SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '9E1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		9 / 12 LEU A 686
GLY A 687
VAL A 694
ALA A 707
VAL A 738
VAL A 757
ASN A 808
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-4.1A)
9E1  A1001 (-3.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.53A 1fmoE-5vilA:
21.9		 1fmoE-5vilA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		4 / 7 VAL A 738
ILE A 752
ARG A 802
LEU A 810
 9E1  A1001 (-4.1A)
None
None
9E1  A1001 (-4.5A)
 0.79A 1iepB-5vilA:
19.0		 1iepB-5vilA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
VAL A 738
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-4.1A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.53A 1t46A-5vilA:
24.4		 1t46A-5vilA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 10 TYR A 793
PHE A 823
MET A 754
GLN A 739
GLY A 742
 None
None
9E1  A1001 (-2.8A)
None
None
 1.47A 1uhoA-5vilA:
undetectable		 1uhoA-5vilA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 9 LEU A 686
VAL A 694
ALA A 707
MET A 754
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.83A 1xbbA-5vilA:
27.7		 1xbbA-5vilA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 VAL A 694
LYS A 709
VAL A 738
VAL A 757
ASN A 808
LEU A 810
ASP A 822
 9E1  A1001 ( 4.0A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.1A)
9E1  A1001 (-3.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.50A 2eufB-5vilA:
20.2		 2eufB-5vilA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 11 GLY A 687
GLY A 689
VAL A 694
ALA A 707
MET A 754
SER A 761
LEU A 810
 9E1  A1001 ( 3.4A)
9E1  A1001 (-2.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 ( 3.9A)
9E1  A1001 (-4.5A)
 0.97A 2evaA-5vilA:
7.0		 2evaA-5vilA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		9 / 12 LEU A 686
GLY A 687
VAL A 694
ALA A 707
VAL A 757
ASP A 803
LYS A 805
ASN A 808
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-3.9A)
None
None
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.6A)
 0.77A 2fumA-5vilA:
29.0		 2fumA-5vilA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		9 / 12 LEU A 686
GLY A 687
VAL A 694
ALA A 707
MET A 754
VAL A 757
LYS A 805
ASN A 808
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.9A)
None
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.6A)
 0.65A 2fumB-5vilA:
28.9		 2fumB-5vilA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 686
GLY A 687
VAL A 694
ALA A 707
MET A 754
VAL A 757
ASN A 808
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.9A)
9E1  A1001 ( 4.0A)
 0.51A 2fumC-5vilA:
20.2		 2fumC-5vilA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 686
GLY A 687
VAL A 694
ALA A 707
MET A 754
LYS A 805
ASN A 808
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 ( 4.0A)
 0.58A 2fumD-5vilA:
19.8		 2fumD-5vilA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 VAL A 694
ALA A 707
GLU A 725
VAL A 738
ILE A 752
GLY A 760
LEU A 810
 9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.1A)
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.64A 2gqgB-5vilA:
27.7		 2gqgB-5vilA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 12 VAL A 694
ALA A 707
GLU A 725
VAL A 738
GLY A 760
LEU A 810
 9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.1A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.53A 2hyyC-5vilA:
19.3		 2hyyC-5vilA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 ALA A 707
LYS A 709
GLU A 725
ILE A 752
GLY A 760
LEU A 810
SER A 821
 9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
9E1  A1001 (-2.7A)
 0.80A 2y6oA-5vilA:
12.6		 2y6oA-5vilA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 10 LEU A 686
VAL A 694
LYS A 709
VAL A 738
ILE A 752
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.1A)
None
 0.77A 3cs9A-5vilA:
19.0		 3cs9A-5vilA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 9 LEU A 686
VAL A 694
LYS A 709
VAL A 738
ILE A 752
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.1A)
None
 0.71A 3cs9B-5vilA:
15.8		 3cs9B-5vilA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 9 LEU A 686
VAL A 694
VAL A 738
ILE A 752
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.1A)
None
9E1  A1001 (-4.5A)
 0.62A 3cs9B-5vilA:
15.8		 3cs9B-5vilA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		11 / 12 LEU A 686
GLY A 687
GLY A 692
VAL A 694
ALA A 707
LYS A 709
MET A 754
SER A 761
ASN A 808
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
None
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-2.8A)
9E1  A1001 ( 3.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.69A 3eygA-5vilA:
28.0		 3eygA-5vilA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		10 / 12 LEU A 686
GLY A 687
GLY A 692
VAL A 694
ALA A 707
LYS A 709
MET A 754
SER A 761
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
None
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-2.8A)
9E1  A1001 ( 3.9A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.84A 3fupA-5vilA:
21.4		 3fupA-5vilA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		9 / 12 LEU A 686
GLY A 687
VAL A 694
ALA A 707
LYS A 709
VAL A 738
MET A 754
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.1A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.70A 3fupB-5vilA:
18.9		 3fupB-5vilA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 11 LEU A 686
VAL A 694
