SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '9ER'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		3 / 3 PHE A  18
LEU A  70
SER A 283
 9ER  A1201 ( 4.8A)
None
None
 0.90A 1e7aA-5zkpA:
undetectable		 1e7aA-5zkpA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		3 / 3 TYR A  77
ASP A  10
HIS A 275
 9ER  A1201 (-4.5A)
None
9ER  A1201 (-4.5A)
 0.84A 3e23A-5zkpA:
undetectable		 3e23A-5zkpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 8 TYR A  76
LEU A 279
CYH A 280
TYR A  22
 None
9ER  A1201 (-4.8A)
None
9ER  A1201 (-4.6A)
 1.28A 3po7A-5zkpA:
2.4		 3po7A-5zkpA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 10 LEU A  70
PHE A  26
GLY A  29
ILE A  25
PHE A  97
 None
None
None
None
9ER  A1201 (-3.9A)
 1.20A 3qpsA-5zkpA:
undetectable		 3qpsA-5zkpA:
undetectable