SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '985'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.72A 1fmoE-3f2aA:
23.0		 1fmoE-3f2aA:
26.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
ASN A 787
LEU A 789
ASP A 800
PHE A 946
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
AGS  A1985 (-4.8A)
 0.57A 1fmoE-4crsA:
39.3		 1fmoE-4crsA:
37.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.77A 1iepA-4crsA:
20.6		 1iepA-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
GLY A 743
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 ( 4.5A)
 0.72A 1iepB-4crsA:
16.7		 1iepB-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 GLN B 459
ASP B 460
LEU B 101
ASN B 483
 KR0  B1985 (-3.6A)
None
None
None
 1.26A 1ig3A-5fq6B:
undetectable
1ig3B-5fq6B:
undetectable		 1ig3A-5fq6B:
14.81
1ig3B-5fq6B:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
ALA A 684
TYR A 739
ALA A 740
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
AGS  A1985 (-4.8A)
 0.53A 1muoA-4crsA:
20.6		 1muoA-4crsA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.69A 1opjA-4crsA:
15.9		 1opjA-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
VAL A 721
GLY A 743
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 ( 4.5A)
 0.67A 1opjB-4crsA:
20.4		 1opjB-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.93A 1t46A-4crsA:
20.9		 1t46A-4crsA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.72A 1t46A-4crsA:
20.9		 1t46A-4crsA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 9 LEU A 663
VAL A 671
ALA A 684
MET A 737
ALA A 740
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
AGS  A1985 (-3.9A)
None
AGS  A1985 (-4.8A)
 0.57A 1xbbA-4crsA:
23.6		 1xbbA-4crsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 9 LEU A  44
VAL A  52
LYS A  67
LEU A 106
LEU A 118
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
None
None
 0.65A 1xkkA-3f2aA:
16.9		 1xkkA-3f2aA:
23.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		9 / 10 LEU A  44
PHE A  49
ALA A  65
ILE A 104
LEU A 120
ARG A 122
ASP A 128
LEU A 174
ILE A 185
 985  A   1 (-4.1A)
985  A   1 (-4.0A)
985  A   1 (-3.5A)
985  A   1 ( 4.7A)
985  A   1 (-4.3A)
None
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 (-3.7A)
 0.78A 1yi4A-3f2aA:
44.6		 1yi4A-3f2aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		9 / 10 LEU A  44
PHE A  49
ALA A  65
LEU A 120
ARG A 122
PRO A 123
ASP A 128
LEU A 174
ILE A 185
 985  A   1 (-4.1A)
985  A   1 (-4.0A)
985  A   1 (-3.5A)
985  A   1 (-4.3A)
None
None
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 (-3.7A)
 0.51A 1yi4A-3f2aA:
44.6		 1yi4A-3f2aA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 VAL A  52
LYS A  67
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.7A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.61A 2eufB-3f2aA:
26.7		 2eufB-3f2aA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 VAL A 671
LYS A 686
VAL A 721
ASP A 744
ASN A 787
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.0A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.63A 2eufB-4crsA:
27.1		 2eufB-4crsA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 11 GLY A 666
VAL A 671
ALA A 684
MET A 737
TYR A 739
ALA A 740
LEU A 789
 AGS  A1985 (-2.9A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
AGS  A1985 (-3.9A)
AGS  A1985 (-4.8A)
 0.53A 2evaA-4crsA:
23.2		 2evaA-4crsA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		8 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
ASP A 167
LYS A 169
ASN A 172
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
None
985  A   1 (-4.6A)
985  A   1 ( 4.0A)
 0.84A 2fumA-3f2aA:
21.3		 2fumA-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A 169
ASN A 172
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
985  A   1 (-4.6A)
985  A   1 ( 4.0A)
 0.88A 2fumB-3f2aA:
21.2		 2fumB-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
MET A 737
TYR A 739
LYS A 784
ASN A 787
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
AGS  A1985 ( 3.8A)
MG  A1986 ( 3.2A)
AGS  A1985 ( 3.3A)
 0.69A 2fumB-4crsA:
26.1		 2fumB-4crsA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
MET A 737
TYR A 739
ASN A 787
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
MG  A1986 ( 3.2A)
 0.52A 2fumC-4crsA:
24.6		 2fumC-4crsA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
GLY A  45
GLY A  47
VAL A  52
ALA A  65
LYS A 169
ASN A 172
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
985  A   1 (-4.6A)
 0.81A 2fumD-3f2aA:
19.5		 2fumD-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
GLY A  47
VAL A  52
ALA A  65
LYS A 169
ASN A 172
ASP A 186
 985  A   1 (-4.1A)
None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
985  A   1 (-4.6A)
985  A   1 ( 4.0A)
 0.88A 2fumD-3f2aA:
19.5		 2fumD-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
GLY A 666
VAL A 671
ALA A 684
MET A 737
LYS A 784
ASN A 787
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
AGS  A1985 ( 3.8A)
MG  A1986 ( 3.2A)
 0.90A 2fumD-4crsA:
24.7		 2fumD-4crsA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.60A 2gqgB-4crsA:
24.1		 2gqgB-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.53A 2gqgB-4crsA:
24.1		 2gqgB-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 2hyyA-4crsA:
20.8		 2hyyA-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.72A 2hyyB-4crsA:
20.9		 2hyyB-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.61A 2hyyC-4crsA:
21.0		 2hyyC-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
ILE A 708
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 1.01A 2hyyC-4crsA:
21.0		 2hyyC-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		8 / 12 LEU A  44
GLY A  45
VAL A  52
LYS A  67
GLU A  89
LEU A  93
LEU A 118
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
MG  A 314 ( 4.8A)
None
985  A   1 ( 4.0A)
 0.78A 2ivuA-3f2aA:
20.1		 2ivuA-3f2aA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.77A 2oiqA-4crsA:
4.8		 2oiqA-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
(Aromatoleum
aromaticum) 		4 / 6 THR A 207
ASP A 216
ASN A 218
ASP A 223
 None
None
ACT  A1978 ( 4.2A)
MO  A1985 ( 2.5A)
 1.16A 2okcA-2ivfA:
undetectable		 2okcA-2ivfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 ASN A 563
GLU A 564
TYR A 624
GLU A 645
TRP A 708
 DGJ  A1985 (-2.8A)
EDO  A2021 ( 3.0A)
EDO  A2021 ( 4.4A)
DGJ  A1985 (-2.9A)
DGJ  A1985 (-3.7A)
 0.63A 2v3dA-4cu8A:
15.5		 2v3dA-4cu8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 ASN A 563
GLU A 564
TYR A 624
GLU A 645
TRP A 708
 DGJ  A1985 (-2.8A)
EDO  A2021 ( 3.0A)
EDO  A2021 ( 4.4A)
DGJ  A1985 (-2.9A)
DGJ  A1985 (-3.7A)
 0.65A 2v3dB-4cu8A:
13.4		 2v3dB-4cu8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
ALA A 684
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.69A 2xp2A-4crsA:
8.2		 2xp2A-4crsA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
ALA A 684
LYS A 686
GLU A 705
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.81A 2zvaA-4crsA:
18.6		 2zvaA-4crsA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
ALA A 684
LYS A 686
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.81A 2zvaA-4crsA:
18.6		 2zvaA-4crsA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
ALA A 684
LYS A 686
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.60A 3c7qA-4crsA:
19.9		 3c7qA-4crsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 ALA A 684
GLU A 705
LEU A 720
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 3cs9A-4crsA:
16.3		 3cs9A-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
LEU A 720
GLY A 743
ALA A 799
 AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 ( 4.5A)
 0.70A 3cs9B-4crsA:
17.0		 3cs9B-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 9 LEU A 663
VAL A 671
LYS A 686
VAL A 721
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.8A)
 0.84A 3cs9B-4crsA:
17.0		 3cs9B-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 6 LEU A  44
VAL A  52
LYS A  67
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.8A)
 0.57A 3cs9D-3f2aA:
16.8		 3cs9D-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		3 / 3 ASP A 744
ASP A 800
ASP A 947
 AGS  A1985 (-4.0A)
AGS  A1985 ( 3.3A)
None
 0.77A 3douA-4crsA:
undetectable		 3douA-4crsA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		9 / 12 LEU A  44
GLY A  45
GLY A  50
VAL A  52
ALA A  65
LYS A  67
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.75A 3eygA-3f2aA:
18.5		 3eygA-3f2aA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
GLY A 666
GLY A 669
VAL A 671
ALA A 684
MET A 737
ASN A 787
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
 0.61A 3eygA-4crsA:
18.1		 3eygA-4crsA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
GLY A 669
VAL A 671
ALA A 684
LYS A 686
MET A 737
ASN A 787
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
AGS  A1985 (-4.2A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
 0.64A 3eygA-4crsA:
18.1		 3eygA-4crsA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		8 / 12 LEU A  44
GLY A  45
GLY A  50
VAL A  52
ALA A  65
LYS A  67
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.75A 3fupA-3f2aA:
17.3		 3fupA-3f2aA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
GLY A 666
GLY A 669
VAL A 671
ALA A 684
MET A 737
TYR A 739
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
 0.59A 3fupA-4crsA:
11.5		 3fupA-4crsA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
GLY A 669
VAL A 671
ALA A 684
LYS A 686
MET A 737
TYR A 739
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
 0.69A 3fupA-4crsA:
11.5		 3fupA-4crsA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
GLY A 666
VAL A 671
ALA A 684
LYS A 686
VAL A 721
MET A 737
TYR A 739
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.2A)
None
 0.62A 3fupB-4crsA:
24.2		 3fupB-4crsA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
MET A 737
TYR A 739
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
 0.59A 3fupB-4crsA:
24.2		 3fupB-4crsA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 11 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.45A 3g0eA-4crsA:
19.9		 3g0eA-4crsA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 11 LEU A 663
VAL A 671
ALA A 684
TYR A 739
GLY A 743
ASP A 744
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
 0.53A 3g0fA-4crsA:
20.9		 3g0fA-4crsA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 10 LEU A 663
