SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '992'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		7 / 12 TYR A  62
LEU A 162
LEU A 165
ASP A 197
ALA A 198
HIS A 299
ASP A 300
 AC1  A 992 ( 3.6A)
None
AC1  A 990 ( 4.8A)
AC1  A 992 ( 3.3A)
AC1  A 992 (-3.5A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.61A 1dedA-1oseA:
27.3		 1dedA-1oseA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		8 / 12 TYR A  62
LEU A 165
ARG A 195
ASP A 197
ALA A 198
GLU A 233
HIS A 299
ASP A 300
 AC1  A 992 ( 3.6A)
AC1  A 990 ( 4.8A)
AC1  A 992 ( 3.7A)
AC1  A 992 ( 3.3A)
AC1  A 992 (-3.5A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.70A 1dedB-1oseA:
24.9		 1dedB-1oseA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA651_1
(AMYLOMALTASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		5 / 12 TYR A  62
GLN A  63
HIS A 201
GLU A 233
HIS A 299
 AC1  A 992 ( 3.6A)
GLC  A 991 ( 3.7A)
AC1  A 992 ( 3.8A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
 1.14A 1eswA-1oseA:
14.1		 1eswA-1oseA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA651_1
(AMYLOMALTASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		5 / 12 TYR A  62
GLN A  63
HIS A 299
ASP A 300
TRP A  58
 AC1  A 992 ( 3.6A)
GLC  A 991 ( 3.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
None
 1.01A 1eswA-1oseA:
14.1		 1eswA-1oseA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN
(Escherichia
coli;
Escherichia
coli) 		3 / 3 GLN B 588
TYR A 194
ARG A 195
 None
None
AMP  A 992 (-4.0A)
 0.95A 1gtbA-3pcoB:
undetectable		 1gtbA-3pcoB:
12.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		10 / 12 TRP A  58
GLN A  63
HIS A 101
VAL A 163
GLY A 164
ALA A 198
GLU A 233
ILE A 235
ASP A 300
HIS A 305
 None
GLC  A 991 ( 3.7A)
AC1  A 992 ( 3.7A)
AC1  A 990 (-4.3A)
AC1  A 990 (-3.5A)
AC1  A 992 (-3.5A)
AC1  A 992 ( 2.7A)
BGC  A 993 (-3.9A)
AC1  A 992 (-3.0A)
GLC  A 991 ( 4.0A)
 0.46A 1kxhA-1oseA:
50.9		 1kxhA-1oseA:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		6 / 12 TRP A  58
HIS A 101
GLY A 104
GLU A 233
ASP A 300
HIS A 305
 None
AC1  A 992 ( 3.7A)
AC1  A 990 ( 3.8A)
AC1  A 992 ( 2.7A)
AC1  A 992 (-3.0A)
GLC  A 991 ( 4.0A)
 1.21A 1kxhA-1oseA:
50.9		 1kxhA-1oseA:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		3 / 3 TRP A  59
TYR A  62
LEU A 165
 AC1  A 990 ( 3.9A)
AC1  A 992 ( 3.6A)
AC1  A 990 ( 4.8A)
 0.23A 1kxhA-1oseA:
50.9		 1kxhA-1oseA:
47.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		5 / 12 GLU A 134
ARG B 135
ILE A 147
ARG A 142
ARG A 102
 None
None
None
None
HEM  A 992 (-3.7A)
 1.46A 1l7fA-1pbyA:
undetectable		 1l7fA-1pbyA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		9 / 12 TRP A  58
TYR A  62
HIS A 101
ARG A 195
ASP A 197
LYS A 200
GLU A 233
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.6A)
AC1  A 992 ( 3.7A)
AC1  A 992 ( 3.7A)
AC1  A 992 ( 3.3A)
BGC  A 993 ( 2.8A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.71A 1mxdA-1oseA:
28.9		 1mxdA-1oseA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT
(Paracoccus
denitrificans) 		5 / 12 LEU A  51
MET A  44
HIS A  47
ARG A  42
ILE A  59
 None
None
HEM  A 991 (-3.9A)
HEM  A 992 ( 2.7A)
HEM  A 991 ( 4.6A)
 1.45A 1ot7B-1pbyA:
undetectable		 1ot7B-1pbyA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		4 / 5 SER A 222
GLU A 171
TYR A 169
SER A  76
 None
SAM  A 992 (-2.8A)
SAM  A 992 ( 4.6A)
None
 1.44A 1vidA-3t7vA:
undetectable		 1vidA-3t7vA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWC_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		6 / 11 TYR A  62
GLN A  63
ASP A 197
HIS A 299