ALA A 707
VAL A 738
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-4.1A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.41A 3g0eA-5vilA:
22.6		 3g0eA-5vilA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 12 LEU A 686
VAL A 694
ALA A 707
GLU A 725
VAL A 738
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.1A)
9E1  A1001 (-4.5A)
 0.70A 3gvuA-5vilA:
19.3		 3gvuA-5vilA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 ALA A 707
LYS A 709
GLU A 725
VAL A 738
ILE A 752
GLY A 760
LEU A 810
SER A 821
 9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-4.1A)
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
9E1  A1001 (-2.7A)
 0.87A 3k54A-5vilA:
24.8		 3k54A-5vilA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 686
GLY A 687
VAL A 694
ALA A 707
LYS A 709
VAL A 738
MET A 754
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.1A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.6A)
 0.65A 3lxkA-5vilA:
22.3		 3lxkA-5vilA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 686
GLY A 687
VAL A 694
ALA A 707
VAL A 738
MET A 754
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-4.1A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.83A 3lxkA-5vilA:
22.3		 3lxkA-5vilA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 686
GLY A 687
VAL A 694
ALA A 707
LYS A 709
SER A 761
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 ( 3.9A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.73A 3lxnA-5vilA:
27.4		 3lxnA-5vilA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 686
GLY A 687
VAL A 694
ALA A 707
LYS A 709
VAL A 757
SER A 761
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.9A)
9E1  A1001 ( 3.9A)
9E1  A1001 (-4.5A)
 0.62A 3lxnA-5vilA:
27.4		 3lxnA-5vilA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 9 LEU A 686
LYS A 709
ILE A 752
ARG A 802
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 (-2.8A)
None
None
9E1  A1001 (-4.5A)
 1.05A 3oxzA-5vilA:
19.3		 3oxzA-5vilA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 12 LEU A 686
VAL A 694
ALA A 707
GLU A 725
VAL A 738
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.1A)
9E1  A1001 (-4.5A)
 0.62A 3pyyB-5vilA:
19.0		 3pyyB-5vilA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 686
ALA A 707
LYS A 709
GLU A 725
ILE A 752
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.95A 3ue4A-5vilA:
18.9		 3ue4A-5vilA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
GLY A 760
LEU A 794
HIS A 801
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-3.4A)
None
None
 0.57A 3wzeA-5vilA:
18.6		 3wzeA-5vilA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		4 / 8 VAL A 738
LEU A 810
ILE A 820
ASP A 822
 9E1  A1001 (-4.1A)
9E1  A1001 (-4.5A)
None
9E1  A1001 (-3.6A)
 0.66A 3wzeA-5vilA:
18.6		 3wzeA-5vilA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 686
ALA A 707
LYS A 709
GLU A 725
LEU A 794
HIS A 801
ARG A 802
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
None
None
None
9E1  A1001 (-4.5A)
 0.77A 3zosA-5vilA:
18.1		 3zosA-5vilA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 ALA A 707
LYS A 709
GLU A 725
LEU A 794
HIS A 801
ARG A 802
LEU A 810
 9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
None
None
None
9E1  A1001 (-4.5A)
 0.77A 3zosB-5vilA:
18.2		 3zosB-5vilA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
VAL A 738
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-4.1A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.40A 4ag8A-5vilA:
20.2		 4ag8A-5vilA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.43A 4agcA-5vilA:
18.0		 4agcA-5vilA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 11 LEU A 686
ALA A 707
VAL A 738
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 (-3.5A)
9E1  A1001 (-4.1A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.53A 4agdA-5vilA:
15.1		 4agdA-5vilA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
GLY A 760
LEU A 794
HIS A 801
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-3.4A)
None
None
 0.57A 4asdA-5vilA:
18.7		 4asdA-5vilA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLY A 760
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 1.08A 4hjoA-5vilA:
15.9		 4hjoA-5vilA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 VAL A 694
ALA A 707
ASP A 803
LYS A 805
ASN A 808
LEU A 810
ASP A 822
 9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
None
None
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.66A 4i41A-5vilA:
26.5		 4i41A-5vilA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 ALA A 707
GLU A 725
VAL A 738
ILE A 752
MET A 754
GLY A 760
LEU A 810
ASP A 822
 9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.1A)
None
9E1  A1001 (-2.8A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.91A 4mxyA-5vilA:
22.9		 4mxyA-5vilA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 ALA A 707
GLU A 725
VAL A 738
ILE A 752
MET A 754
GLY A 760
LEU A 810
ASP A 822
 9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.1A)
None
9E1  A1001 (-2.8A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.91A 4mxzA-5vilA:
22.9		 4mxzA-5vilA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 6 LEU A 686
GLY A 687
VAL A 694
ALA A 707
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-4.5A)
 0.33A 4o0wA-5vilA:
22.7		 4o0wA-5vilA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 8 GLY A 689