VAL A 671
ALA A 684
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
 0.38A 3g0fB-4crsA:
14.0		 3g0fB-4crsA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.61A 3g5dA-4crsA:
17.8		 3g5dA-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.79A 3g5dB-4crsA:
17.8		 3g5dB-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 3g5dB-4crsA:
17.8		 3g5dB-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 VAL A  52
ALA A  65
GLU A  89
LEU A  92
LEU A  93
ILE A 104
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
MG  A 314 (-3.6A)
None
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.64A 3gp0A-3f2aA:
17.1		 3gp0A-3f2aA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.68A 3gvuA-4crsA:
21.0		 3gvuA-4crsA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 ALA A  65
LYS A  67
GLU A  89
LEU A  92
LEU A  93
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
MG  A 314 ( 4.8A)
 0.73A 3hecA-3f2aA:
20.7		 3hecA-3f2aA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 ALA A  65
LYS A  67
GLU A  89
LEU A  93
ILE A 104
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.60A 3hecA-3f2aA:
20.7		 3hecA-3f2aA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 VAL A  52
ALA A  65
LYS A  67
LEU A  93
ILE A 104
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.71A 3hegA-3f2aA:
20.4		 3hegA-3f2aA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 MET A 747
HIS A 750
GLY A 742
GLY A 743
LEU A 663
 None
None
None
None
AGS  A1985 (-4.2A)
 1.00A 3i5uA-4crsA:
undetectable		 3i5uA-4crsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 MET A 747
HIS A 750
GLY A 742
GLY A 743
LEU A 663
 None
None
None
None
AGS  A1985 (-4.2A)
 1.01A 3i5uB-4crsA:
undetectable		 3i5uB-4crsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 6 GLU A 564
ASN A 563
SER A 625
PHE A 601
 EDO  A2021 ( 3.0A)
DGJ  A1985 (-2.8A)
None
None
 1.17A 3i9jB-4cu8A:
undetectable		 3i9jB-4cu8A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 ALA A 684
GLU A 705
LEU A 720
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.72A 3ik3A-4crsA:
20.9		 3ik3A-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
LEU A 720
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.61A 3ik3B-4crsA:
20.6		 3ik3B-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.71A 3k5vA-4crsA:
20.4		 3k5vA-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.68A 3k5vB-4crsA:
20.2		 3k5vB-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 8 ALA A  65
LYS A  67
GLU A  89
LEU A 118
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
 0.27A 3lfaA-3f2aA:
20.4		 3lfaA-3f2aA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
MET A 737
TYR A 739
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 ( 4.5A)
 0.74A 3lxkA-4crsA:
24.1		 3lxkA-4crsA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
MET A 737
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.84A 3lxkA-4crsA:
24.1		 3lxkA-4crsA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.82A 3ms9A-4crsA:
20.3		 3ms9A-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.73A 3ms9B-4crsA:
20.5		 3ms9B-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.84A 3mssA-4crsA:
20.5		 3mssA-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.63A 3mssB-4crsA:
20.5		 3mssB-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.70A 3mssB-4crsA:
20.5		 3mssB-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.84A 3mssC-4crsA:
20.5		 3mssC-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
ILE A 708
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.91A 3mssC-4crsA:
20.5		 3mssC-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.77A 3mssD-4crsA:
20.5		 3mssD-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
ALA A 684
ILE A 708
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.88A 3mssD-4crsA:
20.5		 3mssD-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
(Aromatoleum
aromaticum) 		5 / 12 HIS A 194
HIS A 855
HIS A 849
ASP A 223
ILE A 217
 MD1  A1987 (-3.9A)
MGD  A1986 ( 3.6A)
MGD  A1986 (-3.6A)
MO  A1985 ( 2.5A)
None
 1.31A 3njzA-2ivfA:
0.0		 3njzA-2ivfA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.69A 3octA-4crsA:
8.6		 3octA-4crsA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 ALA A 684
GLU A 705
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.73A 3oezA-4crsA:
16.3		 3oezA-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
None
AGS  A1985 (-4.8A)
 0.72A 3oezA-4crsA:
16.3		 3oezA-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.68A 3oezB-4crsA:
16.4		 3oezB-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A  93
ILE A 104
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.68A 3ohtA-3f2aA:
5.1		 3ohtA-3f2aA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A  93
ILE A 104
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.69A 3ohtB-3f2aA:
5.1		 3ohtB-3f2aA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 ALA A 684
GLU A 705
LEU A 720
VAL A 721
GLY A 743
ALA A 799
ASP A 800
 AGS  A1985 (-3.5A)
None
None
None
None
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 1.10A 3oxzA-4crsA:
20.6		 3oxzA-4crsA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.82A 3pyyA-4crsA:
20.4		 3pyyA-4crsA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.69A 3pyyB-4crsA:
20.4		 3pyyB-4crsA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 3qlgA-4crsA:
21.5		 3qlgA-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
VAL A 721
TYR A 739
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.79A 3qlgA-4crsA:
21.5		 3qlgA-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.75A 3qlgA-4crsA:
21.5		 3qlgA-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 3qlgA-4crsA:
21.5		 3qlgA-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.68A 3qlgB-4crsA:
22.0		 3qlgB-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.65A 3qlgB-4crsA:
22.0		 3qlgB-4crsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
TYR A 739
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.70A 3rgfA-4crsA:
16.7		 3rgfA-4crsA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.48A 3sxrA-4crsA:
24.4		 3sxrA-4crsA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.47A 3sxrB-4crsA:
23.9		 3sxrB-4crsA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.84A 3ue4B-4crsA:
23.2		 3ue4B-4crsA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
VAL A  52
ALA A  65
LYS A  67
LEU A 118
ASP A 131
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
None
None
985  A   1 (-4.8A)
 0.95A 3ug2A-3f2aA:
18.3		 3ug2A-3f2aA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 LEU A 673
ILE A 937
GLY A 743
ASP A 791
ALA A 740
 None
None
None
None
AGS  A1985 (-3.9A)
 1.21A 3uj7B-4crsA:
undetectable		 3uj7B-4crsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 GLY A 666
GLY A 669
ALA A 684
LYS A 686
LEU A 688
VAL A 721
ASP A 800
 AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 ( 3.3A)
 0.99A 3v5wA-4crsA:
13.1		 3v5wA-4crsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 GLY A 666
GLY A 669
VAL A 671
ALA A 684
LYS A 686
LEU A 688
VAL A 721
LEU A 789
 AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.90A 3v5wA-4crsA:
13.1		 3v5wA-4crsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 8 VAL A  52
LYS A  67
ILE A 104
ILE A 185
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 ( 4.7A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.45A 3warA-3f2aA:
25.4		 3warA-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 5 ILE A 708
VAL A 721
LEU A 789
ASP A 800
 None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 1.12A 3wzdA-4crsA:
15.7		 3wzdA-4crsA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 5 LYS A 686
ILE A 708
VAL A 721
LEU A 789
 AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.92A 3wzdA-4crsA:
15.7		 3wzdA-4crsA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
ALA A  65
LYS A  67
GLU A  89
HIS A 165
ARG A 166
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
None
985  A   1 (-4.8A)
 0.78A 3zosA-3f2aA:
15.5		 3zosA-3f2aA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
ALA A 684
LYS A 686
GLU A 705
LEU A 773
ARG A 781
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.84A 3zosA-4crsA:
20.6		 3zosA-4crsA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 ALA A  65
LYS A  67
GLU A  89
ILE A 104
HIS A 165
ARG A 166
LEU A 174
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
985  A   1 ( 4.7A)
None
None
985  A   1 (-4.8A)
 0.83A 3zosB-3f2aA:
15.6		 3zosB-3f2aA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 ALA A 684
LYS A 686
GLU A 705
LEU A 773
ARG A 781
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.79A 3zosB-4crsA:
20.7		 3zosB-4crsA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 6 THR A 936
ILE A 937
THR A 951
PHE A 946
 None
None
None
AGS  A1985 (-4.8A)
 0.96A 4acbC-4crsA:
undetectable		 4acbC-4crsA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.67A 4ag8A-4crsA:
20.6		 4ag8A-4crsA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A  93
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
MG  A 314 ( 4.8A)
985  A   1 (-4.8A)
 0.54A 4agcA-3f2aA:
16.3		 4agcA-3f2aA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.8A)
 0.52A 4agcA-4crsA:
15.2		 4agcA-4crsA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 11 LEU A 663
ALA A 684
VAL A 721
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
 0.43A 4agdA-4crsA:
19.9		 4agdA-4crsA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 9 LEU A 663
VAL A 671
ALA A 684
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.78A 4anqA-4crsA:
21.7		 4anqA-4crsA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 9 LEU A 663
VAL A 671
ALA A 684
MET A 737
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.78A 4ansA-4crsA:
21.6		 4ansA-4crsA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
ILE A 708
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 1.33A 4bkjA-4crsA:
20.4		 4bkjA-4crsA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 10 LEU A 663
VAL A 671
ALA A 684
TYR A 739
ALA A 740
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
AGS  A1985 (-4.8A)
 0.46A 4ckjA-4crsA:
24.7		 4ckjA-4crsA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
ILE A 708
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 1.04A 4csvA-4crsA:
17.1		 4csvA-4crsA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 4csvA-4crsA:
17.1		 4csvA-4crsA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		9 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A 118
ASP A 131
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
None
None
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.85A 4i22A-3f2aA:
16.1		 4i22A-3f2aA:
25.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		12 / 12 PHE A  49
VAL A  52
ALA A  65
ILE A 104
ASP A 128
ASP A 131
ASP A 167
LYS A 169
ASN A 172
LEU A 174
ILE A 185
ASP A 186
 985  A   1 (-4.0A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 4.7A)
985  A   1 (-4.7A)
None
None
None
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.67A 4i41A-3f2aA:
44.5		 4i41A-3f2aA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 4 LEU A  44
LEU A 120
GLN A 127
GLU A 171
 985  A   1 (-4.1A)
985  A   1 (-4.3A)
None
None
 0.49A 4i41A-3f2aA:
44.5		 4i41A-3f2aA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		10 / 11 PHE A  49
ALA A  65
LYS A  67
LEU A 120
VAL A 126
ASP A 128
GLU A 171
LEU A 174
ILE A 185
ASP A 186
 985  A   1 (-4.0A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.3A)
None
985  A   1 (-4.7A)
None
985  A   1 (-4.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.56A 4iaaA-3f2aA:
44.3		 4iaaA-3f2aA:
95.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		10 / 11 PHE A  49
VAL A  52
ALA A  65
LYS A  67
LEU A 120
VAL A 126
ASP A 128
GLU A 171
LEU A 174
ILE A 185
 985  A   1 (-4.0A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.3A)
None
985  A   1 (-4.7A)
None
985  A   1 (-4.8A)
985  A   1 (-3.7A)
 0.60A 4iaaA-3f2aA:
44.3		 4iaaA-3f2aA:
95.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 11 VAL A 671
ALA A 684
LYS A 686
ASP A 744
LEU A 789
ASP A 800
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.78A 4iaaA-4crsA:
28.3		 4iaaA-4crsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 GLY A  45
VAL A  52
ALA A  65
LEU A 106
LEU A 118
LEU A 174
ILE A 185
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
None
985  A   1 (-4.8A)
985  A   1 (-3.7A)
 0.66A 4ifgA-3f2aA:
22.9		 4ifgA-3f2aA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 10 ALA A 684
VAL A 721
MET A 737
GLY A 743
LEU A 789
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
 0.34A 4ks8A-4crsA:
28.9		 4ks8A-4crsA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 7 VAL A  52
ALA A  65
ASP A 128
LEU A 174
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
 0.77A 4l9iA-3f2aA:
22.2		 4l9iA-3f2aA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 8 GLY A  47
VAL A  52
ALA A  65
LYS A  67
ASP A 128
 None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.7A)
 0.87A 4l9iB-3f2aA:
23.0		 4l9iB-3f2aA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 8 VAL A  52
ALA A  65
LYS A  67
ASP A 128
LEU A 174
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
 0.92A 4l9iB-3f2aA:
23.0		 4l9iB-3f2aA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
GLY A  50
VAL A  52
ALA A  65
LYS A  67
LEU A 120
ASP A 186
 985  A   1 (-4.1A)
None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.3A)
985  A   1 ( 4.0A)
 1.07A 4mkcA-3f2aA:
17.3		 4mkcA-3f2aA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		8 / 12 LEU A  44
VAL A  52
ALA A  65
LYS A  67
LEU A 120
ASP A 128
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.3A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.86A 4mkcA-3f2aA:
17.3		 4mkcA-3f2aA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLY A 743
ASP A 744
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.66A 4mkcA-4crsA:
22.2		 4mkcA-4crsA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.81A 4mxxB-4crsA:
21.0		 4mxxB-4crsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.85A 4mxyA-4crsA:
22.7		 4mxyA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.93A 4mxyA-4crsA:
22.7		 4mxyA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.83A 4mxyA-4crsA:
22.7		 4mxyA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.81A 4mxyA-4crsA:
22.7		 4mxyA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 ALA A 684
VAL A 721
MET A 737
TYR A 739
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.83A 4mxyB-4crsA:
22.6		 4mxyB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.89A 4mxyB-4crsA:
22.6		 4mxyB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.80A 4mxyB-4crsA:
22.6		 4mxyB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.85A 4mxzA-4crsA:
22.7		 4mxzA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.93A 4mxzA-4crsA:
22.7		 4mxzA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.83A 4mxzA-4crsA:
22.7		 4mxzA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.81A 4mxzA-4crsA:
22.7		 4mxzA-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 ALA A 684
VAL A 721
MET A 737
TYR A 739
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.83A 4mxzB-4crsA:
22.6		 4mxzB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.89A 4mxzB-4crsA:
22.6		 4mxzB-4crsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.80A 4mxzB-4crsA:
22.6		 4mxzB-4crsA:
25.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 11 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A  67
ASN A 172