ASP A 300
TRP A  58
 AC1  A 992 ( 3.6A)
GLC  A 991 ( 3.7A)
AC1  A 992 ( 3.3A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
None
 0.97A 2owcA-1oseA:
13.4		 2owcA-1oseA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWW_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		6 / 11 TYR A  62
GLN A  63
ASP A 197
HIS A 299
ASP A 300
TRP A  58
 AC1  A 992 ( 3.6A)
GLC  A 991 ( 3.7A)
AC1  A 992 ( 3.3A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
None
 0.97A 2owwA-1oseA:
13.4		 2owwA-1oseA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		4 / 6 SER A 222
GLU A 171
TYR A 169
SER A  76
 None
SAM  A 992 (-2.8A)
SAM  A 992 ( 4.6A)
None
 1.40A 2zvjA-3t7vA:
undetectable		 2zvjA-3t7vA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		7 / 12 LEU A 162
ARG A 195
ASP A 197
ALA A 198
GLU A 233
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.7A)
AC1  A 992 ( 3.3A)
AC1  A 992 (-3.5A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.61A 3aicA-1oseA:
4.8		 3aicA-1oseA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		7 / 12 LEU A 162
ARG A 195
ASP A 197
ALA A 198
GLU A 233
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.7A)
AC1  A 992 ( 3.3A)
AC1  A 992 (-3.5A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.62A 3aicB-1oseA:
4.9		 3aicB-1oseA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		7 / 12 ARG A 195
ASP A 197
ALA A 198
GLU A 233
HIS A 299
ASP A 300
TYR A  62
 AC1  A 992 ( 3.7A)
AC1  A 992 ( 3.3A)
AC1  A 992 (-3.5A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
AC1  A 992 ( 3.6A)
 0.69A 3aicC-1oseA:
4.3		 3aicC-1oseA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		7 / 12 LEU A 162
ARG A 195
ASP A 197
ALA A 198
GLU A 233
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.7A)
AC1  A 992 ( 3.3A)
AC1  A 992 (-3.5A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.66A 3aicD-1oseA:
7.5		 3aicD-1oseA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		7 / 12 LEU A 162
ARG A 195
ASP A 197
ALA A 198
GLU A 233
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.7A)
AC1  A 992 ( 3.3A)
AC1  A 992 (-3.5A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.64A 3aicE-1oseA:
3.0		 3aicE-1oseA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		7 / 12 LEU A 162
ARG A 195
ASP A 197
ALA A 198
GLU A 233
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.7A)
AC1  A 992 ( 3.3A)
AC1  A 992 (-3.5A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.63A 3aicF-1oseA:
10.5		 3aicF-1oseA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		7 / 12 LEU A 162
ARG A 195
ASP A 197
ALA A 198
GLU A 233
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.7A)
AC1  A 992 ( 3.3A)
AC1  A 992 (-3.5A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.60A 3aicG-1oseA:
11.0		 3aicG-1oseA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		7 / 12 LEU A 162
ARG A 195
ASP A 197
ALA A 198
GLU A 233
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.7A)
AC1  A 992 ( 3.3A)
AC1  A 992 (-3.5A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.67A 3aicH-1oseA:
4.3		 3aicH-1oseA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2v5p CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		4 / 8 GLY A1719
THR A1748
PRO A1749
ILE A1722
 None
None
NAG  A2992 (-3.7A)
None
 0.68A 3el0A-2v5pA:
undetectable		 3el0A-2v5pA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		4 / 7 TYR A 342
ILE A 367
GLY A 359
TYR A  62
 None
None
None
AC1  A 992 ( 3.6A)
 0.93A 3elzA-1oseA:
undetectable		 3elzA-1oseA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