VAL A 694
ALA A 707
ASN A 808
LEU A 810
ASP A 822
 9E1  A1001 (-2.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.58A 4ogrA-5vilA:
27.9		 4ogrA-5vilA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 9 GLY A 689
VAL A 694
ALA A 707
ASN A 808
LEU A 810
ASP A 822
 9E1  A1001 (-2.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.50A 4ogrI-5vilA:
22.5		 4ogrI-5vilA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 11 ALA A 707
GLU A 725
ILE A 752
MET A 754
LEU A 810
ASP A 822
 9E1  A1001 (-3.5A)
None
None
9E1  A1001 (-2.8A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.84A 4qmsA-5vilA:
23.0		 4qmsA-5vilA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 12 ALA A 707
LYS A 709
ILE A 752
SER A 761
PHE A 823
 9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 ( 3.9A)
None
 0.97A 4rzvA-5vilA:
9.0		 4rzvA-5vilA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLY A 760
ASN A 808
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.68A 4twpA-5vilA:
18.4		 4twpA-5vilA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		4 / 6 LEU A 686
VAL A 694
ILE A 737
ILE A 820
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
None
None
 0.54A 4tyjA-5vilA:
24.9		 4tyjA-5vilA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 10 LEU A 686
VAL A 694
GLU A 725
LEU A 732
ILE A 737
VAL A 738
ILE A 820
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
None
None
None
9E1  A1001 (-4.1A)
None
 0.84A 4u0iA-5vilA:
24.2		 4u0iA-5vilA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		4 / 8 ALA A 707
MET A 754
LEU A 810
SER A 821
 9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.5A)
9E1  A1001 (-2.7A)
 0.46A 4wboB-5vilA:
22.6		 4wboB-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		4 / 8 LEU A 686
ALA A 707
MET A 754
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.5A)
 0.62A 4wboB-5vilA:
22.6		 4wboB-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		4 / 6 LEU A 686
ALA A 707
MET A 754
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.5A)
 0.63A 4wboC-5vilA:
20.9		 4wboC-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 12 GLY A 689
VAL A 694
ALA A 707
LYS A 709
ILE A 752
 9E1  A1001 (-2.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
 0.71A 5hieA-5vilA:
9.1		 5hieA-5vilA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 12 GLY A 687
GLY A 689
VAL A 694
ALA A 707
LYS A 709
ASP A 822
 9E1  A1001 ( 3.4A)
9E1  A1001 (-2.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.6A)
 0.82A 5hieC-5vilA:
4.7		 5hieC-5vilA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 12 GLY A 689
VAL A 694
ALA A 707
LYS A 709
ILE A 752
 9E1  A1001 (-2.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
 0.73A 5hieD-5vilA:
13.3		 5hieD-5vilA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 11 LEU A 686
GLY A 687
VAL A 694
ALA A 707
VAL A 738
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-4.1A)
9E1  A1001 (-4.5A)
 0.49A 5lvnA-5vilA:
24.0		 5lvnA-5vilA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 10 LEU A 686
VAL A 694
LYS A 709
GLU A 725
ILE A 752
GLY A 760
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-2.8A)
None
None
9E1  A1001 (-3.4A)
 0.67A 5mo4A-5vilA:
18.4		 5mo4A-5vilA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 10 LEU A 686
VAL A 694
ALA A 707
MET A 754
VAL A 757
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.9A)
9E1  A1001 (-4.5A)
 0.60A 5n3hA-5vilA:
22.6		 5n3hA-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 10 VAL A 694
ALA A 707
VAL A 738
MET A 754
VAL A 757
LEU A 810
 9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-4.1A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.9A)
9E1  A1001 (-4.5A)
 0.50A 5n3hA-5vilA:
22.6		 5n3hA-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		4 / 8 ALA A 707
GLU A 725
LEU A 810
ASP A 822
 9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.54A 5owrA-5vilA:
20.4		 5owrA-5vilA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 12 ALA A 707
GLU A 725
VAL A 738
GLY A 760
LEU A 810
 9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.1A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.32A 5te0A-5vilA:
25.1		 5te0A-5vilA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		5 / 9 LEU A 686
ALA A 707
VAL A 738
MET A 754
GLY A 760
 9E1  A1001 (-3.7A)
9E1  A1001 (-3.5A)
9E1  A1001 (-4.1A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.4A)
 0.69A 5w5vA-5vilA:
14.1		 5w5vA-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.83A 5y7zA-5vilA:
23.9		 5y7zA-5vilA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.83A 5y7zA-5vilA:
23.9		 5y7zA-5vilA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 686
VAL A 694
ALA A 707
GLU A 725
GLY A 760
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.60A 5y80A-5vilA:
23.1		 5y80A-5vilA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 12 VAL A 694
ALA A 707
LYS A 709
MET A 754
ASP A 807
LEU A 722
 9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-2.8A)
None
None
 1.16A 5yu9D-5vilA:
24.0		 5yu9D-5vilA:
26.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens) 		6 / 12 VAL A 694
ALA A 707
GLU A 725
VAL A 738
ILE A 752
LEU A 810
 9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.1A)
None
9E1  A1001 (-4.5A)
 0.58A 6hd4B-5vilA:
12.5		 6hd4B-5vilA:
30.12