ASP A 254","9FS A 501 (-3.4A);9FS A 501 (-4.3A);9FS A 501 (-4.7A);None","0.52A","5owrA-5vo1A:20.4","5i9xA-5vo1A:31.71"],["5P9I_A_1E8A701_1","TYROSINE-PROTEIN KINASE BTK","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",7,"GLY A 134;VAL A 139;ALA A 150;GLY A 196;LEU A 243;SER A 253;PHE A 255","9FS A 501 ( 4.0A);9FS A 501 (-4.5A);9FS A 501 (-3.4A);9FS A 501 (-3.6A);9FS A 501 (-4.7A);9FS A 501 ( 4.3A);None","0.72A","5p9iA-5vo1A:28.1","5owrA-5vo1A:31.02"],["5P9I_A_1E8A701_1","TYROSINE-PROTEIN KINASE BTK","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",7,"VAL A 139;ALA A 150;ILE A 188;GLY A 196;LEU A 243;SER A 253;PHE A 255","9FS A 501 (-4.5A);9FS A 501 (-3.4A);None;9FS A 501 (-3.6A);9FS A 501 (-4.7A);9FS A 501 ( 4.3A);None","0.71A","5p9iA-5vo1A:28.1","5p9iA-5vo1A:30.48"],["5TE0_A_XINA401_1","AP2-ASSOCIATED PROTEIN KINASE 1","5vo1","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12","Homo sapiens",6,"LEU A 141;ALA A 150;PHE A 192;GLY A 196;GLN A 197;LEU A 243","None;9FS A 501 (-3.4A);9FS A 501 (-4.3A);9FS A 501 (-3.6A);9FS A 501 ( 4.0A);9FS A 501 (-4.7A)","0.69A","5te0A-5vo1A:20.9","5p9iA-5vo1A:30.48"]]