GLY A  25
GLY A  28
VAL A  30
ALA A  43
LYS A  45
MET A  93
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.5A)
 0.81A 3eygA-5isoA:
25.6		 3eygA-5isoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		10 / 12 LEU A  22
GLY A  23
GLY A  25
GLY A  28
VAL A  30
ALA A  43
MET A  93
ASN A 144
LEU A 146
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.82A 3eygA-5isoA:
25.6		 3eygA-5isoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
(Escherichia
coli) 		5 / 12 THR A 112
ASN A 263
LEU A 312
THR A 203
LEU A 305
 None
None
None
AMP  A 992 (-3.7A)
None
 0.98A 3fsuA-3pcoA:
undetectable		 3fsuA-3pcoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
(Escherichia
coli) 		5 / 12 THR A 112
LEU A 267
LEU A 312
THR A 203
LEU A 305
 None
None
None
AMP  A 992 (-3.7A)
None
 1.28A 3fsuA-3pcoA:
undetectable		 3fsuA-3pcoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
GLY A  25
GLY A  28
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
 0.73A 3fupA-5isoA:
26.1		 3fupA-5isoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
GLY A  25
GLY A  28
VAL A  30
ALA A  43
MET A  93
TYR A  95
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-3.5A)
 0.79A 3fupA-5isoA:
26.1		 3fupA-5isoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
GLY A  28
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
 0.78A 3fupA-5isoA:
26.1		 3fupA-5isoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
GLY A  28
VAL A  30
ALA A  43
MET A  93
TYR A  95
LEU A 146
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.74A 3fupA-5isoA:
26.1		 3fupA-5isoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
9 KDA SUBUNIT
(Paracoccus
denitrificans) 		4 / 8 ASP C  49
LEU C  51
LEU A 133
THR A 132
 None
None
HEM  A 992 (-4.4A)
None
 0.75A 3roxA-1pbyC:
undetectable		 3roxA-1pbyC:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		6 / 12 THR A 114
GLY A 116
GLY A 148
TYR A 169
ARG A 190
MET A 237
 MD0  A 993 (-4.0A)
SF4  A 991 ( 3.7A)
SAM  A 992 ( 3.8A)
SAM  A 992 ( 4.6A)
SAM  A 992 (-3.3A)
MD0  A 993 (-3.9A)
 1.03A 3t7vA-3t7vA:
63.9		 3t7vA-3t7vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		12 / 12 THR A 114
GLY A 116
GLY A 148
TYR A 169
GLU A 171
ARG A 182
ARG A 190
LEU A 209
MET A 237
GLN A 242
VAL A 310
ALA A 311
 MD0  A 993 (-4.0A)
SF4  A 991 ( 3.7A)
SAM  A 992 ( 3.8A)
SAM  A 992 ( 4.6A)
SAM  A 992 (-2.8A)
SAM  A 992 ( 2.7A)
SAM  A 992 (-3.3A)
SAM  A 992 (-4.8A)
MD0  A 993 (-3.9A)
SAM  A 992 (-4.2A)
SAM  A 992 (-3.7A)
SAM  A 992 ( 3.8A)
 0.03A 3t7vA-3t7vA:
63.9		 3t7vA-3t7vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
(Escherichia
coli) 		11 / 12 SER A 171
ARG A 195
GLN A 208
GLU A 210
PHE A 248
PHE A 250
THR A 251
GLY A 271
GLY A 273
ALA A 294
GLY A 296
 PHE  A 980 (-3.5A)
AMP  A 992 (-4.0A)
PHE  A 980 ( 3.6A)
PHE  A 980 (-3.0A)
PHE  A 980 (-3.6A)
PHE  A 980 (-4.5A)
PHE  A 980 ( 4.1A)
PHE  A 980 (-4.0A)
None
PHE  A 980 ( 4.0A)
PHE  A 980 (-3.6A)
 0.61A 3tegA-3pcoA:
25.1		 3tegA-3pcoA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
(Escherichia
coli) 		11 / 12 SER A 171
GLN A 174
ARG A 195
GLN A 208
PHE A 248
PHE A 250
THR A 251
GLY A 271
GLY A 273
ALA A 294
GLY A 296
 PHE  A 980 (-3.5A)
PHE  A 980 ( 4.5A)
AMP  A 992 (-4.0A)
PHE  A 980 ( 3.6A)
PHE  A 980 (-3.6A)
PHE  A 980 (-4.5A)
PHE  A 980 ( 4.1A)
PHE  A 980 (-4.0A)
None
PHE  A 980 ( 4.0A)
PHE  A 980 (-3.6A)
 0.65A 3tegA-3pcoA:
25.1		 3tegA-3pcoA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
(Escherichia
coli) 		6 / 9 SER A 171
ARG A 195
GLN A 208
GLU A 210
ALA A 294
GLY A 296
 PHE  A 980 (-3.5A)
AMP  A 992 (-4.0A)