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.6A)
985  A   1 ( 4.0A)
 0.90A 4o0sA-3f2aA:
23.1		 4o0sA-3f2aA:
30.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 8 VAL A 671
ALA A 684
ASP A 744
ASN A 787
LEU A 789
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.0A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
 0.55A 4ogrA-4crsA:
26.5		 4ogrA-4crsA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 7 ALA A  65
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.68A 4ogrE-3f2aA:
13.1		 4ogrE-3f2aA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 7 ALA A 684
ASP A 744
ASN A 787
LEU A 789
ASP A 800
 AGS  A1985 (-3.5A)
AGS  A1985 (-4.0A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.48A 4ogrE-4crsA:
25.9		 4ogrE-4crsA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 9 VAL A  52
ALA A  65
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.70A 4ogrI-3f2aA:
13.8		 4ogrI-3f2aA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 VAL A 671
ALA A 684
ASP A 744
ASN A 787
LEU A 789
ASP A 800
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.0A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.69A 4ogrI-4crsA:
26.5		 4ogrI-4crsA:
25.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		10 / 12 LEU A 663
GLY A 666
GLY A 669
VAL A 671
ALA A 684
LYS A 686
VAL A 721
LEU A 789
ALA A 799
PHE A 946
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 (-4.8A)
 0.57A 4otiA-4crsA:
26.0		 4otiA-4crsA:
77.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
LYS A 686
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.91A 4otwA-4crsA:
20.2		 4otwA-4crsA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 ALA A 684
GLU A 705
TYR A 739
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.47A 4qmnA-4crsA:
28.8		 4qmnA-4crsA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 11 ALA A 684
LYS A 686
GLU A 705
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.81A 4qmsA-4crsA:
29.0		 4qmsA-4crsA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
LEU A 773
ARG A 781
ALA A 799
 AGS  A1985 (-3.5A)
None
None
TPO  A 816 ( 3.0A)
AGS  A1985 ( 4.5A)
 0.86A 4qrcA-4crsA:
16.0		 4qrcA-4crsA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 5 LEU A 702
SER A 701
ASP A 800
ASP A 786
 None
None
AGS  A1985 ( 3.3A)
None
 1.23A 4qtuD-4crsA:
undetectable		 4qtuD-4crsA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 5 LEU A 663
VAL A 721
TYR A 739
ARG A 781
 AGS  A1985 (-4.2A)
None
None
TPO  A 816 ( 3.0A)
 0.72A 4r7iA-4crsA:
20.5		 4r7iA-4crsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLY A 743
ASN A 787
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.64A 4twpA-4crsA:
23.3		 4twpA-4crsA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLY A 743
ASN A 787
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.54A 4twpB-4crsA:
18.9		 4twpB-4crsA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 6 LEU A 663
VAL A 671
ARG A 781
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
TPO  A 816 ( 3.0A)
None
 0.73A 4tyjA-4crsA:
21.3		 4tyjA-4crsA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 10 LEU A 663
VAL A 671
GLU A 705
VAL A 721
TYR A 739
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
None
None
None
 0.67A 4u0iA-4crsA:
21.0		 4u0iA-4crsA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 11 LEU A 663
GLY A 666
VAL A 671
ALA A 684
TYR A 739
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.70A 4u5jA-4crsA:
17.9		 4u5jA-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 11 LEU A 663
VAL A 671
ALA A 684
TYR A 739
GLY A 743
ASN A 787
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.56A 4u5jA-4crsA:
17.9		 4u5jA-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
ALA A 684
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
 0.58A 4u5jB-4crsA:
17.9		 4u5jB-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 7 VAL A 671
ALA A 740
ARG A 781
ILE A 798
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.9A)
TPO  A 816 ( 3.0A)
None
 0.49A 4uxqA-4crsA:
16.0		 4uxqA-4crsA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.75A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
LYS A 686
TYR A 739
ARG A 781
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
 0.79A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
TYR A 739
ARG A 781
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
None
 0.48A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.68A 4v01B-4crsA:
20.8		 4v01B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
ILE A 708
TYR A 739
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
None
AGS  A1985 (-4.8A)
None
 0.70A 4v01B-4crsA:
20.8		 4v01B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 9 LEU A 663
VAL A 671
LYS A 686
TYR A 739
ARG A 781
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
None
 0.82A 4v01B-4crsA:
20.8		 4v01B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
ALA A 740
ALA A 799
GLY A 802
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
AGS  A1985 ( 4.5A)
None
 1.29A 4v04A-4crsA:
15.0		 4v04A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
GLU A 705
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.75A 4v04A-4crsA:
15.0		 4v04A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 10 LEU A 663
VAL A 671
LYS A 686
TYR A 739
ARG A 781
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
 0.96A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 10 LEU A 663
VAL A 671
TYR A 739
ARG A 781
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
None
 0.79A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 ALA A 684
GLU A 705
ALA A 740
ALA A 799
ASP A 800
GLY A 802
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
None
 1.45A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.75A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 8 LEU A 663
ALA A 684
MET A 737
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
AGS  A1985 (-4.8A)
 0.41A 4wboB-4crsA:
35.4		 4wboB-4crsA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 6 LEU A 663
ALA A 684
MET A 737
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
AGS  A1985 (-4.8A)
 0.45A 4wboC-4crsA:
35.1		 4wboC-4crsA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
ALA A  65
LYS A  67
GLU A  89
LEU A 118
ASP A 131
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
None
985  A   1 (-4.8A)
 0.81A 4wkqA-3f2aA:
23.7		 4wkqA-3f2aA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.74A 4xeyA-4crsA:
22.9		 4xeyA-4crsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
ALA A 684
GLU A 705
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.78A 4xliA-4crsA:
24.0		 4xliA-4crsA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
ALA A 684
LYS A 686
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.79A 4xliB-4crsA:
18.3		 4xliB-4crsA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
ALA A 684
LYS A 686
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.67A 4xliB-4crsA:
18.3		 4xliB-4crsA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 VAL A  52
ALA A  65
LYS A  67
ASP A 186
PHE A 187
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 ( 4.0A)
None
 0.68A 4xv2A-3f2aA:
18.0		 4xv2A-3f2aA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 ALA A  65
LYS A  67
LEU A  93
ASP A 186
PHE A 187
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.0A)
None
 0.78A 4xv2B-3f2aA:
18.1		 4xv2B-3f2aA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 7 GLY A 743
GLY A 742
ALA A 740
ILE A 937
 None
None
AGS  A1985 (-3.9A)
None
 0.73A 4yjiA-4crsA:
undetectable		 4yjiA-4crsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
ALA A 684
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.70A 5aaaA-4crsA:
22.0		 5aaaA-4crsA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 10 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.91A 5aabA-4crsA:
21.7		 5aabA-4crsA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 663
ALA A 684
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.53A 5ajqA-4crsA:
24.8		 5ajqA-4crsA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		9 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.80A 5bvwA-4crsA:
20.5		 5bvwA-4crsA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 VAL A  52
ALA A  65
LYS A  67
LEU A  93
PHE A 187
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
None
 0.71A 5cswA-3f2aA:
22.6		 5cswA-3f2aA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 VAL A  52
ALA A  65
LYS A  67
LEU A  93
PHE A 187
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
None
 0.73A 5cswB-3f2aA:
18.1		 5cswB-3f2aA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 MET A 682
GLU A 941
CYH A 659
CYH A 660
LEU A 663
 None
None
None
None
AGS  A1985 (-4.2A)
 1.42A 5fhzD-4crsA:
undetectable		 5fhzD-4crsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 VAL A  52
ALA A  65
ILE A 104
ASP A 131
PHE A 187
GLY A 188
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 4.7A)
None
None
None
 1.21A 5hesA-3f2aA:
7.0		 5hesA-3f2aA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
LYS A 686
TYR A 739
ALA A 740
PHE A 801
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-3.9A)
None
 0.81A 5hesB-4crsA:
20.8		 5hesB-4crsA:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 7 GLY A  45
LEU A 106
ASP A 186
PHE A 187
 985  A   1 ( 3.9A)
None
985  A   1 ( 4.0A)
None
 0.85A 5hieB-3f2aA:
22.3		 5hieB-3f2aA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 10 ASP A 839
ALA A 799
ILE A 798
PHE A 801
VAL A 712
 None
AGS  A1985 ( 4.5A)
None
None
None
 1.25A 5i6xA-4crsA:
undetectable		 5i6xA-4crsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 GLY A  45
VAL A  52
ALA A  65
ASP A 128
LEU A 174
ASP A 186
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.66A 5l2iA-3f2aA:
22.9		 5l2iA-3f2aA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
VAL A 721
ASP A 744
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.45A 5l2iA-4crsA:
8.0		 5l2iA-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 GLY A  45
VAL A  52
ALA A  65
ASP A 128
LEU A 174
ASP A 186
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.94A 5l2tA-3f2aA:
7.8		 5l2tA-3f2aA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 VAL A 671
ALA A 684
VAL A 721
ASP A 744
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.74A 5l2tA-4crsA:
8.0		 5l2tA-4crsA:
26.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 11 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
ALA A 740
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-3.9A)
AGS  A1985 (-4.8A)
 0.30A 5lvnA-4crsA:
27.1		 5lvnA-4crsA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 10 LEU A 663
VAL A 671
LYS A 686
GLU A 705
GLY A 743
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
None
 0.68A 5mo4A-4crsA:
16.1		 5mo4A-4crsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
LEU A 720
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.56A 5mo4A-4crsA:
12.9		 5mo4A-4crsA:
21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 10 LEU A 663
VAL A 671
ALA A 684
VAL A 721
MET A 737
TYR A 739
LEU A 789
PHE A 946
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
AGS  A1985 (-4.8A)
 0.61A 5n3hA-4crsA:
39.0		 5n3hA-4crsA:
40.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 8 ALA A  65
GLU A  89
LEU A 174
ASP A 186
 985  A   1 (-3.5A)
MG  A 314 (-3.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.58A 5owrA-3f2aA:
16.2		 5owrA-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 8 ALA A 684
GLU A 705
LEU A 789
ASP A 800
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.35A 5owrA-4crsA:
22.9		 5owrA-4crsA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 12 LEU A 673
ALA A 684
GLU A 705
VAL A 721
GLY A 743
LEU A 789
 None
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
 0.39A 5te0A-4crsA:
26.9		 5te0A-4crsA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 LEU A  44
VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A 118
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
 0.68A 5vcyA-3f2aA:
24.9		 5vcyA-3f2aA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 9 LEU A 663
ALA A 684
VAL A 721
MET A 737
GLY A 743
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
 0.64A 5w5vA-4crsA:
14.8		 5w5vA-4crsA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.68A 5y7zA-4crsA:
26.4		 5y7zA-4crsA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.68A 5y7zA-4crsA:
26.4		 5y7zA-4crsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
ALA A  65
LYS A  67
GLU A  89
LEU A 118
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.78A 5y7zB-3f2aA:
26.0		 5y7zB-3f2aA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 LEU A 663
ALA A 684
LYS A 686
GLU A 705
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.69A 5y7zB-4crsA:
26.5		 5y7zB-4crsA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.66A 5y80A-4crsA:
25.8		 5y80A-4crsA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 8 LEU A  44
VAL A  52
LYS A  67
ILE A 185
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.59A 5y9mA-3f2aA:
18.5		 5y9mA-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 8 LEU A  44
VAL A  52
LYS A  67
ILE A 185
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.59A 5y9mX-3f2aA:
24.6		 5y9mX-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 7 VAL A  52
LYS A  67
ILE A 185
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.33A 5yf9B-3f2aA:
18.7		 5yf9B-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 9 LEU A  44
VAL A  52
LYS A  67
ILE A 185
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.58A 5yf9X-3f2aA:
25.0		 5yf9X-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 9 VAL A  52
LYS A  67
ILE A 104
ILE A 185
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 ( 4.7A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.39A 5yf9X-3f2aA:
25.0		 5yf9X-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A 118
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
None
 0.53A 5yu9A-3f2aA:
16.0		 5yu9A-3f2aA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 GLY A  45
VAL A  52
ALA A  65
LEU A 118
ASP A 131
LEU A 174
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
None
985  A   1 (-4.8A)
 0.85A 5yu9B-3f2aA:
16.1		 5yu9B-3f2aA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 7 VAL A  52
LYS A  67
ILE A 104
ILE A 185
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 ( 4.7A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.48A 5ywmX-3f2aA:
19.1		 5ywmX-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
GLU A 705
TYR A 739
ALA A 740
GLY A 743
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.64A 5zv2A-4crsA:
15.8		 5zv2A-4crsA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
ALA A 740
GLY A 743
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.64A 5zv2B-4crsA:
16.1		 5zv2B-4crsA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		3 / 3 TYR A 739
LEU A 789
ASP A 800
 None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.78A 5zv2B-4crsA:
16.1		 5zv2B-4crsA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.69A 6bsdA-4crsA:
20.3		 6bsdA-4crsA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE B 457
VAL B 487
ARG B 485
ASP B 597
 KR0  B1985 (-4.0A)
None
None
None
 1.00A 6hu9a-5fq6B:
undetectable
6hu9e-5fq6B:
undetectable		 6hu9a-5fq6B:
21.61
6hu9e-5fq6B:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 TRP A 708
HIS A 484
THR A 483
GLU A 564
 DGJ  A1985 (-3.7A)
DGJ  A1985 ( 3.8A)
None
EDO  A2021 ( 3.0A)
 0.94A 6mn4E-4cu8A:
undetectable		 6mn4E-4cu8A:
15.08