SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '96V'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5J_A_08HA1_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5v84	CAT EYE SYNDROME CRITICAL REGION PROTEIN 2 (Homo sapiens)	4 / 7	TRP A 457 PRO A 458 ASN A 514 MET A 523	None 96V A 602 (-4.5A) 96V A 602 (-2.6A) None	0.41A	3u5jA-5v84A: 16.2	3u5jA-5v84A: 28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_A_08JA1_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5v84	CAT EYE SYNDROME CRITICAL REGION PROTEIN 2 (Homo sapiens)	5 / 8	TRP A 457 PRO A 458 VAL A 463 ASN A 514 MET A 523	None 96V A 602 (-4.5A) 96V A 602 (-3.9A) 96V A 602 (-2.6A) None	0.28A	3u5kA-5v84A: 16.6	3u5kA-5v84A: 28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_B_08JB2_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5v84	CAT EYE SYNDROME CRITICAL REGION PROTEIN 2 (Homo sapiens)	4 / 7	TRP A 457 PRO A 458 VAL A 463 ASN A 514	None 96V A 602 (-4.5A) 96V A 602 (-3.9A) 96V A 602 (-2.6A)	0.27A	3u5kB-5v84A: 16.5	3u5kB-5v84A: 28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_C_08JC3_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5v84	CAT EYE SYNDROME CRITICAL REGION PROTEIN 2 (Homo sapiens)	5 / 8	TRP A 457 PRO A 458 VAL A 463 ASN A 514 MET A 523	None 96V A 602 (-4.5A) 96V A 602 (-3.9A) 96V A 602 (-2.6A) None	0.35A	3u5kC-5v84A: 16.6	3u5kC-5v84A: 28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_D_08JD4_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5v84	CAT EYE SYNDROME CRITICAL REGION PROTEIN 2 (Homo sapiens)	5 / 8	TRP A 457 PRO A 458 VAL A 463 ASN A 514 MET A 523	None 96V A 602 (-4.5A) 96V A 602 (-3.9A) 96V A 602 (-2.6A) None	0.33A	3u5kD-5v84A: 16.7	3u5kD-5v84A: 28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5v84	CAT EYE SYNDROME CRITICAL REGION PROTEIN 2 (Homo sapiens)	5 / 9	TRP A 457 PRO A 458 VAL A 463 ASN A 514 MET A 523	None 96V A 602 (-4.5A) 96V A 602 (-3.9A) 96V A 602 (-2.6A) None	0.29A	4c66A-5v84A: 16.3	4c66A-5v84A: 28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5PBE_A_TYLA2001_1 (BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B)	5v84	CAT EYE SYNDROME CRITICAL REGION PROTEIN 2 (Homo sapiens)	4 / 6	PRO A 458 VAL A 463 TYR A 471 ASN A 514	96V A 602 (-4.5A) 96V A 602 (-3.9A) None 96V A 602 (-2.6A)	0.54A	5pbeA-5v84A: 16.7	5pbeA-5v84A: 34.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y1Y_A_HNQA201_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5v84	CAT EYE SYNDROME CRITICAL REGION PROTEIN 2 (Homo sapiens)	5 / 8	PRO A 458 VAL A 463 CYH A 510 TYR A 513 ASN A 514	96V A 602 (-4.5A) 96V A 602 (-3.9A) 96V A 602 ( 3.9A) 96V A 602 ( 4.3A) 96V A 602 (-2.6A)	0.43A	5y1yA-5v84A: 16.5	5y1yA-5v84A: 28.87

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3U5J_A_08HA1_1","BROMODOMAIN-CONTAINING PROTEIN 4","5v84","CAT EYE SYNDROME CRITICAL REGION PROTEIN 2","Homo sapiens",4,"TRP A 457;PRO A 458;ASN A 514;MET A 523","None;96V A 602 (-4.5A);96V A 602 (-2.6A);None","0.41A","3u5jA-5v84A:16.2",null],["3U5K_A_08JA1_1","BROMODOMAIN-CONTAINING PROTEIN 4","5v84","CAT EYE SYNDROME CRITICAL REGION PROTEIN 2","Homo sapiens",5,"TRP A 457;PRO A 458;VAL A 463;ASN A 514;MET A 523","None;96V A 602 (-4.5A);96V A 602 (-3.9A);96V A 602 (-2.6A);None","0.28A","3u5kA-5v84A:16.6","3u5jA-5v84A:28.87"],["3U5K_B_08JB2_1","BROMODOMAIN-CONTAINING PROTEIN 4","5v84","CAT EYE SYNDROME CRITICAL REGION PROTEIN 2","Homo sapiens",4,"TRP A 457;PRO A 458;VAL A 463;ASN A 514","None;96V A 602 (-4.5A);96V A 602 (-3.9A);96V A 602 (-2.6A)","0.27A","3u5kB-5v84A:16.5","3u5kA-5v84A:28.87"],["3U5K_C_08JC3_1","BROMODOMAIN-CONTAINING PROTEIN 4","5v84","CAT EYE SYNDROME CRITICAL REGION PROTEIN 2","Homo sapiens",5,"TRP A 457;PRO A 458;VAL A 463;ASN A 514;MET A 523","None;96V A 602 (-4.5A);96V A 602 (-3.9A);96V A 602 (-2.6A);None","0.35A","3u5kC-5v84A:16.6","3u5kB-5v84A:28.87"],["3U5K_D_08JD4_1","BROMODOMAIN-CONTAINING PROTEIN 4","5v84","CAT EYE SYNDROME CRITICAL REGION PROTEIN 2","Homo sapiens",5,"TRP A 457;PRO A 458;VAL A 463;ASN A 514;MET A 523","None;96V A 602 (-4.5A);96V A 602 (-3.9A);96V A 602 (-2.6A);None","0.33A","3u5kD-5v84A:16.7","3u5kC-5v84A:28.87"],["4C66_A_H4CA1168_0","BROMODOMAIN-CONTAINING PROTEIN 4","5v84","CAT EYE SYNDROME CRITICAL REGION PROTEIN 2","Homo sapiens",5,"TRP A 457;PRO A 458;VAL A 463;ASN A 514;MET A 523","None;96V A 602 (-4.5A);96V A 602 (-3.9A);96V A 602 (-2.6A);None","0.29A","4c66A-5v84A:16.3","3u5kD-5v84A:28.87"],["5PBE_A_TYLA2001_1","BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B","5v84","CAT EYE SYNDROME CRITICAL REGION PROTEIN 2","Homo sapiens",4,"PRO A 458;VAL A 463;TYR A 471;ASN A 514","96V A 602 (-4.5A);96V A 602 (-3.9A);None;96V A 602 (-2.6A)","0.54A","5pbeA-5v84A:16.7","4c66A-5v84A:28.87"],["5Y1Y_A_HNQA201_1","BROMODOMAIN-CONTAINING PROTEIN 4","5v84","CAT EYE SYNDROME CRITICAL REGION PROTEIN 2","Homo sapiens",5,"PRO A 458;VAL A 463;CYH A 510;TYR A 513;ASN A 514","96V A 602 (-4.5A);96V A 602 (-3.9A);96V A 602 ( 3.9A);96V A 602 ( 4.3A);96V A 602 (-2.6A)","0.43A","5y1yA-5v84A:16.5","5pbeA-5v84A:34.27"]]