PHE  A 980 ( 3.6A)
PHE  A 980 (-3.0A)
PHE  A 980 ( 4.0A)
PHE  A 980 (-3.6A)
 0.58A 3tehA-3pcoA:
28.6		 3tehA-3pcoA:
45.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT
(Paracoccus
denitrificans) 		3 / 3 LYS A  31
ARG A  42
LEU A 122
 HEM  A 992 (-2.7A)
HEM  A 992 ( 2.7A)
HEM  A 991 (-4.3A)
 1.22A 3v4tE-1pbyA:
undetectable		 3v4tE-1pbyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		5 / 12 LEU A 209
GLU A 171
MET A 226
ILE A 262
ILE A 274
 SAM  A 992 (-4.8A)
SAM  A 992 (-2.8A)
None
None
None
 1.12A 4j24A-3t7vA:
undetectable		 4j24A-3t7vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		5 / 12 LEU A 209
GLU A 171
MET A 226
ILE A 262
ILE A 274
 SAM  A 992 (-4.8A)
SAM  A 992 (-2.8A)
None
None
None
 1.08A 4j24B-3t7vA:
undetectable		 4j24B-3t7vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		5 / 12 LEU A 209
GLU A 171
MET A 226
ILE A 262
ILE A 274
 SAM  A 992 (-4.8A)
SAM  A 992 (-2.8A)
None
None
None
 1.11A 4j24C-3t7vA:
undetectable		 4j24C-3t7vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		5 / 12 LEU A 209
GLU A 171
MET A 226
ILE A 262
ILE A 274
 SAM  A 992 (-4.8A)
SAM  A 992 (-2.8A)
None
None
None
 1.06A 4j26B-3t7vA:
undetectable		 4j26B-3t7vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 301
GLU A 300
PHE A 315
 AMP  A 992 (-3.7A)
None
None
 0.82A 4kszA-3pcoA:
undetectable		 4kszA-3pcoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		4 / 8 VAL A 210
LEU A 170
ASP A 197
ILE A 196
 None
None
AC1  A 992 ( 3.3A)
None
 0.84A 4lzrA-1oseA:
undetectable		 4lzrA-1oseA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		5 / 12 GLU A 134
ARG B 135
ILE A 147
ARG A 142
ARG A 102
 None
None
None
None
HEM  A 992 (-3.7A)
 1.46A 4mwvA-1pbyA:
undetectable		 4mwvA-1pbyA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
(Escherichia
coli) 		5 / 11 ARG A 301
LEU A 305
LEU A 231
LEU A 267
LEU A 239
 AMP  A 992 (-3.7A)
None
None
None
None
 1.34A 4or0A-3pcoA:
undetectable		 4or0A-3pcoA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
GLY A  23
GLY A  28
VAL A  30
ALA A  43
LEU A 146
ALA A 156
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.49A 4otiA-5isoA:
25.2		 4otiA-5isoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		3 / 3 SER A 277
GLU A 171
GLU A 117
 MD0  A 993 (-2.6A)
SAM  A 992 (-2.8A)
None
 0.76A 4ymgB-3t7vA:
undetectable		 4ymgB-3t7vA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		5 / 12 ARG A 195
ASP A 197
GLU A 233
HIS A 299
ASP A 300
 AC1  A 992 ( 3.7A)
AC1  A 992 ( 3.3A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.36A 5csyB-1oseA:
5.1		 5csyB-1oseA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		5 / 12 CYH A  78
GLY A 148
LEU A 168
ARG A 190
TYR A  66
 SF4  A 991 (-2.3A)
SAM  A 992 ( 3.8A)
None
SAM  A 992 (-3.3A)
None
 0.83A 5fepA-3t7vA:
38.3		 5fepA-3t7vA:
30.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		5 / 12 CYH A  78
SER A 146
GLY A 148
LEU A 168
ARG A 190
 SF4  A 991 (-2.3A)
MD0  A 993 (-2.8A)
SAM  A 992 ( 3.8A)
None
SAM  A 992 (-3.3A)
 0.51A 5fepA-3t7vA:
38.3		 5fepA-3t7vA:
30.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		5 / 12 CYH A  78
GLY A 148
LEU A 168
ARG A 190
TYR A  66
 SF4  A 991 (-2.3A)
SAM  A 992 ( 3.8A)
None
SAM  A 992 (-3.3A)
None
 0.80A 5fesA-3t7vA:
38.5		 5fesA-3t7vA:
30.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		5 / 12 CYH A  78
SER A 146
GLY A 148
LEU A 168
ARG A 190
 SF4  A 991 (-2.3A)
MD0  A 993 (-2.8A)
SAM  A 992 ( 3.8A)
None
SAM  A 992 (-3.3A)
 0.51A 5fesA-3t7vA:
38.5		 5fesA-3t7vA:
30.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3t7v METHYLORNITHINE
