SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '9EW'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 5nzp D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 5 GLY B 152
ASP B 175
ARG B 158
GLN B 189
 9EW  B 301 ( 4.6A)
9EW  B 301 ( 4.6A)
None
None
 1.44A 3qx3B-5nzpB:
undetectable		 3qx3B-5nzpB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5nzp D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU B 217
ASN B 218
GLY B 215
LEU B 151
GLN B 224
 None
None
None
9EW  B 301 ( 4.8A)
None
 1.25A 4p6xA-5nzpB:
undetectable		 4p6xA-5nzpB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5nzp D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU B 217
ASN B 218
GLY B 215
LEU B 151
GLN B 224
 None
None
None
9EW  B 301 ( 4.8A)
None
 1.29A 4p6xE-5nzpB:
undetectable		 4p6xE-5nzpB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5nzp D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU B 217
ASN B 218
GLY B 215
LEU B 151
GLN B 224
 None
None
None
9EW  B 301 ( 4.8A)
None
 1.30A 4p6xI-5nzpB:
undetectable		 4p6xI-5nzpB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5nzp D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 ARG B 155
THR B 207
PRO B 208
PRO B 176
 None
9EW  B 301 (-4.2A)
None
9EW  B 301 (-4.5A)
 1.27A 6a4iB-5nzpB:
undetectable		 6a4iB-5nzpB:
19.69