SYNTHASE PYLB
(Methanosarcina
barkeri) 		4 / 5 SER A 222
GLU A 171
TYR A 169
SER A  76
 None
SAM  A 992 (-2.8A)
SAM  A 992 ( 4.6A)
None
 1.44A 5fhrA-3t7vA:
undetectable		 5fhrA-3t7vA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT
(Komagataella
pastoris) 		4 / 6 SER A 664
GLY A 637
ASN A 636
ILE A 603
 None
None
SO4  A 992 ( 4.0A)
None
 1.16A 5j4nA-3opyA:
undetectable		 5j4nA-3opyA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		4 / 8 VAL A 234
ASP A 236
HIS A 201
GLN A 243
 None
None
AC1  A 992 ( 3.8A)
None
 0.84A 5w3jB-1oseA:
undetectable		 5w3jB-1oseA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		6 / 12 TRP A  58
TYR A  62
GLU A 240
TYR A 151
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.6A)
BGC  A 993 ( 3.3A)
BGC  A 993 (-4.2A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 1.30A 6ag0A-1oseA:
26.7		 6ag0A-1oseA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		9 / 12 TRP A  58
TYR A  62
HIS A 101
GLU A 240
ASP A 197
LYS A 200
HIS A 201
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.6A)
AC1  A 992 ( 3.7A)
BGC  A 993 ( 3.3A)
AC1  A 992 ( 3.3A)
BGC  A 993 ( 2.8A)
AC1  A 992 ( 3.8A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 1.09A 6ag0A-1oseA:
26.7		 6ag0A-1oseA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		9 / 12 TRP A  58
TYR A  62
HIS A 101
LEU A 162
ASP A 197
LYS A 200
HIS A 201
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.6A)
AC1  A 992 ( 3.7A)
None
AC1  A 992 ( 3.3A)
BGC  A 993 ( 2.8A)
AC1  A 992 ( 3.8A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.78A 6ag0A-1oseA:
26.7		 6ag0A-1oseA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		6 / 12 GLU A 240
ASP A 197
LYS A 200
HIS A 201
HIS A 299
ASP A 300
 BGC  A 993 ( 3.3A)
AC1  A 992 ( 3.3A)
BGC  A 993 ( 2.8A)
AC1  A 992 ( 3.8A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 1.01A 6ag0C-1oseA:
26.7		 6ag0C-1oseA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		6 / 12 LEU A 162
ASP A 197
LYS A 200
HIS A 201
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.3A)
BGC  A 993 ( 2.8A)
AC1  A 992 ( 3.8A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.53A 6ag0C-1oseA:
26.7		 6ag0C-1oseA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		6 / 12 TRP A  58
GLU A 240
ASP A 197
LYS A 200
HIS A 201
HIS A 299
 None
BGC  A 993 ( 3.3A)
AC1  A 992 ( 3.3A)
BGC  A 993 ( 2.8A)
AC1  A 992 ( 3.8A)
AC1  A 992 ( 3.9A)
 1.10A 6ag0C-1oseA:
26.7		 6ag0C-1oseA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 1ose PORCINE
ALPHA-AMYLASE
(Sus
scrofa) 		6 / 12 TRP A  58
LEU A 162
ASP A 197
LYS A 200
HIS A 201
HIS A 299
 None
None
AC1  A 992 ( 3.3A)
BGC  A 993 ( 2.8A)
AC1  A 992 ( 3.8A)
AC1  A 992 ( 3.9A)
 0.73A 6ag0C-1oseA:
26.7		 6ag0C-1oseA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
(Escherichia
coli) 		6 / 10 ARG A 195
HIS A 202
PHE A 206
GLU A 268
GLY A 298
ARG A 301
 AMP  A 992 (-4.0A)
AMP  A 992 (-3.6A)
AMP  A 992 (-3.5A)
AMP  A 992 (-3.8A)
AMP  A 992 ( 4.4A)
AMP  A 992 (-3.7A)
 0.80A 6bniA-3pcoA:
15.0		 6bniA-3pcoA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
(Escherichia
coli) 		6 / 10 ARG A 195
HIS A 202
PHE A 206
GLU A 268
GLY A 298
ARG A 301
 AMP  A 992 (-4.0A)
AMP  A 992 (-3.6A)
AMP  A 992 (-3.5A)
AMP  A 992 (-3.8A)
AMP  A 992 ( 4.4A)
AMP  A 992 (-3.7A)
 0.78A 6bniB-3pcoA:
15.8		 6bniB-3pcoA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT
(Paracoccus
denitrificans) 		4 / 5 GLN A 112
THR A  66
HIS A  62
GLY A  35
 HEM  A 992 (-3.1A)
None
None
None
 1.13A 6gbnC-1pbyA:
undetectable		 6gbnC-1pbyA:
23.09